PAIN

This study tested two tools to help older adults (65+) on long-term opioid therapy use painkillers more safely. The PainTracker tool helps doctors focus on improving daily function and mental health, while the Opioid Misuse Measure screens for risky opioid use. Researchers studie…

This study tested a weight management program for young adult cancer survivors (ages 18-39) who have obesity and are within 5 years of finishing cancer treatment. The program combined healthy eating, physical activity, and symptom management to help reduce cardiovascular disease …

This study tested whether a workplace program called GLAD can be used to prevent muscle and joint pain in blue-collar workers. 70 workers and safety professionals took part in an 8-week program with education, ergonomic changes, and exercises. The main goal was to see if workers …

This study looks at whether adding core muscle exercises to a hip and knee workout can lower pain and improve knee alignment in women with patellofemoral pain syndrome (knee pain around the kneecap). Thirty-six women aged 19-35 with a healthy weight will be assigned to different …

This study compares two types of braces—self-ligating and conventional—to see which straightens teeth faster and causes less discomfort. It involves 30 people aged 14 to 20 with mild to moderate crowding who do not need tooth extractions. Researchers will measure how much teeth m…

This phase 2 trial tests an experimental painkiller called YZJ-4729 in people experiencing moderate to severe pain after orthopedic surgery. Participants receive either YZJ-4729, morphine, or a placebo through an IV, and researchers measure pain relief over 48 hours. The goal is …

This study tests a new drug called YZJ-4729 for people experiencing moderate to severe pain after abdominal surgery. Participants are randomly assigned to receive one of several doses of YZJ-4729, a placebo, or the standard painkiller morphine. The goal is to see how well YZJ-472…

This study compares two common opioids, morphine and hydromorphone, to see which provides better pain relief with less nausea and vomiting after same-day surgeries. About 400 adults undergoing procedures like gallbladder removal or hernia repair will receive one of the two drugs …

This trial compares two types of nerve blocks—femoral nerve block and adductor canal block—for controlling pain after anterior cruciate ligament (ACL) reconstruction. Participants receive one of the two blocks before surgery, and researchers track their pain levels and painkiller…

This trial investigates whether applying a heated pack to the arm for 5 or 10 minutes before inserting a dialysis needle can reduce pain in people with an arteriovenous fistula. About 51 adults on hemodialysis will be randomly assigned to receive heat for 5 minutes, 10 minutes, o…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This study looked at whether adding medical cannabis to a behavioral program helps adults with long-term non-cancer pain lower their opioid dose and manage pain better. 87 participants on stable, high-dose opioids were randomly assigned to either start medical cannabis or not, wh…

This study tested whether repeating positive affirmations during a routine pregnancy test (Non-Stress Test) can lower pain, anxiety, fear, and stress. 90 pregnant women participated, with some using affirmations and others receiving standard care. The goal is to see if this simpl…

This study looked at whether applying cyanoacrylate (a medical glue) or concentrated growth factor (a substance made from the patient's own blood) can improve healing and reduce pain at the gum graft donor site. Sixty healthy adults who had gum graft surgery were involved. The go…

This study tests whether a new dental anesthesia pen causes less pain and anxiety than a traditional syringe in children aged 6 to 12 who need a filling. Each child will try both methods (with a two-week break in between) so they can compare the experience directly. The goal is t…

This study tested whether teaching good sleep habits could help people with painful diabetic nerve damage sleep better and feel better overall. Twenty-four patients were split into two groups: one received a booklet and face-to-face sleep training from a nurse, while the other co…

This study tested whether a 635-nm low-level laser can reduce pain from orthodontic separators. Eighty healthy patients received laser on one side of the mouth and no treatment on the other. They rated spontaneous and chewing pain for 7 days. The goal is to see if this simple las…

This study tested whether coughing during a blood draw can reduce pain. Twenty-one healthy men had blood drawn twice—once with coughing and once without—and rated their pain. The goal was to understand how the 'cough-trick' works. If effective, it could offer a simple, drug-free …

This study tested a new dental sponge called Colibricare (Coli-sorb®) in 124 patients having their wisdom teeth removed. The sponge was compared to a standard gauze and a commercial sponge. Researchers measured how quickly bleeding stopped, pain levels, swelling, and wound healin…

This study tested whether wearing virtual reality glasses during a common kidney stone treatment (ESWL) can lower patients' pain, anxiety, and improve comfort. Seventy adults undergoing the procedure for the first time took part. Researchers measured pain, anxiety, and comfort le…

This trial tests whether applying platelet-rich fibrin (PRF) — a wound dressing made from a patient's own blood — to the roof of the mouth after gum graft surgery improves pain, sleep, and overall quality of life compared to standard dressings. About 78 adults needing gum surgery…

This study tested a phone-based counseling program called SBIRT-PM for veterans with chronic pain who were also at risk for substance misuse. Over 1,100 veterans participated, receiving up to four phone calls over 12 weeks to help them engage in non-drug pain treatments and reduc…

This study tested whether a nerve block (PECS II) or local anesthesia works better for pain after breast cancer surgery, without using opioids. 124 women undergoing breast surgery were randomly assigned to receive one of the two methods. Researchers measured pain, nausea, and opi…

This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which a…

This study tests whether repeated acupressure can help reduce agitation, pain, and sleep disturbances in intensive care unit (ICU) patients who are on mechanical ventilators. Participants receive either real acupressure or a light touch (sham) twice daily for four days. Researche…

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This study tested a light and laser device (photo-biomodulation) on the wound of 180 women after planned C-sections. The goal was to see if using the device twice a day could reduce pain and the need for strong painkillers. Researchers measured pain during movement and after six …

This study tested whether hypnosis sessions led by a nurse over video call are practical for people with long-term nerve pain. Thirty adults with peripheral neuropathic pain for over a year took part. The goal was to see if patients would complete five sessions and if it helped w…

This study tested a 3-day prenatal education program for first-time mothers to see if it could reduce fear of childbirth, change pain beliefs, and boost confidence for a normal delivery. 126 pregnant women participated, with half receiving the program and half not. The program us…

This study tested two different nerve blocks to see which one provides better pain relief after surgery for a belly button hernia. Thirty adults received either an external oblique intercostal block or a rectus sheath block before their operation. Researchers measured how much mo…

This study tested whether using virtual reality (VR) during a knee pain procedure called genicular nerve radiofrequency ablation could reduce pain and improve satisfaction. Forty adults used a VR headset during the procedure and rated their pain and satisfaction. The goal was to …

