Could an immune booster before kidney surgery keep cancer away?

NCT ID NCT03055013

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 28, 2026 · Updated 6 times

Summary

This phase 3 trial tests whether adding the immune-boosting drug nivolumab before and after kidney cancer surgery can prevent the cancer from coming back. About 819 patients with localized kidney cancer are randomly assigned to receive either surgery alone or surgery plus nivolumab. The main goal is to see if the combination improves the chance of staying cancer-free for five years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Nivolumab (a drug that helps the immune system attack cancer cells)
What this could lead to: If it works, this could offer a new standard treatment to reduce the risk of kidney cancer coming back after surgery.
What could go wrong: This is a large phase 3 trial, but results are not yet final. Nivolumab can cause immune-related side effects, and it may not prove better than surgery alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

819 people

The number who actually took part.

Started

Apr 2017

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ELIGIBILITY CRITERIA FOR RANDOMIZATION: * Patients must have a renal mass consistent with a clinical stage \>= T2Nx renal cell carcinoma (RCC) or TanyN+ RCC for which radical or partial nephrectomy is planned * Patients must have no clinical or radiological evidence of distant metastases (M0) unless the presumed M1 disease is planned to be resected/definitively treated (e.g., thermal ablation, stereotactic radiation) at the same time or up to 12 weeks after the date of the initial procedure such that the patient is considered "no evidence of disease" (M1 NED) * Liver, bone, or brain metastases are not permitted * No more than 3 metastases are permitted, and all must be able to be removed or definitively treated within 12 weeks of the primary tumor resection * If histological confirmation of RCC has not been done within 12 months prior to randomization, patient must be willing to undergo a core biopsy for this purpose if randomized to Arm A * NOTE: This histologic confirmation can be a (1) standard of care diagnostic biopsy or (2) a research biopsy or a planned metastasectomy. Tissue must be obtained with results available prior to the neoadjuvant dose * Patients randomized to Arm A: core tumor biopsy must have demonstrated RCC of any histology, including sarcomatoid, unclassified, or "unknown histology" (if preoperative biopsy was uninformative) with exception below for non-diagnostic biopsies * If the biopsy performed following randomization clearly demonstrates a benign condition, oncocytoma or a different type of cancer that is not RCC, the patient is not eligible and must come off study * A non-diagnostic biopsy is considered a good faith effort and does not need to be repeated unless deemed clinically necessary by the treating investigator * Patient must not have any prior systemic or local anti-cancer therapy for the current RCC * Patient must not have undergone a partial nephrectomy for the current RCC * Patient must not have had a metastasectomy for the current RCC diagnosis unless performed to render patient NED (in addition to the planned nephrectomy) within 6 months prior to the current diagnosis * Patient must not have received current or past antineoplastic systemic therapies for RCC: i.e., chemotherapy, hormonal therapy, immunotherapy, or standard or investigational agents for treatment of RCC * Patient must not have received prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 antibody, or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways * Patient must be \>= 18 years of age. Because no dosing or adverse event data are currently available on the use of nivolumab therapy in patients \< 18 years of age, children are excluded from this study * Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Patient must not have a prior history of RCC that was treated with curative intent within the past 5 years * Patients with a prior RCC that was treated \> 5 years before, are eligible if the current tumor is consistent with a new primary in the opinion of the treating investigator * Patients with bilateral synchronous RCCs are eligible if they can be resected or definitively treated at the same time or within a 12 week window from time of initial nephrectomy (partial or radical) or procedure and maintain adequate residual renal function; the patient is not eligible if both kidneys are to be completely removed and subsequent hemodialysis will be required * Permitted forms of local therapy for second tumor: * Partial or radical nephrectomy * If kidney tumor is =\< 3 cm: thermal ablation (e.g., radiofrequency ablation, cryoablation or stereotactic radiosurgery) * Patients cannot have concurrent malignancies, with the following exceptions: * Adequately treated basal cell or squamous cell skin cancer * In situ cervical cancer * A history of superficial Ta urothelial cancer is permitted (as long as not currently undergoing treatment) whereas T1 or greater disease