PAIN

This study tested a brief, one-time computer program designed to help adults with chronic pain who drink hazardously and take prescription opioids. The program provided personalized feedback to increase knowledge about the dangers of mixing alcohol and opioids and to motivate saf…

This small pilot study tested whether adding exercise and pain-focused talk therapy to standard residential drug treatment is practical and helpful for adults with opioid addiction and chronic pain. Researchers wanted to see if participants could stick with the program and if it …

This study tested a new program designed to help young adult cancer survivors who have obesity. The program used video calls to teach strategies for managing weight, diet, activity, and lingering symptoms like pain and fatigue. Researchers wanted to see if the program was practic…

This study tested a specific anesthesia plan for patients aged 60+ undergoing heart surgery. Researchers compared a guided approach using brain wave monitoring to standard care. The goal was to see if the new plan could reduce post-surgery confusion, improve pain control with les…

This study tested a simple, non-invasive heart rate monitor (called ANI) to see if it could accurately detect pain and discomfort in patients who are unable to communicate, such as those receiving end-of-life palliative care. Researchers compared the monitor's readings to pain as…

This study tested whether a new handheld device called VerTouch could help doctors find the best spot for spinal injections more easily than the standard methods of touch or ultrasound. Researchers compared the three techniques in 86 patients undergoing spinal procedures, primari…

This study tested a medical device called the ANI monitor to see if it could accurately measure pain in sedated and ventilated children in the pediatric intensive care unit. Researchers enrolled 50 children to see if the device's readings matched up with standard behavioral pain …

This study tested whether wearing virtual reality (VR) glasses during a common kidney stone treatment could help patients feel less pain and anxiety. Researchers compared 70 patients receiving the shock wave treatment, with some using VR glasses and others receiving standard care…

This study tested whether wearing virtual reality (VR) glasses could help reduce pain and anxiety for women getting a copper intrauterine device (IUD) inserted. 70 women were randomly assigned to either use VR glasses during the procedure or receive standard care without VR. Rese…

This early-stage study tested the safety of a new pain medication called SBS-1000 in healthy adults. Researchers gave increasing doses to 48 participants to see how their bodies handled the drug and to check for side effects. The goal was to determine safe dosage levels before te…

This study tested whether having a live musician play in the Intensive Care Unit (ICU) could help patients feel better. Researchers wanted to see if the music reduced patients' pain and anxiety, and if it was helpful for their families and the medical staff. They measured how pat…

This study tested a digital app designed to help hospice patients and their caregivers manage pain at home. The app provides education about pain medication, makes it easier to report pain to nurses, and helps people follow their pain management plan. Researchers wanted to see if…

This trial tested whether applying a special gel called PuraBond during surgery to remove mouth or throat lesions helps patients recover with less pain. 73 patients were randomly assigned to have the gel applied or not during their operation. The main goal was to see if using the…

This study tested whether a special long-acting numbing medication (Liposomal Bupivacaine) could provide better pain relief after hernia repair surgery. Researchers gave the medication to 19 patients having either open or minimally invasive hernia surgery. The goal was to see if …

This study tested whether fun, structured play activities could help reduce anxiety for children getting chemotherapy and their parents. 62 children aged 4-10 and their parents participated. The children played age-appropriate games during their treatment, and anxiety levels for …

This study tested whether an investigational drug called LEVI-04 could safely reduce pain and improve physical function in people with knee osteoarthritis. Over 500 participants with moderate to severe knee pain received either the drug or a placebo injection. The main goal was t…

This small pilot study tested a program designed to help cancer survivors quit smoking and better manage their pain. The program combined counseling techniques with a prescription medication (varenicline/Chantix) that can aid both smoking cessation and pain relief. Researchers ai…

This study tested whether listening to music during wound dressing changes helps reduce pain and anxiety for people with venous leg ulcers. Researchers compared two types of music (instrumental Turkish and Western) to no music in 97 patients. They measured pain and anxiety levels…

This study tested whether an investigational drug called MR-107A-02 works better than a placebo (inactive pill) or standard pain medication for relieving acute pain after bunion removal surgery. It involved 410 patients who had moderate to severe pain after their nerve block wore…

This study tested if using simple toys could make blood draws easier for young children. Researchers gave 120 children aged 4-6 either a liquid hourglass to watch or a spiky ball to hold during the procedure. They measured if these toys helped reduce the children's pain, fear, an…

