University Of California, San Francisco

This study compares banked donor breast milk to preterm formula for late preterm infants (born at 34–36 weeks) who need extra nutrition while their mothers' milk supply increases. Researchers will track the babies' weight gain and analyze their gut bacteria to see which supplemen…

This study tests whether giving a guaranteed income of $6,750—either as a lump sum or monthly payments—helps people with HIV who have recently been in jail stay connected to care and keep the virus under control. Thirty-three participants will be randomly assigned to receive the …

This study tests whether a health advocate can help families of children who recently had a liver transplant. The advocate works with the family for 90 days to find resources, coordinate appointments, and communicate concerns to the medical team. The goal is to see if this suppor…

This study looks at whether giving low-income people with diabetes or hypertension a monthly grocery card ($80 or $120) helps them control their disease and feel less stressed about food. About 4,450 adults in California are taking part. Researchers will check changes in blood su…

This study tests four different tools—coaching, education, text messages, and health coaching—to help cancer survivors improve their diet, physical activity, and weight. About 350 adults who have completed treatment for several cancer types will use these tools for up to 48 weeks…

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug leads to better functio…

This study tests whether a combination of weekly video-counseling sessions and a mobile app can help young adults (18-29) living with HIV achieve viral suppression. Participants who are not virally suppressed will be randomly assigned to receive the intervention or standard care.…

This trial tests a procedure called expansile duraplasty, where surgeons open the spinal cord's covering and sew in a patch to give the swollen cord more room. Researchers will compare recovery in 66 adults who receive this extra surgery versus those who get standard care alone. …

This study looks at whether a trained friend, family member, or partner can safely give long-acting HIV injections at home. It involves 1,000 people with HIV who are already on the injectable treatment and have the virus under control. The goal is to make it easier for people to …

This study aims to find out if 5 days of antibiotics works as well as 10 days for children hospitalized with pneumonia, skin infections, or urinary tract infections. About 1,200 children will be randomly assigned to either a 5-day or 10-day course, with some receiving a placebo a…

This study tests a new, less invasive surgical approach for people with persistent atrial fibrillation (AFib), a heart rhythm problem that can be hard to treat. The procedure combines two techniques: ablation (creating tiny scars to block faulty signals) and closing off the left …

This early-phase trial tests a new treatment for children and young adults with a rare, aggressive brain tumor called H3.3K27M-mutated diffuse midline glioma. The treatment involves taking a patient's own immune cells (T cells), genetically modifying them in the lab to recognize …

This study tests whether giving the targeted drug osimertinib before surgery can shrink tumors in people with early-stage EGFR-mutant non-small cell lung cancer. About 27 adults with stage I to IIIA disease will receive the drug before their operation. The main goal is to see how…

This study tests whether a drug called Angiotensin II can help control blood pressure during liver transplant surgery, reducing the need for other strong blood pressure medicines. It involves 50 adults with severe liver disease who are receiving a liver from a deceased donor. The…

This study tests giving a single dose of radiation directly to the tumor site during breast-conserving surgery for early-stage breast cancer. The goal is to see if this one-time treatment works as well as standard radiation therapy that requires multiple visits. Over 1,200 partic…

This early-phase study tests a new drug (BGB-290) combined with chemotherapy (temozolomide) in teens and young adults with a type of brain tumor called glioma that has an IDH mutation. The goal is to find the safest dose and see how well the combination works for both newly diagn…

This study aimed to see if communities with low levels of trachoma could stop receiving yearly azithromycin treatments without the infection coming back. Researchers planned to compare groups that continued or stopped the medicine over three years. However, the trial was withdraw…

This early study tests a daily injection of vosoritide (Voxzogo) in 6 children aged 5 to 10 with MPS IVA or VI, rare conditions that cause growth problems. The main goal is to see if the drug is safe and tolerable over 96 weeks. Researchers will also look at changes in height and…

This study tests whether adding a daily nutrient supplement (SQ-LNS) to monthly malaria prevention visits can reduce both malaria and malnutrition in children aged 6-24 months in Burkina Faso. Researchers will compare malaria rates and nutritional status between children receivin…

