New injection aims to ease Post-Surgery pain without Morphine's downsides
NCT ID NCT06890533
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This phase 3 trial tests an experimental painkiller called YZJ-4729 for people experiencing moderate to severe pain after abdominal surgery. Participants receive either YZJ-4729, a placebo (saline), or morphine, and researchers measure pain intensity over 24 hours. The goal is to see if YZJ-4729 works well and is safe compared to standard treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
YZJ-4729 tartrate injection
What this could lead to
If successful, this could provide a new painkiller option for people recovering from abdominal surgery, potentially with fewer side effects than morphine.
What could go wrong
This is an early-phase trial, so the drug may not prove more effective or safer than existing treatments. Side effects typical of opioids are possible.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Affiliated Hospital of Jiangnan University
Wuxi, China
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Affiliated Zhongshan Hospital of Dalian University
Dalian, China
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Cangzhou Central Hospital
Cangzhou, China
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Cangzhou People's Hospital
Cangzhou, China
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Changde First People's Hospital
Changde, China
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Changsha Hospital Affiliated to Hunan University
Changsha, China
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Deyang People's Hospital
Deyang, China
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Dongguan People's Hospital
Dongguan, China
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Ganzhou People's Hospital
Ganzhou, China
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Guangdong Province Traditional Chinese Medical Hospital
Guangzhou, China
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Haikou People's Hospital
Haikou, China
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Henan Provincial People's Hospital
Zhengzhou, China
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Huzhou Central Hospital
Huzhou, China
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JiangXi Provincial People's Hospital
Nanchang, China
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Liuzhou People's Hospital
Liuzhou, China
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Liuzhou Workers' Hospital
Liuzhou, China
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Luoyang Central Hospital
Luoyang, China
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Ma'anshan People's Hospital
Ma’anshan, China
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Mianyang Central Hospital
Mianyang, China
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Ningbo Medical Center Lihuili Hospital
Ningbo, China
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Qingdao Central Hospital of Rehabilitation University
Qingdao, China
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Shanghai First Maternity and Infant Hospital
Shanghai, China
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Shanghai Fourth People's Hospital
Shanghai, China
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Sichuan Provincial People's Hospital
Chengdu, China
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Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Guangzhou, China
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Taizhou People's Hospital
Taizhou, China
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The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
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The First Affiliated Hospital of Jinan University
Guangzhou, China
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The First Affiliated Hospital of University of South China
Hengyang, China
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The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
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The First Hospital of Jiaxing
Jiaxing, China
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The First Hospital of Jilin University
Ch’ang-ch’un, China
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The First People's Hospital of Guangyuan
Guangyuan, China
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The Fourth Affiliated Hospital of Harbin Medical University
Ha’erbin, China
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The Fourth Hospital OF Changsha
Changsha, China
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The Second Affiliated Hospital of Chongqing Medical University
Chongqing, China
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The Second Hospital of Tianjin Medical University
Tianjin, China
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The Second Nanning People's Hospital
Nanning, China
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The Second People's Hospital of Chengdu
Chengdu, China
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The Second People's Hospital of Hefei
Hefei, China
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The Second People's Hospital of Neijiang
Neijiang, China
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The Second People's Hospital of Yibin
Yibin, China
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The Third People's Hospital of Chengdu
Chengdu, China
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The Third Xiangya Hospital of Central South University
Changsha, China
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Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
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Wuhan Third Hospital
Wuhan, China
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Zhangzhou Municipal of Fujian Province
Zhangzhou, China
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Zhongshan Hospital Xiamen University
Xiamen, China
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Zhuzhou Central Hospital
Zhuzhou, China