Kidney cancer trial: to cut or not to cut after immunotherapy?

NCT ID NCT03977571

Recruiting now Disease control Sponsor: Niels Fristrup Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether removing the kidney tumor after starting immunotherapy helps people with advanced kidney cancer live longer. About 400 participants will be randomly assigned to have surgery or not. The goal is to see if delayed surgery improves overall survival compared to no surgery at all.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cytoreductive nephrectomy (surgery to remove part or all of the kidney)
What this could lead to: If successful, this could show that delayed kidney removal after immunotherapy helps people with advanced kidney cancer live longer.
What could go wrong: This is a Phase 2/3 trial, so results are not yet proven. Surgery carries risks like infection or bleeding, and the benefit over no surgery is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

kidney cancer Neoplasms, Multiple Primary renal cell carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KIDNEY CANCER RENAL CELL CARCINOMA, METASTATIC SYNCHRONOUS NEOPLASM

Contacts and locations

Locations

Department of Oncology, Aarhus University Hospital
RECRUITING

Aarhus, Central Region of Denmark, 8200, Denmark
Department of Oncology, Herlev Hospital
RECRUITING

Herlev, 2730, Denmark
Department of Oncology, Odense University Hospital
RECRUITING

Odense, 5000, Denmark
Department of Oncology, Stavanger Universitetssykehus
RECRUITING

Stavanger, Norway
Department of Oncology, Ålesund Universitetsykehus
RECRUITING

Ålesund, Norway
Department of Urology, Haukeland University Hospital
RECRUITING

Bergen, Norway

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