Can an antihistamine help heal MS?
NCT ID NCT02040298
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 2 trial tested clemastine fumarate, a common allergy medicine, to see if it could repair damaged nerves in people with relapsing-remitting multiple sclerosis. Fifty participants took either the drug or a placebo for several months. The study measured nerve signals in the eyes and brain to check for improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
clemastine fumarate (an antihistamine drug)
What this could lead to
If it works, this could point toward a treatment that helps repair nerve damage in people with multiple sclerosis.
What could go wrong
This is a small, early-phase trial with only 50 people. The drug is being tested for a new use, and it may not work or could cause side effects like fatigue.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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UCSF Multiple Sclerosis Center
San Francisco, California, 94518, United States