New combo attack on stubborn cancers shows promise in early trial
NCT ID NCT03728361
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests whether combining the immunotherapy drug nivolumab with the chemotherapy drug temozolomide can shrink tumors in people with small-cell lung cancer that has returned or not responded to treatment, or advanced neuroendocrine tumors. About 55 participants will receive both drugs intravenously and by mouth. The main goal is to see how many patients have their tumors shrink or disappear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab (Opdivo) and temozolomide (Temodar)
- What this could lead to
- If it works, this combination could offer a new treatment option for patients with hard-to-treat small-cell lung cancer or advanced neuroendocrine tumors.
- What could go wrong
- This is a phase II trial with only 55 participants, so results are preliminary. The combination may cause significant side effects and may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ohio State University Comprehensive Cancer Center-COHORT 1
Columbus, Ohio, 43210, United States
-
Ohio State University Comprehensive Cancer Center-COHORT 2
Columbus, Ohio, 43210, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could adding chest radiation extend life in advanced lung cancer?
- Can a black seed extract boost immunotherapy against a rare cancer?
- Can a pill restore the Body's tumor suppressor to fight multiple cancers?
- Can a new drug tame advanced solid tumors?
- Can a remote approach bring clinical trials to lung cancer patients?