This study looked at whether classical massage can reduce pain and improve daily function in people with myofascial pain syndrome, a condition that causes muscle knots and radiating pain. Sixty adults aged 30–50 with active trigger points in the upper back took part. Researchers …

This study tested new non-drug treatments to reduce nerve pain in the feet and legs of people with HIV. 161 adults with HIV-related nerve pain tried these approaches to see if they could ease pain and improve quality of life. The goal was to find better ways to manage this common…

This study tested whether using a ShotBlocker device, a cold needle, or both together can reduce pain and boost satisfaction during intramuscular injections. 132 adults getting vitamin B12 shots took part. Researchers measured pain on a 0-10 scale and asked about satisfaction. Th…

This study tested whether a simple breathing technique called box breathing can help reduce anxiety, pain, and nausea in patients undergoing a procedure called ERCP. Seventy adults were randomly assigned to either learn the breathing technique or receive standard care. The techni…

This study tested whether a pain plan without strong opioids works as well as one with opioids for children after tonsil surgery. Sixty-two kids aged 3 to 17 were randomly assigned to get either morphine plus other drugs or a combo of dexmedetomidine, acetaminophen, and ketorolac…

This study tested whether listening to audio biofeedback from a device like NOICE could help people tolerate cold pain. 42 healthy adults completed cold pain tasks with and without the audio feedback. Researchers measured pain scores, anxiety, and how long participants could endu…

This study tested whether using a stress ball and listening to relaxing music during a colonoscopy can reduce pain and anxiety. 100 adults undergoing the procedure without sedation were split into two groups: one used the stress ball and music, the other received standard care. T…

This study tested whether acupuncture can reduce pain and improve daily life for people with long COVID. 93 adults with persistent pain after COVID-19 were randomly assigned to receive 8 acupuncture sessions or continue their usual care. Researchers measured pain intensity and it…

This study tested a special pain coping skills program for people with advanced solid tumor cancer who have pain that interferes with daily activities. 211 patients were randomly assigned to either the program or standard care. The program taught ways to manage pain and find mean…

This study tested whether listening to nature sounds while walking after gallbladder surgery could reduce anxiety, pain, and stress. Seventy adults who had laparoscopic cholecystectomy took part. Patients walked 50 meters while hearing nature sounds, then returned to bed. Their a…

This study tested whether adding gentle spinal mobilization to a home exercise program could reduce neck pain and improve fitness in recreational tennis players. Thirty adults with mechanical neck pain were split into two groups: one did only home exercises for three weeks, and t…

This study tested whether adding functional electrical stimulation (FES)-assisted cycling to standard rehab helps stroke survivors with Complex Regional Pain Syndrome (CRPS). Forty participants either received FES cycling plus conventional therapy or conventional therapy alone fo…

This study tested whether applying a hot compress with black seed or ginger essential oil to the knees for 7 days could reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee OA were split into four groups: ginger oil plus heat, bla…

This pilot study tested whether adding group-based pain neuroscience education (PNE) to a community exercise program helps older women with knee osteoarthritis. Nineteen women aged 60+ were randomly assigned to 10 weeks of exercise plus PNE or exercise alone. Researchers measured…

This study tested a fixed-dose combination of acetaminophen and naproxen sodium (two common pain relievers) against a placebo for managing pain after bunionectomy (foot surgery). 143 adults took multiple doses over 48 hours. The main goal was to measure pain reduction using a sta…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested whether a sugar-free sweet solution applied before a dental injection could lower pain in children aged 6 to 12. Fifty-four kids received either the sweet solution or plain water before their shot. Researchers measured pain using child reports, observer ratings,…

This study tested a personalized internet-based program (WebTIPS) to help children ages 1-12 feel less anxious before surgery and recover more smoothly. Over 1,200 parent-child pairs took part, with some using the tailored program and others receiving standard online information.…

This study looked at whether photobiomodulation (PBM) therapy, a type of light treatment, can reduce pain and improve healing for women who had perineal tears or cuts during vaginal birth. 183 women were offered PBM in addition to standard care. Researchers compared pain scores a…

This study looked at three ways to manage pain after severe perineal tears (called OASIS) that can happen during vaginal delivery. Sixty-seven women received either a placebo, epidural morphine alone, or epidural morphine plus intravenous ketamine. The goal was to see which optio…

This study tested whether applying cold to painful joints can reduce pain and improve quality of life in people with rheumatoid arthritis. 90 patients with active pain participated. The goal was to see if this simple, low-cost method could be a helpful addition to standard care.

This study tested whether giving children montelukast before and after tonsillectomy reduces their pain and need for strong painkillers. 116 kids aged 3-8 took part, receiving either montelukast or a placebo. Researchers measured pain scores and how often families contacted docto…

This study tested whether using different amounts of numbing medicine in a back muscle injection (erector spinae plane block) could reduce pain and the need for morphine after a hysterectomy. 80 women having the surgery took part. The goal was to find the best volume for safer, m…

This study looked at whether Reiki, a hands-on relaxation technique, can reduce pain, fatigue, and improve sleep in older adults living in nursing homes. Sixty people aged 50 and older with chronic pain took part. They received Reiki sessions over four weeks, and researchers meas…

This study looked at whether special sponges placed in the tooth socket after extraction can stop bleeding faster and improve healing. Thirty adults who needed a tooth pulled took part. Researchers measured bleeding time, pain, swelling, and wound healing. The goal was to see if …

This study tested whether giving testosterone to older women with chronic back pain and low testosterone could improve pain, physical function, and quality of life. 36 women received weekly injections of either testosterone or a placebo for several weeks. The goal was to see if t…

This study looked at whether a mother's scent and a soft, knitted octopus toy could reduce pain in newborns who had a lack of oxygen at birth (asphyxia) and were receiving cooling treatment. The study included 45 full-term babies in intensive care. Researchers measured pain level…

This study looked at whether aromatherapy (lavender oil foot massage) and reflexology (pressing specific points on the feet) could reduce pain and improve sleep in 90 children with cerebral palsy, aged 6 to 12. Children were split into three groups: aromatherapy, reflexology, or …

This study tested whether guided breathing exercises (4-7-8 breathing and diaphragmatic breathing) can help reduce pain, anxiety, and improve comfort during the needle insertion for dialysis. 90 adults on hemodialysis were split into three groups: two doing different breathing ex…

This study tested whether applying acupressure to a specific point on the hip for one minute before an intramuscular injection could reduce pain, fear, and improve satisfaction. Sixty-eight adults receiving a diclofenac shot were randomly assigned to acupressure or standard care.…

