New drug cocktail aims to fight Hard-to-Treat cancers
NCT ID NCT05803382
First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 6 times
Summary
This early-phase trial is testing whether a new drug called ZEN003694, when added to the chemotherapy capecitabine, is safe for people with advanced solid tumors that have spread or can't be removed by surgery. About 30 participants will receive the combination to find the best dose and check for side effects. The goal is to see if this approach can control tumor growth in patients who have already tried standard treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ZEN003694 (a BET protein inhibitor) and capecitabine (a chemotherapy drug)
- What this could lead to
- If it works, this could point toward a new treatment option for people with advanced solid tumors that have stopped responding to standard therapies.
- What could go wrong
- This is a very early Phase I trial with only 30 people, so it is mainly checking safety and dosing. The combination may not shrink tumors or may cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Memorial Hospital East
ACTIVE_NOT_RECRUITINGShiloh, Illinois, 62269, United States
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Montefiore Medical Center - Moses Campus
RECRUITINGThe Bronx, New York, 10467, United States
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Montefiore Medical Center-Einstein Campus
RECRUITINGThe Bronx, New York, 10461, United States
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Montefiore Medical Center-Weiler Hospital
RECRUITINGThe Bronx, New York, 10461, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGNew York, New York, 10032, United States
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Siteman Cancer Center at Christian Hospital
ACTIVE_NOT_RECRUITINGSt Louis, Missouri, 63136, United States
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Siteman Cancer Center at Saint Peters Hospital
ACTIVE_NOT_RECRUITINGCity of Saint Peters, Missouri, 63376, United States
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Siteman Cancer Center at West County Hospital
ACTIVE_NOT_RECRUITINGCreve Coeur, Missouri, 63141, United States
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Siteman Cancer Center-South County
ACTIVE_NOT_RECRUITINGSt Louis, Missouri, 63129, United States
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UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
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UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITINGIrvine, California, 92612, United States
Contact Email: •••••@•••••
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UF Health Cancer Institute - Gainesville
RECRUITINGGainesville, Florida, 32610, United States
Contact Email: •••••@•••••
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UPMC Hillman Cancer Center
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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University of Cincinnati Cancer Center-UC Medical Center
RECRUITINGCincinnati, Ohio, 45219, United States
Contact Email: •••••@•••••
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University of Cincinnati Cancer Center-West Chester
RECRUITINGWest Chester, Ohio, 45069, United States
Contact Email: •••••@•••••
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Kansas Clinical Research Center
RECRUITINGFairway, Kansas, 66205, United States
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University of Kansas Hospital-Westwood Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Vanderbilt Breast Center at One Hundred Oaks
SUSPENDEDNashville, Tennessee, 37204, United States
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Vanderbilt University/Ingram Cancer Center
SUSPENDEDNashville, Tennessee, 37232, United States
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Washington University School of Medicine
ACTIVE_NOT_RECRUITINGSt Louis, Missouri, 63110, United States
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