New drug aims to shrink polyps in inherited colon cancer condition

NCT ID NCT06557733

Terminated Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This phase 2 trial tests whether the drug TPST-1495 can reduce the number and size of polyps in the small bowel and colon of people with familial adenomatous polyposis (FAP), an inherited condition that greatly raises colon cancer risk. About 38 participants will take the drug by mouth and undergo endoscopies to measure polyp changes. The study is currently on hold.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TPST-1495 (a drug that blocks certain prostaglandin receptors to reduce polyp growth)
What this could lead to: If it works, this could offer a new way to reduce polyp burden in people with FAP, potentially lowering their cancer risk without needing more surgeries.
What could go wrong: This is a small, early-phase trial (38 people) that is currently suspended. The drug may not shrink polyps enough, and side effects could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Adenomatous Polyposis Coli classic familial adenomatous polyposis colorectal carcinoma colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CARCINOMA FAMILIAL ADENOMATOUS POLYPOSIS

Contacts and locations

Locations

Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States

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