This study tested whether watching calming nature scenes together in virtual reality could help hospice patients and their caregivers feel better. 26 patient-caregiver pairs tried the shared VR experience. Researchers measured changes in quality of life, fear of death, and pain, …

This study tested whether a 10% lidocaine spray, applied to the skin two minutes before inserting an IV catheter, reduces pain in women aged 18-45. Each volunteer received four IV insertions—two on the hand and two on the forearm—with either the spray or a placebo. The goal was t…

This study tested a mobile prayer program called PUSH (Pray Until Something Happens) to see if it could help adults with sickle cell disease feel less stress and pain. 40 people who had pain and used opioids took part. They listened to guided prayer recordings on a smartphone. Th…

This study tested whether smelling lemongrass essential oil during a tooth extraction could lower pain, anxiety, and stress. Twenty-one people aged 12 to 25 who needed two upper premolars removed took part. Each person received aromatherapy for one tooth and a placebo for the oth…

This study looked at whether a diabetes education program plus cinnamon supplements could help adults with type 2 diabetes who have painful nerve damage in their feet. Sixty-two participants were split into two groups and followed for six months. Researchers measured changes in b…

This study tested whether a medicine called Intravenous Immunoglobulin (IVIG) is safe and helps shorten painful episodes in people with sickle cell disease. 300 participants aged 6 to 65 took part. The goal was to see if IVIG could reduce how long the pain lasts and how much stro…

This study tested whether ozone therapy can reduce pain and tissue thickness in women with lipedema, a painful fat disorder. 45 women received either local or systemic ozone treatments. The goal was to see if ozone's anti-inflammatory effects could improve symptoms and quality of…

This study tested whether chewing gum and applying hot compresses to the lower back could help women feel better after gynecologic cancer surgery. 84 women who had minimally invasive surgery were asked to chew gum three times a day and use hot packs twice a day. Researchers measu…

This study tested whether wearing virtual reality glasses or listening to white noise (rain sounds) can reduce pain and anxiety during IV insertion in adults. 76 participants were randomly assigned to one of three groups: VR, white noise, or standard care. Pain and anxiety were m…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical and helpful. 63 adults with opioid use disorder and pain took part. The goal was to see if they would stick with the program and if it could reduce pain, cravings, …

This study tested whether placing a hot water bag on the abdomen can reduce pain and help restore normal bowel movement in people with ileus (a bowel blockage). Sixty adults with a certain type of ileus took part. Researchers measured pain levels and bowel activity to see if this…

This study looked at 120 full-term newborns to see if placing them in different positions (on their back, side, or stomach) during a heel stick blood test could lower their pain and improve comfort. Researchers measured pain using standard scales and checked heart rate and oxygen…

This study looked at whether aromatherapy can help lower pain for women during childbirth. 94 first-time mothers with a single baby and no major complications were randomly assigned to receive either aromatherapy plus standard pain control or standard pain control alone. Research…

This study tested whether a trained nurse using 'hypnotic communication'—a calm, supportive way of talking—could help men feel less anxious and experience less pain during a prostate biopsy. One hundred men were randomly assigned to receive either standard care or standard care p…

This study tested whether injecting a mix of painkillers (bupivacaine, ketorolac, and epinephrine) around the knee during total knee replacement surgery could reduce pain and improve function better than standard pain medicines alone. Eighty adults with end-stage knee arthritis t…

This study looked at whether breathing a 50:50 mix of oxygen and nitrous oxide (laughing gas) can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, stitches, or tube placements. Researchers observed 100 children and measured their pain usi…

This study tested whether wearing a virtual reality headset showing a nature video could reduce pain and anxiety in 90 adults undergoing coronary angiography, a heart procedure where patients are awake. One group watched the VR video during the procedure, while the other received…

This study tested whether a brief cognitive behavioral therapy program (six 30-minute sessions) can help veterans with chronic musculoskeletal pain improve their daily functioning and reduce pain-related distress. 184 veterans from primary care clinics took part, with some receiv…

This study tested a telephone-based collaborative care program for 516 people with stage III or IV cancer. The program included regular check-ins, personalized exercise plans, and help managing treatment side effects. The goal was to see if it could improve mobility, reduce pain,…

This completed Phase 1 trial from the University of Reading tested whether taking high-dose vitamin B6 (100 mg daily) can increase how much heat and electric shock healthy adults can handle before feeling pain. 43 participants were randomly assigned to get either vitamin B6 or a …

This study tested a smartphone app called e-PainSupport for people receiving home hospice care. The app helps patients and their caregivers report pain levels to nurses and learn about pain management. Researchers wanted to see if using the app could reduce pain intensity. The st…

This study tested whether a structured education program could help patients recover better after back surgery. 70 adults in Erbil, Iraq, received the program, which included tips on pain management, wound care, and safe movement. Researchers measured changes in pain and disabili…

This study tested a drug called dexmedetomidine in 50 newborns with brain injury who were undergoing cooling therapy. The goal was to see if it could provide sedation and pain relief as well as morphine, but with fewer risks. Researchers measured safety and drug levels in the blo…

This study tested whether foot reflexology—a type of focused foot massage—could help people with migraines feel less pain and fatigue and have a better quality of life. 78 adults with migraines took part; half received 10 reflexology sessions over 5 weeks, while the other half co…

This study tested whether adding a gentle manual therapy technique called Mulligan SNAG to standard physical therapy helps people with long-term low back pain. Thirty adults with pain lasting at least six months were split into three groups: standard therapy alone, standard thera…

This study looked at whether adding ketamine to a standard nerve block can better control pain after chest surgery (thoracotomy). Fifty adults scheduled for open chest surgery took part. The main goal was to see how long it took before they needed extra pain medicine. The approac…

This study tested whether a short mindfulness exercise (3 minutes) done in an orthopedic clinic waiting room can help reduce acute pain. Over 600 adults listened to either a mindfulness recording, a pain education recording, or a mix of both. The goal was to see if learning about…

This study tested whether adding a gentle manual therapy called strain counterstrain to standard physiotherapy helps women with fibromyalgia feel better. 105 women were split into three groups: one got standard care, another got standard care plus the therapy, and a control group…

This study tested whether relaxation exercises and virtual reality (VR) can reduce pain, anxiety, and other discomforts after impacted wisdom tooth surgery. 36 adults who had their lower wisdom teeth removed were given either relaxation exercises, VR, or standard education. Resea…

This study tested two devices—Coolsense (cold) and Buzzy (cold + vibration)—to see if they could reduce pain and fear in children aged 6-12 during insulin injections. 90 kids with type 1 diabetes were split into three groups: one used Coolsense, one used Buzzy, and one received s…

