PAIN

This study tested a tool called PainTracker to help doctors guide older adults (65+) who have been on long-term opioid therapy toward safer pain management. The tool asks about a range of pain-related problems, not just opioid misuse, to encourage referrals to non-opioid treatmen…

This study tested whether a workplace program to prevent muscle and joint pain is practical and well-liked by blue-collar workers. 70 workers with physically demanding jobs took part in the program twice a week for eight weeks. Researchers used questionnaires and interviews to se…

This study tested whether one or two doses of radiation therapy works better to reduce pain in cancer patients whose disease has spread to the bones. A total of 102 adults with painful bone metastases received either a single dose or two doses of radiation. The goal was to see if…

This study tested whether guided breathing exercises (4-7-8 breathing and diaphragmatic breathing) can help reduce pain and anxiety during the needle insertion for hemodialysis. 90 adult patients on dialysis were randomly assigned to one of two breathing techniques or usual care.…

This study tested whether working with a care manager and using an online pain coping tool can help people with chronic pain improve their daily function and pain management. 32 adults with long-term pain and at least one social challenge (like food or housing insecurity) took pa…

This study tested whether a Bridge device can reduce pain and the need for opioid painkillers after rotator cuff surgery. 42 adults having outpatient surgery received the device along with standard anesthesia. Researchers tracked pain scores and opioid use for a week after surger…

This study looked at whether live music played in the intensive care unit (ICU) can help critically ill patients feel less pain, anxiety, and stress. Researchers at Vanderbilt University Medical Center enrolled 111 patients, along with their families and staff. They measured chan…

This study tested whether a shared virtual reality (VR) nature experience could help hospice patients and their caregivers feel better. 26 patient-caregiver pairs tried a synchronized VR program with calming nature scenes. Researchers measured quality of life, fear of death, pain…

This study tested whether a medicine called Intravenous Immunoglobulin (IVIG) is safe and works for treating sudden, severe pain episodes in people with sickle cell disease. About 300 people took part. The goal was to see if IVIG could shorten the pain crisis and reduce the need …

This study tested a smartphone-based prayer program called PUSH (Pray Until Something Happens) to see if it could help adults with sickle cell disease feel less stress and pain. 40 people who had pain and used opioids took part. They listened to guided prayer recordings on their …

This study tested whether applying Emla cream before a routine vaccination at 3 months old reduces pain in healthy babies. 72 infants received either Emla cream or a placebo cream. Researchers measured pain using a standard scale and crying time. The goal was to see if the cream …

This study tested whether using ultrasound to guide numbing injections for certain arm nerves works better than the usual blind method. 140 adults having upper arm surgery took part. The goal was to see which approach reduces pain from the tourniquet used during surgery.

This study tested whether gabapentin or clonidine works better for pain after spinal surgery. 90 adults aged 18-60 having one or two-level lumbar laminectomy took part. Pain was measured using a standard 0-10 scale. The goal was to find which drug provides better relief.

This early-stage study tested a new drug called HRS-2129 in 23 healthy adults to see if it is safe and how the body processes it. Participants received multiple doses and had pain tests like cold and heat sensitivity. The goal was to gather safety data and measure how the drug af…

This study tested whether using virtual reality (VR) during pacemaker or defibrillator implantation could lower patients' anxiety and pain. 100 adults having these heart procedures were randomly assigned to use VR or not. Researchers measured anxiety levels before and during the …

This study looked at whether giving children aged 4-6 a liquid hourglass or a spiky ball toy during a blood draw can lower their pain, fear, and anxiety. 120 children were randomly assigned to use one of the toys or receive standard care. The goal was to see if these simple distr…

This study tested whether adding ketamine to a standard nerve block (external oblique intercostal plane block) can improve pain control after open chest surgery (thoracotomy). Fifty adults scheduled for thoracotomy took part. Researchers measured how long it took before patients …

This study tested a non-invasive device called ANI that measures heart rate patterns to assess comfort in 20 non-communicating patients receiving end-of-life palliative care. The goal was to see if the ANI could reliably detect pain or stress during routine care, compared to a st…

This study tested whether adding electrical stimulation to stationary cycling helps stroke survivors with Complex Regional Pain Syndrome (CRPS), a painful arm condition. 40 participants received either standard rehab or standard rehab plus 20 sessions of FES-assisted cycling. Res…

This study looked at whether putting stickers on children aged 5 to 10 can lower their pain and anxiety when getting an IV. 72 children took part. The idea is that stickers might distract kids and help them cope better during this common but stressful procedure.

This study tested whether a mother's scent and a soft, knitted octopus toy could reduce pain in newborns who had birth asphyxia (lack of oxygen) and were receiving cooling treatment. 45 full-term babies in intensive care took part. Researchers measured pain using a special scale.…

This study tested an experimental pain medication called MR-107A-02 in 579 adults who had hernia surgery. The goal was to see if it reduces pain better than a placebo or an existing painkiller. Participants rated their pain on a 0-10 scale, and researchers also tracked how much e…

This study tested a personalized internet program called WebTIPS to help children ages 1-12 feel less anxious before and after surgery. Over 1,200 families participated, with some receiving the tailored program and others receiving standard online information. The goal was to see…

This study tested whether a brief behavioral therapy called Acceptance and Commitment Therapy (ACT) can help at-risk veterans avoid persistent pain and disability after total knee replacement. 402 veterans scheduled for knee surgery were randomly assigned to receive either ACT or…

This study looked at 30 recreational tennis players with neck pain. Half did a home exercise program alone, while the other half also received four sessions of gentle spinal mobilization from a therapist. After three weeks, the researchers checked pain levels, neck movement, stre…

This study tested whether taking high-dose vitamin B6 supplements can raise pain thresholds and tolerance in healthy adults. Researchers used heat and mild electrical shocks to measure pain sensitivity. The goal is to see if a simple vitamin could help people feel less pain.

