Can a breast cancer drug shrink fibroids? new trial aims to find out
NCT ID NCT06143631
First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 3 times
Summary
This study tests whether the drug letrozole can improve symptoms and shrink fibroids in women with uterine fibroids. 140 participants will receive either letrozole or a placebo daily for 12 weeks. The main goal is to see if letrozole reduces symptom severity and improves quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Letrozole 2.5 mg tablet taken daily
- What this could lead to
- If it works, this could offer a non-surgical option to reduce fibroid symptoms like heavy bleeding and pelvic pressure.
- What could go wrong
- This is a relatively small, short-term trial (12 weeks). Letrozole may not work better than placebo, and side effects are possible. Results may not apply to all women.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Duke University
RECRUITINGDurham, North Carolina, 27710, United States
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94115, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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University of Mississippi Medical Center
RECRUITINGJackson, Mississippi, 39216, United States
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- Vitamin cocktail may shrink fibroids, reduce surgery need