University Of California, San Francisco

This phase 2 trial investigates whether metformin, a standard diabetes medication, can improve lung blood pressure and exercise ability in people with heart failure with preserved ejection fraction (HFpEF) and pulmonary hypertension. Participants take metformin or a placebo for 1…

This study tested a voluntary program to help formerly homeless adults living in supportive housing make their homes smoke-free. Researchers provided one-on-one counseling to residents and trained staff to offer smoking cessation referrals. The trial involved 452 participants acr…

This study is testing how the drug guselkumab affects the immune system in people with two types of psoriasis: plaque and guttate. Twenty-five adults will receive guselkumab injections over 44 weeks. Researchers will measure changes in immune cells in the skin to understand how t…

This study tested whether adding mindful eating training to a low-carb diet education helps people with type 2 diabetes follow the diet better. About 125 adults were randomly assigned to get either diet education alone or diet education plus mindful eating sessions. The main goal…

This pilot study tested a 12-week health behavior program for 50 breast cancer survivors to reduce their risk of heart disease. The program included individual coaching and group sessions focused on exercise and wellness. Researchers measured changes in walking distance and self-…

This study tested whether giving insulin as an extended bolus (over time) instead of all at once helps control blood sugar after high-fat, high-protein meals in teens with type 1 diabetes. Thirty teens using a closed-loop insulin pump ate a standardized breakfast and received eit…

This study looked at the best ways to treat a rare but serious eye infection called acanthamoeba keratitis, which is caused by a parasite. 49 people took part. In the first part, they received either one drug or a combination of two drugs. In the second part, they were given ster…

This study compared two types of glaucoma surgery—standard trabeculectomy and a smaller 'micro' version—to see which one lowers eye pressure better and causes fewer complications. Researchers followed 100 patients for 3 months after surgery. The goal is to find out if the smaller…

This study looked at whether giving people home blood pressure monitors and teaching them to use online portals and texting with their doctors can help them better control their high blood pressure. Over 500 adults with uncontrolled hypertension took part for 12 months. The goal …

This study looked at whether it is safe to stop giving annual azithromycin to communities with low levels of trachoma, an eye infection that can cause blindness. Over 3,900 people in Niger took part. Researchers compared stopping treatment after at least 5 years versus continuing…

This study tested a smartphone app called LetSync designed to help Black men who have sex with men and their partners stay engaged in HIV care and take their medications as prescribed. About 144 participants (80 couples) used the app for up to 14 months. The researchers measured …

This study tested whether giving monthly fruit and vegetable vouchers to young kidney transplant patients (ages 2-25) who struggle with food insecurity could improve their diet and health. Nineteen participants received an EBT card loaded with funds for six months. Researchers me…

This study tested whether providing six months of diabetes-tailored meals and nutrition counseling can improve blood sugar control and reduce food insecurity in adults with type 2 diabetes. 281 participants received either the food support plus counseling or usual care. The main …

This study tested a two-part approach to help employees lose belly fat and improve insulin sensitivity: a workplace ban on sugary drinks and a single counseling session. Over 600 full-time employees who drank at least three sugary beverages a week took part. Researchers measured …

This study tested a program called CareConnect that uses automated phone calls to help cancer patients stop smoking. About 400 cancer patients who smoked took part. The program gave them educational messages and connected them to resources like quitlines or websites. The goal was…

This study tested whether a silver-coated dressing (Silverlon) could reduce infections where the LVAD driveline exits the body. Twenty-five adults with a new LVAD were randomly assigned to receive either the silver dressing or a standard one. Researchers tracked infection rates, …

This study tested whether adding a light-activated dye (rose bengal) to standard antibiotic or antifungal eye drops could improve vision in people with severe corneal infections. About 330 adults in India and Brazil with fungal or amoeba infections received either standard drops …

This study looked at whether finding and treating low-density malaria infections (infections with very few parasites) in children can improve their health and well-being over time. 600 children in Tanzania, aged 6 months to 10 years, took part. The goal was to see if this approac…

