New drug cocktail aims to outsmart recurrent glioblastoma
NCT ID NCT05432804
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding the drug selinexor to standard chemotherapy (temozolomide) can better control recurrent glioblastoma, an aggressive brain cancer. About 97 adults whose tumor has returned after initial treatment will receive either the combo or chemotherapy alone. The goal is to find the safest dose and see if the combination improves time without tumor growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
selinexor and temozolomide
What this could lead to
If successful, this combination could offer a new treatment option that slows or shrinks recurrent glioblastoma tumors better than standard chemotherapy alone.
What could go wrong
This is an early-phase trial (phase 1/2) with only 97 participants, so results may not apply broadly. Selinexor can cause side effects like nausea, fatigue, and low blood counts.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Comprehensive Cancer Center
RECRUITINGDuarte, California, 91010, United States
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Emory University Hospital Midtown
RECRUITINGAtlanta, Georgia, 30308, United States
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Huntsman Cancer Institute/University of Utah
ACTIVE_NOT_RECRUITINGSalt Lake City, Utah, 84112, United States
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Keck Medicine of USC Koreatown
RECRUITINGLos Angeles, California, 90020, United States
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Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITINGNew York, New York, 10016, United States
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Los Angeles General Medical Center
RECRUITINGLos Angeles, California, 90033, United States
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Mayo Clinic Hospital in Arizona
RECRUITINGPhoenix, Arizona, 85054, United States
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Mayo Clinic in Florida
RECRUITINGJacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
RECRUITINGRochester, Minnesota, 55905, United States
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Moffitt Cancer Center
RECRUITINGTampa, Florida, 33612, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
ACTIVE_NOT_RECRUITINGNew York, New York, 10032, United States
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Ohio State University Comprehensive Cancer Center
RECRUITINGColumbus, Ohio, 43210, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Roswell Park Cancer Institute
ACTIVE_NOT_RECRUITINGBuffalo, New York, 14263, United States
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Rutgers Cancer Institute of New Jersey
RECRUITINGNew Brunswick, New Jersey, 08903, United States
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Rutgers New Jersey Medical School
RECRUITINGNewark, New Jersey, 07101, United States
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Saint Barnabas Medical Center
RECRUITINGLivingston, New Jersey, 07039, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UC San Diego Moores Cancer Center
RECRUITINGLa Jolla, California, 92093, United States
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UCHealth University of Colorado Hospital
RECRUITINGAurora, Colorado, 80045, United States
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UM Sylvester Comprehensive Cancer Center at Coral Gables
RECRUITINGCoral Gables, Florida, 33146, United States
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UM Sylvester Comprehensive Cancer Center at Deerfield Beach
RECRUITINGDeerfield Beach, Florida, 33442, United States
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USC / Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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University of California Davis Comprehensive Cancer Center
RECRUITINGSacramento, California, 95817, United States
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University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Chicago Medicine-Orland Park
RECRUITINGOrland Park, Illinois, 60462, United States
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University of Cincinnati Cancer Center-UC Medical Center
RECRUITINGCincinnati, Ohio, 45219, United States
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University of Cincinnati Cancer Center-West Chester
RECRUITINGWest Chester, Ohio, 45069, United States
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University of Kentucky/Markey Cancer Center
RECRUITINGLexington, Kentucky, 40536, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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University of Oklahoma Health Sciences Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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University of Virginia Cancer Center
ACTIVE_NOT_RECRUITINGCharlottesville, Virginia, 22908, United States
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University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITINGMadison, Wisconsin, 53718, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITINGMadison, Wisconsin, 53792, United States
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VCU Massey Comprehensive Cancer Center
RECRUITINGRichmond, Virginia, 23298, United States
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Wake Forest University Health Sciences
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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