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DNA vaccine trial aims to train immune system against hepatitis c

NCT ID NCT02772003

Ongoing Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This early-stage trial tests a DNA vaccine called INO-8000, given with an immune booster, to see if it can help people with chronic hepatitis C fight the virus. The study involves 33 participants and focuses on safety and finding the best dose. The vaccine is delivered through injection and a brief electrical pulse to help cells take up the DNA.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
DNA vaccine (INO-8000) with an immune booster (INO-9012) given via injection and electroporation
What this could lead to
If it works, this could point toward a treatment that helps the immune system control chronic hepatitis C, potentially reducing the risk of liver cancer.
What could go wrong
This is a very early phase I trial with only 33 participants, so safety and dosing are the main focus. The vaccine may not produce a strong enough immune response, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic hepatitis C virus infection hepatitis hepatitis C virus infection Hepatitis, Chronic hepatocellular carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC HEPATITIS HEPATITIS C INFECTION HEPATOCELLULAR CARCINOMA

Contacts and locations

Locations

  • Case Western Reserve University

    Cleveland, Ohio, 44106, United States

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

  • Temple University Hospital

    Philadelphia, Pennsylvania, 19140, United States

  • University of Puerto Rico

    San Juan, 00936, Puerto Rico

More trials for these conditions

Other studies related to the condition(s) this trial covers.