This study looked at whether progressive relaxation exercises can help people with lumbar disc herniation (a slipped disc in the lower back) feel less afraid of moving, have less pain, and enjoy a better quality of life. About 96 adults with confirmed slipped discs were randomly …

This completed trial tested whether reflexology (a type of foot massage) can reduce pain during episiotomy repair after vaginal birth. 80 women were randomly assigned to receive either reflexology plus standard local anesthesia or standard care alone. Pain was measured using a vi…

This study tested whether giving children aged 4-6 a liquid hourglass or a spiky ball during a blood draw can reduce their pain, fear, and anxiety. 120 children were randomly assigned to use one of the toys or receive standard care. The goal was to see if these simple distraction…

This study tested a new drug called MR-107A-02 for treating acute pain after hernia repair surgery. About 579 adults took part, comparing the drug to a placebo and to tramadol, a standard painkiller. The goal was to see if MR-107A-02 reduces pain intensity and the need for extra …

This study tested Korean manupuncture, a hand-based therapy, for reducing pain in women with endometriosis. 74 women were randomly assigned to receive either real or placebo sessions. The goal was to see if this gentle, non-drug approach could help manage pain that often doesn't …

This study looked at whether nursing care based on Kolcaba's Comfort Theory could reduce pain and improve comfort in healthy, full-term newborns right after a vaginal birth. Sixty newborns were included. The approach focused on physical, emotional, and environmental comfort. Resu…

This study tested a nasal spray containing two painkillers (sufentanil and ketamine) for children aged 1 to 17 with moderate to severe pain in the emergency room. The goal was to see if it is safe, tolerable, and effective. Results showed the spray reduced pain and was well-toler…

This study tested two simple devices—ShotBlocker and a vibration pen—to see if they could reduce pain in healthy infants during routine vaccinations. 96 babies aged 2-6 months were randomly assigned to one of the devices or a control group. Pain was measured using a standard scal…

This study looked at whether working with a care manager (patient navigator) and using an online pain coping program can help people with chronic pain improve how they manage their pain and daily activities. The study included 32 adults who had daily pain for at least 3 months an…

This study looked at two fun ways to help children aged 6 to 9 feel less scared and hurt during their first dental visit. One group played with toy dental tools, another used virtual reality glasses, and a third got standard care. The goal was to see if these activities before nu…

This study tested several non-drug methods—like a textured plastic device called ShotBlocker, a vibrating ice pack (Buzzy), and a skin-tapping technique—to reduce pain from injections in children aged 4 to 6. 120 kids in a pediatric emergency department took part. The goal was to…

This study looked at whether structured play activities could reduce anxiety in children aged 4-10 receiving chemotherapy and their parents. 62 children and their parents took part in play sessions during chemo. Anxiety levels were measured before and after play. The goal is to s…

This study tested whether a program called PQ-ResPOND could help manage pain in children with severe neurologic disabilities like cerebral palsy. About 54 children and their parents took part, with some receiving the program (surveys plus a palliative care team consult) and other…

This completed study looked at how Voltaren Gel (a topical pain reliever) affects mobility and quality of life in 196 adults with knee osteoarthritis pain. Participants used the gel as directed for up to 3 weeks while wearing an activity tracker. The goal was to see if the gel he…

This study tested whether using virtual reality (VR) during the removal of a tube from the groin after a heart procedure could reduce pain and anxiety. One hundred adults were randomly assigned to either wear VR goggles showing calming scenes or receive standard care. Researchers…

This study tested a special device called the Bridge to see if it could help reduce pain and the need for opioid painkillers after rotator cuff surgery. 42 adults having outpatient surgery took part. The goal was to find a better way to manage pain after the procedure.

This study tested whether playing active or watching passive virtual reality (VR) games can change how healthy people feel heat and pressure pain. 265 adults used a VR headset in different ways, and researchers measured their pain thresholds. The goal is to see if VR could be a n…

This study tested whether gabapentin or clonidine works better for pain after spinal surgery. 90 adults aged 18-60 having one or two-level lumbar laminectomy took part. Pain was measured using a standard 0-10 scale, and anxiety was also tracked. The goal is to find which medicine…

This study looked at whether a doctor's encouraging words can help patients feel less pain and anxiety during a colonoscopy done without sedation. Over 100 adults took part, with some hearing positive phrases like "You're doing great" during the procedure. The goal was to see if …

This study tested whether showing children a short educational film before a bone marrow biopsy can reduce their anxiety, fear, and pain, and increase their satisfaction. Sixty children aged 7 to 12 took part. The goal was to see if a simple video could make a stressful medical p…

This study tested whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. 70 women were randomly assigned to either use the VR headset or receive standard care. Pain and anxiety were measured right after the procedure. The goal is to find a simple…

This study tested whether giving nerve pain medications pregabalin or gabapentin alongside standard opioids could lower the amount of opioids needed by adults hospitalized with orthopedic injuries. 109 participants were randomly assigned to receive one of the two add-on drugs. Th…

This study tested whether letting children play digital games or watch cartoons before and during stitches can lower their pain, fear, and anxiety. 90 children aged 5-10 in the ER were split into three groups: one played games, one watched cartoons, and one received standard care…

This study tested a single injection of a long-acting painkiller called SDE in 221 adults recovering from hemorrhoid surgery. Half received the drug and half a placebo. Researchers measured pain levels and how much extra pain medicine was needed over 48 hours. The goal was to see…

This study tested whether a telerehabilitation program—where patients do exercises at home with remote support from a physiotherapist via video calls, phone, and texts—can reduce pain and improve knee function in people with knee osteoarthritis. 118 patients aged 50 and older wit…

This study tested whether inhaling lavender essential oil can help reduce anxiety and pain in people with moderate to severe pain. 68 adults who had pain but no allergy to lavender took part. They either inhaled lavender oil or a placebo for 30 minutes, and their anxiety and pain…

This study tested whether breathing exercises and using a stress ball during dressing changes can reduce pain, anxiety, and improve comfort in burn patients. 210 adults with burns on 15% or less of their body took part. Researchers measured pain, anxiety, comfort, and vital signs…

This study tested whether using virtual reality (VR) during wound dressing changes can reduce pain and improve sleep in adults with moderate to severe burns. Sixty patients took part, and the researchers compared VR to standard care. The goal was to see if VR could make a painful…

This study looked at whether kinesiological taping (a special tape applied to the skin) or foot massage can help women who had a C-section feel less pain, tiredness, and mood problems. 97 new mothers were split into three groups: one got taping, one got foot massage, and one got …