is excluded if \< 3 years from diagnosis; concurrent persistent disease is not permitted * Adequately treated stage I or II cancer from which the patient is currently in complete remission * Any other cancer and stage from which the patient has been disease-free for at least 3 years prior to the time of randomization and as long as they are not receiving any current treatment (e.g. adjuvant or maintenance systemic or local therapy) * Concurrent low risk prostate cancer on active surveillance * Patient must not have active known or suspected autoimmune disease. The following autoimmune disorders are permitted: patients with vitiligo, type I diabetes mellitus, controlled/stable hypo or hyperthyroidism due to autoimmune or non-autoimmune conditions (hormone replacement is allowed), psoriasis not requiring systemic treatment, or other conditions not expected to recur * Patient must not have any ongoing condition requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalent) or other immunosuppressive medications with the exceptions outlined below; patient must not have received any treatment with other immunosuppressive agents within 14 days prior to the first dose of study drug with the following exceptions: * Topical, ocular, intra-articular, intranasal, inhaled steroids and adrenal replacement steroid doses \> 10 mg daily prednisone or the equivalent are permitted in the absence of active autoimmune disease * A brief (less than 3 weeks) course of corticosteroids (any amount) for prophylaxis (for example: contrast dye allergy) or for treatment of non-autoimmune conditions (for example: nausea, delayed-type hypersensitivity reaction caused by a contact allergen) is permitted * Patient must not have uncontrolled adrenal insufficiency * Patient must not have known evidence of chronic active liver disease or evidence of acute or chronic hepatitis B Virus (HBV) or hepatitis C (HCV); HBV and HCV testing must be completed within 8 weeks prior to randomization * NOTE: If the patient has been treated and cured, and the HCV ribonucleic acid (RNA) is undetectable, the patient is eligible for this study * Patient must not have any serious intercurrent illness, including ongoing or active infection requiring parenteral antibiotics * Patient must not have known evidence of human immunodeficiency virus (HIV) infection, since the effects of nivolumab on anti-retroviral therapy have not been studied; HIV testing is only required if past or current history is suspected * Patient must not have any known medical condition (e.g. a condition associated with uncontrolled diarrhea such as ulcerative colitis or acute diverticulitis) that, in the investigator's opinion, would increase the risk associated with study participation or interfere with the interpretation of safety results * Patient must not have had any major surgery within 28 days prior to randomization * Patient must not be currently enrolled in other clinical trials testing a therapeutic intervention * Patient must not have any history of severe hypersensitivity to a monoclonal antibody * Patient must have the ability to understand and the willingness to sign a written informed consent document * Patients must not be pregnant or breast-feeding, as the effects of nivolumab on the developing human fetus or in the nursing infant are unknown; all patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a patient of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months) * Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception, as described in the informed consent form (ICF), or by abstaining from sexual intercourse for the duration of their participation in the study; patients of childbearing potential must use adequate methods to avoid pregnancy for 5 months after the last dose of nivolumab * White blood cells \>= 2000/uL (within 8 weeks prior to randomization) * Absolute neutrophil count (ANC) \>= 1,500/mm\^3 (within 8 weeks prior to randomization) * Platelet count \>= 100,000/mm\^3 (within 8 weeks prior to randomization) * Hemoglobin \>= 9.0 g/dL (within 8 weeks prior to randomization) * Serum creatinine =\< 1.5 x upper limit of normal (ULN) or calculated creatinine clearance (CrCl) \>= 40mL/min (within 8 weeks prior to randomization) * Total bilirubin =\< 1.5 x ULN (except subjects with Gilbert syndrome, who can have total bilirubin \< 3.0 x ULN) (within 8 weeks prior to randomization) * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x ULN (within 8 weeks prior to randomization)

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Conditions

The condition(s) this trial relates to.

renal cell adenocarcinoma renal cell carcinoma sarcomatoid renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metastatic renal cell carcinoma Sarcomatoid renal cell carcinoma Stage II renal cell cancer ajcc V7 Stage III renal cell cancer ajcc V7 Unclassified renal cell carcinoma

Contacts and locations

Locations

AIS Cancer Center at San Joaquin Community Hospital

Bakersfield, California, 93301, United States
Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Albany Medical Center

