Could a DIY swab replace the pelvic exam for cervical cancer screening?
NCT ID NCT06498661
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether women can collect their own vaginal samples for HPV testing as accurately as a doctor's sample. It involves 750 women referred for colposcopy or cervical procedures. The goal is to see if self-collection is a reliable alternative to traditional pelvic exams, which could make screening easier and more accessible.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Self-collected vaginal sample for HPV testing
- What this could lead to
- If successful, this could make cervical cancer screening more accessible and comfortable, potentially increasing screening rates and catching pre-cancers earlier.
- What could go wrong
- This is an early-phase study focused on accuracy, not on long-term health outcomes. Self-collection may not be as sensitive as clinician collection, and results may vary by device or assay.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Louisiana State University Health Science Center
New Orleans, Louisiana, 70112, United States
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Montefiore Medical Center-Einstein Campus
The Bronx, New York, 10461, United States
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UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, 27599, United States
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UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania, 15213, United States
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UT MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
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University of Puerto Rico
San Juan, 00936, Puerto Rico
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VCU Massey Comprehensive Cancer Center
Richmond, Virginia, 23298, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A gel that could help the cervix heal from HPV?
- A Two-Pronged immune attack against HPV: could it prevent cervical cancer?
- Better swab, better catch: study aims to sharpen anal cancer screening
- New PET tracer could spot cancers that standard scans overlook
- Virtual peer mentoring aims to boost cervical cancer screening in ethiopian HIV clinics
- HPV vaccine trial aims to protect women with HIV from cervical cancer