Could a pill replace chemo for some breast cancers? major trial launches

NCT ID NCT07391774

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 23 times

Summary

This study compares two treatments for people with high-stage, estrogen-positive, HER2-negative breast cancer that has a low genetic risk of returning. One group gets standard hormone therapy plus a targeted pill (ribociclib), while the other gets chemotherapy first, then the same hormone therapy and pill. The goal is to see if skipping chemo works just as well, with fewer side effects. About 1,978 participants are being recruited.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANATOMIC STAGE II BREAST CANCER AJCC V8 are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast carcinoma estrogen-receptor positive breast cancer Her2-receptor negative breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANATOMIC STAGE II BREAST CANCER AJCC V8 ANATOMIC STAGE IIIA BREAST CANCER AJCC V8 ANATOMIC STAGE IIIC BREAST CANCER AJCC V8 ESTROGEN RECEPTOR-POSITIVE BREAST CARCINOMA HER2-NEGATIVE BREAST CARCINOMA

Contacts and locations

Show contact details

Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Alta Bates Summit Medical Center-Herrick Campus
RECRUITING

Berkeley, California, 94704, United States

Contact Email: •••••@•••••
Asplundh Cancer Pavilion
RECRUITING

Willow Grove, Pennsylvania, 19090, United States

Contact Email: •••••@•••••
Baptist Cancer Center-Grenada
RECRUITING

Grenada, Mississippi, 38901, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Collierville
RECRUITING

Collierville, Tennessee, 38017, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Desoto
RECRUITING

Southhaven, Mississippi, 38671, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Golden Triangle
RECRUITING

Columbus, Mississippi, 39705, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Oxford
RECRUITING

Oxford, Mississippi, 38655, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Union County
RECRUITING

New Albany, Mississippi, 38652, United States

Contact Email: •••••@•••••
Beebe Health Campus
RECRUITING

Rehoboth Beach, Delaware, 19971, United States

Contact Email: •••••@•••••
Beebe South Coastal Health Campus
RECRUITING

Millville, Delaware, 19967, United States

Contact Email: •••••@•••••
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Broadlawns Medical Center
RECRUITING

Des Moines, Iowa, 50314, United States
California Pacific Medical Center-Pacific Campus
RECRUITING

San Francisco, California, 94115, United States

Contact Email: •••••@•••••
Cancer Care Center of O'Fallon
RECRUITING

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur
RECRUITING

Decatur, Illinois, 62526, United States
Cancer Center of Western Wisconsin
RECRUITING

New Richmond, Wisconsin, 54017, United States
Cedars-Sinai Cancer - Tarzana
RECRUITING

Tarzana, California, 91356, United States
Centro Comprensivo de Cancer de UPR
RECRUITING

San Juan, 00927, Puerto Rico
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Decatur Memorial Hospital
RECRUITING

Decatur, Illinois, 62526, United States
Doctors Cancer Center
RECRUITING

Manati, 00674, Puerto Rico
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center-South University Clinic
RECRUITING

Fargo, North Dakota, 58103, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Saint Joseph's Medical Center
RECRUITING

Brainerd, Minnesota, 56401, United States

Contact Email: •••••@•••••
Essentia Health Saint Mary's - Detroit Lakes Clinic
RECRUITING

Detroit Lakes, Minnesota, 56501, United States

Contact Email: •••••@•••••
Essentia Health Saint Mary's Hospital - Superior
RECRUITING

Superior, Wisconsin, 54880, United States
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Essentia Health-Hayward Clinic
RECRUITING

Hayward, Wisconsin, 54843, United States

Contact Email: •••••@•••••
Essentia Health-Spooner Clinic
RECRUITING

Spooner, Wisconsin, 54801, United States

Contact Email: •••••@•••••
Good Samaritan University Hospital
RECRUITING

West Islip, New York, 11795, United States
Greater Baltimore Medical Center
RECRUITING

Baltimore, Maryland, 21204, United States
HSHS Saint Elizabeth's Hospital
RECRUITING

O'Fallon, Illinois, 62269, United States
Helen F Graham Cancer Center
RECRUITING

Newark, Delaware, 19713, United States
Illinois CancerCare - Washington
RECRUITING

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington
RECRUITING

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton
RECRUITING

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage
RECRUITING

Carthage, Illinois, 62321, United States
Illinois CancerCare-Eureka
RECRUITING

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg
RECRUITING

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic
RECRUITING

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb
RECRUITING

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic
RECRUITING

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin
RECRUITING

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria
RECRUITING

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru
RECRUITING

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton
RECRUITING

Princeton, Illinois, 61356, United States
Iowa Methodist Medical Center
RECRUITING

Des Moines, Iowa, 50309, United States
Jefferson Cherry Hill Hospital
RECRUITING

Cherry Hill, New Jersey, 08002, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Lexington Medical Center
RECRUITING

West Columbia, South Carolina, 29169, United States

Contact Email: •••••@•••••
Mary Greeley Medical Center
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Ames
RECRUITING

