Can ozone ease the pain of lipedema? new study tests two methods

NCT ID NCT06954870

Completed Symptom relief Sponsor: Ankara Etlik City Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether ozone therapy can reduce pain and tissue thickness in women with lipedema, a painful fat disorder. 45 women received either local or systemic ozone treatments. The goal was to see if ozone's anti-inflammatory effects could improve symptoms and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ozone therapy
What this could lead to: If it works, this could point toward a non-drug way to ease pain and improve daily life for women with lipedema.
What could go wrong: This is a small, early-stage study with no placebo group, so results may not be reliable or apply to everyone. Ozone therapy also carries risks like infection or irritation at the injection site.

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Conditions

The condition(s) this trial relates to.

Lipedema Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACTIVITIES OF DAILY LIVING LIPEDEMA MUSCULOSKELETAL ULTRASOUND PAIN

Contacts and locations

Locations

Ankara Etlik City Hospital, Department of Physical Medicine and Rehabilitation

Ankara, 06200, Turkey (Türkiye)

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