Immunotherapy combo shows promise against rare sarcoma

NCT ID NCT03141684

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This phase 2 trial tests the immunotherapy drug atezolizumab, alone or with bevacizumab, in 63 people with advanced alveolar soft part sarcoma that cannot be surgically removed. Atezolizumab helps the immune system attack cancer cells, while bevacizumab cuts off the tumor's blood supply. The goal is to see if these drugs can shrink tumors and control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atezolizumab (an immunotherapy drug) and bevacizumab (a drug that blocks blood vessel growth)
What this could lead to: If successful, this could provide a new treatment option for people with advanced alveolar soft part sarcoma, potentially shrinking tumors and controlling the disease.
What could go wrong: This is a phase 2 trial with only 63 participants, so results are preliminary. The drugs may not work for everyone, and side effects from immunotherapy or bleeding risks from bevacizumab are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

alveolar soft part sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC ALVEOLAR SOFT PART SARCOMA UNRESECTABLE ALVEOLAR SOFT PART SARCOMA

Contacts and locations

Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital and Medical Center of Omaha

Omaha, Nebraska, 68114, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Emory University Hospital Midtown

Atlanta, Georgia, 30308, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Keck Medical Center of USC Pasadena

Pasadena, California, 91105, United States
Keck Medicine of USC Buena Park

Buena Park, California, 90621, United States
Keck Medicine of USC Koreatown

Los Angeles, California, 90020, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
NCI - Center for Cancer Research

Bethesda, Maryland, 20892, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032, United States
National Cancer Institute Developmental Therapeutics Clinic

Bethesda, Maryland, 20892, United States
National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Smilow Cancer Center/Yale-New Haven Hospital

New Haven, Connecticut, 06510, United States
Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105, United States
Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital-Orange Care Center

Orange, Connecticut, 06477, United States
Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital-Waterbury Care Center

Waterbury, Connecticut, 06708, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California, 92663, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Yale University

New Haven, Connecticut, 06520, United States
Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, 06473, United States

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