Ames, Iowa, 50010, United States
McFarland Clinic - Marshalltown
RECRUITING

Marshalltown, Iowa, 50158, United States
McFarland Clinic - Trinity Cancer Center
RECRUITING

Fort Dodge, Iowa, 50501, United States
Medical Oncology Hematology Consultants PA
RECRUITING

Newark, Delaware, 19713, United States
Mercy Hospital
RECRUITING

Cedar Rapids, Iowa, 52403, United States
Mercy Medical Center - Des Moines
RECRUITING

Des Moines, Iowa, 50314, United States
Miller-Dwan Hospital
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Mills Health Center
RECRUITING

San Mateo, California, 94401, United States

Contact Email: •••••@•••••
Missouri Baptist Medical Center
RECRUITING

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital
RECRUITING

Sullivan, Missouri, 63080, United States
Mount Sinai Chelsea
RECRUITING

New York, New York, 10011, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Mount Sinai West
RECRUITING

New York, New York, 10019, United States
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
RECRUITING

Jonesboro, Arkansas, 72401, United States
Northwest Wisconsin Cancer Center
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Old Irving Park
RECRUITING

Chicago, Illinois, 60641, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Huntley Hospital
RECRUITING

Huntley, Illinois, 60142, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

Contact Email: •••••@•••••
Northwestern Medicine McHenry Hospital
RECRUITING

McHenry, Illinois, 60050, United States
Northwestern Medicine Oak Brook
RECRUITING

Oak Brook, Illinois, 60523, United States
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Associates at Mercy Medical Center
RECRUITING

Cedar Rapids, Iowa, 52403, United States
PROncology
RECRUITING

San Juan, 00927, Puerto Rico

Contact Email: •••••@•••••
Palo Alto Medical Foundation Health Care
RECRUITING

Palo Alto, California, 94301, United States

Contact Email: •••••@•••••
Parkland Health Center - Farmington
RECRUITING

Farmington, Missouri, 63640, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Ridley-Tree Cancer Center
RECRUITING

Santa Barbara, California, 93105, United States

Contact Email: •••••@•••••
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
SIH Cancer Institute
RECRUITING

Carterville, Illinois, 62918, United States

Contact Email: •••••@•••••
SSM Health Good Samaritan
RECRUITING

Mount Vernon, Illinois, 62864, United States
Saint Anthony Regional Hospital
RECRUITING

Carroll, Iowa, 51401, United States
Saint Francis Medical Center
RECRUITING

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center
RECRUITING

Shakopee, Minnesota, 55379, United States
Sainte Genevieve County Memorial Hospital
RECRUITING

Sainte Genevieve, Missouri, 63670, United States
San Juan City Hospital
RECRUITING

San Juan, 00936, Puerto Rico
Sidney Kimmel Cancer Center Washington Township
RECRUITING

Sewell, New Jersey, 08080, United States

Contact Email: •••••@•••••
Southeastern Medical Oncology Center-Clinton
RECRUITING

Clinton, North Carolina, 28328, United States
Southeastern Medical Oncology Center-Goldsboro
RECRUITING

Goldsboro, North Carolina, 27534, United States
Southeastern Medical Oncology Center-Jacksonville
RECRUITING

Jacksonville, North Carolina, 28546, United States
Southern Illinois University School of Medicine
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Clinic
RECRUITING

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital
RECRUITING

Springfield, Illinois, 62781, United States
Stamford Hospital/Bennett Cancer Center
RECRUITING

Stamford, Connecticut, 06904, United States
Sutter Auburn Faith Hospital
RECRUITING

Auburn, California, 95602, United States

Contact Email: •••••@•••••
Sutter Medical Center Sacramento
RECRUITING

Sacramento, California, 95816, United States

Contact Email: •••••@•••••
Sutter Roseville Medical Center
RECRUITING

Roseville, California, 95661, United States

Contact Email: •••••@•••••
Sutter Solano Medical Center/Cancer Center
RECRUITING

Vallejo, California, 94589, United States

Contact Email: •••••@•••••
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Tower Cancer Research Foundation
RECRUITING

Beverly Hills, California, 90211, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UI Health Care Mission Cancer and Blood - Ankeny Clinic
RECRUITING

Ankeny, Iowa, 50023, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
RECRUITING

Des Moines, Iowa, 50309, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
RECRUITING

Des Moines, Iowa, 50314, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
RECRUITING

Waukee, Iowa, 50263, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
RECRUITING

Clive, Iowa, 50325, United States
UI Healthcare Mission Cancer and Blood - Fort Dodge
RECRUITING

Fort Dodge, Iowa, 50501, United States

Contact Email: •••••@•••••
UM Upper Chesapeake Hematology and Oncology - Aberdeen
RECRUITING

Aberdeen, Maryland, 21001, United States
UM Upper Chesapeake Medical Center
RECRUITING

Bel Air, Maryland, 21014, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University of California Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of Maryland Shore Medical Center at Easton
RECRUITING

Easton, Maryland, 21601, United States
University of Maryland/Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.