University Of California, San Francisco

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to receive either a 5-day or 10-day course, with some taking a plac…

This study was designed to see if it is safe to stop yearly mass antibiotic treatment in communities where trachoma is now rare. Researchers planned to compare communities that continued treatment for three more years with those that stopped. The trial was withdrawn before any pa…

This study tests two approaches—one focused on patients and one on clinics—to help people from diverse backgrounds monitor their blood pressure at home. About 330 adults with uncontrolled high blood pressure will take part. The goal is to see which strategy works best to safely i…

This early-stage trial is testing the safety and best dose of two drugs, trametinib and everolimus, given together to children and young adults whose gliomas (a type of brain tumor) have come back after prior treatment. The study aims to find the highest dose that causes fewest s…

This study tests whether a special scan called PSMA PET can help pick men with castration-resistant prostate cancer that has spread to the bones who will get the most benefit from Ra-223 radiation therapy. Ra-223 is a radioactive drug that targets bone tumors. The trial enrolled …

This study explores whether people living with HIV can receive their long-acting injectable medication at home from a trained friend, family member, or partner instead of going to a clinic. The goal is to make treatment easier to stick with and improve viral suppression. About 1,…

This study compares different patient- and clinic-focused strategies to help control high blood pressure in English- and Spanish-speaking adults. Researchers will enroll 2,500 participants to see which approach works best for lowering blood pressure. The goal is to find more effe…

This study tests whether giving the drug osimertinib before surgery can shrink tumors in people with early-stage EGFR-mutant non-small cell lung cancer. About 27 adults with stage I to IIIA disease will receive osimertinib, then have surgery. The main goal is to see how many pati…

This study tests if a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. About 50 adults with severe liver disease who are already on a blood pressure drug during surgery will re…

This study tests a new, less invasive surgical approach for people with persistent atrial fibrillation (AFib), a type of irregular heartbeat that is hard to treat. The procedure combines a small incision under the breastbone with a catheter to destroy abnormal heart tissue and cl…

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug improves daily function…

This study tests if adding a procedure called expansile duraplasty to standard spinal cord injury surgery can improve recovery. Researchers will compare strength, movement, and independence in 66 adults who recently had a spinal cord injury. Half will get the extra procedure, hal…

This study tests a program that combines weekly video chats with a counselor and a mobile app to help young adults (ages 18-29) living with HIV get their virus levels under control. Participants who are not yet virally suppressed will be randomly assigned to either the program or…

This study tests whether certain FDA-approved drugs, used off-label, can help people recover better after a traumatic brain injury (TBI). About 672 adults with moderate to severe TBI will receive either a study drug or a placebo within 24 hours of injury. Recovery is measured by …

This early-phase trial tests a new treatment for people with a rare, aggressive brain tumor called H3.3K27M-mutated diffuse midline glioma. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack the tumor. Before receiving the cells, patients g…

This early-stage study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in adolescents and young adults with IDH-mutant gliomas, a type of brain tumor. The goal is to find the safest dose and check for side effects. About 78 participants with newly diagnosed o…

This study tests whether giving antibiotics more often to entire communities can eliminate trachoma, an eye infection that can cause blindness. Over 300,000 people in Ethiopia are taking part. The goal is to see if this intensive approach works better than the current yearly trea…

This study tests whether a mix of a DNA vaccine, a booster vaccine, an immune stimulant, and special antibodies can help people with HIV control the virus after stopping their daily antiretroviral therapy. About 11 participants will receive the combination and then pause their re…

This study tests whether adding a light-activated dye (rose bengal) to standard antibiotic drops helps people with severe bacterial eye infections see better after 6 months. About 60 adults with corneal ulcers and vision loss will receive either the dye treatment plus antibiotics…

This study looks at giving a single dose of radiation directly to the area where a breast tumor was removed, right during surgery. The goal is to kill any leftover cancer cells and see if this approach works as well as standard radiation therapy. About 1,259 people with early-sta…

This study looks at whether young people (ages 8-20) with type 2 diabetes will use a continuous glucose monitor (CGM) and if it helps them manage their blood sugar. About 30 participants will wear the device for 6 months, and researchers will track how often they use it and if th…

This early-phase study tests whether vosoritide, a daily injection, can safely improve growth in children with MPS IVA or VI, two rare genetic disorders that cause short stature and bone problems. Six children aged 5 to 10 will receive the drug for 96 weeks, with researchers moni…

This study looks at how the drug guselkumab affects the immune system in people with plaque or guttate psoriasis. About 25 adults with recent-onset guttate or plaque psoriasis will receive treatment. The goal is to understand changes in immune cells that cause psoriasis symptoms.

