Stem cell transplant offers lifesaving hope for rare immune disorder

This study tests whether a stem cell transplant from a matched sibling, unrelated donor, or half-matched parent can fix the immune system in people with DOCK8 deficiency, a genetic condition that causes severe infections and cancer. Participants receive chemotherapy and sometimes radiation before the transplant, then drugs to prevent the donor cells from attacking their body. The goal is to reduce life-threatening infections and improve long-term health.