Triple-Drug cocktail shows promise against rare neuroendocrine tumors

NCT ID NCT04079712

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This phase 2 trial is testing a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—in 17 people with advanced neuroendocrine cancer that has spread. The goal is to see if the combination can shrink tumors or stop them from growing. Cabozantinib blocks enzymes that help cancer cells grow, while nivolumab and ipilimumab boost the immune system to attack the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cabozantinib, nivolumab, and ipilimumab
What this could lead to: If this combination works, it could offer a new treatment option for people with advanced neuroendocrine cancer that has not responded to prior therapy.
What could go wrong: This is a small, early-phase trial with only 17 participants, so results may not apply to everyone. The drug combination can cause significant side effects, and it is not yet known if it will improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

large cell neuroendocrine carcinoma neuroendocrine carcinoma neuroendocrine neoplasm small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC LARGE CELL NEUROENDOCRINE CARCINOMA METASTATIC NEUROENDOCRINE CARCINOMA METASTATIC NEUROENDOCRINE NEOPLASM METASTATIC SMALL CELL NEUROENDOCRINE CARCINOMA

Contacts and locations

Locations

Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Farmington Health Center

Farmington, Utah, 84025, United States
HaysMed

Hays, Kansas, 67601, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Los Angeles General Medical Center

Los Angeles, California, 90033, United States
MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States
Siteman Cancer Center at Christian Hospital

St Louis, Missouri, 63136, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Health Truman Medical Center

Kansas City, Missouri, 64108, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Clinical Research Center

Fairway, Kansas, 66205, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Utah Sugarhouse Health Center

Salt Lake City, Utah, 84106, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Wake Forest Baptist Health - Wilkes Medical Center

Wilkesboro, North Carolina, 28659, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Wake Forest University at Clemmons

Clemmons, North Carolina, 27012, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States

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