This study tested whether a phone counseling program could help veterans with chronic pain and risky substance use. Over 1100 post-9/11 veterans applying for service-related compensation were randomly assigned to receive either the counseling calls or usual care. The counseling a…

This study looked at whether playing an active virtual reality (VR) game or just watching a passive VR experience changes how much heat or pressure pain healthy adults can handle. Researchers at Stanford University tested 265 healthy volunteers to see if the type of VR activity a…

This study tested whether letting a child choose and place a sticker on their skin during an IV needle insertion could reduce their pain and anxiety. Researchers compared 72 children aged 5-10 years who received the sticker to a group who did not. The goal was to find a simple, n…

This study aimed to find the best dose of inhaled ketamine for quickly reducing pain in children and teenagers in the emergency room. Researchers compared three different strengths of the medicine, given through a special breath-activated nebulizer, in 80 young patients with vari…

This study tested whether various health and wellness products sold directly to consumers could help reduce pain. Over 2,000 adults in the US who wanted less pain took part from home over 7 weeks. Participants received either an active product or a placebo (a look-alike with no a…

This study tested two ways to reduce the pain children feel when a common anesthesia drug is given through an IV. Researchers compared a special hypnosis technique called the 'magic glove' to a standard numbing medicine (lidocaine). They enrolled 100 children aged 7 to 14 to see …

This study aimed to see if a 50/50 mix of oxygen and nitrous oxide (sometimes called 'laughing gas') could safely reduce pain and anxiety in children aged 1 to 16 during minor procedures like getting an IV or stitches. Researchers observed 100 children to measure their pain level…

This study tested three different holding positions to see which one best reduces pain and discomfort in newborns during routine heel stick blood sampling. Researchers observed 120 healthy, full-term newborns while nurses took blood samples, measuring their pain levels, comfort, …

This study tested whether inhaling lavender essential oil could help reduce anxiety and pain as a complementary therapy. Researchers compared 68 patients with moderate to severe pain who either inhaled diluted lavender oil or plain water for 30 minutes. They measured changes in a…

This study looked at whether two simple, non-drug methods could help people with burns feel better during painful dressing changes. Researchers tested if doing breathing exercises or squeezing a stress ball could reduce pain and anxiety for 210 adult outpatients. They measured pa…

This study tested whether a wearable device that plays specific light and sound patterns could help reduce chronic nerve pain. Seventy-five adults with neuropathic pain used the device at home for 8-14 weeks. Researchers compared the real device to a fake one to see if it improve…

This study aimed to see if guided strength and stretching sessions with a physical therapist, plus a home exercise plan, work better than just a home exercise plan alone. It focused on helping second-year dental students prevent and reduce the neck, shoulder, and back pain common…

This study tested whether a single dose of an immune protein therapy (IVIG) could safely shorten severe pain crises in people with sickle cell disease. About 300 children and adults were given either IVIG or a placebo saline solution during a hospital stay for a pain crisis. Rese…

This study tested whether a local anesthetic delivered through a small catheter placed directly in the surgical wound could effectively control pain after major chest surgery. It focused on patients who could not safely receive the standard epidural pain relief method due to medi…

This study compared two different ways of giving a nerve block to control pain after breast cancer surgery (mastectomy). Researchers tested a new technique called the proximal intercostal block against a standard method to see if it was easier to perform, faster, and safer. They …

This study tested whether a brief mindfulness session could help reduce pain for patients waiting in an orthopedic clinic. Researchers also wanted to see if explaining how mindfulness works beforehand made it more effective. Over 600 adult patients participated in the trial, whic…

This study tested whether listening to slow-tempo music could help prevent or reduce delirium in older adults who are critically ill and on a breathing machine in the ICU. Delirium is a serious state of confusion linked to longer hospital stays and future memory problems. Researc…

This study tested whether Korean manupuncture, a hand-based acupuncture technique, could reduce pain in women with endometriosis. Seventy-four women with diagnosed endometriosis were randomly assigned to receive either the real hand treatment or a placebo version. The goal was to…

This University of Washington study tested whether acupuncture could help reduce pain in people with long COVID. Researchers enrolled 82 participants with persistent pain following COVID-19 to see if running a larger trial was practical. They compared pain levels over 5 months be…

This study tested four simple, drug-free methods to reduce pain and fear in 4-6 year olds getting shots in the emergency room. Researchers compared a special tapping technique, a palm stimulator, a plastic device called ShotBlocker, and a vibrating bee-shaped gadget called Buzzy®…

