Depression study probes blood markers and gut bugs during antidepressant treatment

NCT ID NCT00285935

First seen Nov 01, 2025 · Last updated May 08, 2026 · Updated 22 times

Summary

This study looked at 228 adults with major depression and healthy volunteers to see if natural compounds in the blood, genetic markers, and gut bacteria differ between the groups. Depressed participants took a standard antidepressant for 8 weeks while researchers tracked changes in mood, memory, and brain chemistry. The goal was to understand which biological differences improve with treatment, not to test a new therapy.

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Contacts and locations

Locations

  • University of California San Francisco

    San Francisco, California, 94143-0984, United States

Conditions

Explore the condition pages connected to this study.