Stem cell transplant offers hope for rare immune disorder

This study tests whether a stem cell transplant from a matched sibling, unrelated donor, or half-matched parent can fix the immune system in people with DOCK8 deficiency, a genetic condition that causes severe infections and cancer. Participants aged 4 to 35 receive chemotherapy and sometimes radiation before the transplant, then drugs to prevent the donor cells from attacking their body. The goal is to reduce life-threatening infections and improve long-term health.