Could a simple Self-Swap replace the speculum for cervical cancer screening?

NCT ID NCT06611540

Ongoing Diagnosis Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This study compares self-collected vaginal samples to clinician-collected samples for HPV testing in 500 people referred for colposcopy. The goal is to see if self-collection is accurate enough to improve cervical cancer screening rates. Participants will provide both types of samples, and researchers will measure how well each detects precancerous changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HPV Self-Collection
What this could lead to: If successful, this could make cervical cancer screening easier and more accessible by allowing people to collect their own samples at home.
What could go wrong: This is an early-stage study focused on accuracy, not on preventing cancer directly. Self-collection may be less sensitive than clinician-collected samples, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical carcinoma human papilloma virus infection Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CARCINOMA HUMAN PAPILLOMAVIRUS INFECTION

Contacts and locations

Locations

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Minneapolis VA Medical Center

Minneapolis, Minnesota, 55417, United States
Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
UofL Health Medical Center Northeast

Louisville, Kentucky, 40245, United States

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