This study tested whether acupuncture, a traditional needle-based therapy, could help reduce severe foot and leg pain caused by nerve damage in people living with HIV. Nearly 200 participants were randomly assigned to receive either real acupuncture, a fake version, or no treatme…

This study tested whether giving back massages to patients after open-heart surgery could help them feel better. Researchers wanted to see if massage could reduce pain, improve sleep quality, and lower levels of the stress hormone cortisol. They compared 96 patients who received …

This study tested whether hypnosis and virtual reality could help reduce pain during repeated medical procedures like wound care. Researchers compared these mind-based distraction techniques in 52 patients who experienced painful treatments at least three times. The goal was to s…

This study tested whether a single, long-acting pain injection given before surgery could help manage pain for people recovering from hemorrhoid removal. It involved 221 adults who were scheduled for this surgery. Researchers compared the injection to a placebo (a dummy shot) to …

This study tested whether using virtual reality glasses or listening to white noise could help adults feel less pain and anxiety when getting an IV needle inserted. Researchers randomly assigned 76 adult patients to either use VR, listen to white noise, or receive standard care (…

This study tested an alternative pain control method for patients who cannot receive the standard epidural pain relief after chest surgery. Researchers compared a local anesthetic delivered through a small catheter placed near the spine against a placebo, with both groups also ha…

This study compared two types of nerve block injections given during robotic prostate surgery to see which one better controls pain afterward. Researchers followed 108 men to measure their pain levels, need for extra pain medication, and how quickly they could get up and walk. Th…

This study tested a new topical gel and mouthwash to see if it could reduce severe mouth sores in people receiving radiation for head and neck cancer. It also looked at whether using the products could improve patients' long-term quality of life after treatment ended. The trial i…

This study tested whether a gas mixture called Kalinox could safely reduce pain for adults with cancer during short, invasive procedures like bone marrow tests or spinal taps. It compared the gas to standard pain relief methods and a placebo to see which worked better. The goal w…

This study tested whether a simple breathing exercise could help people feel better after weight loss surgery. Researchers taught 60 patients a specific 4-7-8 breathing pattern to use hourly after their operation. They then compared the pain and nausea levels of these patients to…

This study tested if listening to nature sounds while getting out of bed could help patients feel better after gallbladder surgery. Researchers worked with 70 adults to see if this simple method reduced their anxiety, pain, and stress levels. They measured these feelings using qu…

This study tested whether sharing a short, immersive nature experience in virtual reality could help hospice patients and their caregivers. Twenty-six people (patients and their caregivers together) tried a personalized 5-15 minute VR session. Researchers measured if this shared …

This study tested if listening to music could make a specific bladder function test less painful and embarrassing. Researchers randomly assigned 90 adults undergoing the test to either listen to music or not. The goal was to see if this simple, non-drug approach could improve com…

This study tested whether a guided exercise program delivered through video calls (telerehabilitation) could help people with knee arthritis feel better. Researchers compared this home-based program to standard medical care in 118 patients over 50 years old. The main goal was to …

This study tested whether a special calming communication technique, delivered by a trained nurse, could help men feel less anxious and experience less pain during a prostate biopsy. About 100 men were randomly assigned to receive either this special support or standard care duri…

This study tested whether using virtual reality and relaxation exercises could help people feel better after having their wisdom teeth removed. Researchers compared three groups: one doing relaxation exercises, one using VR plus relaxation, and a standard care group. They measure…

This study tested whether a fast-acting cooling spray could safely reduce the pain adults feel when getting an IV needle placed in the emergency room. Researchers compared the spray to a harmless water spray in 300 stable patients. The goal was to find a quick, needle-free way to…

This study tested whether regular phone check-ins and support from care managers could help people with advanced cancer stay mobile and manage pain. Over 500 participants with stage 3 or 4 cancer were assigned to different levels of phone-based support for six months. The goal wa…

This study tested whether aromatherapy could help reduce pain for women during childbirth. It involved 94 first-time mothers in labor. Researchers compared pain levels between women who received aromatherapy plus standard care and those who received standard care alone.

