PAIN

This study tests a new device called Freesolve, a temporary magnesium scaffold that props open blocked heart arteries and then dissolves over time. About 1,859 people with up to two new blockages will receive either this scaffold or a standard permanent stent. The goal is to see …

This study follows 4800 adults who use a Boston Scientific neurostimulation device for pain. It aims to see how well the device works in everyday life, including pain relief and quality of life. Participants are already scheduled to try the device as part of their normal care.

This pilot study tests whether artificial intelligence can recognize pain by analyzing facial expressions in people with fibromyalgia. Researchers will compare 61 fibromyalgia patients with 61 healthy volunteers. They will also check saliva samples for biological markers of pain.…

This study is testing whether a combined PET and MRI scan, using a radioactive tracer called FDG, can accurately locate the source of chronic pain that persists after joint surgery. Researchers will scan 128 people with and without pain to see if the scan can spot where pain is c…

This study is testing whether an augmented reality (AR) system can help doctors guide needles during MRI scans. The AR system overlays digital information onto the real world, potentially making procedures like biopsies or injections more precise. Researchers will enroll 25 peopl…

This study tests whether the oral medication venlafaxine, typically used for depression, can prevent postherpetic neuralgia—a persistent nerve pain that often follows a shingles rash. Researchers will enroll 832 adults who have had a shingles rash for less than 30 days and are ex…

This study tests whether squeezing a stress ball during oral care procedures helps lower pain, anxiety, and stress in conscious intensive care patients. Participants will be randomly assigned to use a stress ball or receive standard care. The goal is to see if this simple, low-co…

This study is testing a new type of spinal cord stimulator that automatically adjusts its signal based on how your nerves respond. It aims to improve pain relief and quality of life for 25 adults with long-term, hard-to-treat pain in the trunk or limbs. The device is already appr…

This study tests whether artificial intelligence-assisted breathing exercises can reduce pain, fatigue, and improve breathing in 111 patients recovering from open heart surgery. Participants will follow an AI-generated video to perform rhythmic breathing for three days. Researche…

This pilot study compares two discharge pain plans for adults after major orthopedic surgery: one with opioids and one without. Researchers want to see if it's possible to run a larger trial that could reduce opioid use. About 100 patients will be randomly assigned to either plan…

This study compares two drugs, pregabalin and mirogabalin, to see which works better for fibromyalgia pain. About 674 adults with moderate to severe fibromyalgia who haven't tried these medications will take one of the drugs for several weeks. The main goal is to see how many peo…

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This study tests whether playing an immersive virtual reality game during painful burn treatments (like dressing changes) can reduce pain and the need for opioid painkillers. Fifty adult burn patients will be randomly assigned to receive either standard care alone or standard car…

This pilot study tests if patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) using a pump, instead of waiting for a nurse to bring pills. About 24 adults will be enrolled, and researchers will measure how many agree…

This study aims to train psychotherapists to deliver personalized, evidence-based therapies to cancer patients and their caregivers who are experiencing high levels of distress. Therapists will choose from treatments like cognitive behavioral therapy and mindfulness-based stress …

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study tests whether listening to live or recorded music before neurosurgery can lower stress, improve mood, and reduce pain. Researchers will measure changes in vital signs, stress hormones, and how patients feel using questionnaires. The goal is to find a simple, drug-free …

This study tests whether hemp-derived CBD (with or without THC) can help older adults (60+) who use cannabis for pain, anxiety, depression, or sleep problems. Over 8 weeks, 385 participants will take either CBD+THC, CBD alone, or a placebo. The goal is to see if CBD can reduce sy…

This study compares two types of nerve blocks—ESPBs and TAPs—for controlling pain after DIEP flap breast reconstruction surgery. About 102 women with breast cancer will receive one of the two blocks before surgery. The goal is to see if the newer ESPB method provides equivalent p…

This study tests a program called SPARK for adults aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants receive 8 nurse visits at home to help them cope with pain and improve their mood. The goal is to see if this approach reduces pain int…

