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New hope for rare sarcoma: drug duo targets tumors

NCT ID NCT05333458

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 6 times

Summary

This study tests whether combining two drugs, atezolizumab and selinexor, can shrink tumors in people with a rare cancer called alveolar soft part sarcoma (ASPS). About 27 adults with advanced or spreading ASPS will receive the combination. The goal is to see if this approach works better than current standard treatments like radiation or chemotherapy.

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Conditions

The condition(s) this trial relates to.

alveolar soft part sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED ALVEOLAR SOFT PART SARCOMA ADVANCED SOFT TISSUE SARCOMA METASTATIC ALVEOLAR SOFT PART SARCOMA REFRACTORY ALVEOLAR SOFT PART SARCOMA UNRESECTABLE ALVEOLAR SOFT PART SARCOMA

Contacts and locations

Locations

  • Keck Medicine of USC Koreatown

    RECRUITING

    Los Angeles, California, 90020, United States

  • Los Angeles General Medical Center

    RECRUITING

    Los Angeles, California, 90033, United States

    Contact Email: •••••@•••••

  • MedStar Georgetown University Hospital

    SUSPENDED

    Washington D.C., District of Columbia, 20007, United States

  • National Cancer Institute Developmental Therapeutics Clinic

    RECRUITING

    Bethesda, Maryland, 20892, United States

  • National Institutes of Health Clinical Center

    ACTIVE_NOT_RECRUITING

    Bethesda, Maryland, 20892, United States

  • Ohio State University Comprehensive Cancer Center

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Smilow Cancer Hospital Care Center at Saint Francis

    RECRUITING

    Hartford, Connecticut, 06105, United States

    Contact Email: •••••@•••••

  • Smilow Cancer Hospital Care Center-Trumbull

    RECRUITING

    Trumbull, Connecticut, 06611, United States

    Contact Email: •••••@•••••

  • UPMC Hillman Cancer Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • USC / Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

  • UT MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • University of Oklahoma Health Sciences Center

    RECRUITING

    Oklahoma City, Oklahoma, 73104, United States

  • Yale University

    RECRUITING

    New Haven, Connecticut, 06520, United States

    Contact Email: •••••@•••••

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