This study tested whether using virtual reality (VR) glasses could help reduce pain and keep vital signs stable when a chest tube is removed after open heart surgery. Researchers compared 82 patients who used VR glasses during the procedure to patients who received standard care.…

This study tested whether a special therapeutic taping method could help people with rheumatoid arthritis in their knee. Researchers compared the real taping technique against a fake, placebo tape to see which was better at reducing pain, improving walking ability, and lessening …

This study tested a nasal spray containing two pain-relieving drugs (sufentanil and ketamine) for children aged 1 to 17 who came to the emergency room with moderate or severe pain from an injury. The main goals were to see if the spray was safe, well-tolerated, and effective at r…

This study tested different pain relief methods for women who experienced severe tears during childbirth. It involved 67 women who received either a placebo, a low-dose ketamine and morphine combination, or morphine alone shortly after delivery. The goal was to see which method b…

This study tested if a specific injection technique in the hip area could make shots less painful for children. Researchers compared 90 kids aged 6-12, giving some the new technique and others the standard method. They found the new technique led to significantly less pain and a …

This study compared two medications, gabapentin and clonidine, to see which works better for reducing pain after spinal surgery. Researchers enrolled 90 adults having back surgery to measure their pain levels after receiving one of these drugs. The goal was to determine which med…

This study tested five different devices used to give numbing shots in the roof of the mouth before a tooth extraction. Researchers wanted to see which method caused the least pain and fear for patients. They measured pain, fear levels, and physical responses like heart rate in 2…

This study tested whether adding foot reflexology to usual migraine care helps reduce pain and fatigue. 78 adults with migraine were split into two groups: one received 10 sessions of foot reflexology, while the other continued their usual treatment only. Researchers measured cha…

This study tested a program that teaches relaxation and mindfulness skills to help people manage chronic pain. Researchers wanted to see if adding a fitness tracker to the program made it more helpful. They enrolled 82 adults with long-term pain to try the program and see if it w…

This study tested a small device worn on the ear, called the Bridge, to see if it could help manage pain after outpatient rotator cuff surgery. It involved 42 patients and compared their results to a group of past patients who had the same surgery. The main goal was to see if the…

This study tested a computer program called PAINRelieveIt to see if it could help manage severe pain for cancer patients receiving hospice care at home. The program provided personalized pain reports to nurses and educational materials to patients and their family caregivers. Res…

This study tested whether a simple, non-drug approach could help adults with sickle cell disease manage pain and stress while in the hospital. Researchers had 46 patients try a tablet program with guided relaxation videos to see if it was practical and helpful. The goal was to se…

This study tested whether phone-based education and support from a nurse could help people with fibromyalgia manage their pain and improve their daily activity levels. It involved 44 participants, half of whom received several educational phone calls over about a month. The goal …

This study looked back at past patient records to compare different nerve-blocking techniques used for pain relief after knee replacement surgery. Researchers analyzed 126 patients to see which method provided the best pain control with the fewest side effects, like muscle weakne…

This study tested whether personalized meal plans encouraging more fish and less red meat could help women manage common symptoms after breast cancer treatment. Researchers worked with 98 women who had finished treatment 1-2 years prior and were experiencing fatigue, pain, depres…

This study tested whether certain health and wellness products could help reduce pain and improve related issues like anxiety and sleep. It involved 1,000 adults across the US who reported pain, comparing active products against placebos. Participants tracked their symptoms onlin…

This study tested two simple devices—a ShotBlocker (a plastic shield with pressure points) and a vibration pen—to see if they could reduce pain in babies during routine vaccinations. Researchers compared these methods against no special intervention in 96 healthy infants aged 2 t…

This study tested whether watching nature videos through virtual reality headsets could help patients feel less pain and anxiety during coronary angiography, a common heart test. Researchers divided 90 adults having this procedure into two groups: one watched VR videos during the…

This study tested if injecting a numbing medicine (ropivacaine) into the nose at the end of sinus surgery helps reduce pain afterward. It was a Phase 3 trial involving 184 patients who had surgery for chronic sinus problems. Researchers compared the injection to a placebo (saltwa…

This study tested whether a cooling spray could reduce pain for women receiving a numbing injection before a gynecologic procedure. 98 participants were randomly assigned to receive either the real cooling spray or a harmless placebo spray just before the injection. Researchers m…

This study compared two methods of pain control for patients having hip fracture surgery. Researchers tested whether a newer nerve block (PENG block) could provide similar pain relief as a standard block (femoral nerve block) while better preserving patients' ability to use their…

This study looked at whether spraying a cold mist on the skin before a blood thinner injection could reduce pain and bruising. It involved 101 adults who had orthopedic surgery and needed daily injections to prevent blood clots. Researchers compared the pain and bruising at injec…