This study tested two methods to block nerves in the upper arm during surgery to reduce pain from a tourniquet. 140 adults having upper arm surgery received either a blind injection or an ultrasound-guided injection. The goal was to see which approach provides better pain relief …

This completed study tested two types of nerve blocks—the transversalis fascia plane (TFP) block and the transversus abdominis plane (TAP) block—to see which one works better for pain relief after robotic-assisted partial prostatectomy. 108 men received one of the blocks with bup…

This study looked at whether doing exercises at work or at home is better for office workers with low back pain. 57 workers participated, and researchers measured pain, daily function, and quality of life. The goal was to find the most effective way to ease pain and improve movem…

This study tested whether injecting the numbing drug ropivacaine into the nose can reduce pain after endoscopic sinus surgery. 184 adults having sinus surgery were randomly given either ropivacaine or a saltwater placebo injection. The main goal was to measure pain intensity and …

This study looked at a different way to manage pain after chest surgery (thoracotomy) for people who cannot get an epidural. A thin tube placed by the surgeon near the wound delivered either a numbing medicine (ropivacaine) or a saltwater placebo for 48 hours. All participants al…

This study tested whether reflexology (a type of foot massage) could reduce pain, improve sleep, and stabilize vital signs in 70 stroke patients. Half received reflexology twice a week for six weeks plus standard care, while the other half got standard care alone. The results are…

This study tested a new device called Miraπ that physically moves a stroke patient's affected hand during mirror therapy. It compared this device to standard mirror therapy in 24 stroke patients with one-sided hand paralysis and pain. The goal was to see if the device could impro…

This study tested whether listening to music during wound dressing changes can help reduce pain and anxiety in people with venous leg ulcers. 97 patients were split into three groups: one listened to Turkish instrumental music, one to Western music without lyrics, and one had no …

This study tested a pain relief method for people having chest surgery who cannot get an epidural. Instead, surgeons placed a small tube near the spine to deliver the numbing drug ropivacaine for 48 hours. All patients also received morphine through a pump they control themselves…

This study tested whether low level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani patients aged 18-30 received either standard braces or braces plus laser treatment on their front teeth every three we…

This study looked at whether using virtual reality glasses or music during burn dressing changes can lower pain, anxiety, and fear of pain. 120 adults with burns on less than 15% of their body took part. Researchers measured their pain and anxiety levels using standard scales.

This pilot study tested whether a guided imagery therapy mobile app could help children aged 7 to 12 with chronic abdominal pain. Four children listened to 10-15 minute recorded sessions five days a week for eight weeks. The study compared immediate app use to a delayed start gro…

This completed study tested three different dietary supplements against a placebo for pain relief in 1,000 adults. Participants took the products for six weeks, and researchers measured changes in pain, anxiety, and sleep. The study was double-blind, meaning neither participants …

This study tested whether using a virtual reality headset before a gastrointestinal endoscopy could help children aged 6 to 15 feel less anxious and have less pain afterward. Sixty-six children were split into two groups: one got standard care, the other got a short VR session wi…

This study tested whether one dose of radiation works as well as two doses for reducing pain from cancer that has spread to the bones. 102 adults with painful bone metastases took part. The goal was to see if a single treatment could provide similar pain relief and reduce the nee…

This study looked at whether music therapy can reduce pain and anxiety in people who had coronary artery bypass grafting (CABG). Sixty adults were enrolled, and those in the music group listened to music before and during surgery. Afterward, they reported their pain and anxiety l…

This study tested whether using virtual reality (VR) goggles during a blood draw could reduce pain, anxiety, and emotional distress in school-age children. 86 children were randomly assigned to either active VR (where they could control the experience) or passive VR (just watchin…

This study tested whether lidocaine or benzocaine sprays could reduce pain and improve satisfaction during needle insertion for hemodialysis. 60 patients were randomly assigned to receive one of the two numbing sprays or a placebo. The goal was to see if these sprays make the pro…

This study tested whether a hypnosis technique called the 'magic glove' could prevent pain when children receive propofol, a common anesthesia drug. One hundred children aged 7 to 14 were randomly assigned to receive either the hypnosis technique or lidocaine mixed with propofol.…

This completed trial tested whether kinesiologic taping (a special elastic tape) applied to the knee can reduce pain, improve mobility, and lessen fear of movement in people with rheumatoid arthritis. Thirty adults aged 45 to 60 were randomly assigned to receive either real kines…

This study tested a combination of brain monitoring and specific drugs during heart surgery to see if it could reduce confusion, pain, and blood pressure problems afterward. 70 older adults (60+) having heart bypass or valve surgery took part. The approach used EEG monitoring and…

This study compares two types of ultrasound-guided nerve blocks for controlling pain after mastectomy: the standard paravertebral block and a newer proximal intercostal block. Researchers want to see if the newer block offers better needle visibility, faster procedure time, and i…

This study looked at whether giving children stickers during an IV insertion can lower their pain and anxiety. 72 children aged 5 to 10 took part. The idea is that stickers can distract kids and make the experience less scary.

This study looked at whether back massage after open heart surgery can help with pain, sleep, and stress. 96 adults who had elective open heart surgery were included. The massage group received three 30-minute back massages on the first day after surgery. Researchers measured pai…

This study tested whether interacting with a live parrot, a robotic parrot, or a picture of a parrot could reduce pain during blood draws in 240 adults with chronic diseases. Participants were randomly assigned to one of the three groups, and their pain was measured using a stand…

This study tested how easy it is for people with multiple sclerosis (MS) to use a mobile app called MeTime MS. The app guides users through self-acupressure, a technique that involves pressing on specific points on the body to help with fatigue and pain. Ten adults with MS who ha…

This study looked at 304 children aged 2 to 17 with broken arm or leg bones who came to the emergency room in severe pain. Researchers wanted to see if giving paracetamol (Tylenol) or ibuprofen (Advil) along with morphine worked better than morphine alone. They measured pain leve…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study looked at whether watching parrots, fish, or turtles could help reduce pain and anxiety when inserting a needle into a port catheter in 120 adults receiving palliative care. Patients were randomly assigned to one of the animal therapies, and their pain and anxiety leve…

This pilot study tested a program called DAPPER for African American women aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants received 8 nurse visits at home to help manage their pain and mood. The study aimed to see if the program could…

This study compared two types of nerve blocks for pain relief in 100 people with hip fractures. The goal was to see which block better preserves leg muscle strength while still controlling pain. The PENG block may offer a way to reduce pain without weakening the leg as much as th…