This study looked at whether a root canal for an infected tooth with an abscess can be done in one visit instead of two. Fifty-nine adults received either a single-visit treatment or a two-visit treatment with a calcium hydroxide medication placed in between. After 12 months, bot…

This study tested whether adding a precise, high-dose radiation treatment (SBRT) to the hormone therapy apalutamide helps control prostate cancer that has stopped responding to standard hormone therapy and spread to a few spots. Twenty-six men with this type of cancer took part. …

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This pilot study tested a 'polypill' that combines four heart failure medications into one capsule, aiming to make it easier for patients to stick with their treatment. The trial included 35 adults with heart failure and reduced ejection fraction, some of whom also had HIV. Resea…

This study tested a microfluidic chip that gently separates healthy, motile sperm from semen without harsh chemicals. Researchers compared it to the standard spinning method in 393 couples undergoing IVF for unexplained infertility. The goal was to see if the chip leads to higher…

This study looked at whether giving an extra hormone (FSH) along with the usual hCG trigger before egg retrieval in IVF can improve egg quality and pregnancy rates. 232 women undergoing IVF took part. The goal was to see if this approach, which mimics a natural menstrual cycle, l…

This study tested two common treatments for depression and PTSD—talk therapy (IPT) and an antidepressant (fluoxetine)—in a large public hospital in Kenya. Over 2,100 adults participated to see if these treatments could be effectively delivered by non-specialists in primary care. …

This study looked at whether stopping coffee helps prevent atrial fibrillation (AFib) from returning after a heart shock treatment called cardioversion. Two hundred coffee drinkers with AFib were randomly assigned to either keep drinking coffee or avoid it for six months. Researc…

This study looked at whether taking birth control pills every day for 6 months (continuous) works better than the usual 3-weeks-on, 1-week-off schedule for women with Polycystic Ovary Syndrome (PCOS). The goal was to see which approach lowers testosterone levels and improves symp…

This pilot study tested a new urine test that measures tenofovir levels to see how well HIV-negative women are taking their daily PrEP medication. Researchers provided real-time feedback based on the test results, along with standard counseling, to 100 women. The goal was to see …

This study tested whether a diabetes drug (SGLT2 inhibitor) could prevent cystine kidney stones in people with cystinuria, a genetic condition that causes painful, recurring stones. Ten adults took the drug to see if it would add glucose to their urine and stop cystine from formi…

This study tested a program where people living with HIV who use stimulants (like methamphetamine) could earn rewards for staying drug-free and taking their HIV medications. 37 adults took part in a primary care clinic. The goal was to see if this reward system was practical and …

This small pilot study tested whether injecting the Gardasil 9 HPV vaccine directly into genital warts could reduce their size and number. Only 2 adults with at least 3 warts each took part. The goal was to see if this approach is safe and worth studying further.

This study tested whether adding an injection of the antifungal drug voriconazole into the eye could improve treatment for fungal corneal ulcers. 70 people with moderate to severe infections received either standard antifungal drops alone or drops plus three injections over 10 da…

This phase 2 trial tested clemastine fumarate, a common allergy medicine, to see if it could repair damaged nerves in people with relapsing-remitting multiple sclerosis. Fifty participants took either the drug or a placebo for several months. The study measured nerve signals in t…

This study tested the drug everolimus in 65 children whose low-grade gliomas had come back or worsened. The goal was to see if the drug could stop or slow tumor growth. Children took everolimus pills daily, and doctors tracked tumor changes with MRI scans. The study focused on ho…

This study tested a 12-session telehealth counseling program for young people aged 18-29 living with HIV. The program used text messaging and video calls to help them stay engaged in care, manage mental health, and reduce substance use. Fifty participants were enrolled to see if …

This study tested a new method called metagenomic deep sequencing (MDS) to find the cause of eye infections. 100 adults with suspected infectious uveitis or endophthalmitis were randomly assigned to have their doctors receive MDS results or not, in addition to standard tests. The…

This study tested a low-cost method to find undiagnosed dementia in primary care. Researchers used electronic health records to identify patients at risk. Over 1,200 adults without a prior dementia diagnosis took part. The goal was to see if this approach could increase new demen…