This study tests suzetrigine, a new FDA-approved non-opioid pain medication, in 210 adults undergoing total hip replacement. Participants receive either suzetrigine or a placebo for seven days, starting before surgery. The goal is to see if suzetrigine reduces the amount of opioi…

This study tests a device called NOVABLOC that uses mild electrical pulses to block pain signals from nerves in the leg. The goal is to see if it reduces pain and the need for opioid painkillers after total knee replacement. About 120 adults with knee osteoarthritis will be rando…

This study tests if trauma-adapted yoga, added to usual care, can improve mental health and quality of life for 180 teens diagnosed with ADHD or PTSD. Participants will be randomly assigned to a yoga group or a waiting list. The study also explores if online yoga is a feasible op…

This study tests whether a small electrical device (TENS) can reduce pain for women undergoing an in-office procedure for stress urinary incontinence. About 100 women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to se…

This study is testing a new pain treatment for people having total knee replacement surgery. The goal is to see if it can help patients use fewer opioids after the operation. About 60 adults will take part, and the study will track how many stay completely opioid-free.

This study tests whether Reiki, a gentle hands-on relaxation therapy, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions right away or after a waiting period. Researchers will measure changes in fa…

This study tests whether combining prenatal stretching with kinesiotaping (a special elastic tape) can reduce low back pain, improve mobility, and enhance quality of life in pregnant women. Thirty-four women with back pain between 20 and 34 weeks of pregnancy will be randomly ass…

This study looks at whether watching a calming video before and during a thyroid biopsy can help reduce pain and anxiety and increase comfort. About 68 adults will take part, with half watching the video and half getting standard care. Researchers will measure pain, anxiety, and …

This study tests a program called PAIN-CPG-EIT, designed to help nursing home staff better assess and manage pain in residents with dementia. The program includes monthly team meetings, staff education, mentoring, and ongoing checks. Researchers will compare this approach to educ…

This study is testing whether applying a special mud (peloid) to the jaw and chewing muscles can reduce pain and improve jaw function in adults with temporomandibular joint (TMJ) disorders. Forty participants will receive 20-minute mud treatments five days a week for two weeks. R…

This study tests whether listening to music during a first-trimester abortion procedure can help reduce pain and anxiety. 176 women will be randomly assigned to either receive routine care plus music through headphones, or routine care alone. Researchers will measure pain and anx…

This study looks at whether giving children a nerve block before elbow fracture surgery can help control pain afterward and reduce the need for strong painkillers like oxycodone. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either …

This study tests a coaching program called OPTIONS that helps veterans with chronic pain learn non-medication strategies. Around 296 veterans with musculoskeletal pain will work with a coach to align pain management with their personal values and goals. The main goal is to see if…

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and …

This study tests whether using a virtual reality (VR) headset with a guided meditation app during a vasectomy can lower pain, anxiety, and distress. About 90 adult men will be randomly assigned to either use VR or receive standard care. They will answer short questionnaires befor…

This study looks at whether listening to music for 10 minutes during labor can lower anxiety and pain and improve satisfaction. About 106 women in labor will either listen to music or not. They will rate their anxiety and pain levels and answer questions about their care.

This early-phase study tests whether giving oxytocin (a nasal spray) alongside oxycodone can reduce the drug's abuse potential while still easing pain. Researchers will measure pain response, subjective effects, and decision-making in 45 healthy older adults over six lab sessions…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay in the PICU for more than 48 hours will be randomly …

This study looks at whether adding a simple nerve-stimulation technique (using deep breathing to activate the vagus nerve) to standard physical therapy can better reduce pain and improve jaw movement in people with jaw joint disorders. Sixty adults with jaw muscle pain will recei…

This study compares a standard opioid painkiller (oxycodone) to a placebo in people recovering from orthopedic surgery like joint replacements. The goal is to see if a non-opioid pain management plan can control pain just as well. About 80 adults having various orthopedic procedu…