This study explores whether altering the gut microbiome can improve how people with Parkinson's disease respond to their medication. Researchers will first analyze gut bacteria in 86 participants, then give some antibiotics to reset the microbiome. The goal is to reduce 'OFF' tim…

This study looks at how treating obstructive sleep apnea with CPAP affects insulin resistance and hormone levels in women with Polycystic Ovary Syndrome (PCOS). Researchers will measure changes in fat production, testosterone, and insulin secretion in 20 participants. The goal is…

This study tests a stepped alcohol treatment program delivered by phone or video for 180 adults with chronic liver disease who drink too much. Participants are randomly assigned to either the program or usual care. The goal is to see if the program helps reduce drinking and impro…

This study looks at whether giving steroids early helps children who had a stroke due to a condition called focal cerebral arteriopathy (FCA). About 80 kids will either get steroids right away or only if their disease gets worse. All children will also receive standard care with …

This study looks at whether using a special blood pressure monitor at home can find atrial fibrillation (an irregular heartbeat) sooner in older adults with high blood pressure. About 1,900 people aged 60 and older will take daily readings and answer app surveys for up to 18 mont…

This study tests different screening methods to find high-grade lesions (precancer) in the cervix or anus of people living with HIV. These lesions are caused by HPV and can turn into cancer if not caught early. The goal is to see which combination of tests works best to detect th…

This study aimed to see if a more thorough approach to finding malaria cases in high-risk villages and among forest workers could reduce the spread of two types of malaria in southern Laos. The plan was to compare this enhanced method to standard care over 18 months. However, the…

This study tests a combination of team-based clinic practices and patient-friendly technology to help more people complete a colonoscopy after an abnormal stool-based screening test. The goal is to catch colon cancer early or prevent it entirely. About 2,000 adults who speak Engl…

This study compares two online sleep programs for pregnant people with insomnia to see if one can prevent depression after childbirth. About 456 participants will receive either digital cognitive behavioral therapy for insomnia or basic sleep hygiene education over six weeks. Res…

This study in Burkina Faso tests whether adding a nutritional supplement (small-quantity lipid-based nutrient supplements) to the monthly malaria prevention medicine already given to young children can reduce both malaria and malnutrition during the rainy season. About 438 childr…

This study looks at whether women in Uganda can prevent cervical cancer by using a self-administered HPV test at home or in community health campaigns. The test checks for the virus that can lead to cervical cancer, allowing early treatment. Over 2,500 women aged 25-49 are taking…

This study tests a new program that combines mindful eating with motivational interviewing to help reduce binge eating in adults with overweight. About 100 participants will take online surveys, provide body measurements and glucose samples, and meditate daily. Some will also rec…

This study explores whether making music together can improve social attention and emotional connection for people with frontotemporal dementia or Alzheimer's disease and their caregivers. About 80 pairs (patient and caregiver) will take part in rhythmic musical activities. The g…

This pilot study tests whether combining a gentle, noninvasive brain stimulation technique (tACS) with digital meditation can improve thinking skills and wellbeing in older adults with mild cognitive impairment (MCI). About 90 participants aged 60-85 will use a meditation app whi…

This study compares two ways of reintroducing food to hospitalized teens and young adults (ages 12-24) with atypical anorexia nervosa. One method uses a personalized calorie plan, while the other follows a higher-calorie standard. The goal is to see which approach helps patients …

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood symptoms. The information is shared with their neurologist, who gets alerts if there are concerns. The goal is to improve depression screening and care. About 10…

This study tests whether a behavioral sleep treatment can improve sleep and other Gulf War Illness (GWI) symptoms in 80 Gulf War veterans aged 48-80. Participants will receive sleep therapy and be monitored for changes in symptom severity and sleep quality. The goal is to find a …

This study tests whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can reduce chronic neuropathic pain—pain from nerve damage that lasts over 6 months. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal…

This small study tests whether using inflatable cuffs on the legs (blood flow restriction) during low-intensity stepping exercise can improve mobility and quality of life in people with advanced Parkinson's disease. Four participants will exercise twice a week for 8 weeks on a Nu…

This study looks at whether two different wellness programs are practical and liked by breast cancer survivors. About 106 people who finished treatment for early-stage breast cancer will be randomly assigned to either an Ayurveda program (with diet, yoga, and touch therapy) or a …

This study tests a portable cooling cap (AMMA) worn during chemotherapy to prevent hair loss in women with early-stage breast cancer. About 40 women receiving specific chemo drugs will use the cap. The goal is to see if the cap keeps hair loss mild (Grade 2 or less) and safe.

