CBD vs THC: can cannabidiol take the edge off cannabis's psychoactive effects?

NCT ID NCT06099379

Recruiting now Knowledge-focused Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether different doses of cannabidiol (CBD) can reduce the psychoactive effects of THC in healthy adults who use cannabis occasionally. One hundred participants will inhale various combinations of CBD and THC and report their experiences. The goal is to find out if CBD can make the 'high' from THC less intense or more manageable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: cannabidiol (CBD) and tetrahydrocannabinol (THC) - inhaled
What this could lead to: If it works, this could help people better understand how CBD might reduce the 'high' from THC, potentially leading to safer cannabis products.
What could go wrong: This is an early-phase study in healthy volunteers, not patients. The results may not apply to regular users or medical conditions, and the effects of CBD on THC are still uncertain.

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Conditions

The condition(s) this trial relates to.

cannabis dependence thrombocytopenia 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS THC

Contacts and locations

Locations

Centre de recherche du Centre Hospitalier Universitaire de Montréal
RECRUITING

Montreal, Quebec, H2X0A9, Canada

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