This small pilot study tested whether a mobile app with guided relaxation sessions could help children with chronic stomach pain. Kids aged 7-12 with functional abdominal pain disorders used the app for 8 weeks, listening to 10-15 minute sessions most days. Researchers measured c…

This early-stage study aimed to check the safety and basic effects of a new pain medication called HRS-2129. It involved 23 healthy adults who received the drug and underwent tests to see how it changed their sensitivity to hot and cold pain. The main goal was to see if the drug …

This study tested whether two common numbing sprays, lidocaine and benzocaine, could reduce pain and improve satisfaction when patients receive their dialysis needle. It involved 60 adults on regular hemodialysis who were randomly assigned to receive one of the sprays or a placeb…

This study tested whether using virtual reality (VR) glasses or listening to music could help reduce pain and anxiety for burn patients during painful dressing changes. It involved 120 adult patients with burns, comparing these methods to standard care. The goal was to see if the…

This study tested whether applying a numbing cream called Emla before a routine baby vaccine helps reduce pain. It involved 72 healthy three-month-old infants getting their first pneumococcal shot. Researchers compared pain scores, crying time, and heart rate between babies who g…

This study tested whether spending time with live animals could help reduce pain and anxiety for cancer patients in palliative care during a specific needle procedure. Researchers compared the effects of interacting with parrots, fish, or turtles to a group with no animal interac…

This study tested whether one or two radiation treatments work better for relieving pain from cancer that has spread to bones. Researchers enrolled 102 patients with painful bone metastases and randomly assigned them to receive either one or two radiation sessions. The goal was t…

This study tested whether a virtual reality (VR) program could help children and teenagers manage pain after surgery. Researchers first developed a training and treatment plan using the VR technology. Then, they tested if using this plan was practical and if it helped reduce pati…

This study tested if a gentle, painless laser treatment could help people wearing braces. Researchers wanted to see if the laser could reduce common problems like pain and gum inflammation, and possibly help teeth move faster. They compared two groups of 108 young adults getting …

This study tested whether playing games in virtual reality (VR) could help people with frozen shoulder feel better. Researchers compared VR exercises to standard stretching exercises to see which was better at reducing pain and improving arm movement and quality of life. A small …

This study tested whether using virtual reality (VR) goggles could help reduce pain, anxiety, and distress in school-age children getting a blood draw. Researchers compared children using active VR games, passive VR videos, and no VR. The goal was to see if distraction with VR te…

This study looked at whether a person's genetics can help doctors give better pain medicine after surgery. Researchers studied 100 older adults having lung surgery to see if their specific CYP2D6 gene affects how their body processes the painkiller oxycodone. The goal was to use …

This study tested whether sleeping at least one extra hour each night for three weeks could help healthy college students better tolerate pain and experience fewer pain symptoms. Researchers monitored 36 students' sleep and measured their responses to pressure and cold pain befor…

This study tested two simple devices to see if they could make insulin injections less painful and frightening for children with Type 1 diabetes. Researchers compared a cold-only device and a combined cold-and-vibration device against standard injection care in 90 children aged 6…

This study tested whether a doctor's positive and encouraging words could make a colonoscopy less painful and scary for patients who choose not to use sedation. Researchers compared two groups: one where the doctor used supportive phrases during the procedure and one with no spec…

This study tested how easy a new mobile app was to use for people with MS. The app guides users through self-administered acupressure techniques aimed at managing pain and fatigue. Ten adults with MS tried the app for six weeks, and researchers interviewed them about their experi…

This study tested a group workshop called STEP-Home, designed to help post-9/11 Veterans who were struggling to adjust after military service. The workshop taught practical skills for managing emotions, solving problems, and focusing attention to improve daily life and community …

This study tested two fun methods to help children feel less scared and experience less pain when getting a numbing shot at the dentist. Researchers compared using virtual reality glasses, a special play session with toy dental tools, and regular care in 66 kids aged 6-9. They me…

This study tested two physical therapy methods to help people with bruxism (teeth grinding or clenching). Thirty young adults were split into two groups: one did a home exercise program, and the other received hands-on manual therapy from a therapist. Researchers measured pain, j…

This study compared two different injection treatments for shoulder arthritis pain. Researchers tested whether platelet-rich plasma (PRP), made from a patient's own blood, works better than standard steroid injections at reducing pain and improving shoulder movement. The trial in…

This study tested if adding a steroid medicine to a standard numbing shot at the surgical site could better control pain after major spine surgery. It involved 118 adults having specific back operations. The main goal was to see if this combination reduced patients' need for stro…

