New cocktail of immune drugs takes on tough colorectal cancer

NCT ID NCT06149481

First seen Nov 01, 2025 · Last updated Apr 27, 2026 · Updated 25 times

Summary

This study tests a combination of up to four experimental drugs (retifanlimab, TriAdeno vaccine, N-803, and SX-682) in adults with metastatic colorectal cancer that has spread and not responded to prior treatments. The goal is to see if the immune-boosting cocktail can shrink tumors or slow the disease. Participants receive the drugs over up to 2 years, with regular monitoring and two tumor biopsies.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-••••

Conditions

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