Can MRI replace unnecessary biopsies for prostate cancer patients?

NCT ID NCT04692675

Recruiting now Knowledge-focused Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 5 times

Summary

This study looks at whether a special MRI scan (mpMRI) can better monitor prostate cancer in men who choose active surveillance instead of immediate treatment. About 500 men with low-risk prostate cancer will get regular MRIs, biopsies, and blood tests over several years. The goal is to see if MRI can accurately detect cancer growth and possibly reduce the need for repeat biopsies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: multiparametric magnetic resonance imaging (mpMRI)
What this could lead to: If successful, this could show that mpMRI helps doctors better track prostate cancer progression, potentially reducing the need for frequent biopsies.
What could go wrong: This is an observational study, not a treatment trial. It may not change current practice, and results depend on how well imaging matches biopsy findings.

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Conditions

The condition(s) this trial relates to.

Disease Progression prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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