Albany, New York, 12208, United States
Alta Bates Summit Medical Center-Herrick Campus

Berkeley, California, 94704, United States
Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada
Asante Rogue Regional Medical Center

Medford, Oregon, 97504, United States
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield

Brookfield, Wisconsin, 53045, United States
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa

Wauwatosa, Wisconsin, 53226, United States
Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States
Aspirus Cancer Care-Antigo-Volm Cancer Center

Antigo, Wisconsin, 54409, United States
Aspirus Cancer Care-Wausau

Wausau, Wisconsin, 54401, United States
Aspirus Medford Hospital

Medford, Wisconsin, 54451, United States
Atlanta VA Medical Center

Decatur, Georgia, 30033, United States
Audie L Murphy VA Hospital

San Antonio, Texas, 78229, United States
Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209, United States
Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226, United States
Aurora Cancer Care-Racine

Racine, Wisconsin, 53406, United States
Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105, United States
Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022, United States
Aurora Health Center-Fond du Lac

Fond du Lac, Wisconsin, 54937, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Baptist MD Anderson Cancer Center

Jacksonville, Florida, 32207, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
Ben Taub General Hospital

Houston, Texas, 77030, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care

Winchester, Massachusetts, 01890, United States
Bethesda North Hospital

Cincinnati, Ohio, 45242, United States
Beverly Hospital

Beverly, Massachusetts, 01915, United States
Bon Secours Memorial Regional Medical Center

Mechanicsville, Virginia, 23116, United States
Bon Secours Saint Francis Medical Center

Midlothian, Virginia, 23114, United States
Bon Secours Saint Mary's Hospital

Richmond, Virginia, 23226, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
CHUM - Centre Hospitalier de l'Universite de Montreal

Montreal, Quebec, H2X 3E4, Canada
California Pacific Medical Center-Pacific Campus

San Francisco, California, 94115, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Care and Hematology-Fort Collins

Fort Collins, Colorado, 80528, United States
Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States
CancerCare Manitoba

Winnipeg, Manitoba, R3E 0V9, Canada
Carle Cancer Center

Urbana, Illinois, 61801, United States
Carle Physician Group-Effingham

Effingham, Illinois, 62401, United States
Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938, United States
Carle at The Riverfront

Danville, Illinois, 61832, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont

Sherbrooke, Quebec, J1H 5N4, Canada
Chelsea Hospital

Chelsea, Michigan, 48118, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303, United States
Community Cancer Institute

Clovis, California, 93611, United States
Comprehensive Cancer Centers of Nevada - Central Valley

Las Vegas, Nevada, 89169, United States
Comprehensive Cancer Centers of Nevada - Town Center

Las Vegas, Nevada, 89144, United States
Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
Cotton O'Neil Cancer Center / Stormont Vail Health

Topeka, Kansas, 66606, United States
Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Dickstein Cancer Treatment Center

White Plains, New York, 10601, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
ECU Health Oncology Kenansville

Kenansville, North Carolina, 28349, United States
ECU Health Oncology Kinston

Kinston, North Carolina, 28501, United States
ECU Health Oncology Richlands

Richlands, North Carolina, 28574, United States
East Jefferson General Hospital

Metairie, Louisiana, 70006, United States
Eastern Connecticut Hematology and Oncology Associates

Norwich, Connecticut, 06360, United States
Eastern Maine Medical Center

Bangor, Maine, 04401, United States
Edward Hines Jr VA Hospital

Hines, Illinois, 60141, United States
Edward Hospital/Cancer Center

Naperville, Illinois, 60540, United States
Edward Hospital/Cancer Center?Plainfield

Plainfield, Illinois, 60585, United States
Eisenhower Medical Center

Rancho Mirage, California, 92270, United States
Elmhurst Memorial Hospital

Elmhurst, Illinois, 60126, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Englewood Hospital and Medical Center

Englewood, New Jersey, 07631, United States
Farmington Health Center

Farmington, Utah, 84025, United States
Fox Chase Cancer Center

Philadelphia, Pennsylvania, 19111, United States
Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States
Franciscan Health Mooresville