This study tested whether using a virtual reality (VR) headset during painful wound dressing changes could help adults with serious burns. Researchers compared 60 patients who used VR to a group receiving standard care, measuring their pain levels and sleep quality. The goal was …

This study tested whether adding either pregabalin or gabapentin to standard opioid painkillers could help reduce the total amount of opioids needed by patients recovering from bone injuries. It involved 109 hospitalized adults with orthopedic trauma who were expected to stay mor…

This study tested if adding guided relaxation exercises to standard care helps people with a slipped disc in their lower back. 96 participants were randomly assigned to either receive standard care alone or standard care plus a 5-week program of supervised relaxation exercises. T…

This study looked at the safety of a numbing drug called ropivacaine when used to block pain during circumcision in boys. Researchers reviewed over 2,000 procedures at a single hospital to see if the drug caused any serious side effects, especially damage to the tip of the penis.…

This study tested whether a drug called dexmedetomidine is a safe and effective alternative to morphine for managing pain and sedation in newborns with brain injury who are undergoing therapeutic cooling. It involved 50 newborns and aimed to find the right dose and check for safe…

This study tested whether showing a short educational video to children before a bone marrow aspiration and biopsy could make the experience less scary and painful. Researchers worked with 60 children, aged 7 to 12, who were having the procedure for the first time. They compared …

This study tested whether an investigational drug called MR-107A-02 could safely and effectively relieve acute pain after hernia repair surgery. It involved 579 adults who had just undergone the operation and were experiencing moderate to severe pain. The drug was compared agains…

This study tested whether simple distractions like playing digital games or watching cartoons could help children feel less pain, fear, and anxiety while getting stitches in the emergency room. Researchers worked with 90 children aged 5 to 10, dividing them into groups that eithe…

This study looked at whether using Voltaren Gel (diclofenac) for knee osteoarthritis pain could help people move more and improve their daily life. About 200 adults with mild knee arthritis used the gel for three weeks while wearing an activity tracker to measure their movement. …

This small pilot study tested whether people with chronic pain could better manage their symptoms by using an online pain-coping program. Some participants also received phone calls from a care coordinator to help address life challenges like housing or food insecurity. The main …

This study tested whether listening to slow, calming music could reduce anxiety and pain for patients getting injections in their eye. 144 adult patients were randomly split into two groups: one listened to piano music before and during the procedure, while the other did not. Res…

This study aimed to find out if doing exercises at work is better than doing them at home for reducing back pain in office workers. Researchers compared the two approaches in 57 office workers with ongoing low back pain. They measured changes in pain levels, daily function, and q…

This study aimed to find out which type of cannabis oil works best to relieve common symptoms in cancer patients. Researchers tested three different oil formulas (with varying levels of THC and CBD) against a placebo oil in 91 patients. Each patient tried all the oils in a random…

This study tested if adding common over-the-counter pain relievers (paracetamol/acetaminophen and ibuprofen) to morphine provides better pain relief for children with broken arm or leg bones in the emergency room. It involved 304 children aged 2 to 17 years. Researchers compared …

This study tested a new device called Miraπ that physically moves a patient's weakened limb during mirror therapy. It compared this device to standard mirror therapy for people recovering from a stroke. The goal was to see if the device could better improve hand function and redu…

This study tested whether watching a live parrot, a robotic parrot, or a picture of a parrot could help reduce the pain adults with chronic illnesses feel when getting their blood drawn. Researchers compared these three distraction methods in 240 participants to see which was mos…

This study tested whether adding medical cannabis to a behavioral support program could help adults with long-term, non-cancer pain reduce their prescription opioid medication. 87 participants who were already taking high doses of opioids for pain were randomly assigned to either…

This small pilot study tested whether eight home visits from a nurse could help older African American women manage chronic pain and depressive symptoms. The program, called DAPPER, combined counseling and practical support to help participants set personal goals for improving th…

This study compared two tools used to remove impacted wisdom teeth: a newer ultrasonic device and a traditional rotary drill. It involved 22 young adults who had both wisdom teeth removed, one with each tool. Researchers measured pain, swelling, and a marker of inflammation to se…

This study tested whether using virtual reality (VR) could help patients feel less pain and anxiety during the removal of a catheter from the groin after a heart imaging test. One hundred patients were randomly assigned to either use a VR headset during the procedure or receive s…

This study tested whether using virtual reality (VR) could help children feel less anxious and have less pain when getting a gastrointestinal endoscopy (a camera tube to look inside the stomach and intestines). Sixty-six children in Egypt were randomly assigned to either use a VR…