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study is testing whether giving parents extra face-to-face education about pain management helps reduce their child's pain after day surgery. Researchers will compare two groups of children ages 1-6: one group's parents receive additional teaching, while the other gets stand…

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medication can reduce the amount of opioids needed after preventive femur surgery. The study includes 60 adults with bone lesions from cancer who are getting a metal rod placed in the thig…

This study tests whether aromatherapy (lavender and orange oils) and digital anesthesia can reduce pain and anxiety in children aged 6-12 during tooth extractions. Researchers will compare these methods to traditional anesthesia to see which is more comfortable and less stressful…

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests a mouth rinse called MucoLock for people with ongoing mouth pain or burning sensation (stomatitis). About 25 adults will swish the rinse for 5 minutes, three times a day, for 28 days. Researchers will measure changes in pain scores and quality of life to see if t…

This study tests whether using a virtual reality headset after heart or chest surgery can lower the amount of strong painkillers (opioids) patients need. Sixty people aged 16 to 40 will be split into three groups: one using interactive VR games, one watching passive VR videos, an…

This study tests whether a single dose of methadone, a long-acting opioid, can control pain better than standard short-acting opioids (like fentanyl) in infants and young children after cleft palate repair. About 60 children aged 6 months to 4 years will participate. The goal is …

This study tests whether giving testosterone to men with chronic back pain who take opioids can improve their pain, sexual function, fatigue, and quality of life. The men have low testosterone caused by opioids. Half will get testosterone injections and half a placebo. The trial …

This phase 2 trial is testing a topical gel and mouthwash made from olive oil, betaine, and xylitol (XCM-OM118) to see if it can reduce severe oral mucositis (painful mouth sores) in head & neck cancer patients receiving radiation. The study will enroll 63 adults and track how ma…

This study tests a special adhesive patch made with zinc oxide to hold catheters (thin tubes placed in veins) in place for hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein swelling, and pain. About 400 patients wh…

This study looks at whether combining pain neuroscience education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. Researchers will tr…

This early-phase study is testing a new drug, HRS-6257, in 80 healthy adults to see if it is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor side effects and measure drug levels in the blood. The study also …

This study tests whether a physiotherapist-guided online exercise program can reduce pain and improve physical function in remote white-collar workers. Thirty-three participants with low back or neck pain will do supervised exercises twice a week for six weeks. The goal is to see…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This study tests whether listening to a brief mindfulness audio recording while waiting for an orthopedic appointment can help reduce pain. 400 adults will be randomly assigned to hear either a mindfulness practice or a standard pain management recording. The goal is to see if a …

This study tests whether the BETY exercise program, which combines physical exercises with pain management and emotional support, can help people with knee osteoarthritis who recently received injections. Sixty adults with knee osteoarthritis will be enrolled. The goal is to see …

This study looks at whether standing in the shower instead of sitting on the toilet helps women urinate more easily after having a catheter removed following vaginal surgery. The goal is to see if this position reduces pain, lowers the amount of urine left in the bladder, and dec…

This study tests whether wearing virtual reality goggles during a heart device implant (like a pacemaker) under local anesthesia can reduce pain and anxiety. About 150 adults will be randomly assigned to use VR or not during the procedure. Researchers will measure pain levels and…

This study tests whether adding a newer pain medication called mirogabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus mirogabalin.…

This early-stage study tests a new drug, TT5, for pain relief. It involves 94 healthy adults and surgical patients to check safety and how the drug moves through the body. Participants receive either TT5 or a placebo, and researchers monitor side effects and vital signs. The goal…

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This early-phase trial at Yale tests whether dronabinol (Marinol), a synthetic form of THC, can reduce pain sensitivity and improve attention and mood in 36 adults with opioid use disorder who are stable on methadone or buprenorphine. Participants receive either 2.5 mg, 5 mg of d…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults having the procedure will be randomly assigned to either listen to music or not. Afterward, they will rate their pain on a 0–10 scale. If music helps, it cou…

