Can a breast cancer drug shrink fibroids? new trial aims to find out
NCT ID NCT06143631
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether the drug letrozole can improve symptoms and shrink fibroids in women with uterine fibroids. 140 participants will receive either letrozole or a placebo daily for 12 weeks. The main goal is to see if letrozole reduces symptom severity and improves quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Letrozole 2.5 mg tablet taken daily
What this could lead to
If it works, this could offer a non-surgical option to reduce fibroid symptoms like heavy bleeding and pelvic pressure.
What could go wrong
This is a relatively small, short-term trial (12 weeks). Letrozole may not work better than placebo, and side effects are possible. Results may not apply to all women.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Duke University
RECRUITINGDurham, North Carolina, 27710, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic
RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94115, United States
Contact
Contact Email: •••••@•••••
Contact
Contact Email: •••••@•••••
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University of Mississippi Medical Center
RECRUITINGJackson, Mississippi, 39216, United States
Contact
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••