This study tested if special tape placed on the knee can reduce pain and fear of movement in people with rheumatoid arthritis. Thirty adults aged 45 to 60 were split into two groups: one got the real tape, the other got a fake tape without therapeutic effect. Researchers measured…

This study tested a pain-relief method for people recovering from chest surgery (thoracotomy) who cannot have standard epidural pain control. A small tube placed in the wound delivered either a numbing medicine (ropivacaine) or a saltwater placebo for 48 hours. All patients also …

This study looked at whether the 4-7-8 breathing technique (a slow, patterned breathing exercise) can help reduce pain, nausea, and vomiting in people who just had weight-loss surgery. Sixty adults were split into two groups: one practiced the breathing technique hourly for 24 ho…

This study looked at whether kinesiological taping (a special tape placed on the skin) or foot massage can help women who had a C-section feel less pain, fatigue, and mood changes. 97 new mothers were split into three groups: one got taping, one got foot massage, and one got stan…

This study looked at whether applying cold to joints can reduce pain and improve quality of life for people with rheumatoid arthritis. Researchers tested this simple, low-cost method on 90 patients who had pain. The goal was to see if cold therapy could be a helpful addition to s…

This study tested whether spraying a cold mist on the skin before a blood-thinner injection can lessen pain and bruising. 101 adults who had orthopedic surgery and needed daily heparin shots took part. Researchers measured pain levels and bruise size to see if the cold spray help…

This study looked at ways to reduce pain in women who had severe tears (called OASIS) during childbirth. 67 women received either a placebo, a low dose of ketamine plus morphine, or morphine alone through an epidural. The goal was to see which option worked best for pain one week…

This study looked at 304 children aged 2 to 17 with broken arm or leg bones to see if adding paracetamol and/or ibuprofen to morphine provides better pain relief than morphine alone. The goal was to find the most effective combination for managing severe pain in the emergency roo…

This study looked at whether photobiomodulation (PBM) therapy, a type of light treatment, can help with pain and healing in women who had tears or cuts during vaginal delivery. 183 women were offered PBM in addition to standard care. Researchers compared pain and healing in those…

This study tested whether regular phone calls from a nurse could help people with fibromyalgia manage their pain and stay active. 44 adults were split into two groups: one received three nurse-led training calls, the other got usual care. After two months, the nurse-call group re…

This study tested if a sugar-free flavored sweet solution applied before a dental injection can reduce pain in children aged 6-12. Fifty-four kids received either the sweet solution or plain water before local anesthesia. Researchers measured pain using child reports, observer ra…

This study tested whether using virtual reality (VR) during wound dressing changes can reduce pain and improve sleep in adults with moderate to severe burns. Sixty patients aged 18 to 60 with burns covering 25-60% of their body took part. The VR group used a headset showing calmi…

This study looked at whether a 50% oxygen and 50% nitrous oxide (laughing gas) mixture can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, catheter placement, or stitch removal. Researchers observed 100 children and measured pain using a…

This study tested five different devices for giving numbing shots in the roof of the mouth during tooth extractions. 200 healthy adults took part to see which method caused the least pain and fear. The goal is to find the most comfortable way to deliver dental anesthesia.

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with hand paralysis and pain. The goal was to see if the device could better improve …

This study tested a new medicine called MR-107A-02 to see if it can safely relieve pain after bunionectomy (foot surgery). About 410 adults took part. The goal was to measure how well the drug reduces pain and whether it can cut down the need for stronger opioid painkillers.

This study tested a new medicine called LEVI-04 to see if it can reduce pain in people with knee osteoarthritis. About 518 adults with knee pain took either the drug or a placebo. The main goal was to measure pain changes using standard pain scales. The trial is complete, and res…

This study looked at whether using different amounts of numbing medicine in a back muscle injection (erector spinae plane block) can reduce pain and the need for morphine after a total abdominal hysterectomy. 80 women having this surgery took part. The goal was to find the best v…

This study tested a team-based care program for 516 people with stage III or IV cancer. The program aimed to help them stay mobile, reduce pain, and improve quality of life. Researchers found that the program helped maintain physical function and eased pain over six months.

This study looked at whether a gentle therapy called strain counterstrain can help women with fibromyalgia feel less pain and fatigue. 105 women were split into three groups: one got usual care, another got usual care plus this therapy, and a third got no treatment. The therapy w…

This study tested whether watching a nature-themed virtual reality video during coronary angiography (a heart artery scan) could reduce pain and anxiety. 90 adults who had never had the procedure before took part. Half used VR, half got standard care. The goal was to see if this …

This study tested whether using virtual reality (VR) during a knee pain treatment called genicular nerve radiofrequency ablation could help reduce pain and improve patient satisfaction. Forty adults who were already scheduled for the procedure took part. The goal was to see if VR…

This study looked at whether acupuncture can ease pain for people with long COVID. 93 adults were split into two groups: one got 8 acupuncture sessions plus usual care, the other just usual care. Over 5 months, they filled out surveys about pain and daily activities to see if acu…

This study tested whether dexmedetomidine, a sedative, is safer than morphine for newborns with brain injury who need cooling therapy. Fifty infants were enrolled to compare side effects and drug levels. The goal is to find a gentler option for pain and sedation that avoids the l…