This study tests whether using a wearable bladder device along with standard pelvic floor therapy at home can help people with multiple sclerosis (MS) who have overactive bladder symptoms. About 20 women with MS will use the device and therapy for three months. The main goal is t…

This study tests whether choosing depression treatments based on a patient's specific symptoms and brain imaging (phenotyping) leads to better results than standard care. About 150 adults with major depression will be enrolled. The goal is to see if personalized treatment selecti…

This study is testing a smartphone app called MS Falls Insight Track (MS FIT) that helps people with multiple sclerosis log falls and near-falls, view their health data, and share information with their care team. The goal is to see if using the app can reduce falls and improve c…

This study tests a new, low-cost device to help people who have trouble opening their mouth fully after radiation treatment for head and neck cancer. The device is a jaw stretcher with sensors that measure pressure and how wide the mouth opens, giving real-time feedback. About 35…

This study tests whether virtual peer groups can help Latinx teenagers with type 1 diabetes use insulin pumps and continuous glucose monitors more often. About 120 teens and their caregivers will join online and in-person sessions to share experiences and get support. The goal is…

This study aims to find brain-based markers that could help doctors better diagnose chronic pain and predict which treatments will work best. Researchers will use a device that gently stimulates the brain with magnetic pulses and records the brain's electrical responses in 100 ad…

This study looks at whether giving a monthly food card to low-income adults with chronic conditions and food insecurity helps them get enough healthy food. About 7,000 people are taking part, with some getting a monthly benefit and others a one-time payment. The goal is to see if…

This study looks at how the brain processes spoken language by recording brain activity in people with epilepsy or brain tumors who already have electrodes placed for medical reasons. Researchers will compare brain signals from English, Spanish, and Mandarin speakers to uncover u…

This study looks at how things like income, education, and social support affect the health of children who get a liver transplant. Researchers will survey 500 families and interview some in depth to understand the challenges they face. The goal is to find ways to help all childr…

This study looks at how two different doses of the antibiotic doxycycline affect the development of antibiotic resistance in people with ocular rosacea, a chronic eye condition. Researchers will compare a standard dose (100 mg) to a lower, anti-inflammatory dose (40 mg or less) t…

This study follows about 2,000 women aged 15-34 who are not pregnant at the start to learn about their pregnancy preferences and how these change over time. Researchers will track those who become pregnant to understand their decision-making and compare health and well-being outc…

This study tests a new MRI technique that tracks how the brain uses sugar (glucose) in people with and without brain tumors (glioma). Researchers will compare the signals from healthy volunteers and patients to see if this method can detect differences in brain metabolism. The go…

This study was designed to test if safely removing mucus plugs from the airways of people with asthma can improve lung function. Researchers planned to use a bronchoscopy procedure to clear the plugs and then measure breathing changes after one week and six months. The study was …

This study follows 2,314 South Asian adults (ages 40-84) in the US to uncover why they have high rates of heart disease and stroke, even without typical risk factors. Researchers measure artery calcium, diabetes, and other markers over time. The goal is to identify unique causes …

This study looks at whether it's possible and acceptable to ask families about social needs (like food, housing, or money) when their child is in the hospital. About 50 families with a child in the hospital will take part. The goal is to see if this kind of help can be added to r…

This study looks at a school-based program called VOCES-NUEVAS designed to help newcomer girls from Latin America feel better mentally and emotionally. About 24 students from four school health centers will take short surveys before and after the program and share their thoughts.…

This study aims to gather detailed information about adults with asthma, including their medical history and lung function. The goal is to create a database that helps researchers better understand asthma and design future studies. Participants will not receive any treatment, but…

This study collects tissue and blood samples from 156 people with advanced prostate, kidney, or bladder cancers. Researchers analyze these samples to find genetic markers that predict how well different treatments work. Participants undergo a biopsy of a growing tumor before star…

This study aimed to give firefighters low-dose chest CT scans to check for lung cancer and other lung diseases caused by smoke and chemical exposure. It focused on firefighters aged 35 and older who never smoked or quit long ago. The study was withdrawn before enrolling anyone, s…

This study looks at how lying flat or upright on a rescue litter affects lung function in 12 healthy volunteers weighing 130-310 pounds. Researchers will measure how much air they can exhale in each position. The goal is to find out if an upright litter might be better for breath…

This study looks at brain activity in 20 people with anorexia nervosa to understand compulsive behaviors. Researchers use brain scans and a non-invasive technique called TMS to see if targeting a specific brain area can help. The goal is to find better ways to treat anorexia in t…

This study invites adults 18 and older to join an online registry that tracks brain health over time. Participants fill out questionnaires and take cognitive tests on the BrainHealthRegistry.org website. The goal is to gather data to speed up research on Alzheimer's and other bra…

This study looks at how advanced genetic testing (exome or genome sequencing) can help find the cause of structural problems in unborn babies. Researchers will test samples from 500 pregnant women whose standard tests did not explain the baby's condition. The goal is to learn mor…