This study tested whether a special type of nursing care could make newborns more comfortable and reduce pain right after a vaginal birth. Researchers provided 60 healthy, full-term babies with care focused on physical comfort (like skin-to-skin contact and gentle touch) and a ca…

This study tested whether a specific foot massage technique, called reflexology, could reduce the pain women feel while being stitched after a vaginal birth (an episiotomy repair). Researchers worked with 80 first-time mothers, randomly assigning half to receive the reflexology t…

This study tested whether listening to music could help patients feel better after major heart surgery. Researchers worked with 60 adults who had coronary artery bypass grafting to see if music therapy could reduce their post-surgery pain and anxiety. The goal was to provide a si…

This study tested whether adding a gentle hands-on therapy called strain counterstrain to standard care helps women with fibromyalgia. 105 participants were split into groups to compare standard care alone versus standard care plus the new therapy over three weeks. Researchers me…

This study tested whether using a virtual reality (VR) headset during surgery could help patients feel less anxious and experience less pain. It involved 100 adults who were getting a pacemaker, defibrillator, or similar heart device implanted. Half the patients used a VR headset…

This study aimed to improve chronic pain care for Veterans aged 65 and older. Researchers talked with Veterans and their caregivers to understand what personal life information would be most helpful for doctors. They then created and tested a computer tool to share this personal …

This study tested whether using ultrasound to guide injections for numbing specific nerves in the upper arm is better than the traditional 'blind' method at reducing tourniquet pain during surgery. It involved 140 adults having upper limb surgery. Researchers compared pain levels…

This study tested two methods to help patients heal faster and feel less pain after gum graft surgery. Researchers compared a medical-grade glue (cyanoacrylate) to a patient's own concentrated growth factors (CGF) applied to the roof-of-the-mouth donor site. The goal was to see w…

This study tested whether a targeted nerve block, given before surgery, could reduce pain and the need for strong opioid painkillers after breast cancer surgery. It involved 70 women having a specific type of breast cancer operation. Researchers compared the nerve block to standa…

This study tested two simple, drug-free methods to help women feel better after a cesarean section. Researchers compared whether applying special kinesiology tape or giving a foot massage was better than usual care at reducing pain, fatigue, and improving mood. They measured how …

This small pilot study tested whether a new support system could help manage recurrent pain in children with severe neurological disabilities, who often cannot communicate their discomfort. The system involved weekly surveys for parents, feedback reports for the care team, and su…

This study tested whether applying acupressure (a type of massage on specific points) could help patients feel less pain and anxiety during a urodynamics test, which checks how the bladder works. 68 adult patients were randomly assigned to receive either acupressure or standard c…

This study tested whether a brief talk therapy program could help veterans better manage chronic pain in primary care settings. 184 veterans with long-term musculoskeletal pain received either six short therapy sessions plus usual care or usual care alone. Researchers measured ho…

This study tested whether spraying a local anesthetic (lidocaine) on the cervix could make getting an IUD less painful. It involved 90 women aged 18-45 who were voluntarily getting an IUD. Researchers compared the pain levels of women who received the numbing spray to those who r…

This study tested whether a complementary therapy called reflexology (a specific type of foot massage) could help people recovering from a stroke. Researchers worked with 70 stroke patients to see if receiving 12 sessions of reflexology over six weeks improved their pain levels, …

This study tested whether adding the drug ketamine to a standard pain-blocking injection could better manage pain for adults recovering from open chest surgery (thoracotomy). Researchers compared how long pain relief lasted and how much extra pain medication 50 patients needed af…

This study aimed to translate and test the reliability of several standard questionnaires used to assess back pain, physical disability, and independence in daily life for Albanian speakers. Researchers worked with 200 Albanian patients experiencing back pain or orthopedic proble…

This study explored whether taking high-dose vitamin B6 supplements could make healthy adults less sensitive to pain. Researchers gave 43 participants either vitamin B6 or a placebo and then tested their pain thresholds using controlled heat and mild electrical stimulation on the…

This study looked at whether swelling in the arm (lymphedema) after breast cancer treatment is connected to chronic muscle pain. Researchers examined 110 breast cancer survivors to see how common this pain is and how it affects arm movement and daily life. The goal was to better …

This study aimed to check the safety of a specific pain-blocking method used during chest surgery. Researchers measured the levels of the numbing drug ropivacaine in the blood of 20 patients to see if it reached potentially toxic amounts. They also tracked patients' pain, opioid …

