University Of California, San Francisco

This study looks at whether a health advocate can help families of children who recently had a liver transplant. The advocate will help find community resources, solve problems, and coordinate doctor visits. The goal is to see if this support reduces the chance of organ rejection…

This study looks at giving radiation therapy (SBRT) soon after surgery for cancer that has spread to the spine, often within the same hospital stay. The goal is to see if this faster approach is safe and helps control tumor growth. About 50 adults with spine metastases will take …

This study tests two antiviral treatments—oral valganciclovir and ganciclovir eye drops—against placebo in adults with CMV anterior uveitis, an eye infection causing inflammation. The goal is to see which approach reduces the virus faster and prevents the infection from coming ba…

This study tests whether probiotics (good bacteria) can help treat anal precancerous lesions (HSIL) and reduce high-risk HPV infection in 90 people living with HIV. The goal is to see if the lesions disappear or shrink, and if the virus clears, potentially preventing anal cancer.…

This study tests whether the oral medication upadacitinib can safely treat adults hospitalized with a severe flare of ulcerative colitis. The goal is to see if it can reduce the need for emergency surgery or rescue treatments by day 14, and whether it can be used without steroids…

This study compares two strategies for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose initiation or a direct-to-inject protocol. The goal is to see which approach helps people stay …

This study will give 4,450 low-income adults with diabetes or hypertension a monthly food card of either $80 or $120. Researchers want to see if the extra grocery support helps people control their blood sugar and blood pressure, and reduces food insecurity. The goal is to find o…

This study tests whether a program called "Mittin" helps women aged 15-49 in Addis Ababa, Ethiopia, use birth control that matches their personal preferences. About 2,715 women using hormonal contraceptives or IUDs will be split into two groups: one receiving standard care and th…

This study tests a drug called emapalumab in 40 adults who had a lung transplant and are now experiencing a sudden drop in lung function (acute lung allograft dysfunction). The goal is to see if the drug can help their lungs recover to near-normal function within 90 days. Partici…

This study tests whether a digital prehabilitation app (HEAL-ME) combined with creatine and whey protein supplements can help maintain muscle health and reduce frailty in people with cirrhosis. About 100 participants will use the app and take supplements for at least 3 months. Th…

This study looks at whether taking an antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) for an extra 6 months after a kidney transplant can prevent urinary tract infections (UTIs). About 50 children and young adults who recently had a kidney transplant will either take TM…

This study will enroll 1,500 pregnant women with HIV in Uganda to find the best way to screen for tuberculosis (TB) and the safest time to start TB prevention medicine. Researchers will compare symptom-based screening versus a blood test, and test starting prevention during pregn…

This study tests a precise radiation treatment (Yttrium-90) for people with liver cancer that cannot be surgically removed. The treatment delivers tiny radioactive beads directly to the tumor's blood supply to shrink it. The goal is to see how well it controls the cancer and whet…

This study tests whether clemastine fumarate, an allergy medicine, can repair damaged myelin (the protective coating around nerves) in people with multiple sclerosis. About 44 adults with relapsing-remitting MS will receive either the drug or a placebo, and advanced MRI scans wil…

This study offers free dental check-ups, cleanings, and supplies to pregnant people with gum disease. It compares two noninvasive oral health methods to see which better reduces gum inflammation and improves pregnancy outcomes. About 160 participants under 20 weeks pregnant with …

This study looks at how to keep HIV self-test kits freely available to adolescent girls and young women in sub-Saharan Africa through local drug shops and pharmacies. Researchers will test different ways to support shop owners, like small payments and encouragement, to keep givin…

This study tests whether giving malaria medicine to school-age children can lower malaria cases in the entire community. Since children often carry the parasite without symptoms, treating them may stop the spread to others. The trial will involve about 4,800 students in The Gambi…

This study tests a new, larger packet of a nutritious supplement (SQ-LNS) that lasts 7 days, compared to the current daily packets. Researchers want to see if families use the weekly packet correctly and like it. The goal is to prevent malnutrition in children aged 6-24 months in…

This study aims to prevent noise-induced hearing loss in Native American adults by using a culturally relevant Talking Circles program. About 400 tribal members aged 18 and older will take part, completing hearing tests and questionnaires over 12 months. The program teaches heari…

This study tests whether personalized dietary counseling through video visits can help people who have had kidney stones eat less salt. One hundred adults with a history of calcium-based kidney stones will be split into two groups: one receiving standard advice, the other receivi…

This study looks at whether a single session of audio-based therapy can reduce anxiety in adults with psoriasis. About 120 participants will listen to a 23-30 minute audio program at home and complete surveys before and after. The goal is to see if this easy-to-access tool can im…

This study will test whether 8 weeks of improvisation music therapy can improve mood and lower stress for people with mild Alzheimer's disease and their care partners. About 40 older adults and their caregivers will attend music sessions and fill out questionnaires before and aft…