This study tested a single injection of a long-acting painkiller (SDE) to manage pain after hemorrhoid removal surgery. 221 adults received either the drug or a placebo, and researchers measured their pain levels over 48 hours. The goal was to see if this shot could provide effec…

This study tested a computer program called PAINRelieveIt to help control cancer pain in hospice patients. It included 262 cancer patients and their caregivers. The program aimed to improve how well patients followed their pain medication plans and reduce pain intensity. Results …

This study tested whether listening to slow-tempo music for seven days could help older adults in the intensive care unit (ICU) avoid delirium—a state of confusion that can lead to longer hospital stays and memory problems. Researchers enrolled 160 patients aged 50 and older who …

This study looked at whether doing progressive relaxation exercises—like tensing and relaxing muscles—can help people with a slipped disc in their lower back. 96 adults were split into two groups: one got standard care, the other added supervised relaxation sessions three times a…

This study tested whether a new program called PQ-ResPOND could help manage recurrent pain in children with severe neurologic disabilities like cerebral palsy. About 54 children and their parents participated, with some receiving the program (surveys, feedback reports, and extra …

This study tested whether live parrots, robotic parrots, or pictures of parrots could reduce pain during blood draws in 240 adults with chronic illnesses. Participants were randomly assigned to one of the three therapies, and their pain levels were measured before and during the …

This study tested a cooling spray (vapocoolant) to see if it reduces pain when placing an IV in emergency department patients. 300 adults who needed an IV were randomly given either the cooling spray or sterile water before the needle. The main goal was to measure pain scores usi…

This study looked at whether listening to nature sounds while walking after laparoscopic gallbladder surgery can lower anxiety, pain, and stress. 70 adult patients having their first gallbladder surgery took part. They were asked to walk while hearing nature sounds, and their anx…

This study tested whether wearing virtual reality glasses during chest tube removal after open heart surgery can lower pain and keep heart rate and blood pressure stable. 82 adults on their second or third day after surgery took part. The goal was to see if a simple, drug-free di…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks, with all visits done by video call. The goal was to see if the device could safely reduce pain and improve quality of life.

This study tested whether a virtual reality program that uses biofeedback (like calming games controlled by breathing) could help children and teens aged 12-18 manage pain after surgery. Researchers worked with 93 participants to see if the approach was practical and well-liked. …

This study tested whether numbing sprays (lidocaine or benzocaine) can reduce pain and improve satisfaction when inserting needles for hemodialysis. Sixty adults on dialysis were randomly assigned to receive one of the two sprays or a placebo. Pain and satisfaction were measured …

This study tested three different doses of inhaled ketamine to relieve acute pain in children aged 7 to 17 in the emergency department. The goal was to find the best dose that reduces pain quickly without needing an IV. Researchers measured pain scores before and 15 minutes after…

This study tested a long-acting numbing medicine called liposomal bupivacaine (Exparel) to control pain after hernia repair surgery. Nineteen adults having open or laparoscopic hernia repair received the drug, and researchers measured their satisfaction with pain control and time…

This study tested whether nursing care based on Kolcaba's Comfort Theory could reduce pain and improve comfort in healthy newborns right after a vaginal delivery. Researchers measured pain, comfort, crying, and vital signs in 60 full-term babies. The goal was to see if a holistic…

This study tested whether a cooling spray (vapocoolant) can reduce the pain of numbing injections given before gynecologic procedures. 98 adults took part. Researchers measured pain levels and patient satisfaction to see if the spray helps.

This study tested non-drug methods to reduce nerve pain in the feet and legs of people with HIV. 196 adults with HIV and long-term nerve pain took part. The goal was to see if these approaches could lower pain and improve daily life.

This study looked at whether showing children a short educational video before a bone marrow aspiration and biopsy can lower their anxiety, fear, and pain, and increase their satisfaction. Sixty children aged 7 to 12 having the procedure for the first time took part. The video wa…

This study tested how easy and useful the MeTime MS app is for adults with multiple sclerosis who have fatigue and chronic pain. Ten participants used the app to guide them through either a relaxing or stimulating acupressure routine at home. After six weeks, researchers intervie…

This study tested whether teaching patients about mindfulness before a brief meditation session helps them feel less pain. Over 600 adults in an orthopedic clinic waiting room took part. The goal was to see if a little education makes the meditation work better for acute pain rel…

This study looked at whether playing digital games or watching cartoons can help children aged 5 to 10 feel less pain, fear, and anxiety while getting stitches in the emergency room. A total of 90 children were split into three groups: one played a digital game, one watched carto…

This study looked at two different nerve blocks (TFP and TAP) to see which one works better for pain after robotic prostate removal. 108 men who were in good health before surgery took part. The goal was to find out which block reduces pain, speeds up recovery, and shortens hospi…

This study tested whether testosterone therapy could improve pain, physical function, and quality of life in 36 women aged 60 and older with chronic back pain, opioid use, and low testosterone. Participants received either testosterone or a placebo to compare effects on pain tole…

This study tested whether hot compresses with black seed or ginger essential oils can reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee pain applied the oils daily for 7 days. The goal was to see if these natural oils offer ext…

This study tested a special anesthesia method during heart surgery in 70 older adults (age 60+). The goal was to see if it could lower the risk of confusion after surgery, keep blood pressure stable, and reduce pain and opioid use. The approach used brain monitoring to guide anes…

This study tested Voltaren Gel (a topical pain reliever) in 196 adults aged 40-85 with knee osteoarthritis pain. Researchers measured changes in physical activity, steps, and quality of life over three weeks. The goal was to see if the gel helps people move better and feel better…