This study aimed to understand how the COVID-19 pandemic impacted the daily lives, stress levels, and healthcare use of adults living with sickle cell disease (SCD). Researchers surveyed 186 adults with SCD in the US, asking about their mental health, pain, and access to medical …

This study looked at whether high estrogen levels affect how much pain women feel from a common anesthesia injection. Researchers observed 90 women aged 18-45 during surgery, comparing those with normal estrogen to those with high levels from fertility treatment. The goal was to …

This study looked at whether a person's body weight affects how much pain they feel after surgery for a slipped disc in the lower back. Researchers studied 75 adults who had this surgery and received a specific type of pain-blocking injection. The goal was to understand if higher…

This study tested whether a vibrating device could distract healthy adults from feeling mild pinprick pain. Researchers enrolled 200 participants without pain conditions to measure their pain thresholds and anxiety levels during the tests. The goal was to gather basic knowledge a…

This study tested if a special pain monitor could predict how a patient's body would react when a breathing tube was placed. Researchers gave 60 surgery patients a small, controlled electric shock while they were under anesthesia and watched their monitor readings. They then chec…

This study aimed to better understand hand osteoarthritis by closely observing 300 patients over many years. Participants underwent detailed exams, scans, and questionnaires at the start and then again after 3 and 8 years. The goal was to learn what factors predict how the diseas…

This study aimed to understand how pain changes in the first week after surgery and see if those patterns can help predict who might develop long-term chronic pain. Researchers followed 392 patients who had various planned surgeries, tracking their daily pain levels. The goal was…

This study aimed to understand which patients are most likely to get significant pain relief from a common treatment for sacroiliac joint pain. Researchers followed 100 patients with this type of low back pain who received an ultrasound-guided injection of numbing medicine and st…

This study aimed to understand how knee pain changes the way people walk. Researchers gave 34 healthy adults two different injections in the knee—one to cause temporary pain and one as a control—and then measured their walking and jumping movements. The goal was to see if walking…

This study aims to create a tool that predicts which patients are likely to feel pain during a colonoscopy done without sedation. Researchers will collect information from 679 patients to identify factors linked to pain and build a more accurate prediction model. The goal is to h…

This study aimed to understand how much pain and stress premature babies experience during a specific breathing treatment called LISA. Researchers tested if a skin sensor could reliably measure this pain alongside standard nurse assessments. The goal was to gather better informat…

This study aimed to understand how the brain responds to pain while a patient is under general anesthesia. Researchers used a special light-based scanner on the heads of 44 young patients undergoing heart procedures to measure blood flow changes in the brain during painful moment…

This study aimed to understand if having your sleep interrupted makes you more sensitive to pain. Researchers tested 30 healthy adults by waking them up multiple times over three nights. They then measured how much pain the participants felt from injections in their knee and shou…

This study aimed to figure out how much improvement on pain and symptom questionnaires is considered meaningful to women with painful periods (primary dysmenorrhea). 100 women performed functional exercises three times a week for three menstrual cycles. Researchers used their res…

This study aimed to understand how puberty affects pain sensitivity in adolescents. Researchers compared pain responses between teens at different puberty stages and measured hormone levels to see if they relate to pain. The goal was to gather knowledge that might help identify w…

This study aimed to test and compare two devices designed to measure pain in children during surgery while they are under general anesthesia. Researchers observed 50 children aged 1 to 12 years old to see how well the devices detected painful events and responded to pain medicati…

This study aimed to understand if women with fibromyalgia experience more chronic pelvic pain and pelvic floor problems than women without fibromyalgia. Researchers compared 128 women, some with fibromyalgia and some without, by asking them to fill out detailed questionnaires abo…

This study aimed to find early signs that could predict which shingles patients would develop long-lasting nerve pain called postherpetic neuralgia (PHN). Researchers followed 151 adults with shingles for 3 months, collecting detailed health information and blood samples to look …

This study aimed to understand how a low dose of the anesthetic gas sevoflurane affects how the brain processes pain and forms memories. Researchers used MRI brain scans on 42 healthy volunteers while they performed memory tasks and experienced mild pain, both with and without th…

This study aimed to understand if pain in the jaw joint (TMJ) is linked to pelvic pain in adults. Researchers wanted to see if shared factors like stress, anxiety, or how the nervous system processes pain might explain why some people have both conditions. 133 adults with chronic…