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New scan could spare leukemia patients from painful biopsies

NCT ID NCT02392429

Ongoing Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a special PET/CT scan using a radioactive tracer called FLT can measure how well chemotherapy is working in people with newly diagnosed acute myeloid leukemia (AML). The scan lights up fast-growing cancer cells, and researchers want to see if it can predict remission as accurately as a bone marrow biopsy. About 87 adults with untreated AML will get the scan after their first round of chemo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
fluorothymidine F 18 (FLT) radioactive tracer
What this could lead to
If successful, this imaging method could help doctors quickly tell if chemotherapy is working, possibly reducing the need for invasive bone marrow biopsies.
What could go wrong
This is a phase 2 trial with only 87 participants, so results may not apply to all patients. The scan is experimental and not yet proven to replace standard biopsy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah, 84112, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • Mount Sinai Hospital

    New York, New York, 10029, United States

  • UNC Lineberger Comprehensive Cancer Center

    Chapel Hill, North Carolina, 27599, United States

  • UT Southwestern/Simmons Cancer Center-Dallas

    Dallas, Texas, 75390, United States

  • University of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pennsylvania/Abramson Cancer Center

    Philadelphia, Pennsylvania, 19104, United States

  • University of Wisconsin Carbone Cancer Center - University Hospital

    Madison, Wisconsin, 53792, United States

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

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