This study looked at whether giving ketamine as a mist through a special inhaler can help reduce acute pain in children aged 7 to 17 in the emergency department. Researchers compared three different doses to see which works best and how quickly. The goal is to find a needle-free …

This study looked at whether giving doctors information about what matters to older Veterans with chronic pain—like how they store medications and what help they get at home—can improve pain care. Researchers talked to 230 Veterans aged 65 and older, their caregivers, and clinici…

This study tested a device called the Sana Pain Reliever for people with long-term nerve pain. 75 adults used the device at home for 8 to 14 weeks. Researchers measured changes in pain symptoms using a standard pain scale. The goal was to see if the device could help reduce pain …

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested a cooling spray (vapocoolant) to see if it reduces pain when placing an IV in emergency department patients. 300 adults who needed an IV were randomly given either the cooling spray or sterile water before the needle. The main goal was to measure pain scores rig…

This study tested whether a 12-minute guided relaxation video on a tablet could help adults with sickle cell disease manage pain and stress during a hospital stay. 46 participants were randomly assigned to watch the relaxation video or discuss their sickle cell experiences. The g…

This study tested whether a 20-minute live classical music session (piano with or without flute) could help reduce anxiety and pain and increase relaxation in critically ill ICU patients. Researchers also looked at how patients, families, and staff felt about the music. The study…

This study tested whether Emla cream, a numbing cream, can reduce pain in 3-month-old babies during their first pneumococcal vaccination. 72 healthy babies were randomly given either Emla cream or a placebo cream before the shot. Pain was measured using a standard scale (FLACC) a…

This study tested a mind-body program called GetActive for adults with chronic pain. The program combines relaxation techniques, coping skills, and physical activity (with or without a Fitbit). 82 participants completed the program, and researchers measured satisfaction, safety, …

This study tested a new drug called MR-107A-02 for treating acute pain after bunionectomy (foot surgery). 410 adults received either the new drug, a placebo, or tramadol (a standard painkiller). The main goal was to see if MR-107A-02 provides better pain relief than placebo, meas…

This study tested whether listening to calming music during urodynamic testing—an invasive procedure for bladder problems—can reduce pain and embarrassment. 90 adults were randomly assigned to listen to classical music or not during the test. Researchers measured pain and embarra…

This study tested whether applying a cold spray to the skin right before a low molecular weight heparin injection can reduce pain and bruising in patients recovering from orthopedic surgery. Researchers measured pain using a simple scale and bruise size with a clear grid. The goa…

This completed study tested whether certain dietary supplements can reduce pain and improve daily life. Over 2,000 adults in the U.S. who wanted less pain took either an active supplement or a placebo for 6 weeks. Researchers measured changes in pain interference and types of pai…

This study tested whether an ultrasound-guided PECS nerve block could reduce opioid use and improve pain control in 70 women undergoing breast cancer surgery. Participants received either the nerve block or standard care. The goal was to see if the block leads to less pain, less …

This study tested whether the 4-7-8 breathing technique (breathe in for 4 seconds, hold for 7, out for 8) can help with pain, nausea, and vomiting after bariatric surgery. Sixty patients were split into two groups: one practiced the breathing technique hourly, the other received …

This study looked at whether guided strength training and stretching, along with a home exercise program, works better than just a home exercise program alone for reducing pain in dental students. Sixteen second-year dental students took part. The goal was to see if these exercis…

This study tested whether using an ultrasonic surgical device (piezosurgery) instead of standard rotary tools reduces pain, swelling, and jaw stiffness after removing impacted wisdom teeth. Twenty-two healthy adults each had one tooth removed with the ultrasonic device and the ot…

This study tested whether adding a steroid (triamcinolone acetonide) to a standard numbing medicine (ropivacaine) could improve pain control after major spinal surgery. 118 adults having spinal surgery received either the combination or the numbing medicine alone. The goal was to…

This study tested whether playing slow tempo music before and during an eye injection (intravitreal injection) can reduce anxiety and pain. 144 adults took part, with half listening to music and the other half receiving standard care. Researchers measured anxiety using saliva tes…

This study tested whether a cooling spray (vapocoolant) applied to the cervix before a numbing injection can reduce pain during gynecologic procedures. 98 adults participated, receiving either the spray or a placebo. The goal was to see if this simple, drug-free approach improves…

This study tested whether listening to slow-tempo music through noise-cancelling headphones twice a day could help older adults in the ICU avoid delirium—a state of confusion linked to longer hospital stays and lasting cognitive problems. Researchers enrolled 160 critically ill p…

This study tested whether a shot of platelet-rich plasma (PRP) from a person's own blood works better than a common steroid shot for shoulder arthritis pain. Fifty adults with mild to moderate shoulder osteoarthritis received either a PRP or steroid injection. Researchers measure…

This study tested whether wearing virtual reality glasses during chest tube removal after open heart surgery can lower pain and keep vital signs stable. 82 patients on their second or third day after surgery took part. Researchers measured pain using a standard scale and tracked …

This study tested five different devices for giving numbing shots in the roof of the mouth (palate) to 200 healthy adults having a molar pulled. The goal was to see which device caused the least pain and fear during the injection. Researchers measured pain, fear levels, and heart…

This study tested whether phone calls from a nurse could help people with fibromyalgia feel less pain and be more active. 44 adults were split into two groups: one got standard care, the other also received an educational booklet and three phone calls over 4 weeks covering exerci…

This study tested whether a gas mixture called Kalinox (50% nitrous oxide and 50% oxygen) can reduce pain during short invasive procedures in adults with cancer, such as spinal taps or bone biopsies. The trial involved 204 participants and compared Kalinox to a placebo gas (oxyge…

This study tested whether a gel called PuraBond, applied to the surgical wound during mouth or throat surgery, can reduce pain and bleeding afterward. 73 patients were randomly assigned to receive the gel or not. Researchers measured pain levels over 30 days and tracked complicat…

This study tested whether a biofeedback-based virtual reality (VR) program could help children and teens aged 12-18 manage pain after surgery. 93 participants used the VR tool before and after their operation. The goal was to see if the approach was feasible and acceptable, not y…

This study tested a computer program called PAINRelieveIt to help hospice patients with cancer pain. 262 patient-caregiver pairs used the touchscreen software to report pain and track medications. The goal was to see if it improved pain control, medication adherence, and satisfac…

This study tested whether a vibrating device placed on the arm can distract from the pain of needle pricks. Two hundred healthy adults received different vibration patterns while having their pain threshold measured. The goal was to see if vibrations could reduce pain and anxiety…