This study tested whether giving antimalarial drugs to everyone in high-risk villages and forest workers could lower malaria cases in Thailand. Over 14,000 people took part. The goal was to see if this approach reduces infections from both Plasmodium falciparum and Plasmodium viv…

This study tested whether a community-based program offering flexible HIV prevention and treatment options could lower the number of new HIV infections. Over 80,000 people aged 15 and older in East African communities took part. The approach focused on delivering the right care t…

This study tested a program called Malkia Klabu ("Queen Club") in Tanzania. The program made local drug shops more welcoming for adolescent girls and young women, so they could easily get HIV prevention services and contraception. Researchers looked at whether this approach incre…

This study tested two strategies to encourage HIV prevention pill use among adults who visit or work at drinking venues in Kenya and Uganda. Over 9,000 people took part. One approach focused only on HIV testing, while the other offered broader health screenings. The goal was to s…

This study tested a program called Manas por Manas to help transgender women in São Paulo, Brazil, overcome stigma and access HIV testing and PrEP (a daily pill that prevents HIV). The program included group sessions led by peers and one-on-one support. Researchers compared HIV t…

This study tested a program to reduce pesticide exposure in 85 California child care centers serving preschool children. Researchers taught staff safer pest control methods and measured changes in pesticide levels in dust and children's wristbands. The goal was to lower children'…

This study tested a new way to help young men who have sex with men (ages 18-30) take their daily HIV prevention pills consistently. Participants provided a urine sample that was tested right away for the HIV prevention drug, and then received a short counseling session based on …

This study tested two kinds of long-lasting insecticide-treated bed nets across Uganda to see which better prevents malaria. Over 215,000 people took part, and researchers tracked malaria cases reported at health clinics. The goal is to find the most effective net for nationwide …

This study tested a school-based program called Fuerte for newcomer immigrant teens who have been in the U.S. for five years or less and are at risk for traumatic stress. The program aims to help teens understand mental health, build social connections, and connect those who need…

This study tested a program where trained peer navigators (women with similar experiences) helped women in the criminal justice system access HIV prevention services like PrEP. The goal was to reduce stigma and improve linkage to care. Thirty women participated, and the study mea…

This study tested a tablet-based tool and clinic training to help women learn about HIV prevention, including PrEP. 141 women from a Florida clinic participated. The goal was to see if these tools helped women make informed choices and start prevention methods.

This study tested whether offering small financial rewards (like a drawing for a prize) could motivate parents to brush their young children's teeth more often. About 244 families with kids in Early Head Start programs took part. The goal was to see if the reward program increase…

This study tested a program to help healthcare providers prescribe HIV PrEP (pre-exposure prophylaxis) more effectively. The program included a web-based tool and a coordinator to support doctors. Ten clinics in San Francisco participated. The goal was to see if the program incre…

This study tested whether brief videos, handouts, or a short talk from ER staff could increase COVID-19 booster vaccination within 30 days. Over 900 adults from emergency departments took part. The goal was to see if simple, low-cost messaging can improve vaccine uptake.

This study tests a program called the Foster Care Family Navigator (FCFN), which pairs families with a navigator who helps them connect to mental health services and stay engaged. The program also uses mobile health tools to support the process. Researchers are enrolling English-…

This study tests whether a home-based, virtually-supervised exercise program combining high-intensity endurance and resistance training is safe and feasible for people with Parkinson's disease. It also looks at how exercise affects thinking skills and related biological markers. …

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested a six-session behavioral sleep program, called Apnea and Insomnia Relief (AIR), in 118 Gulf War veterans with Gulf War Illness. The program combined sleep education, motivation for using a breathing machine, and insomnia therapy, all done via telehealth. Researc…

This small pilot study tested whether using inflatable cuffs on the legs (blood flow restriction) during low-intensity stepping exercise could safely improve mobility and quality of life in people with advanced Parkinson's disease. Three participants exercised twice a week for 8 …