Mooresville, Indiana, 46158, United States
Fred Hutchinson Cancer Center

Seattle, Washington, 98109, United States
Fremont - Rideout Cancer Center

Marysville, California, 95901, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161, United States
George Washington University Medical Center

Washington D.C., District of Columbia, 20037, United States
Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Glens Falls Hospital

Glens Falls, New York, 12801, United States
Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204, United States
Gulfport Memorial Hospital

Gulfport, Mississippi, 39502, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Harold Alfond Center for Cancer Care

Augusta, Maine, 04330, United States
Hartford Hospital

Hartford, Connecticut, 06102, United States
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
HaysMed

Hays, Kansas, 67601, United States
Henry Ford Health Providence Novi Hospital

Novi, Michigan, 48374, United States
Henry Ford Health Providence Southfield Hospital

Southfield, Michigan, 48075, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202, United States
James J Peters VA Medical Center

The Bronx, New York, 10468, United States
Johns Hopkins University/Sidney Kimmel Cancer Center

Baltimore, Maryland, 21287, United States
Juravinski Cancer Centre at Hamilton Health Sciences

Hamilton, Ontario, L8V 5C2, Canada
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kaiser Permanente - Panorama City

Panorama City, California, 91402, United States
Kaiser Permanente Downtown Commons

Sacramento, California, 95814, United States
Kaiser Permanente Los Angeles Medical Center

Los Angeles, California, 90027, United States
Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051, United States
Kaiser Permanente Northwest

Portland, Oregon, 97227, United States
Kaiser Permanente Sacramento Medical Center

Sacramento, California, 95825, United States
Kaiser Permanente San Leandro

San Leandro, California, 94577, United States
Kaiser Permanente South Bay

Harbor City, California, 90710, United States
Kaiser Permanente West Los Angeles

Los Angeles, California, 90034, United States
Kaiser Permanente-Anaheim

Anaheim, California, 92806, United States
Kaiser Permanente-Baldwin Park

Baldwin Park, California, 91706, United States
Kaiser Permanente-Bellflower

Bellflower, California, 90706, United States
Kaiser Permanente-Fontana

Fontana, California, 92335, United States
Kaiser Permanente-Irvine

Irvine, California, 92618, United States
Kaiser Permanente-Oakland

Oakland, California, 94611, United States
Kaiser Permanente-Ontario

Ontario, California, 91761, United States
Kaiser Permanente-Riverside

Riverside, California, 92505, United States
Kaiser Permanente-Roseville

Roseville, California, 95661, United States
Kaiser Permanente-San Diego Zion

San Diego, California, 92120, United States
Kaiser Permanente-San Francisco

San Francisco, California, 94115, United States
Kaiser Permanente-San Marcos

San Marcos, California, 92078, United States
Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119, United States
Kaiser Permanente-South San Francisco

South San Francisco, California, 94080, United States
Kaiser Permanente-Vallejo

Vallejo, California, 94589, United States
Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596, United States
Kaiser Permanente-Woodland Hills

Woodland Hills, California, 91367, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Kingston Health Sciences Centre

Kingston, Ontario, K7L 2V7, Canada
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
LSU Health Baton Rouge-North Clinic

Baton Rouge, Louisiana, 70805, United States
LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, 71103, United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006, United States
Lafayette Family Cancer Center-EMMC

Brewer, Maine, 04412, United States
Lahey Clinic

Burlington, Massachusetts, 01805, United States
Lakeland Regional Health Hollis Cancer Center

Lakeland, Florida, 33805, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lexington Health

West Columbia, South Carolina, 29169, United States
London Regional Cancer Program

London, Ontario, N6A 4L6, Canada
Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States
Louisiana Hematology Oncology Associates LLC

Baton Rouge, Louisiana, 70809, United States
Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States
MaineHealth Cancer Care and IV Therapy - Sanford

Sanford, Maine, 04073, United States
MaineHealth Cancer Care and IV Therapy - South Portland

South Portland, Maine, 04106, United States
MaineHealth Maine Medical Center - Biddeford

Biddeford, Maine, 04005, United States
MaineHealth Waldo Hospital

Belfast, Maine, 04915, United States
Marshfield Clinic-Wausau Center

Wausau, Wisconsin, 54401, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mary Greeley Medical Center

