New painkiller aims to ease Post-Surgery pain without opioid risks
NCT ID NCT06901830
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This phase 2 trial tests an experimental painkiller called YZJ-4729 in people experiencing moderate to severe pain after orthopedic surgery. Participants receive either YZJ-4729, morphine, or a placebo through an IV, and researchers measure pain relief over 48 hours. The goal is to see if YZJ-4729 works well and is safe compared to standard treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- YZJ-4729 tartrate injection
- What this could lead to
- If successful, YZJ-4729 could offer a new option for managing acute pain after surgery, potentially with fewer side effects than morphine.
- What could go wrong
- This is an early phase 2 trial with only 150 participants, so results may not apply to everyone. The drug may not work better than existing treatments or could have unexpected side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Chengdu Second People's Hospital
Chengdu, China
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Dalian University Affiliated Zhongshan Hospital
Dalian, China
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Dongguan People's Hospital
Dongguan, China
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Henan Provincial People's Hospital
Zhengzhou, China
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Jinhua Central Hospital
Jinhua, China
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Mianyang Central Hospital
Mianyang, China
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Ningbo Medical Center Lihuili Hospital
Ningbo, China
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Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
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Shanghai First People's Hospital
Shanghai, China
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Sichuan Provincial People's Hospital
Chengdu, China
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Suzhou University Affiliated Second Hospital
Suzhou, China
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The First Affiliated Hospital of Nanchang University
Nanchang, China
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The First Affiliated Hospital of Ningbo University
Ningbo, China
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The First Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
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The First Hospital of Jilin University
Ch’ang-ch’un, China
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The Second Affiliated Hospital of Fujian Medical University
Quanzhou, China
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The Second People's Hospital of Hefei
Hefei, China
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The Third Hospital of Hebei Medical University
Shijiazhuang, China
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The Third People's Hospital of Chengdu
Chengdu, China
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The Third Xiangya Hospital of Central South University
Changsha, China
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Zhongda Hospital Southeast University
Nanjing, China
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