This study tested whether a yoga program taught by a Black instructor could help Black cancer survivors feel better and improve their quality of life. 13 adults who had cancer in the last 5 years took part. The goal was to see if this approach was acceptable and helpful for manag…

This study tested a web app called PrehabPal designed to help frail adults aged 65 and older prepare for colon cancer surgery. The app creates a personalized prehabilitation program and offers coaching. Researchers compared it to standard written instructions in 132 participants …

This small study tested whether adding whole-body hyperthermia (like a sauna session) to cognitive behavioral therapy (CBT) is feasible for adults with major depression. Sixteen participants received up to 8 weekly or 4 bi-weekly sauna sessions along with 8 weekly CBT sessions. T…

This study tested whether adding whole-body hyperthermia (mild heat sessions) to standard cognitive behavioral therapy (CBT) could help adults with major depression. Thirty participants received either real or sham heat sessions alongside weekly therapy. The main goal was to see …

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested a new type of botulinum toxin injection (DAXI) for people with adductor spasmodic dysphonia, a condition that causes the voice to spasm and sound strained. 22 adults who had previously been helped by standard Botox injections received a single DAXI injection int…

This small study tested whether combining digital cognitive behavioral therapy for insomnia (CBT-I) with sessions in a sauna blanket is feasible for adults with insomnia. Ten participants used an online CBT-I program and a sauna blanket at home for 9 weeks. The goal was to see if…

This study tested a 12-week online program called Brain Health Together for older adults with mild cognitive decline. Participants joined live-streaming exercise and education classes, plus individual coaching, all from home. The goal was to see if the program could improve think…

This study tested a phone-based health coaching program to help people with sleep apnea use their positive airway pressure (PAP) device more often. 27 adults who were not using their device enough took part. The coaching aimed to improve device use and reduce daytime sleepiness.

This study tested a program that helps mothers with depression and their young children (ages 2-4) with behavior problems at the same time. The program combines parenting support with short videos to help moms cope with stress. Researchers wanted to see if treating both together …

This study tested whether a simple walking program using a pedometer could help reduce fatigue and improve quality of life in people with lupus. 101 participants were randomly assigned to either a walking group with personalized step goals or a wait-list control group. The progra…

This pilot study tested two different computerized brain training programs that also involve light physical activity, like reaching or stepping, in people with multiple sclerosis who have memory or attention problems. The goal was to see if these programs could improve thinking s…

This study tested whether a smartphone meditation app (Calm Health) could help reduce anxiety and depression in 100 adults with non-infectious uveitis, an inflammatory eye disease. Participants used the app and reported their symptoms. The goal was to see if digital mindfulness c…

This study tested whether speech-language teletherapy can improve language outcomes in deaf or hard-of-hearing children aged 0-27 months. Researchers enrolled 210 children, some publicly insured and some privately insured, and gave some access to an 18-month teletherapy program. …

This study tested whether using a virtual reality (VR) headset during a kidney biopsy could help children feel less pain and anxiety, possibly reducing the need for sedation. Thirty-two children aged 5 to 17 used a VR headset showing a game during the procedure. The main goal was…

This study tested whether having a peer mentor on Instagram could help teens and young adults stop vaping. Twenty-seven participants from California joined a private Instagram group with mentors who had already quit. The study looked at how many people stayed engaged and complete…

This study tested an online workshop for 109 family caregivers of people with dementia. The workshop taught caregiving skills and ways to manage stress and difficult emotions. The goal was to see if the workshop was easy to use and helpful for caregivers, with the hope of improvi…

This study tested three online wellness programs—Tai Chi, a gentle mindful movement class called PLIE, and health education—in 77 adults aged 55 and older with mild memory or cognitive difficulties. The goal was to see if these programs could improve thinking skills, physical fun…

This study tested whether a medication called lemborexant can help night shift workers sleep longer during the day. 29 full-time night shift workers who had trouble sleeping took either the drug or a placebo for two weeks. The goal was to see if the drug increased total daytime s…

This phase 2 trial tested whether the drug letrozole can reduce pain during ovarian stimulation in 60 women with endometriosis. Participants received either letrozole or a placebo daily, and researchers measured changes in pain scores. The goal is to find a way to make fertility …

