Drug everolimus shows promise in slowing Children's brain tumors
NCT ID NCT01734512
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested the drug everolimus in 65 children whose low-grade gliomas had come back or worsened. The goal was to see if the drug could stop or slow tumor growth. Children took everolimus pills daily, and doctors tracked tumor changes with MRI scans. The study focused on how many children remained progression-free after 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Everolimus (a drug that blocks a protein called mTOR to slow tumor growth)
- What this could lead to
- If successful, everolimus could offer a new treatment option to control tumor growth and delay progression in children with low-grade gliomas.
- What could go wrong
- This is a small, single-arm phase 2 study without a placebo group, so results may not be definitive. The drug may cause side effects like mouth sores, infections, or metabolic changes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital Oakland
Oakland, California, 94609, United States
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Children's Hospitals and Clinics of Minneapolis
Minneapolis, Minnesota, 55404, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Johns Hopkins University
Baltimore, Maryland, 21218, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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St. Louis Children's Hospital, Washington University
St Louis, Missouri, 63130, United States
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The Children's Hospital Of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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University of California, Los Angeles
Los Angeles, California, 90027, United States
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University of California, San Diego Rady Children's Hospital
San Diego, California, 92123, United States
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University of California, San Francisco
San Francisco, California, 94158, United States
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University of Florida
Gainesville, Florida, 32611, United States
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University of Utah
Salt Lake City, Utah, 84112, United States
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University of Washington, Seattle
Seattle, Washington, 98195, United States
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