This study tests whether dry needling—a technique where thin needles are inserted into muscles—can reduce pain and improve quality of life for people with chronic low back pain. Researchers will also check if the approach is practical and acceptable. The study includes 42 adults,…

This study tests whether using a kaleidoscope or watching cartoons during a dental numbing shot can lower pain, fear, and anxiety in children ages 7 to 12. About 126 kids will be randomly assigned to one of three groups: using a kaleidoscope, watching cartoons, or standard care (…

This study tests a numbing injection (erector spinae plane block) given before lumbar spine fusion surgery. The injection contains ropivacaine, dexmedetomidine, and a contrast dye. Researchers will measure how much pain relief it provides and how far the medication spreads. 32 ad…

This study tests whether using a virtual reality headset during interventional radiology procedures can reduce pain and anxiety in children aged 8 and older. About 500 participants will use the VR headset while undergoing their procedure, and researchers will compare their pain a…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear and increase their satisfaction. About 60 adults having their first cataract surgery will be asked to squeeze a stress ball during the procedure. Researchers will measure pai…

This study tests whether using a virtual reality headset showing calming scenes (like puppies in a meadow) can reduce pain and discomfort for older adults in long-term care during wound dressing changes. Up to 20 residents will use VR for two weeks, with pain and mood measured be…

This study tests whether a handheld device called Grasp can reduce pain and distress in children and adolescents aged 8-15 during needle procedures like blood draws or injections. Participants will either use the device or receive standard care, then report their pain and distres…

This early-stage study tests the safety of an experimental pain drug called SBS-147 in 80 healthy adults. Some participants get the drug, others a placebo. The study has two parts: a single dose group and a group that takes the drug daily for a week. Researchers will monitor side…

This study tests whether giving coloring activities (nature scenes, geometric shapes, word searches, or free drawing) to adults waiting in the emergency department can lower their self-reported pain and anxiety. Researchers will measure changes using standard questionnaires. If e…

This study tests a simple, drug-free method called hypnotic communication to help patients feel calmer during a heart procedure (coronary angiography). About 306 adults will either receive this special calming talk from a nurse or standard care. The goal is to see if it reduces s…

This study tests whether a small device that sends gentle electrical pulses to the gums can reduce pain from braces. About 150 teens and adults will have the device used on one side of their mouth and a fake device on the other. They will rate their pain over three days to see if…

This study compares two medications, pregabalin and a newer drug called crisugabalin, to see which works better for easing fibromyalgia pain. Over 1,100 adults with moderate to severe fibromyalgia will take one of the two drugs, and researchers will measure how many get at least …

This study tests whether a high-frequency TENS device can reduce pain when an IUD is placed. About 86 women will be randomly assigned to receive either TENS or a placebo device during the procedure. Researchers will measure pain scores right at insertion to see if TENS helps.

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in women undergoing breast biopsies. About 600 women will be randomly assigned to one of three groups: VR, music, or usual care. Researchers will measure anxiety and pain …

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study looks at whether wearing a lumbar brace for 4 weeks after an ER visit for low back pain can lower pain, improve spine function, and reduce the need for painkillers. About 152 adults aged 18-65 in Edmonton will be enrolled. The goal is to find a safer, non-drug option f…

This study tests whether a loxoprofen patch can safely reduce pain from shingles (herpes zoster). Researchers will compare standard treatment alone to standard treatment plus the patch in 750 adults with moderate to severe pain. The goal is to see if the patch provides better pai…

This study tests whether playing with a therapeutic toy doll before getting a shot can reduce fear, anxiety, and pain in children aged 4-6. Half the kids will practice the injection steps on a doll first, while the other half get the shot as usual. Researchers will measure fear a…

This study tests whether adding the muscle relaxant baclofen to standard shingles treatment can better reduce moderate to severe pain. Researchers will enroll 750 adults with shingles rash for less than 90 days. Participants will receive either baclofen plus usual care or usual c…

This study tests whether adding the antidepressant tulodesvenlafaxine to standard shingles treatment can better relieve pain. It includes 750 adults with moderate to severe shingles pain. The goal is to see if this drug reduces pain scores more than usual care alone.