This study tested whether sending personalized text messages could help colorectal cancer survivors eat more whole grains and less refined grains. Forty-six survivors who had finished active treatment received text messages and nutrition materials. The main goal was to see if peo…

This study tested whether a smartphone app that retrains attention can help people with post-traumatic stress disorder (PTSD). Over 1,300 adults with PTSD symptoms used one of four app versions for two weeks. Researchers measured changes in PTSD symptoms right after training and …

This study tested whether montelukast (Singulair), a common asthma drug, can reduce the number and severity of infusion reactions in people receiving monoclonal antibody treatments for blood disorders. Forty adults were given montelukast along with standard premedication before t…

This study tested a device called PTeye that uses near-infrared light to help surgeons spot parathyroid glands during surgery for hyperparathyroidism. The goal was to see if it could reduce the number of tissue samples sent to the lab and lower the risk of needing a second surger…

This study tested whether mindfulness training helps people with type 2 diabetes better manage food cravings and stick to a low-carb diet. Sixty adults participated, learning skills to notice cravings without automatically eating. The goal was to improve long-term diet adherence …

This study tested an online sleep program for preschool-aged children with autism who have trouble sleeping. 20 children participated to see if the program was easy to use and helped improve sleep. The goal was to make sleep help more accessible for families.

This study tested whether a health coach can help low-income patients with COPD or asthma get better access to lung specialists and follow their advice. 328 patients from public clinics were randomly assigned to either usual care or a health coach who prepared them for specialist…

This small study tested a cognitive training app called D-kit/EF1 in 11 children aged 4-8 with borderline or mild intellectual disability. Children used the app for 30 minutes a day, 5 times a week for 12 weeks, while a comparison group watched educational videos. The goal was to…

This study tested three different programs to help adults with type 1 diabetes manage the stress and worry that often comes with the condition. 296 participants were split into groups, each trying a different approach: one focused on emotional awareness, another on problem-solvin…

This study tested two sleep medications (suvorexant and zolpidem) against a placebo in 40 adults with Progressive Supranuclear Palsy (PSP). The goal was to see if targeting the brain's wake-promoting system could improve sleep quality and daytime well-being. Each person tried all…

This study compared two types of nerve blocks—femoral and adductor canal—for people having knee arthroscopy (like ACL repair or meniscus surgery). The goal was to see which block provides better pain control while keeping the quadriceps muscle strong. 132 participants received on…

This study tested whether giving teens extra education and coping skills through a smartphone app could help them manage pain and recover faster after scoliosis surgery. Forty adolescents aged 11 to 18 took part. The app provided videos on what to expect and how to cope, aiming t…

This study looked at two tools to help people with chronic kidney disease (CKD) stay healthier. One tool gave doctors a registry to track patients, and the other offered phone coaching from a health coach. The goal was to see if these approaches could lower blood pressure and imp…

This large study in rural Ethiopia looked at whether providing clean water, sanitation, and face-washing education can reduce trachoma infections in communities that have already received many rounds of antibiotics. Over 47,000 people from 40 communities took part. The goal is to…

This completed study at the University of California, San Francisco tested whether repetitive transcranial magnetic stimulation (rTMS) can temporarily change how the brain processes visual information. 106 healthy adults received targeted magnetic pulses to the visual cortex whil…

This study gave 300 low-income Black young adults (ages 18-24) in San Francisco and Oakland $500 per month for a year, plus optional financial discussion groups. Researchers wanted to see if this guaranteed income could reduce depression, increase investments in education or job …

This study tested whether providing grocery delivery (via Instacart) and weekly nutrition coaching calls helps cancer survivors who struggle to afford healthy food. Forty survivors who had finished active cancer treatment took part. The goal was to see if this support was practic…

This study looked at whether the Patient Agreement Form, required by the FDA for the abortion pill mifepristone, actually helps people learn about the procedure. Over 600 people seeking medication abortion or miscarriage management were randomly assigned to take a knowledge quiz …

