KIDNEY CANCER

This study looks at six different ways to give two drugs in sequence to people with metastatic kidney cancer. Participants receive one of three drugs (everolimus, bevacizumab, or pazopanib) and may later switch to another. The goal is to see which sequence works best and is safes…

This study looks at ways to reduce the need for blood transfusions during surgery for advanced kidney cancer. About 240 adults with large kidney tumors will be enrolled. The goal is to see if special blood-saving techniques can lower the number of transfusions needed, which may l…

This early-phase study tests a new gene therapy for people with advanced clear cell kidney cancer. Doctors take a patient's own white blood cells, modify them in the lab to better recognize and attack cancer cells, and then return them to the patient. The main goals are to check …

This study tests whether combining two drugs—nivolumab and a radioactive antibody called 177Lu-girentuximab—is safe and effective for people with advanced clear cell kidney cancer that has a specific protein (CAIX). Nine participants will receive the treatment to find the best do…

This study tests a new drug called AZD6244 given with standard chemotherapy for people with advanced solid tumors (like breast, colon, lung, melanoma, or kidney cancer) that have no curative options. The main goal is to see if the combination is safe and tolerable, and to find th…

This study compares two ways to perform robotic partial nephrectomy (removing part of the kidney) for kidney cancer. One method uses stitches to close the wound, while the other does not. The goal is to see if the stitch-free method is just as safe and effective, with fewer compl…

This early-phase study tests a personalized vaccine made from each patient's unique tumor mutations, combined with the immunotherapy drug ipilimumab, for people with high-risk kidney cancer. The goal is to see if the treatment is safe and can boost the immune system to fight the …

This study looks at how safe and effective a new robotic surgery system (Medtronic Hugo) is for removing cancers of the prostate, bladder, or kidney. About 144 adults who need these surgeries will take part. The main goal is to see if the surgery can be completed without switchin…

This study tests a drug called 177Lu-PSMA-617, which delivers radiation directly to cancer cells, in people with advanced clear cell kidney cancer that has spread. The goal is to see if it can shrink tumors and how safe it is. The trial involves 24 participants and is currently a…

This study aimed to see if adding the diabetes drug acarbose to standard immunotherapy was safe and could help control advanced kidney cancer. It planned to enroll people with metastatic renal cell carcinoma. However, the study was withdrawn before any participants were enrolled.

This study tests whether giving two drugs—lenvatinib and pembrolizumab—before surgery can shrink tumors in people with locally advanced kidney cancer that hasn't spread to other parts of the body. About 18 participants will receive the combination for 12 weeks before their operat…

This study tests a new device that uses focused sound waves to destroy kidney tumors without making any cuts. About 67 adults with a single small kidney tumor (3 cm or less) will receive this treatment. The goal is to see if the device can safely and effectively eliminate the tum…

This study aimed to see if a material called PuraBond could safely and effectively stop bleeding during robotic partial nephrectomy for kidney cancer. It was designed for adults undergoing this surgery. However, the study was withdrawn before any participants were enrolled, so no…

This study collects tumor tissue from about 416 people with various advanced cancers to develop and train a new diagnostic platform called Elephas. The goal is to see how accurately the platform can predict whether a patient will respond to immunotherapy, compared to standard met…

This study collects DNA from over 21,000 people with different cancers (like breast, colon, and lung) in New York. Researchers will look for inherited gene changes that might be linked to cancer. The goal is to find clues for future studies, not to test a treatment.

This study looks at whether a 12-week survivorship program can be added to the usual follow-up care for men with advanced prostate, kidney, bladder, testicular, or penile cancer. Researchers will ask 72 men about their experience to see if the program is practical and helpful. Th…

This study is looking at two substances in the blood, called MMP2 and MMP9, to see if they can help predict how well certain drugs work in people with kidney cancer that has spread. The researchers will measure these markers in 50 patients and track their cancer progression. The …

This study looks at the financial burden (called financial toxicity) that people face after having robotic surgery for prostate, bladder, or kidney cancer. Researchers will ask 120 patients to fill out questionnaires about their expenses, travel costs, and support needs. The goal…

This study tests a new system that helps doctors better understand the needs of older adults with cancer. The system combines checks on aging, mental health, lifestyle, and social factors. About 35 patients aged 65 and older will try it during their first cancer visit. The goal i…

This study tests a small implantable device that releases tiny amounts of 19 different cancer drugs directly into kidney tumors. The device is placed and removed during planned surgery. The goal is to see if this approach is safe and can help doctors learn which drugs work best f…