Ames, Iowa, 50010, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
McFarland Clinic - Ames

Ames, Iowa, 50010, United States
McFarland Clinic - Boone

Boone, Iowa, 50036, United States
McFarland Clinic - Jefferson

Jefferson, Iowa, 50129, United States
McFarland Clinic - Marshalltown

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center

Fort Dodge, Iowa, 50501, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Medical Center of the Rockies

Loveland, Colorado, 80538, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Meharry Medical College

Nashville, Tennessee, 37208, United States
Memorial Hospital North

Colorado Springs, Colorado, 80920, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Mercy Cancer Center-West Lakes

Clive, Iowa, 50325, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Pittsburg

Pittsburg, Kansas, 66762, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Medical Center - Des Moines

Des Moines, Iowa, 50314, United States
Mercy Medical Center-West Lakes

West Des Moines, Iowa, 50266, United States
MetroHealth Medical Center

Cleveland, Ohio, 44109, United States
Miami Cancer Institute

Miami, Florida, 33176, United States
Midstate Medical Center

Meriden, Connecticut, 06451, United States
Mills-Peninsula Medical Center

Burlingame, California, 94010, United States
Minneapolis VA Medical Center

Minneapolis, Minnesota, 55417, United States
Miriam Hospital

Providence, Rhode Island, 02906, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Montefiore Medical Center - Moses Campus

The Bronx, New York, 10467, United States
Montefiore Medical Center-Einstein Campus

The Bronx, New York, 10461, United States
Montefiore Medical Center-Weiler Hospital

The Bronx, New York, 10461, United States
NYP/Weill Cornell Medical Center

New York, New York, 10065, United States
Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
Niagara Health System-Saint Catharines General

Saint Catharines, Ontario, L2S 0A9, Canada
Northshore Oncology Associates-Covington

Covington, Louisiana, 70433, United States
Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042, United States
Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States
Northwestern University

Chicago, Illinois, 60611, United States
Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, 27103, United States
Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121, United States
Odette Cancer Centre- Sunnybrook Health Sciences Centre

Toronto, Ontario, M4N 3M5, Canada
Oncology Center of The South Incorporated

Houma, Louisiana, 70360, United States
Onslow Memorial Hospital

Jacksonville, North Carolina, 28546, United States
OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102, United States
OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89183, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Our Lady of the Lake Physician Group

Baton Rouge, Louisiana, 70808, United States
Pacific Central Coast Health Center-San Luis Obispo

San Luis Obispo, California, 93401, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Palo Alto Medical Foundation Health Care

Palo Alto, California, 94301, United States
Palo Alto Medical Foundation-Camino Division

Mountain View, California, 94040, United States
Palo Alto Medical Foundation-Santa Cruz

Santa Cruz, California, 95065, United States
Palo Alto Medical Foundation-Sunnyvale

Sunnyvale, California, 94086, United States
Parkview Regional Medical Center

Fort Wayne, Indiana, 46845, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Penobscot Bay Medical Center

Rockport, Maine, 04856, United States
Poudre Valley Hospital

Fort Collins, Colorado, 80524, United States
Presbyterian Intercommunity Hospital

Whittier, California, 90602, United States
Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Laurens

Clinton, South Carolina, 29325, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045, United States
QEII Health Sciences Centre/Nova Scotia Health Authority

Halifax, Nova Scotia, B3H 2Y9, Canada
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Ralph H Johnson VA Medical Center

Charleston, South Carolina, 29401, United States
Rambam Medical Center

Haifa, 31096, Israel
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Reid Health

Richmond, Indiana, 47374, United States
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson

Franklin, Wisconsin, 53132, United States
Renown Regional Medical Center

Reno, Nevada, 89502, United States
Rex Hematology Oncology Associates-Blue Ridge

Raleigh, North Carolina, 27607, United States
Rhode Island Hospital

Providence, Rhode Island, 02903, United States
Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903, United States
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital

New Brunswick, New Jersey, 08903, United States
Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States
Saint Francis Hospital

Greenville, South Carolina, 29601, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Joseph Medical Center Hematology and Oncology - Silverdale

Silverdale, Washington, 98383, United States
Saint Joseph's Healthcare Charlton Campus