This study looks at whether the MS drug ocrelizumab effectively removes B cells from lymph nodes, not just from the blood. Researchers will analyze lymph node samples from 5 people with relapsing-remitting MS who are starting ocrelizumab. The goal is to understand why some immune…

This study tests a program called Meet Me on the Pitch that combines soccer with mental health support for teens ages 14-21. The goal is to see if it helps youth feel better, connect with others, and do well in school. About 480 teens who already play soccer with Soccer Without B…

This study looks at how ocrelizumab, a multiple sclerosis (MS) drug, changes certain markers in the spinal fluid of people newly diagnosed with relapsing MS or a high-risk first episode. Researchers want to see if early treatment can reduce signs of chronic inflammation in the br…

This study looks at how a meditation app affects emotional well-being in lonely adults aged 60 and older. Researchers use brain scans and heart monitors to see changes in the brain. The goal is to understand, not to cure or treat any disease.

This study aimed to understand why some people with asthma develop mucus plugs in their airways. Researchers planned to use a thin, camera-guided tube to collect samples from the lungs of 60 adults—some with asthma and mucus plugs, some with asthma but no plugs, and healthy volun…

This study follows 1,500 adults aged 65 and older who have had a traumatic brain injury (TBI), along with similar healthy participants. Researchers will track their recovery over 12 months using brain scans, blood tests, and health history. The goal is to create better tools for …

This study looks at how the cerebellum, a part of the brain, helps us learn and adjust our speech. Researchers will study people with cerebellar ataxia (a condition affecting coordination) and healthy volunteers. They will use speaking tasks, brain scans (MRI), and a technique th…

This study follows 578 women aged 21 and older who choose either radiofrequency ablation (Acessa) or myomectomy for uterine fibroids. Researchers track symptom changes and re-treatment rates over 3 years using questionnaires and medical records. The goal is to understand long-ter…

This study gives improvisation training to ear, nose, and throat surgical residents to see if it improves their sense of connection, mood, and ability to make quick decisions under pressure. Ten residents take part, with a control group continuing standard education. The goal is …

This study looks at whether young adults (ages 21-25) who use strong cannabis concentrates can improve their memory and attention by switching to less potent products. Researchers will test thinking skills, collect blood and urine samples, and see if genetics affect how THC is pr…

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will use a special ultrasound scan to measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to better understand this liver condition in people with HIV, …

This study looks at whether learning music improvisation can help older adults (60+) better regulate their thoughts and actions. Researchers will compare participants who take improvisation training to those who don't, measuring changes in cognitive skills and brain activity. The…

This study works with about 30 family child care home directors in California to lower their exposure to pesticides. Experts provide education, collect carpet dust samples, and give monthly advice for 7 months. The goal is to help directors use safer pest control methods and unde…

This study follows 300 children who had seizures as newborns to understand how genes influence their risk of developing epilepsy later in childhood. Researchers will combine genetic, brain scan, and EEG data to create a risk score. The goal is to better predict which children nee…

This study looks at 500 babies and fetuses with a serious condition called hydrops fetalis (severe swelling) or other birth defects. Researchers use a special genetic test called exome sequencing to find hidden genetic causes that standard tests miss. The goal is to better unders…

This study aims to learn more about blood sugar patterns in women with PCOS using continuous glucose monitors (CGMs). Researchers will compare women with and without PCOS to see if CGMs can reveal unique glucose problems. They will also test whether wearing a CGM for 90 days can …

This study looks at how a meditation program called TARA affects brain connections and depression symptoms in 120 teens aged 14-18 with mild to moderate depression. Researchers will use MRI scans to measure changes in a brain region called the putamen and track mood improvements.…

This study looks at whether a simple blood test can predict memory and thinking problems in men with prostate cancer who are receiving hormone therapy (ADT). Researchers will track 32 men over time, testing their memory and measuring a blood marker linked to Alzheimer's risk. The…

This study is testing whether giving families who are homeless or at risk of losing their homes $1,000 each month for two years can help them find and keep stable housing. Researchers will also look at how this cash affects their health and overall well-being. About 300 families …

This study follows 1,436 women in Nepal who sought pregnancy termination services. Researchers track their physical and mental health, as well as the health of their children, for three years. The goal is to understand the consequences of unwanted pregnancy and being denied a leg…

This study aims to uncover the genetic reasons behind non-immune hydrops fetalis, a condition where abnormal fluid builds up in a fetus, often leading to stillbirth or severe health problems. Researchers will use advanced DNA and RNA sequencing on 500 affected fetuses or newborns…

This study planned to help adults with heart disease who also face social challenges (like trouble finding food or housing) avoid going back to the hospital. It would have used a screening tool to identify these patients and connect them with community resources. However, the stu…