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Ice or spray? study tests simple ways to take the sting out of dental needles

NCT ID NCT07703553

Symptom relief Sponsor: Harran University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study tests whether cooling the injection site with an ice pen, applying a numbing spray, or using both together can reduce pain from dental anesthesia needles. About 192 adults needing a standard dental injection will be randomly assigned to one of four groups: ice alone, spray alone, both, or no pre-treatment. Participants will rate their pain right after the needle goes in, and researchers will also observe their reactions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
10% lidocaine spray and ice pen (cryotherapy)
What this could lead to
If successful, this could identify a simple, low-cost method to make dental injections less painful for patients.
What could go wrong
This is a small, single-center trial, so results may not apply to all dental settings. Pain is subjective, and individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

192 people

The number who actually took part.

Started

Feb 2026

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged between 18 and 65 years. Systemically healthy individuals classified as ASA I or II. Patients presenting to the Harran University Faculty of Dentistry Hospital who require local anesthesia during dental treatment. Treatment plan requiring mandibular block anesthesia, anterior/posterior infiltration, or palatal infiltration. No regular use of analgesics (NSAIDs, paracetamol, etc.) within the last 7 days. No history of allergy to cold application or topical anesthetics. Exclusion Criteria: * Regular use of analgesics (NSAIDs, paracetamol, etc.) within the last 7 days. Chronic pain syndrome, migraine, or systemic diseases requiring continuous use of analgesics. Pregnancy or lactation. Presence of active lesions in the oral mucosa, severe periodontal infection, or pathology at the injection site. History of allergy to topical gel or cold application. Psychiatric disorders or conditions preventing compliance with dental treatment.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Injection site pain Pain

Contacts and locations

Locations

  • Harran University Faculty of Dentristry,Departman of Endodonti

    Sanliurfa, Outside of the US, 63300, Turkey (Türkiye)

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