This study tested a machine learning model that uses electronic health records to predict which cancer patients receiving infusion therapy are at risk of needing emergency care or hospitalization within 30 days. Researchers analyzed data from over 4,700 patients at UCSF. The goal…

This study tested whether telemedicine could help people in rural Nigeria get urology care faster. 220 adults were split into two groups: one had a standard in-person consultation, the other a virtual consultation with a urologist. Researchers measured how long it took to see a s…

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study looked at blood and airway samples from 23 adults during an acute asthma attack and again after recovery. The goal was to understand what happens in the body during an attack. This is a pilot study, meaning it is small and meant to generate ideas for future research, n…

This pilot study tested whether giving a sedative pill (alprazolam) before cataract surgery works as well as IV sedation (midazolam) in adults 65 and older. Twenty participants were randomly assigned to one of the two approaches, and researchers measured how well their thinking a…

This study tested a new urine-based rapid test (UTRA) that checks if people with HIV are taking their medication tenofovir as prescribed. The goal is to catch adherence problems early, before the virus level in blood rises. Researchers compared the urine test results with blood d…

This study looked at whether a set of care guidelines (called a pathway) could help doctors and nurses in community hospitals use the best treatments for children hospitalized with asthma, pneumonia, or bronchiolitis. Over 11,000 children took part across many hospitals. The goal…

This study tested two text-message programs for low-income Latino parents of children ages 1 to 5. One program aimed to reduce sugary drinks and juice, the other to encourage reading aloud. Researchers measured changes in children's drink intake and how often parents read to them…

This study looked at how a single dose of methamphetamine affects the HIV virus in people who are already on effective HIV treatment. Fourteen HIV-positive adults with no history of meth use took part. The goal was to see if meth causes the virus to become more active and increas…

This study examined blood and tumor samples from 25 people with advanced melanoma who were starting standard pembrolizumab treatment. Researchers looked at T cells—key immune cells—to find patterns that might predict whether the therapy works. The goal is to better understand why…

This study looked at how nicotine is absorbed and affects the body when using a standardized research e-cigarette compared to a person's usual brand e-cigarette. Thirty-two regular e-cigarette users participated in a crossover study where they used both types. Researchers measure…

This study looked at whether genetics play a role in how often people have extra heartbeats (called PACs and PVCs). Researchers used portable heart monitors to track 156 identical and fraternal twins. By comparing the two groups, they hope to understand if these common heart rhyt…

This study looked at whether a person's blood group antigens are linked to asthma attacks. Researchers followed 126 people with asthma to see if certain blood types had more flare-ups requiring steroids. The goal was to understand, not treat, the disease.

This study tested different ways of sharing a short video about flu and COVID-19 vaccines to see how trust changes based on who shares it. Over 500 adults in California watched the video, which was created with input from Indigenous community members. The video was shared either …

This pilot study tested an 8-week text-message program for Korean American caregivers of people with dementia. The messages covered dementia knowledge, caregiving skills, self-care, and support resources. Seventeen caregivers completed the program, and researchers measured change…

This study looked at how low oxygen levels (hypoxia) in people with obstructive sleep apnea affect the body's ability to use insulin. Researchers measured insulin resistance in the liver and fat tissue of 48 non-diabetic adults. The goal was to understand why some sleep apnea pat…

This study collected sputum (mucus coughed up from the lungs) from healthy volunteers and people with cystic fibrosis. Researchers tested whether certain sugar-like compounds could block bacterial and fungal proteins from binding to mucus, and whether these compounds could make t…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This study tested whether offering extra support, like weekly phone calls or text messages, helps people in cardiac rehabilitation sign up for and use a Food is Medicine program. 84 adults from San Francisco were randomly assigned to receive navigation calls, texts, both, or neit…

This study looked at whether giving people different monthly amounts of money to buy fruits and vegetables helps them eat healthier and feel less food insecure. 242 adults in Stockton, CA were randomly assigned to receive $40, $80, or $110 per month for 6 months. Researchers trac…