This study tested a pain relief method for people having chest surgery who cannot get an epidural. Surgeons placed a small tube near the spine to deliver numbing medicine for 48 hours. All patients also received morphine through a pump. The goal was to see if this approach reduce…

This study tested two simple, non-drug methods to help children aged 6 to 9 feel less pain and anxiety during their first dental visit. One group played with toy dental tools before the procedure, another used virtual reality glasses, and a third group had no special preparation.…

This pilot study tested a program called DAPPER for African American women aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help them manage their pain and mood. The study measured changes in pain int…

This study tested whether an ultrasound-guided PECS nerve block could reduce opioid use and improve pain control in 70 women undergoing breast cancer surgery. Participants received either the nerve block or standard care. The goal was to see if the block could lower the need for …

This study looked at whether using breathing exercises and squeezing a stress ball during dressing changes can help burn patients feel less pain and anxiety. 210 adults with burns on up to 15% of their body took part. The goal was to see if these simple techniques improve comfort…

This study tested a nasal spray containing two pain medicines (sufentanil and ketamine) for children aged 1 to 17 with moderate to severe pain in the emergency room. The goal was to see if the spray is safe, tolerable, and works well for pain relief. 155 children took part, and r…

This study looked at whether structured play activities can reduce anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in recreational play during treatment. Anxiety levels were measured before and after play. The goal w…

This study looked at whether manual therapy (hands-on treatment) or home exercises could reduce pain and improve jaw movement in people with bruxism (teeth grinding). Thirty young adults with bruxism were split into two groups: one did exercises at home for 8 weeks, the other rec…

This study tested whether certain health and wellness products could help reduce pain in adults. Over 2,000 people took either the product or a placebo, and researchers measured changes in how much pain interfered with daily life. The goal was to see if these products offer real …

This study tested two non-drug methods—hypnosis and virtual reality—to help people feel less pain during repeated medical procedures like wound dressing changes. 52 patients tried both techniques in a crossover design, meaning each person experienced both methods. The goal was to…

This study compared two types of ultrasound-guided nerve blocks for pain control in 20 women undergoing mastectomy. The goal was to see if a newer, more side-lying block (proximal intercostal) offers better needle visibility, faster setup, and improved safety compared to the stan…

This study looked at whether cannabis oil extracts can help cancer patients manage symptoms like pain, nausea, anxiety, and sleep problems. Each participant tried three different cannabis oil blends (high THC/low CBD, low THC/high CBD, and equal THC/CBD) and a placebo oil, withou…

This study looked at whether massage therapy after open heart surgery can reduce pain, improve sleep quality, and lower stress hormone levels. 96 adults who had elective open heart surgery took part. Some received back massages, while others received standard care. Researchers me…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical for adults with opioid use disorder and chronic pain. 63 participants were enrolled to see if they would stick with the program. The goal was to explore if this app…

This study tested whether wearing virtual reality glasses during intrauterine device (IUD) insertion can lower pain and anxiety. 70 women were randomly assigned to either use VR or receive standard care. Pain and anxiety levels were measured right after the procedure. The goal is…

This study tested if a doctor's calm, positive words during a colonoscopy (done without sedation) can lower patients' pain and anxiety. Over 100 adults were split into two groups: one heard encouraging phrases like "You're doing great," while the other had standard care. The goal…

This study tested whether foot reflexology—a type of focused foot massage—could help people with migraines feel less pain and fatigue and improve their daily life. 78 adults with migraines took part; half received 10 reflexology sessions over 5 weeks, while the other half continu…

This study tested whether a shot of platelet-rich plasma (PRP) from a patient's own blood works better than a steroid shot for shoulder arthritis pain. Fifty adults with mild to moderate shoulder osteoarthritis received one of the two injections. Researchers tracked changes in pa…

This study tested whether wearing virtual reality (VR) glasses during a kidney stone treatment called ESWL can lower patients' pain, anxiety, and improve comfort. Seventy adults having ESWL for the first time took part. Researchers measured pain, anxiety, and comfort levels using…

This study looked at whether aromatherapy (using essential oils) can help reduce pain for women during labor. 94 first-time mothers with a single baby and no major complications were randomly assigned to receive either aromatherapy along with standard pain control or standard pai…

This study tested a program to help young adult cancer survivors (ages 18-39) with obesity lose weight and manage symptoms like pain, fatigue, and distress. The goal was to reduce their risk of heart disease. 38 survivors took part in a pilot trial to see if the program was feasi…

This study tested whether low-level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani adults aged 18-30 with mild crowding received either LLLT or no laser during their first six months of treatment. The …

This study looked at whether adding medical marijuana to a 24-week support program helps adults with long-term pain reduce their opioid painkiller dose and improve pain. 87 people on high-dose opioids took part. The goal was to see if marijuana could make it easier to lower opioi…

This study tested a short form of talk therapy (Brief CBT-CP) for veterans with long-term muscle or bone pain. 184 veterans took part, with some getting the therapy plus usual care and others just usual care. The goal was to see if the therapy helps them move more, feel less dist…

This study tested whether injecting the numbing drug ropivacaine into the nose during sinus surgery could lower pain afterward. 184 adults having endoscopic sinus surgery took part. The goal was to see if this simple step could reduce the need for painkillers and improve recovery…

This study tested whether using an ultrasonic surgical device (piezosurgery) instead of a traditional rotary drill reduces pain, swelling, and jaw stiffness after removing impacted wisdom teeth. Twenty-two healthy adults each had one tooth removed with the ultrasonic tool and the…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble readjusting to civilian life. The workshop taught practical skills like managing emotions, solving problems, and paying attention, without calling it therapy to make it more welcoming. The go…

This study looked at whether doing exercises at work or at home works better for office workers with low back pain. 57 workers took part, and researchers measured pain, daily function, and quality of life. The goal was to find the best way to ease pain and improve movement for pe…

This study tested whether watching virtual reality during a blood draw could help school-age children feel less pain, fear, and upset. 86 children took part. The results showed that using VR can make the experience less stressful for kids.