This early-phase trial tests whether a combination of two experimental vaccines, an immune booster, and two powerful antibodies can help people with HIV control the virus after stopping their daily antiretroviral therapy. Eleven participants will receive the regimen while on ART,…

This study tests different strategies to help people from diverse backgrounds monitor their blood pressure at home. About 330 adults with uncontrolled high blood pressure will receive training on using a blood pressure monitor and a mobile app, plus SMS reminders and education. T…

This study is testing whether the drug ocrelizumab (Ocrevus) can improve signs of inflammation in the spinal fluid of people newly diagnosed with relapsing multiple sclerosis (MS) or a high-risk first attack (clinically isolated syndrome). Thirty participants will receive ocreliz…

This study looks at whether giving steroids early to children who had a stroke from a condition called focal cerebral arteriopathy (FCA) can help reduce damage to the brain's arteries. About 80 children aged 1 to 18 will be randomly assigned to get steroids right away or only if …

This study tests different patient- and clinic-focused strategies to help people with high blood pressure get it under control. Researchers will compare changes in blood pressure readings from clinic and home monitoring. The goal is to find the most effective approach for English…

This study looks at whether using a CPAP machine to treat obstructive sleep apnea can help improve insulin resistance and hormone levels in women with Polycystic Ovary Syndrome (PCOS). Researchers will measure changes in fat production, testosterone, and insulin in 20 women aged …

This study compares two ways of reintroducing food (refeeding) to hospitalized patients aged 12-24 with atypical anorexia nervosa. The goal is to see which method helps patients reach medical stability faster and with fewer side effects. Participants will be followed for one year…

This phase II trial tests whether using PSMA PET scans to select patients with castration-resistant prostate cancer that has spread to bones can improve the effectiveness of radium-223 therapy. Radium-223 is a radioactive drug that targets bone tumors. The study involves only 2 p…

This study tests whether certain FDA-approved drugs, used off-label, can help people recover better after a traumatic brain injury (TBI). About 672 adults with moderate to severe TBI will receive either an experimental drug or a placebo within 24 hours of their injury. The main g…

This study tests whether a light-activated dye called rose Bengal, combined with antibiotics and steroids, can improve vision in people with severe bacterial eye infections. About 60 adults with corneal ulcers and vision loss will receive either the dye treatment or a sham proced…

This study tests whether giving antibiotics more often to entire communities can eliminate trachoma, an eye infection that can cause blindness. Over 300,000 people in Ethiopia are taking part. The goal is to see if this intensive approach works better than the current yearly trea…

This study tests whether giving low-income adults with chronic conditions a monthly grocery card (about $80 per month) improves food security and health compared to a one-time payment. About 7,000 participants are randomly assigned to receive the monthly benefit or a lump sum aft…

This study tests whether a stepped alcohol treatment delivered via video or phone calls can help people with advanced liver disease cut back on unhealthy drinking. About 180 participants will be randomly assigned to either the treatment program or usual care. The goal is to see i…

This study tests whether choosing depression treatments based on a person's specific symptoms (like anhedonia or anxious distress) works better than the usual trial-and-error method. 150 adults with major depressive disorder will receive either standard care or a treatment matche…

This study explores whether altering gut bacteria with an antibiotic (rifaximin) can improve motor symptoms and medication response in people with Parkinson's disease. Researchers will first analyze how gut bacteria relate to symptoms, then give some participants rifaximin and ot…

This study is testing whether a special home blood pressure monitor that can detect atrial fibrillation (AFib) helps diagnose the condition faster in older adults with high blood pressure. About 1,900 participants aged 60 and older will take daily blood pressure readings and answ…

This study uses a device that combines magnetic stimulation and brain wave recording (TMS-EEG) to find biological markers for chronic pain. Researchers will measure brain responses in 100 adults with chronic pain and see if these signals can help diagnose pain types and predict h…

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This study looks at whether women in rural Uganda can screen themselves for cervical cancer using a simple HPV test at home. Over 2,500 women aged 25-49 will collect their own samples during community health campaigns. The goal is to see if this approach increases screening rates…