This study tests whether adding hormone replacement therapy (HRT) to standard care can improve frozen shoulder symptoms in women going through menopause. About 60 women will receive either HRT plus standard care or standard care alone. The goal is to see if the hormones help redu…

This early study tests if a new device that uses short electric pulses is safe for treating cancer spots just under the skin in people with metastatic breast cancer. About 20 adults will receive the treatment, and researchers will watch for side effects and check quality of life.…

This study looks at whether cutting back on dietary salt can reduce the severity of eczema (atopic dermatitis). Forty adults will follow a low-salt diet for 24 weeks and take either sodium tablets or a placebo to see how salt intake affects their skin. Researchers will measure ec…

This study tests a new, non-invasive brain stimulation technique called kTMP (kilohertz transcutaneous magnetic perturbations) to help people who have had a stroke and still have arm or hand weakness. Researchers will enroll 100 adults aged 18-80 who have had a stroke causing wea…

This study looks at whether an artificial intelligence (AI) tool can safely and accurately help breast cancer patients learn about their condition and treatment. About 35 adults with breast cancer will use the AI tool to ask questions and get answers. Doctors will check if the in…

This study tests a grain-of-rice-sized microdevice that places tiny amounts of approved drugs directly into patches of psoriasis or eczema. The goal is to see if the device can safely predict how a person's skin will respond to standard treatments. Ten adults with these skin cond…

This study collects tumor samples and health information from up to 50,000 adults with hereditary cancers. Researchers will use these samples to create lab models of tumors, helping them understand how these cancers grow and find better treatments. Participants donate tissue and …

This study looks at how to best present AI predictions to doctors to improve diagnosis of chest pain and shortness of breath. About 100 healthcare professionals will review simulated patient cases and see AI predictions shown in different ways—some with uncertainty ranges. The go…

This study tests a program where a trained navigator helps kidney stone patients attend their follow-up urology appointments after an ER visit. About 31 adults at high risk of missing appointments will receive support for 12 weeks. The goal is to see if this approach is feasible …

This study will gather genetic data and biological samples from up to 10,000 people with genetic or suspected genetic conditions. Researchers will analyze the data and samples in computers and in lab dishes to find disease-causing mutations and test how well gene-editing tools ca…

This study looks at two different FDA-approved machines that create platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from your own blood and may help with joint pain. The researchers will check if the PRP from each machine has different amounts or types…

This study aims to create an AI-powered 'digital twin' for 50 young people (ages 10-21) with type 2 diabetes. The digital twin will use each person's health data to predict how their diabetes will progress and how they might respond to treatments. Researchers hope this tool will …

This study will see if setting up special eye care centers in rural South Asia helps more people visit an eye doctor, get glasses, and see better. About 40,000 people will take part. Some communities will get a vision center right away, while others will wait. The researchers wil…

This study tests if an app called HeartBot II, which uses an AI chatbot, can improve women's awareness and knowledge of heart attack symptoms. About 200 women will be randomly assigned to use the app right away or wait 12 weeks. Participants complete surveys at the start, 12 week…

This study looks at whether sharing results from a blood test that measures recent alcohol use (called PEth) during counseling helps people with HIV who drink too much cut back. About 80 adults in Uganda will take part. Half will get standard counseling plus their PEth results, a…

This study looks at how standard brain radiation therapy affects thinking and memory in 40 adults with brain tumors (primary or metastatic). Researchers will measure specific proteins in the blood and use brain scans to understand the biological changes behind cognitive decline. …

This study looks at whether changing how much salt you eat can affect sodium levels in the skin and the severity of eczema or psoriasis. Fifty adults will follow a low-salt diet and take either salt tablets or placebo pills for several weeks. Researchers will measure skin sodium …

This study tests a 6-week group bootcamp for caregivers of infants (3-15 months old) diagnosed with or at high risk for cerebral palsy. The program, led by a team of doctors and therapists, teaches parents how to better interact with and support their child. The goal is to improv…

This study looks at how things like race, income, education, and life history may affect the health of people with meningioma, the most common type of brain tumor. Researchers will gather information from 3,000 adults to find patterns that could explain why some groups have worse…

This study looks at how substance use may cause inflammation and scarring in the hearts of people with HIV. Researchers will use a single cardiac MRI to measure heart damage. The study involves 400 participants from existing HIV research groups. No treatment is given—this is an o…

This study tests a new program designed to help people who have been seriously injured. Researchers want to see if the program is acceptable and useful for meeting the medical and social needs of injury survivors. About 25 adults treated at Zuckerberg San Francisco General Hospit…

This study tests whether a special pain management program, called a Transitional Pain Service, can help prevent long-term pain and reduce opioid use after surgery. It uses a computer algorithm to identify patients at higher risk for chronic pain. About 126 adult surgery patients…