This study tested two non-drug approaches for bruxism (teeth grinding) in 30 young adults. One group received hands-on manual therapy to the jaw and neck, while the other did home exercises. Both groups also learned about bruxism. The goal was to see if these treatments could red…

This study tested three types of medicinal cannabis oil (with different levels of THC and CBD) against a placebo in 91 cancer patients. The goal was to see which oil, if any, helps with pain, nausea, anxiety, and sleep problems. Each patient tried multiple oils and a placebo in a…

This study tested whether a long-acting painkiller called Exparel (liposomal bupivacaine) can control pain better after open or laparoscopic hernia repair. Nineteen adults having hernia surgery received Exparel along with standard care. Researchers measured patient satisfaction w…

This study tested whether a device called VerTouch can help doctors find the best spot for epidural or spinal anesthesia more accurately than using touch or ultrasound. Researchers compared the number of needle adjustments needed with each method in 86 adults undergoing these pro…

This study tested whether hypnosis or virtual reality can reduce pain during repeated medical procedures like wound dressing. 52 patients received standard pain care, standard care plus hypnosis, or standard care plus virtual reality in a random order. The goal was to see if thes…

This study tested a special way to give intramuscular injections to children aged 6-12. Instead of the usual method, nurses used a precise ventrogluteal technique with a 90-degree angle and quick needle insertion and removal. The 90 children were split into two groups: one got th…

This study tested a program to help cancer survivors quit smoking and manage pain. Nineteen survivors received counseling and the medication varenicline (Chantix). The goal was to see if the program was practical and helpful, not yet to prove it works.

This study tested whether spraying a numbing medicine (lidocaine) on the cervix before inserting an IUD can reduce pain. Researchers enrolled 90 women aged 18-45 who wanted an IUD. The goal was to see if the spray makes the procedure more comfortable.

This completed Phase 1 study tested the safety and tolerability of HRS-2129, a new drug for pain, in 23 healthy adults aged 18 to 55. Researchers measured side effects and how the body processes the drug, along with pain responses to cold and heat. Because it was only in healthy …

This study tested whether playing virtual reality games can help people with frozen shoulder (adhesive capsulitis) feel less pain, move their shoulder better, and improve their quality of life. Thirty-six adults with the condition used VR exercises as part of their treatment. Res…

This study tested whether acupressure — a technique that applies pressure to specific points on the body — can reduce pain, anxiety, and stabilize heart rate and blood pressure in people undergoing urodynamics, a test that checks how well the bladder works. Sixty-eight adults wer…

This study follows children and adolescents aged 5 to 16 who receive an mRNA COVID-19 vaccine to monitor for side effects like injection site pain, fever, and other reactions. Participants report symptoms for a week after each dose, and some provide blood samples to measure antib…

This study tests whether a new paracetamol tablet that dissolves in the mouth (orodispersible) works the same as two existing paracetamol tablets. Healthy adults aged 18 to 55 take a single dose of each tablet on separate days, and researchers measure how much paracetamol gets in…

This study looks at how pain intensity, the burden of caregiving, and quality of life are related in mothers who are the primary caregivers for children with disabilities. Researchers use simple questionnaires to measure pain, caregiver strain, and both physical and mental well-b…

This study tests a generic version of meloxicam nanocrystal injection (a pain reliever) against the brand-name drug ANJESO® in 20 healthy adults aged 18 to 45. Researchers compare how the body absorbs and processes each drug, and check for side effects. The goal is to see if the …

This study tested a drug called suzetrigine, which blocks a specific nerve channel (NaV1.8) involved in pain signaling. In 67 healthy volunteers, tiny amounts were injected into the skin alongside a placebo and lidocaine. Participants received six different types of brief pain (e…

This study looked at how smoking affects pain threshold, neck position sense, and grip strength in 132 women aged 18-45, comparing smokers to non-smokers. Researchers measured pressure pain threshold, how accurately women could sense their neck position, and hand grip strength. T…

This study surveyed 186 adults with sickle cell disease in the U.S. to learn how the COVID-19 pandemic impacted their stress, anxiety, pain, and healthcare use. Participants completed online questionnaires about their medical history, mental health, and experiences during the pan…

This study tested 137 people with chronic pain of unknown cause to see if they had Fabry disease, a rare genetic disorder. Researchers used blood tests to check for the condition. The goal was to find out how common Fabry disease is in this group and help diagnose it earlier.

This study follows 87 women who had chronic low back pain 13 years ago to see how their pain, daily activities, and ability to work have changed. Researchers are looking for patterns that might predict who will improve or worsen over time. The goal is to better understand the lon…

This study looked at 30 living liver donors to see how well nerve blocks (interfascial plane blocks) control pain after surgery. Researchers mapped where the blocks worked on the skin and checked pain levels and painkiller use in the first 24 hours. The goal is to better understa…

This pilot study tested a program called STEPPT to see if it could reduce ethnic disparities in physical therapy referrals and attendance for spine pain. The program included educating clinic staff, updating electronic health records to automate referrals, and providing patient n…

This study looked at how a gene called CYP2D6 influences pain relief from the drug oxycodone in 100 older adults (age 60+) having lung cancer surgery. Researchers measured pain and sedation levels to see if genetic differences affect how well the drug works and how safe it is. Th…

This completed study tested three different intensities of gentle neck movements designed to stimulate the vagus nerve in 128 healthy adults. Researchers measured changes in heart rate, balance, pain sensitivity, and digestion (via stool samples). The goal was to find the best 'd…

This study tested whether changes in pupil size can reliably measure pain. Twenty adults with hip or knee arthritis received brief heat pulses while researchers recorded their pupil responses and pain ratings. The goal was to see if pupil diameter could serve as an objective pain…

This study looked at 110 medical secretaries to see how their office setup, posture, and work organization relate to muscle and joint pain. Participants filled out questionnaires about their work environment and any discomfort. The goal is to find patterns that could lead to bett…

This study tested a quick, one-minute risk matrix to predict which patients will have severe pain after gynecologic laparoscopy done as day surgery. Researchers followed 487 women and checked if the tool could identify those at high risk. If it works, doctors could use it to plan…

This study tested whether a heart-rate based index (ANI) can detect pain in 17 children with cerebral palsy during injections and physical therapy. Researchers measured heart rate changes before and after painful procedures and compared them to standard pain scores. The goal was …

This study looked at how a low dose of the anesthetic sevoflurane affects memory and brain responses to pain. Forty-two healthy adults inhaled sevoflurane or no drug while receiving mild electric shocks and performing memory tasks. Brain scans (fMRI) measured activity changes. Th…