This study aimed to see if sending health workers to find malaria cases in high-risk villages and among forest workers could lower malaria rates better than usual care. It planned to track infections over 18 months in southern Laos. However, the study was withdrawn before any par…

This study tests ways to help more people complete a colonoscopy after an abnormal stool-based colorectal cancer screening test. The researchers will use team-based best practices in clinics and a patient app with enhanced instructions and navigation. About 2,000 adults who speak…

This study tests whether a digital sleep program (CBT-I) can prevent depression in pregnant people with insomnia. 456 participants will either use the CBT-I app or receive standard sleep hygiene education. Researchers will track who develops depression through one year after birt…

This phase 3 trial tests whether a 'miracle fruit' cube (miraculin) can improve taste loss in head and neck cancer patients undergoing radiation therapy. Taste problems are common and hard to treat during radiation. The study will compare the fruit cube to a placebo in 40 patient…

This study tests a mobile health app designed to reduce parenting stress for caregivers of justice-involved youth aged 12-17. The app aims to help parents feel more mindful and less stressed, which may improve their teen's engagement in substance use treatment. Researchers will m…

This study tests whether 12 weeks of piano improvisation training can improve thinking skills and self-control in adults aged 60 and older, including those with mild cognitive impairment. Participants will either take piano improvisation lessons or listen to music with an instruc…

This pilot study looks at whether giving fluoride varnish during regular cancer checkups can help protect the teeth of head and neck cancer patients who have had radiation and lack easy access to a dentist. About 43 uninsured or underinsured adults will receive 4-5 fluoride treat…

This study tests a portable scalp cooling system called Amma to see if it can prevent hair loss in women receiving chemotherapy for early-stage breast cancer. Forty women with stage I-III breast cancer will use the cooling cap during their chemo sessions. The goal is to see if mo…

This study tests a personal health app called MS FIT that lets people with multiple sclerosis log falls and near-falls, view their health data, and share it with their doctor. The goal is to improve communication about fall risks and provide educational tips. About 100 participan…

This study tests a new program that combines mindful eating with motivational interviewing to help people with overweight reduce binge eating. One hundred participants will either receive the full program (counseling plus daily meditation) or just daily meditation. The main goal …

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a program called Meet Me on the Pitch (MMotP) that combines soccer with behavioral health sessions for teens aged 14-21. The goal is to improve mental health, well-being, and academic support. Researchers will compare the program to standard sports activities in …

This study tests whether a wearable device, used at home alongside pelvic floor therapy, can help people with multiple sclerosis manage bladder problems. Twenty women with MS will use the device for three months. The main goal is to see if the approach is practical and easy to us…

This pilot study tests whether combining a gentle, noninvasive brain stimulation technique (tACS) with digital meditation can improve thinking skills and well-being in older adults with mild cognitive impairment (MCI). About 90 adults aged 60-85 with MCI will participate. The goa…

This study tests a new low-cost device designed to help people who developed lockjaw (trismus) after radiation treatment for head and neck cancer. The device is a non-invasive jaw stretcher with sensors that measure pressure and how wide the mouth opens, giving real-time feedback…

This study tests whether a digital meditation app can improve emotional well-being in lonely adults aged 60 and older. Participants use the app five days a week for six weeks. Brain scans and surveys measure changes in loneliness, anxiety, and stress.

This study explores whether a simple music activity—tapping along to rhythms together—can improve social attention and feelings of closeness in people with frontotemporal dementia or Alzheimer's disease, and their caregivers. Eighty patient-caregiver pairs will participate in a c…

This study tests a smartphone app called MS CATCH that lets people with multiple sclerosis regularly report their mood to their neurologist. The goal is to improve how doctors screen and treat depression in MS. About 100 adults with MS and mild-to-moderate depression are taking p…

This study investigates how the brain processes speech sounds to understand language. Researchers will record brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds while their…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study tests a new type of brain implant that can both sense brain activity and deliver stimulation in real time. It involves 25 people with Parkinson's disease or dystonia who already need deep brain stimulation. The goal is to see if closed-loop stimulation (which adjusts a…

