Could menopause hormones unfreeze stiff shoulders?
NCT ID NCT07278323
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding hormone replacement therapy (HRT) to standard care helps relieve frozen shoulder in women around menopause. Sixty participants will receive either HRT plus usual treatment or usual treatment alone for six months. Researchers will measure shoulder pain, function, and range of motion to see if HRT provides extra benefit.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hormone replacement therapy (estradiol patch and oral progestin)
What this could lead to
If it works, this could offer a new way to ease frozen shoulder pain and stiffness in women going through menopause.
What could go wrong
This is a small, early-phase study with only 60 participants. The added benefit of HRT over standard care alone may be small or absent, and HRT carries known risks like blood clots and hormone-sensitive cancers.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UCSF Orthopaedic Institute
RECRUITINGSan Francisco, California, 94158, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••