Breathing gas may ease pain of cancer procedures

NCT ID NCT00646945

Completed Symptom relief Sponsor: Air Liquide Santé International Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether a gas mixture called Kalinox (50% nitrous oxide and 50% oxygen) can reduce pain during short invasive procedures in adults with cancer, such as spinal taps or bone biopsies. The trial involved 204 participants and compared Kalinox to a placebo gas (oxygen/nitrogen mix). The main goal was to measure pain using a visual scale and to check for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Kalinox (50% nitrous oxide / 50% oxygen gas mixture)
What this could lead to: If it works, this could provide a simple, fast-acting pain relief option for cancer patients undergoing short, painful procedures.
What could go wrong: This is a completed phase 4 trial, so results are already known. The gas may cause side effects like nausea or dizziness, and it may not work better than standard pain relief or a placebo.

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Conditions

The condition(s) this trial relates to.

cancer neoplasm Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANCER PAIN

Contacts and locations

Locations

Centre Alexis Vautrin

Vandœuvre-lès-Nancy, 54 500, France

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