This study looks at how ozone, a common air pollutant, affects immune cells in the lungs of people with COPD. Researchers will expose 72 participants (including healthy non-smokers, smokers without COPD, and COPD patients) to ozone in a controlled chamber and track changes in the…

This study looks at how long-term exposure to secondhand tobacco smoke changes the lungs of never-smoking flight attendants who worked on planes before smoking was banned. Researchers want to see if a bronchodilator, a medicine that opens airways, can help with breathing problems…

The BREATHE study tests whether a one-hour interactive lesson on air pollution can change how middle-school students think and act about pollution. About 600 students will be split into two groups: one gets the air pollution lesson, the other a lesson on vaccines. Researchers wil…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study follows 500 adults with vocal cord paralysis or atrophy who undergo laryngeal framework surgery. Researchers will track voice quality, swallowing ability, and complication rates for two years after surgery. The goal is to understand which surgical techniques work best …

This study tests whether virtual peer groups can help Latinx teenagers with type 1 diabetes use insulin pumps and continuous glucose monitors more effectively. About 120 teens and their caregivers will join online sessions covering topics like family relationships, school, and wo…

This study explores whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce compulsive behaviors in people with anorexia nervosa. Twenty participants will receive multiple sessions of rTMS targeting a brain region l…

This study works with about 30 family child care home directors in California to see if teaching them integrated pest management (IPM) can cut down on pesticide use and exposure. Directors get education, carpet dust tests, and monthly advice for 7 months. The goal is to lower hea…

This study looks at whether two different health programs are practical and acceptable for women who have finished treatment for early-stage breast cancer. One program combines nutrition advice, lifestyle changes, yoga, and therapeutic touch (Ayurveda). The other is a self-guided…

This nationwide registry follows 578 women with uterine fibroids who choose either radiofrequency ablation (Acessa) or myomectomy. Researchers track symptom changes, quality of life, and need for repeat treatment over three years. The goal is to understand which procedure provide…

This study follows over 2,000 women aged 15-34 who are not pregnant at the start to understand their feelings about pregnancy and how those feelings change. Researchers track who becomes pregnant, what decisions they make, and how pregnancy affects their health, stress, and well-…

This study looks at a program called VOCES-NUEVAS for newcomer girls from Latin America in Oakland schools. The goal is to see if the program fits well in schools and helps improve mental health. About 24 girls will take short surveys before and after the program, and give feedba…

This national study is looking at 500 babies and fetuses with non-immune hydrops fetalis or other birth defects to find hidden genetic causes. Researchers are using a detailed genetic test called exome sequencing to look for DNA changes that might explain these conditions. The go…

This study looks for genetic causes of non-immune hydrops fetalis, a condition where fluid builds up abnormally in a fetus, leading to high risks of stillbirth or death. Researchers will use whole genome sequencing on 500 affected fetuses or newborns and their parents. The goal i…

This study looks at 500 pregnant women whose fetuses have structural anomalies not explained by standard genetic tests. Researchers will use advanced genomic sequencing to find possible genetic causes. The goal is to learn more about these conditions and how families use this inf…

This pilot study at UCSF Benioff Children's Hospital tests whether it's practical and acceptable to screen families of hospitalized children for unmet social needs like food or housing insecurity, and then connect them with resources. Researchers will develop a screening protocol…

This study looks at whether young adults (ages 21-25) who use high-potency cannabis concentrates can improve their memory and thinking by switching to less potent products. Researchers will test participants' cognitive performance and collect blood and urine samples. The goal is …

This study planned to give low-dose chest CT scans to firefighters aged 35 and older to see how many had lung cancer, other cancers, or lung diseases from job-related smoke and chemical exposure. It was withdrawn before any firefighters were enrolled, so no results are available.…

This study looks at how lying flat, sitting up, or being vertical in a rescue litter affects lung function. Researchers will test 12 healthy volunteers weighing 130-310 pounds. The goal is to see if a vertical position is better for breathing than lying flat, which could help res…

This study will examine lymph nodes from 5 people with relapsing-remitting multiple sclerosis who are starting ocrelizumab treatment. The goal is to see how effectively the drug removes B cells from lymph nodes, since these cells are known to be important in MS but are not well s…