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal sei…

This study tested whether a simple app, available in English, Spanish, and Cantonese, could help glaucoma patients better remember their multiple eye drop schedules. Twenty participants either used the app or received standard instructions. After one month, researchers compared h…

This study looked at over 3,600 adults having major surgery to find out which of two blood pressure drugs (norepinephrine or phenylephrine) works best to prevent complications like kidney injury or death. Patients received one of the two drugs during their operation. The goal was…

This study explored whether music improvisation training can improve self-regulation and brain function in older adults, including those with mild memory problems. Fifty-three volunteers aged 60 and over took part in the training. The goal was to see if this creative activity cou…

This study tested a 12-week web-based diet program with text messages for 50 colorectal cancer survivors. The goal was to see if survivors would use the program and if it could help them eat healthier. The study did not test whether the diet changes actually prevent cancer from c…

This completed study examined 217 Hispanic people living with HIV in California, Mexico, and Puerto Rico to see if the types of bacteria in the anus are linked to high-risk HPV infection and pre-cancerous lesions. Researchers collected anal swabs and questionnaires to compare mic…

This study looked at whether using dialysis less often helps people recover from acute kidney injury that requires dialysis. 220 hospitalized adults were assigned to either a conservative (less frequent) dialysis plan or the usual thrice-weekly schedule. The goal was to see if th…

This small pilot study looked at whether people with major depression who eat a lot of ultra-processed foods could cut back on them. Twenty adults tried a personalized plan to reduce these foods. The goal was to see if it was possible and acceptable, not to measure mood changes. …

This study looked at whether sodium lauryl sulfate (SLS), a common ingredient in many drug products, changes how the allergy drug fexofenadine (Allegra) is absorbed in the body. Twelve healthy adults took fexofenadine alone or with low or high amounts of SLS. Researchers measured…

This study looked at how the eczema drug dupilumab (Dupixent) affects immune cells and genes in the skin. Seventeen adults with moderate-to-severe eczema took the drug, and researchers measured changes in skin samples over 12 weeks. The goal was to understand the biological effec…

This study tested a family-based telehealth program for teens aged 12–18 involved with child welfare and their caregivers. The program aimed to improve communication and emotion regulation through weekly video sessions. 93 participants were enrolled, and researchers measured chan…

This pilot study tested whether remote smartphone tests of thinking, memory, and motor function can identify older adults who may be vulnerable to cognitive problems after spine surgery. 34 participants completed the tests before surgery, and researchers tracked who developed pos…

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. 15 adults with overweight or obesity took part. Researchers measured weight, waist size, and heart health over time to understand what helps…

This study looked at how not getting enough sleep affects blood pressure and feelings of discrimination in 77 African American adults. Participants underwent sleep restriction and had their heart health measured during social tasks. The goal was to understand links between sleep,…

This study looked at how race-based social rejection impacts sleep and nighttime heart function. About 139 African American and Caucasian adults spent two nights in a sleep lab—one after a rejection task and one after a neutral task. Researchers measured how quickly they fell asl…

This study looked at how nicotine enters the body when people use JUUL e-cigarettes compared to smoking regular tobacco cigarettes. Seventeen healthy adult smokers took part, and researchers measured nicotine levels and heart rate after each product. The goal was to understand th…

This completed study tested a tablet-based screening system for substance use, depression, and anxiety in over 10,000 HIV-positive adults during routine clinic visits. Patients who screened positive were offered behavioral treatments like motivational interviewing and cognitive b…

This completed study from the University of California, San Francisco enrolled 228 adults with major depression and healthy volunteers. Researchers measured blood levels of natural steroids, genetic markers, and gut bacteria before and after 8 weeks of standard SSRI treatment. Th…

This study tested whether a special video game that combines physical movement with mental challenges can improve attention and memory in healthy adults. 49 participants played the game for 36 minutes a day, 3 days a week for 8 weeks. The goal was to see if the combined training …

This study tested a program called the Care Ecosystem, which provides phone- and web-based support and care coordination for people with dementia and their caregivers. Over 1,200 participants from six health systems took part. The goal was to see if this approach improves quality…