This study tested whether breathing in lavender essential oil can help reduce anxiety and pain. 68 adults with moderate to severe pain took part. They inhaled either lavender oil or a placebo for 30 minutes, and their pain and anxiety levels were measured before and after. The go…

This study tested a gas mixture called Kalinox (nitrous oxide and oxygen) to see if it helps reduce pain during short medical procedures in adults with cancer, such as spinal taps or bone biopsies. A total of 204 patients took part, and the study compared Kalinox to standard pain…

This study tested a manual therapy technique called Mulligan SNAG for people with long-term low back pain. Thirty adults were split into three groups: one received SNAG plus standard physiotherapy, another received standard physiotherapy alone, and a third received a fake SNAG tr…

This study tested whether a lidocaine spray applied to the cervix can reduce pain during intrauterine device (IUD) insertion. 90 women aged 18-45 who wanted an IUD took part. The goal was to see if this simple spray makes the routine procedure more comfortable.

This study tested a special way of talking called 'hypnotic communication' to help men feel less anxious and have less pain during a prostate biopsy. About 100 men took part, with half receiving this calming talk from a trained nurse during the procedure. The goal was to see if t…

This study tested a smartphone app called e-PainSupport for people receiving home hospice care. The app helps patients and their caregivers report pain to nurses and learn about pain management. The goal was to see if using the app could reduce how much pain patients feel. 88 pat…

This study looked at whether guided strength training and stretching, along with a home exercise plan, works better than just a home exercise plan alone for reducing pain in dental students. Sixteen second-year dental students took part. The goal was to see if these exercises cou…

This study looked at whether reflexology (a type of foot massage) can reduce pain, improve sleep, and stabilize vital signs in people who have had a stroke. Seventy adults were split into two groups: one received 12 reflexology sessions over six weeks plus usual care, the other r…

This study looked at whether acupressure can help adults feel less pain and anxiety during a urodynamics test (a procedure that checks how well the bladder works). Sixty-eight people took part; half received acupressure before the test, and the other half got standard care. Resea…

This study tested two treatments—cyanoacrylate (a medical glue) and concentrated growth factor (a gel made from the patient's own blood)—to see if they could reduce pain and speed up healing after gum graft surgery. Sixty healthy adults who needed a gum graft took part. The resul…

This study tested two simple tools—a ShotBlocker and a vibration pen—to see if they could reduce pain in healthy infants during routine vaccinations. 96 babies aged 2 to 6 months were split into three groups: one using the ShotBlocker, one using the vibration pen, and one receivi…

This study tested a program to help cancer survivors quit smoking and manage pain. Nineteen survivors joined the program, which included counseling and support. The goal was to see if the program was practical and helpful for participants.

This study looked at whether using virtual reality glasses or listening to music can help burn patients feel less pain and anxiety during dressing changes. 120 adults with burns on less than 15% of their body took part. The goal was to see if these simple, drug-free methods could…

This study tested several non-drug methods to reduce pain from injections in 120 preschool children aged 4 to 6. Methods included a special tapping technique, a palm stimulator, a plastic device called ShotBlocker, and a vibrating cold device called Buzzy. The goal was to find wh…

This small pilot study tested whether adding group-based pain neuroscience education to a community exercise program helps older women with knee osteoarthritis. Nineteen women aged 60+ were randomly assigned to exercise alone or exercise plus five educational sessions about how p…

This study tested whether adding pregabalin or gabapentin to standard opioid painkillers could reduce the amount of opioids needed by adults hospitalized with orthopedic injuries. 109 participants were randomly assigned to receive one of the two nerve-pain medications alongside t…

This study tested whether giving children montelukast, an asthma medication, before tonsil surgery could reduce their pain afterward. 116 children aged 3-8 took part. The goal was to see if the drug could lower the need for stronger painkillers and reduce calls or visits to the d…

This study looked at whether a diabetes education program plus a cinnamon supplement could help adults with type 2 diabetes who have nerve pain in their feet. 62 people took part, with half getting the education and cinnamon, and the other half getting usual care. Researchers che…

This study tested whether listening to music during wound care can help people with venous leg ulcers feel less pain and anxiety. 97 patients were split into three groups: one listened to Turkish instrumental music, another to Western music without lyrics, and a third had standar…

This study looked at whether a specific injection technique (ventrogluteal) could make shots less painful for children. 90 kids aged 6-12 took part. Those who got the special technique reported less pain and had a lower pulse rate than those who got the usual shot. The findings s…

This study tested two small devices—Coolsense (cold only) and Buzzy (cold plus vibration)—to see if they could lower pain and fear in children aged 6–12 during insulin injections. 90 kids with type 1 diabetes were split into three groups: one used Coolsense, one used Buzzy, and o…

This study looked at whether special sponges placed in the tooth socket after extraction can stop bleeding faster and help the wound heal better. Thirty adults who had a tooth pulled were given these sponges, and researchers measured bleeding time, pain, swelling, and gum color c…

This study looked at whether placing a hot water bag on the belly can reduce pain and help the bowels start moving again in people with ileus (a bowel blockage). Sixty adults with a certain type of ileus took part. The main goal was to see if this simple, drug-free method could r…

