New drug combo shows promise in shrinking liver tumors before surgery

NCT ID NCT06050252

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 14 times

Summary

This trial tests whether giving the immunotherapy drug durvalumab along with standard chemotherapy before surgery can shrink high-risk liver cancer (cholangiocarcinoma) and reduce the amount of tissue that needs to be removed. About 27 patients with resectable tumors will receive four cycles of the combination, then undergo surgery. The goal is to see if this approach improves outcomes for patients with this aggressive cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: durvalumab with gemcitabine and cisplatin
What this could lead to: If successful, this could lead to a new treatment option that shrinks high-risk liver tumors before surgery, potentially improving survival.
What could go wrong: This is an early phase II trial with only 27 participants. It may not show benefit, and side effects from the drug combination could be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

intrahepatic cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RESECTABLE INTRAHEPATIC CHOLANGIOCARCINOMA

Contacts and locations

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Locations

Boston Medical Center
ACTIVE_NOT_RECRUITING

Boston, Massachusetts, 02118, United States
Emory Saint Joseph's Hospital
RECRUITING

Atlanta, Georgia, 30342, United States
Emory University Hospital Midtown
RECRUITING

Atlanta, Georgia, 30308, United States
Emory University Hospital/Winship Cancer Institute
RECRUITING

Atlanta, Georgia, 30322, United States
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Los Angeles General Medical Center
ACTIVE_NOT_RECRUITING

Los Angeles, California, 90033, United States
Memorial Hospital East
RECRUITING

Shiloh, Illinois, 62269, United States
NYP/Weill Cornell Medical Center
RECRUITING

New York, New York, 10065, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Ochsner Medical Center Jefferson
RECRUITING

New Orleans, Louisiana, 70121, United States
Ohio State University Comprehensive Cancer Center
RECRUITING

Columbus, Ohio, 43210, United States
Siteman Cancer Center at Christian Hospital
RECRUITING

St Louis, Missouri, 63136, United States

Contact Email: •••••@•••••
Siteman Cancer Center at Saint Peters Hospital
RECRUITING

City of Saint Peters, Missouri, 63376, United States

Contact Email: •••••@•••••
Siteman Cancer Center at West County Hospital
RECRUITING

Creve Coeur, Missouri, 63141, United States

Contact Email: •••••@•••••
Siteman Cancer Center-South County
RECRUITING

St Louis, Missouri, 63129, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center - Guilford
RECRUITING

Guilford, Connecticut, 06437, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center - Westerly
RECRUITING

Westerly, Rhode Island, 02891, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center at Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center at Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center at Long Ridge
RECRUITING

Stamford, Connecticut, 06902, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center at Saint Francis
RECRUITING

Hartford, Connecticut, 06105, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center-Fairfield
RECRUITING

Fairfield, Connecticut, 06824, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital Care Center-Trumbull
RECRUITING

Trumbull, Connecticut, 06611, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital-Derby Care Center
RECRUITING

Derby, Connecticut, 06418, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital-Torrington Care Center
RECRUITING

Torrington, Connecticut, 06790, United States

Contact Email: •••••@•••••
Smilow Cancer Hospital-Waterbury Care Center
RECRUITING

Waterbury, Connecticut, 06708, United States

Contact Email: •••••@•••••
UC Irvine Health/Chao Family Comprehensive Cancer Center
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
UCHealth University of Colorado Hospital
RECRUITING

Aurora, Colorado, 80045, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
RECRUITING

Irvine, California, 92612, United States

Contact Email: •••••@•••••
UF Health Cancer Institute - Gainesville
ACTIVE_NOT_RECRUITING

Gainesville, Florida, 32610, United States
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
UT MD Anderson - League City
RECRUITING

League City, Texas, 77573, United States
UT MD Anderson - Sugar Land
RECRUITING

Sugar Land, Texas, 77478, United States
UT MD Anderson - The Woodlands
RECRUITING

Conroe, Texas, 77384, United States
UT MD Anderson - West Houston
RECRUITING

Houston, Texas, 77079, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
University of Cincinnati Cancer Center-UC Medical Center
RECRUITING

Cincinnati, Ohio, 45219, United States

Contact Email: •••••@•••••
University of Cincinnati Cancer Center-West Chester
RECRUITING

West Chester, Ohio, 45069, United States

Contact Email: •••••@•••••
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Briarcliff
RECRUITING

Kansas City, Missouri, 64116, United States
University of Kansas Cancer Center - Lee's Summit
RECRUITING

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North
RECRUITING

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park
RECRUITING

Overland Park, Kansas, 66210, United States
University of Kansas Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Maryland/Greenebaum Cancer Center
ACTIVE_NOT_RECRUITING

Baltimore, Maryland, 21201, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Texas Health Science Center at San Antonio
WITHDRAWN

San Antonio, Texas, 78229, United States
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
RECRUITING

Madison, Wisconsin, 53718, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
SUSPENDED

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••
Yale-New Haven Hospital North Haven Medical Center
RECRUITING

North Haven, Connecticut, 06473, United States

Contact Email: •••••@•••••

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