This study looked at how watching someone else experience pain relief can actually reduce your own pain. Researchers used brain scans to see which parts of the brain are involved in this effect. 211 healthy adults took part, and the goal was to understand the brain mechanisms beh…

This study looked at how to better diagnose chronic pain in 100 torture survivors. Researchers tested a simple pain questionnaire to see if it could find pain that standard methods miss. They also interviewed survivors about pain treatments and tested whether a digital program co…

This study looked at whether treating obstructive sleep apnea (OSA) can also reduce pain and problems in the jaw and face, known as temporomandibular disorders (TMD). Forty-one adults with OSA but not yet on treatment were checked for TMD before starting therapy and again after a…

This study looked at 75 adults having lower back surgery to see if body weight affects how well a nerve block controls pain. Researchers measured pain levels at rest and while coughing in the first hours after surgery. The goal is to understand if heavier patients need different …

This completed study looked at 128 women to see if those with fibromyalgia also have more chronic pelvic pain and pelvic floor problems. Researchers used pain questionnaires to compare the two groups. The goal was to better understand how these conditions might be related, not to…

This study looked back at records of 126 people who had total knee replacement and received nerve blocks for pain. The goal was to compare different nerve block techniques to see which one provides better pain relief, fewer complications, and faster recovery. The findings could h…

This study tested a new way to measure pain in preterm infants during a procedure called LISA, where surfactant is given to help them breathe. Researchers used skin conductance, which tracks nerve signals, and compared it to a standard pain scale. The goal was to see if this meth…

This study looked at whether sleeping at least an hour more each night for a week could help college students handle pain better. Thirty-six healthy young adults wore watches to track sleep and heart rate, and took pain tests (pressure and cold) before and after the sleep change.…

This study looked at how puberty affects pain sensitivity in 36 healthy adolescents aged 9-16. Researchers measured pain responses to heat and cold, and checked sex hormone levels. The goal was to understand if early or mid-puberty changes pain perception and who might develop ch…

This study tested two non-invasive monitors that track pain in children aged 1-12 during surgery. The monitors measure skin conductance and a pain index to see how well they detect pain events. Researchers compared their readings to find which one is more reliable for guiding pai…

This completed study from the University of Valencia looked at 133 adults with chronic pain to see if jaw (temporomandibular) pain is linked to pelvic pain. Participants filled out questionnaires about their pain, emotions, and sensitivity. The goal was to understand why these pa…

This study tested a device called ANI that measures heart rate changes to assess comfort in patients who cannot speak, such as those in end-of-life care. Twenty non-communicating patients in a palliative care unit were monitored during a painful procedure. The device's readings w…

This study tested whether a device that measures heart rate patterns (called ANI) can predict pain responses when inserting a breathing tube. Researchers gave 60 patients a mild electric shock to mimic pain, then inserted the tube. They found that changes in the ANI score might h…

This study looked at over 2,000 boys who had circumcision to see if a numbing medicine called ropivacaine is safe when injected near the penis. The main concern was whether it could cause tissue death (necrosis) of the glans. The goal was to find out how often this rare problem h…

This study tested whether a device called the ANI monitor can measure pain in sedated children aged 2 and older in the pediatric intensive care unit. Researchers watched how the device responded during painful care and compared it to a standard behavioral pain scale. The goal was…

This study used a special brain imaging technique called near-infrared spectroscopy to see how the brain responds to pain and sounds while people are under general anesthesia. 44 healthy volunteers aged 12-30 were given either a painkiller (remifentanil) or a placebo. The goal wa…

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This early-stage study tested a single dose of a new drug called SBS-1000 in 48 healthy adults to see if it is safe and how the body handles it. Participants were randomly assigned to receive either the drug or a placebo by IV. The main goal was to check for side effects and meas…

This study looked at 679 adults to find out what makes some people feel pain during a colonoscopy without sedation. The goal was to create a tool that predicts pain before the procedure, so doctors can take steps to make it more comfortable. By collecting basic health info and pa…

This study involved 200 people in Albania with back pain or orthopedic problems. Researchers translated and tested several pain and disability questionnaires into Albanian to ensure they work correctly. The goal was to provide reliable tools for doctors and researchers to assess …

This study looked at 100 adults with sacroiliac joint pain to find out which patient traits predict better results from a guided injection of numbing medicine and steroids. The goal was to identify factors like age or pain patterns that could help doctors choose the right treatme…

This study followed 392 adults who had planned surgeries to map their pain levels over the first 7 days after the operation. Researchers wanted to see if certain pain patterns could predict who would still have pain 3 months later. The goal is to better understand and possibly pr…

This study tested a brief, computer-based personalized feedback program for adults with chronic pain who drink heavily and take prescription opioids. The program was designed to educate participants about the risks of mixing alcohol and opioids and to motivate them to reduce drin…

This completed study looked at how temporary knee pain changes walking patterns in 34 healthy adults. Participants received two injections into the knee: one that caused brief pain and one that did not. Researchers measured their walking movements and pain sensitivity to see if t…

This study looked at how disrupted sleep changes the way healthy adults feel pain and move their joints. Thirty participants received painful injections in the knee and shoulder after a night of fragmented sleep. Researchers measured pain intensity and movement patterns to unders…

This observational study followed 300 people with hand osteoarthritis for up to 8 years. Researchers used imaging (X-rays, CT, MRI, ultrasound), physical exams, and questionnaires to track pain, inflammation, and joint changes. The goal was to better understand how the disease pr…

This study looked at 90 women to see if higher estrogen levels make propofol injection more painful. One group had high estrogen from IVF treatment, the other had normal levels. Researchers measured pain using a simple scale. The goal is to understand how hormones affect pain and…

This completed observational study looked at 110 breast cancer patients to see if arm swelling (lymphedema) is linked to a specific type of muscle pain called myofascial pain syndrome. Researchers examined trigger points in key muscles and measured pain thresholds. The goal was t…

This study looked at how the body processes ropivacaine, a numbing medicine, when given as a nerve block for chest surgery. Twenty adults having robotic or video-assisted chest surgery received the block, and researchers measured drug levels in their blood to check for toxicity. …

This study looked at 100 women with primary dysmenorrhea (painful periods) to find out what amount of pain reduction is truly meaningful to them. Participants did an 8-week exercise program, and researchers measured pain and other symptoms using standard questionnaires. The goal …

This study looked at whether a personalized meal plan with more omega-3 fatty acids (found in fish) could reduce fatigue, pain, depression, sleep problems, and stress in women who finished treatment for early-stage breast cancer 1-2 years earlier. Researchers enrolled 98 women an…