This study tests whether a flurbiprofen patch can safely reduce pain in people with shingles (herpes zoster). About 750 adults with moderate to severe pain will either receive the patch plus standard treatments (antivirals, opioids) or standard treatments alone. The goal is to se…

This study tests whether the antidepressant desvenlafaxine can reduce pain from shingles (herpes zoster) better than standard treatments alone. Researchers will enroll 750 adults with moderate to severe pain and compare those taking desvenlafaxine plus usual care to those receivi…

This study tests whether a new oral medication called crisugabalin can provide better pain relief for people with shingles (herpes zoster) compared to standard treatments. The trial will enroll 750 adults with moderate to severe shingles pain. Participants will receive either cri…

This study compares taking pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 750 adults wit…

This study tests whether using a virtual reality headset (REALICA) can lower pain and anxiety in people undergoing common urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults having these procedures for the first time will use the VR device during…

This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without a peer health coach, can reduce pain and opioid use in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants use an app to track pain and mood,…

This study looks at whether teaching people about the science of their pain, combined with specific exercises, can reduce fear of movement, pain intensity, and negative thoughts about pain in adults with non-specific neck pain. Researchers will compare three groups: education plu…

This study tests a mobile team of pain specialists who visit children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities. The team works with families and caregivers to assess and manage pain in the patient's usual …

This study looks at two different exercise programs for people with shoulder impingement syndrome, a common cause of shoulder pain. 66 adults aged 25-65 will be split into three groups: standard physical therapy, a program that uses mental imagery to retrain movement, or a progra…

This pilot study tests whether a single, brief mindfulness session before endometriosis surgery can help women cope with pain and use fewer opioids afterward. Twenty adults with endometriosis will be split into two groups: one gets the mindfulness session plus usual care, the oth…

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. The goal is to prevent skin injuries, reduce discomfort, and lower the risk of catheter-related infections. About 188 adults in intensive care will be ra…

This study tests if using a stress ball can reduce pain, anxiety, and changes in heart rate during chest tube removal after open heart surgery. About 46 adults who have one chest tube after surgery will be split into two groups: one will squeeze a stress ball during the procedure…

This study tests a program that teaches family caregivers how to help their loved ones with mild to moderate dementia manage chronic pain. Researchers will work with 60 people (30 patients and their caregivers) to see if the training improves pain coping and quality of life. The …

This study tests whether immersive virtual reality (VR) exercise can reduce pain, improve shoulder function, sleep, and thinking in people with mild to moderate frozen shoulder (grade 1-2). About 36 adults aged 18-64 who are new to physiotherapy will use VR headsets to gamify the…

This study compares pregabalin alone versus pregabalin plus desvenlafaxine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't improved with non-drug treatments. The goal is to see…

This study tests whether injecting a low dose of two painkillers (flurbiprofen and ropivacaine) into the scalp before brain surgery can reduce pain and the need for strong opioids afterward. About 216 adults having a craniotomy will take part. The goal is to see if this local app…

This study compares pregabalin alone versus pregabalin plus toludesvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't responded to non-drug treatments. The goal is to see if th…

This study tests whether a numbing injection (maxillary nerve block) given before nose surgery can reduce the need for strong painkillers during the operation. 90 adults having septorhinoplasty will be split into two groups: one gets the nerve block plus general anesthesia, the o…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at whether acupuncture can reduce pain in people with sickle cell disease. Researchers will also use brain scans and other tests to understand how acupuncture works. The study involves 120 participants aged 14 to 80 who have chronic pain or recent pain crises.