This study looked at whether watching parrots, fish, or turtles could reduce pain and anxiety when inserting a needle into a port catheter in 120 palliative care patients. Participants rated their pain and anxiety before and after the animal therapy. The goal was to find a simple…

This study tested a phone-based counseling program for veterans with chronic pain who were at risk for substance misuse. Over 1,100 veterans took part, receiving brief counseling and referrals to pain treatment. The goal was to reduce pain and risky substance use. Results showed …

This study looked at whether Reiki, a hands-on relaxation therapy, can ease pain, reduce fatigue, and improve sleep in older adults living in nursing homes. Sixty residents aged 50 and older with chronic pain took part in a four-week Reiki program. Researchers measured changes us…

This study tested whether using virtual reality (VR) during removal of a catheter from the groin after a heart procedure could lower pain, anxiety, and keep vital signs stable. 100 adults were split into two groups: one wore VR goggles showing a calming scene, while the other rec…

This study tested whether using virtual reality (VR) goggles before a stomach scope procedure could help children aged 6-15 feel less anxious, have less pain, and recover faster. 66 children were split into two groups: one used VR with fun, age-appropriate apps, and the other rec…

This study tested whether reflexology (a type of foot massage) can help reduce pain felt during the repair of an episiotomy, a cut made during childbirth. Researchers compared 40 women who received reflexology to 40 who did not, measuring pain using a standard scale. The goal was…

This study tested whether a fixed-dose combination of acetaminophen and naproxen sodium reduces pain better than a placebo after bunionectomy (foot surgery). 143 adults took multiple doses over 48 hours and rated their pain intensity. The goal was to see if the combo pill provide…

This study tested whether a single injection of multiple pain-relieving drugs around the knee joint can better control pain after total knee replacement compared to standard pain medications alone. Eighty adults with end-stage knee arthritis were randomly assigned to receive eith…

This study tested whether a simple hypnosis technique called the 'magic glove' can prevent pain in children aged 7 to 14 when they receive propofol, a common anesthesia drug. One hundred children were randomly assigned to either the hypnosis method or a lidocaine injection. The g…

This study tested whether using virtual reality glasses or listening to white noise can reduce pain and anxiety during a common medical procedure: inserting an IV. 76 adults were randomly assigned to one of three groups: VR, white noise, or standard care. Right after the IV was p…

This study tested two types of nerve blocks for pain relief in 100 people with hip fractures. The goal was to see which block better preserves leg muscle strength after surgery. Participants received either a PENG block or a femoral nerve block, and their pain and muscle strength…

This study tested whether smelling lemongrass essential oil during a tooth extraction can lower pain and anxiety. Twenty-one people aged 12 to 25 had two teeth pulled, one with aromatherapy and one without. Researchers measured pain, anxiety, and stress levels to see if the scent…

This study tested a program that teaches mind-body skills (like deep breathing) and uses a Fitbit to encourage physical activity in 82 adults with long-term pain. The goal was to see if the program was practical and helpful for improving both physical and emotional well-being. Re…

This study tested if a mobile app with guided imagery therapy could help children aged 7 to 12 with chronic belly pain. Four children used the app for 8 weeks, listening to 10-15 minute sessions five days a week. The goal was to see if the app could reduce pain and anxiety. The s…

This study tested whether pressing a specific point on the hip (GB30) before a muscle injection could reduce pain and fear and increase satisfaction. 68 adults who needed a diclofenac injection were randomly assigned to receive acupressure or standard care. Results showed that ac…

This study tested whether a home-based telerehabilitation program can reduce pain, stiffness, and improve physical function in people with knee osteoarthritis. 118 patients over age 50 with mild to moderate knee OA took part. They were assigned to either a telerehab group or a co…

This study tested whether virtual reality (VR) exercises can help people with frozen shoulder (adhesive capsulitis) feel less pain, move better, and improve their quality of life. 36 adults aged 18-65 with frozen shoulder took part. Researchers measured pain, shoulder movement, a…

This study tested whether listening to music during a bladder test (urodynamic testing) can reduce pain and embarrassment. 90 adults took part, with some listening to music during the procedure and others not. The goal was to see if music helps people feel more comfortable during…

This study looked at whether aromatherapy (lavender oil foot massage) or reflexology (pressing specific points on the feet) could reduce pain and improve sleep in 90 children with cerebral palsy, aged 6 to 12. The children were split into three groups: one got aromatherapy, one g…

This study tested whether applying a special gel (PuraBond) to the surgical wound after mouth surgery could reduce pain and complications. 73 adults having surgery for mouth or throat lesions were randomly assigned to receive the gel or not. The main goal was to see if the gel lo…

This study looked at whether listening to music can help reduce pain and anxiety in people who have just had coronary artery bypass surgery. Sixty adults took part, and the researchers measured their pain and anxiety levels after listening to music. The goal was to see if music t…

This study looked at whether relaxation exercises and virtual reality (VR) could help people feel better after having a wisdom tooth removed. 36 adults who had surgery tried these non-drug methods to see if they could reduce pain, jaw stiffness, anxiety, and sleep problems. The g…

This study looked at whether chewing gum and applying warm compresses after gynecologic cancer surgery can reduce pain, help the bowels work sooner, and improve overall comfort. 84 women who had minimally invasive surgery took part. The goal was to find simple, drug-free ways to …

This study tested whether ozone therapy can reduce pain and fat tissue thickness in women with lipedema, a condition that causes painful fat buildup in the legs. 45 women received either local or systemic ozone treatments. The goal was to see if ozone's anti-inflammatory effects …