This study looks at how a meditation program called TARA changes brain connections in teens aged 14 to 18 with mild or moderate depression. Researchers will use brain scans to see if meditation strengthens a key brain area and reduces depression symptoms. The goal is to understan…

This study aims to learn more about blood sugar patterns in women with Polycystic Ovary Syndrome (PCOS) using a continuous glucose monitor (CGM). Researchers will compare women with and without PCOS to see how their blood sugar differs in daily life. They will also test whether w…

This study follows 1,436 women in Nepal who sought pregnancy termination services to understand the health consequences of unwanted pregnancy and being denied a legal abortion. Researchers will track physical and mental health, child development, and family well-being over three …

This study looks at how different doses of the antibiotic doxycycline affect antibiotic resistance in people with ocular rosacea, an inflammatory eye condition. Researchers will compare a low anti-inflammatory dose (40 mg daily) with a standard antibiotic dose (200 mg daily) and …

This study planned to use a special camera (virtual navigation bronchoscopy) to collect samples from mucus plugs in the lungs of people with asthma. The goal was to compare inflammation markers between plugged and non-plugged airways, and with healthy volunteers. However, the stu…

This study gives 300 homeless or housing-unstable families in Santa Clara County, California, $1,000 per month for 24 months to see if it helps them find and keep stable housing. Researchers will also measure effects on health and well-being. Participants can choose between equal…

This study gives online improvisation training to ear, nose, and throat surgical residents to see if it boosts their sense of connection and helps them make quicker, more accurate decisions under pressure. A control group continues standard training. With only 10 participants, th…

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study follows over 2,300 South Asian adults in the US to understand why they have high rates of heart disease and stroke, even without traditional risk factors. Participants are aged 40-84 and have no prior heart events. Researchers will track heart scans, diabetes, and othe…

This study looks at how social factors like income, education, and community support impact recovery in 500 children after liver transplant. Researchers will survey caregivers and interview families to understand barriers to good outcomes. The goal is to find ways to better integ…

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to understand the true scale of this liver condition in this group, which has been largely over…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study aimed to see if removing mucus plugs from the airways of people with asthma is safe and could improve lung function. Researchers planned to use a thin tube with a camera (bronchoscopy) to remove the plugs and then check breathing tests one week and six months later. Ho…

This study follows 1,500 older adults (65+) who come to the emergency department after a traumatic brain injury, along with matched controls. Researchers will track their recovery over 12 months using brain scans, blood tests, and health assessments. The goal is to develop age-ap…

This study collects tissue and blood samples from 156 people with advanced prostate, kidney, or bladder cancers. Researchers analyze these samples to find genetic markers that predict how well different treatments will work. Participants do not receive any experimental treatment …

This study looks at how the cerebellum, a part of the brain, helps us learn and adjust our speech. Researchers will use brain scans, magnetic stimulation, and speaking tasks in people with cerebellar ataxia (a movement disorder) and healthy volunteers. The goal is to better under…

This study tests a new way to measure brain metabolism using a special glucose drink and MRI scans. Researchers will compare healthy volunteers and people with glioma (a type of brain tumor) to see if the technique can detect differences in energy use. The goal is to improve imag…

This study records brain activity from people with epilepsy or brain tumors who already have electrodes implanted for medical reasons. Participants listen to short speech sounds in English, Spanish, or Mandarin while their brain signals are measured. The goal is to understand how…

This study looks at whether teenagers with type 2 diabetes will wear and use a continuous glucose monitor (CGM) — a small sensor that tracks blood sugar levels. Twenty participants will use the FreeStyle Libre CGM for 6 months, while 10 others serve as a comparison group. The mai…

This study is gathering information from adults with asthma to better understand the condition. Researchers will collect medical history and lung function data to create a database for future asthma research. The study does not test any new treatments or medications.

This study was designed to see if helping heart patients with social problems like food, housing, and mental health could keep them out of the hospital. The researchers planned to screen patients and connect them to community resources. However, the study was withdrawn before enr…