Could menopause hormones unfreeze stiff shoulders?

NCT ID NCT07278323

Recruiting now Symptom relief Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding hormone replacement therapy (HRT) to standard care helps relieve frozen shoulder in women around menopause. Sixty participants will receive either HRT plus usual treatment or usual treatment alone for six months. Researchers will measure shoulder pain, function, and range of motion to see if HRT provides extra benefit.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hormone replacement therapy (estradiol patch and oral progestin)
What this could lead to: If it works, this could offer a new way to ease frozen shoulder pain and stiffness in women going through menopause.
What could go wrong: This is a small, early-phase study with only 60 participants. The added benefit of HRT over standard care alone may be small or absent, and HRT carries known risks like blood clots and hormone-sensitive cancers.

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Conditions

The condition(s) this trial relates to.

bursitis frozen shoulder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADHESIVE CAPSULITIS OF THE SHOULDER FROZEN SHOULDER

Contacts and locations

Locations

UCSF Orthopaedic Institute
RECRUITING

San Francisco, California, 94158, United States

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