New drug cocktail shows promise for Hard-to-Treat thyroid cancer
NCT ID NCT03914300
First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This phase II trial tests a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—in 11 patients with advanced thyroid cancer that no longer responds to radioactive iodine or prior targeted therapy. The goal is to see if this mix can shrink tumors or stop them from growing. The study is active but no longer recruiting, and results are pending.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cabozantinib, nivolumab, and ipilimumab
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced thyroid cancer that has stopped responding to standard therapies.
- What could go wrong
- This is a small, early-phase trial with only 11 participants, so results may not apply to everyone. The drug combination can cause significant side effects, and it is not yet known if it works better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010, United States
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HaysMed
Hays, Kansas, 67601, United States
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Los Angeles General Medical Center
Los Angeles, California, 90033, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920, United States
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Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Memorial Sloan Kettering Commack
Commack, New York, 11725, United States
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Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau
Uniondale, New York, 11553, United States
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Memorial Sloan Kettering Westchester
Harrison, New York, 10604, United States
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Mercy Hospital Pittsburg
Pittsburg, Kansas, 66762, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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Moffitt Cancer Center - McKinley Campus
Tampa, Florida, 33612, United States
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Moffitt Cancer Center-International Plaza
Tampa, Florida, 33607, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Salina Regional Health Center
Salina, Kansas, 67401, United States
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The University of Kansas Cancer Center - Olathe
Olathe, Kansas, 66061, United States
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UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, 15232, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California, 92663, United States
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University Health Truman Medical Center
Kansas City, Missouri, 64108, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri, 64064, United States
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University of Kansas Cancer Center - North
Kansas City, Missouri, 64154, United States
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University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri, 64116, United States
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University of Kansas Cancer Center-Overland Park
Overland Park, Kansas, 66210, United States
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University of Kansas Clinical Research Center
Fairway, Kansas, 66205, United States
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University of Kansas Health System Saint Francis Campus
Topeka, Kansas, 66606, United States
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University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205, United States
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University of Kentucky/Markey Cancer Center
Lexington, Kentucky, 40536, United States
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University of Utah Sugarhouse Health Center
Salt Lake City, Utah, 84106, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A radioactive clue that could spare thousands from thyroid surgery
- New hope for Hard-to-Treat thyroid cancer: drug XL092 enters human trials
- New online tool aims to ease cancer worry in young adults
- Coaching boosts thyroid cancer recovery
- New scan could spot hidden thyroid cancer better
- New hope for rare, aggressive thyroid cancer: drug combo shows promise