This study tested whether Korean manupuncture, a type of hand acupuncture, can reduce pain in women with endometriosis. 74 women with endometriosis were randomly assigned to receive either real or placebo hand acupuncture. The goal was to see if this gentle, non-drug approach cou…

This study looked at over 2,000 boys who had circumcision surgery to see if a numbing medicine called ropivacaine is safe when injected near the penis nerve. The main goal was to check for rare but serious side effects like tissue damage. The results help doctors know that this p…

This study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) could lower anxiety and pain. 144 adults having the injection were split into two groups: one listened to slow music, the other had no music. Researchers measured anxiet…

This study tested a standardized care program for 70 adults who had back surgery in Erbil, Iraq. The program aimed to reduce pain, improve daily function, and increase patient knowledge. Researchers measured pain and disability before and 8 weeks after surgery to see if the progr…

This study tested whether a guided relaxation program on a tablet could help adults with sickle cell disease better manage pain and stress while in the hospital. 46 participants used the program to listen to and view calming scenes. The goal was to see if this simple, drug-free a…

This study looked at 120 full-term newborns to see if holding them in different positions (on their back, side, or tummy) during a heel prick blood test affects their pain and comfort. Researchers measured pain using special scales and checked heart rate and oxygen levels. The go…

This study tested whether injecting a steroid (triamcinolone acetonide) along with a numbing drug (ropivacaine) into the surgical site before major spinal surgery could reduce pain and the need for opioid painkillers afterward. 118 adults having spinal surgery took part. The goal…

This study tested whether a 10% lidocaine spray (a numbing medicine) reduces pain when inserting an IV catheter. Forty women each received four IV insertions—some with the spray, some without—and rated their pain on a 0–10 scale. The goal was to see if the spray made the procedur…

This study looked at whether sharing information about a patient's daily life and home environment (called contextual patient-generated health data) can improve pain care for Veterans aged 65 and older with chronic pain. Researchers collected data from patients and their caregive…

This study tested whether certain health and wellness products could help reduce pain and improve related issues like anxiety and sleep. It involved 1,000 adults across the US who reported pain. Participants were randomly assigned to receive either an active product or a placebo …

This study looked at 60 adults having surgery to see if a special heart monitor (called ANI) could predict how they would react when a breathing tube was placed. Researchers gave a mild electric shock to the arm and watched the heart's response, then compared it to the patient's …

This study followed 300 people with hand osteoarthritis for up to 8 years. Researchers used exams, imaging, and surveys to track pain, inflammation, and joint changes. The goal was to learn how the disease progresses and what factors predict outcomes, not to test a new treatment.

This early-stage study tested a single dose of a new drug called SBS-1000 in 48 healthy adults to see if it is safe and how the body handles it. Participants were randomly assigned to receive either the drug or a placebo by IV. The main goal was to check for side effects, not to …

This study involved 100 torture survivors to see if a simple pain questionnaire can detect chronic pain better than current methods. Researchers also interviewed participants about their willingness to try pain treatments and tested whether a digital pain program could work for t…

This study tested a quick, one-minute checklist to identify women at high risk for severe pain after gynecologic day surgery. Researchers followed 487 women and checked if the tool could accurately predict who would have severe pain at home. The goal is to help doctors give bette…

This study looked at whether higher estrogen levels make propofol injection more painful in women. It included 90 female patients, some with high estrogen from IVF treatments and others with normal levels. Researchers measured pain during anesthesia to see if hormones play a role…

This study aimed to find out if pain in the jaw joint (temporomandibular joint) is linked to pelvic pain in adults. Researchers also looked at emotional factors and how the body processes pain. 133 adults with chronic pain filled out questionnaires about their symptoms. No treatm…

This study looked at how safe a newer type of nerve block (erector spinae plane block) is for people having chest surgery. Researchers measured the amount of the numbing drug ropivacaine in the blood of 20 patients to see if it could reach dangerous levels. They also checked pain…

This study looked at whether treating obstructive sleep apnea (OSA) can also reduce pain and problems in the jaw and face, known as temporomandibular disorders (TMD). Researchers followed 40 adults with OSA who had not yet started treatment. They checked for TMD signs and symptom…

This study looked at how temporary knee pain changes the way healthy adults walk. 34 participants received two injections in the knee: one that caused short-term pain and one that did not. Researchers used motion-capture cameras and pain sensitivity tests to measure changes in wa…

This study looked at how a low dose of the anesthetic sevoflurane, combined with short-term pain, affects memory and automatic body responses. Forty-two healthy adults took part in two sessions, including brain scans. The goal was to understand the brain processes involved, not t…

This study looked back at records of 126 people who had total knee replacement surgery and received nerve blocks for pain. The goal was to compare different nerve block techniques to see which one provides the best pain relief, lowest risk of nerve injury, and fastest recovery of…

This study looked at how the brain responds to pain and sound while a person is under general anesthesia. Researchers used a special light-based technique called near-infrared spectroscopy to measure blood flow changes in the brain. 44 healthy volunteers aged 12-30 took part. The…

This study looked at 151 people with shingles to find out who might develop long-lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information to see if certain immune cells could predict this pain. The goal was to create a model that hel…

This study looked at how body mass index (BMI) influences pain levels after lumbar disc surgery when a nerve block is used for pain control. Researchers measured pain in 75 adults at different times after surgery. The goal was to see if higher BMI leads to more pain, which could …

This study looked at how watching someone else experience pain can actually reduce your own pain. Researchers used brain scans to understand the brain activity behind this 'observational learning' effect. 211 healthy adults participated, and the goal was to map the brain areas in…

This study tested whether a device called the ANI monitor can measure pain in sedated children aged 2 and older in the pediatric intensive care unit. Researchers observed 50 children to see if the monitor's readings matched behavioral pain scales. The goal was to find a reliable …

This study tested whether a vibrating device can distract from the pain of needle pricks. Two hundred healthy adults received light pinpricks with and without the device. Researchers measured pain levels and anxiety to see if the vibration helps. The goal is to find a simple way …

This study tested two devices that measure pain in children aged 1 to 12 during surgery. The goal was to see how well they detect pain signals. Fifty children took part, and the results help doctors choose better pain monitors for young patients.