Hamilton, Ontario, L8N 4A6, Canada
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's Hospital

Chesterfield, Missouri, 63017, United States
Salina Regional Health Center

Salina, Kansas, 67401, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Broadway Medical Center

Fargo, North Dakota, 58122, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Shaare Zedek Medical Center

Jerusalem, 91031, Israel
Sibley Memorial Hospital

Washington D.C., District of Columbia, 20016, United States
Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, 46202, United States
Simonds-Sinon Regional Cancer Center

Fitchburg, Massachusetts, 01420, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
South Jordan Health Center

South Jordan, Utah, 84009, United States
Southeastern Medical Oncology Center-Clinton

Clinton, North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro

Goldsboro, North Carolina, 27534, United States
Southeastern Medical Oncology Center-Jacksonville

Jacksonville, North Carolina, 28546, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Sovah Health Martinsville

Martinsville, Virginia, 24112, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
State University of New York Upstate Medical University

Syracuse, New York, 13210, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Summa Health System - Akron Campus

Akron, Ohio, 44304, United States
Sutter Auburn Faith Hospital

Auburn, California, 95602, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Sutter Roseville Medical Center

Roseville, California, 95661, United States
Sutter Solano Medical Center/Cancer Center

Vallejo, California, 94589, United States
Temple University Hospital

Philadelphia, Pennsylvania, 19140, United States
The Carle Foundation Hospital

Urbana, Illinois, 61801, United States
The Hospital of Central Connecticut

New Britain, Connecticut, 06050, United States
The Moncton Hospital

Moncton, New Brunswick, E1C 6Z8, Canada
The University of Kansas Cancer Center - Olathe

Olathe, Kansas, 66061, United States
The Watson Clinic

Lakeland, Florida, 33805, United States
ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911, United States
Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Tulane University School of Medicine

New Orleans, Louisiana, 70112, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth Greeley Hospital

Greeley, Colorado, 80631, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, 90095, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UH Seidman Cancer Center at Saint John Medical Center

Westlake, Ohio, 44145, United States
UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130, United States
UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic

Clive, Iowa, 50325, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
UMass Memorial Medical Center - University Campus

Worcester, Massachusetts, 01655, United States
UNC Health Cancer Care Cary

Cary, North Carolina, 27518, United States
UNC Health Cancer Care Raleigh

Raleigh, North Carolina, 27607, United States
UNC Health Cancer Care Wakefield

Raleigh, North Carolina, 27614, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States
UPMC Susquehanna

Williamsport, Pennsylvania, 17701, United States
USC / Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
USC Norris Oncology/Hematology-Newport Beach

Newport Beach, California, 92663, United States
UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, 75080, United States
UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390, United States
UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, 76104, United States
UTMB Cancer Center at Victory Lakes

League City, Texas, 77573, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
University Cancer Center

Las Vegas, Nevada, 89169, United States
University Health Network-Princess Margaret Hospital

Toronto, Ontario, M5G 2M9, Canada
University Health Truman Medical Center

Kansas City, Missouri, 64108, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Illinois

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of Michigan Rogel Cancer Center

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pennsylvania/Abramson Cancer Center

Philadelphia, Pennsylvania, 19104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Texas Medical Branch

Galveston, Texas, 77555-0565, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
University of Vermont and State Agricultural College

Burlington, Vermont, 05405, United States
University of Virginia Cancer Center

Charlottesville, Virginia, 22908, United States
University of Washington Medical Center - Montlake

Seattle, Washington, 98195, United States
University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038, United States
University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792, United States
VA Palo Alto Health Care System

Palo Alto, California, 94304, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Veterans Administration Medical Center - Birmingham

Birmingham, Alabama, 35233, United States
Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904, United States
Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Wake Forest University Health Sciences

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne Memorial Hospital

Goldsboro, North Carolina, 27534, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
William S Middleton VA Medical Center

Madison, Wisconsin, 53705, United States
Windsor Regional Cancer Centre

Windsor, Ontario, N8W 2X3, Canada
Woodland Cancer Care Center

Michigan City, Indiana, 46360, United States
Yale University

New Haven, Connecticut, 06520, United States

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