This study tested whether changes in pupil size can reliably measure acute pain. Researchers gave short, painful heat pulses to 20 adults with hip or knee arthritis and measured how their pupils reacted. The goal was to see if pupil response could be a trustworthy, objective pain…

This study looked at how broken sleep changes the way healthy adults feel pain and move their shoulders and knees. Thirty participants had their sleep disrupted on purpose, then received painful injections to measure their pain responses. The goal was to understand if poor sleep …

This study examined how genetic differences in the CYP2D6 enzyme influence pain relief from oxycodone in 100 elderly patients undergoing lung cancer surgery. The goal was to tailor pain management to each patient's genetic profile, reducing side effects and improving pain control…

This study looked at how different amounts of gentle, painless neck movements (called mechanical vagus nerve stimulation) affect heart rate, balance, pain sensitivity, and digestion in 128 healthy adults aged 18–60. Researchers measured heart rate, balance, and pain responses bef…

This study looked at how different types of virtual reality (VR) games affect how much heat and pressure people can tolerate before feeling pain. 265 healthy adults played both passive (watching) and active (interacting) VR games. The goal was to see which type of VR might help p…

This study tested a one-time, computer-based feedback program for adults with chronic pain who drink heavily and take prescription opioids. The goal was to see if the program could increase knowledge about the risks of mixing alcohol and opioids, and motivate people to drink less…

This study looked at 110 breast cancer patients to see if arm swelling (lymphedema) is linked to a specific type of muscle pain called myofascial pain syndrome. Researchers measured tender spots in the muscles and compared pain levels between affected and unaffected arms. The goa…

This pilot study tested a program called STEPPT to see if it could reduce differences in how often Hispanic and non-Hispanic White patients with back or neck pain are referred to and attend physical therapy. 144 adults from a community health clinic took part. Researchers measure…

This study looked at whether a personalized meal plan with more omega-3 fatty acids (found in fish) could help breast cancer survivors manage symptoms like fatigue, pain, depression, and sleep problems. Researchers worked with 98 women who had finished treatment for early-stage b…

This study looked at 21 preterm babies to see if a skin sensor could measure pain during a procedure that helps them breathe. The sensor was compared to standard pain scores. The goal was to find better ways to know which babies need pain medicine, so each baby can get the right …

This study looked at 679 adults to find out what makes some people feel more pain during a colonoscopy without sedation. The goal was to create a tool that helps doctors predict who might be in pain, so they can take steps to make the procedure more comfortable. The research only…

This study surveyed 186 adults with sickle cell disease in the U.S. to learn how the COVID-19 pandemic impacted their stress, anxiety, pain, and healthcare use. Participants completed online questionnaires about their medical history, mental health, and experiences during the pan…

This study tested whether a device that tracks heart rate changes (called the Analgesia Nociception Index) can detect pain in 17 children with cerebral palsy. The children were watched during painful procedures like injections and physical therapy. The goal was to see if this too…

This study looked at 100 women with painful periods (primary dysmenorrhea) to find out how much pain or symptom scores need to change to be considered a real improvement. Researchers used standard pain scales and questionnaires to calculate the smallest meaningful difference. The…

This study compared 128 women with and without fibromyalgia to see if those with fibromyalgia also had more chronic pelvic pain and pelvic floor problems. Researchers used pain questionnaires and scales to measure the differences. The goal was to better understand how these condi…

This study followed 392 adults who had planned surgeries to map their pain levels each day for a week. The goal was to see if early pain patterns could predict who develops chronic pain three months later. Researchers used simple pain scores and questionnaires to gather data, aim…

This study looked at whether sleeping at least an hour more each night for a week could help college students feel less pain. 36 participants wore watches to track sleep and heart rate, and took tests for pressure and cold pain. The goal was to see if more sleep leads to higher p…

This study involved 200 Albanian adults with back pain to test whether translated pain and disability questionnaires are accurate and reliable. Participants filled out several standard forms, like the Roland-Morris and Oswestry Disability Index, in Albanian. The goal was to make …

This study looked at 110 medical secretaries to understand how their desk setup, posture, and work habits relate to muscle and joint pain. Participants filled out surveys about their work environment and any discomfort they felt. The goal was to find links between poor ergonomics…

This study looked at 100 adults with sacroiliac joint pain to find out which patient traits predict better results from ultrasound-guided injections of numbing medicine and steroids. Researchers measured pain and disability before and after the shot. The goal was to help doctors …

This study looked at how puberty changes pain sensitivity in healthy teens aged 9-16. Researchers measured pain responses to heat and cold, and checked hormone levels. The goal was to understand if early or mid-puberty affects how teens feel pain and who might develop chronic pai…

This study tested a device called VerTouch that helps doctors find the right spot for spinal injections. It compared VerTouch to feeling for landmarks by hand (palpation) and using ultrasound. 86 adults having spinal procedures took part. The main goal was to see if VerTouch redu…