This study tests a device called NeuroCuple™ that uses no drugs to manage pain after cesarean delivery. Researchers want to see if it reduces pain and the need for opioid painkillers. The study will include 180 women having a C-section. Half will get the real device, and the othe…

This study tests whether training a spinal reflex can reduce neuropathic pain in people with spinal cord injury. Fifteen participants will undergo about 50 sessions of reflex training over 6.5 months. The goal is to see if changing this reflex can lower pain and improve sensation…

This study tests whether adding nerve gliding exercises (neural mobilization) to standard balance training can reduce pain, improve balance, and boost quality of life in people with diabetic neuropathy. Thirty-two adults aged 50-75 with type 2 diabetes and nerve pain will be spli…

This study tests whether wearing a virtual reality headset and noise-cancelling headphones during shock wave treatment for kidney stones can lower pain and anxiety. 72 adults scheduled for the procedure will be randomly assigned to either use VR or receive standard care alone. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study tests whether warm sacral massage using cherry pit pouches and partner-assisted showers can reduce pain and improve the birth experience for first-time mothers. 150 women in active labor will be randomly assigned to massage, shower, or standard care. Pain levels and co…

This study tests whether a 7-minute guided mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for spine pain. Half of the 80 participants will do the mindfulness exercise, while the other half will receive standard pa…

This study looks at how negative emotions like stress, pain, and frustration change the way people make decisions. Healthy adults aged 18 to 55 will experience different emotional triggers—such as heat, cold, or math problems—and then perform computer tasks while their brain acti…

This early-stage study will test a liquid medicine that combines two common pain relievers—ibuprofen and acetaminophen—in children aged 6 to 11. The goal is to measure how the body absorbs and processes the drugs, not to treat pain directly. Only 12 children who have recently had…

This study looks at how social factors like race and ethnicity influence how people express pain and how others assess it. Researchers will measure pain responses and brain activity in healthy volunteers, then test whether feedback can improve accuracy in judging others' pain. Th…

This registry follows 5000 people who have received Dezawa MuseCells as part of their routine care for conditions like osteoarthritis, pain, and wound healing. Participants report their symptoms and any side effects through online surveys over five years. The goal is to understan…

This study looks at how the mere expectation of pain can change the way your muscles work together when you walk. Researchers will apply a harmless cream to healthy volunteers and suggest it might cause pain, then measure muscle activity during treadmill walking. The goal is to u…

This study looks at how cancer treatments can cause nerve pain. Researchers will use simple tests, like checking how you feel heat, cold, and touch, along with small skin samples, to understand why this pain happens. The goal is to find better ways to measure and eventually treat…

This study tests whether low-intensity focused ultrasound can change how the brain processes pain signals. Healthy volunteers will receive ultrasound and fMRI scans to measure brain activity during heat pain. The goal is to understand the technique's effects, not to treat pain di…

This study uses brain scans to understand how low doses of nitrous oxide (laughing gas) change the way the brain processes pain and forms memories. Sixty healthy volunteers will receive mild electric shocks while breathing nitrous oxide or normal air, and their brain activity wil…

This study looks at how the alignment of the knee joint, seen on X-rays, relates to pain, daily function, quality of life, and fear of movement in people with knee osteoarthritis. Researchers will measure alignment and joint space width in 100 adults with knee osteoarthritis and …

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity related to memory and pain. Healthy adults aged 18-59 will have MRI scans and EEG recordings while receiving the drugs alone or together. The goal is to understand brain connectivity…

This study looks at how thoughts and expectations change the way we feel pain. Healthy volunteers aged 18-50 will have brain scans and receive mild pain (heat or electric shocks) while researchers measure their heart rate, sweat, and brain activity. The goal is to understand pain…

This early-stage study is testing how much of the pain medication suzetrigine (JOURNAVX) gets into breast milk after a single dose. Twelve healthy breastfeeding women will provide milk samples to measure the drug and its breakdown product. The goal is to estimate how much a nursi…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study follows about 200 gender minority adults to see if starting gender-affirming hormone therapy changes chronic pain over time. Participants fill out surveys and some also get brain scans and sensory tests. The goal is to understand how hormones, stress, and social factor…

This study aims to better understand pain by testing how people with and without pain disorders respond to various sensations like heat, cold, pressure, and sounds. Researchers will use questionnaires, physical exams, MRI scans, and sensory tests to gather detailed information. T…

This study looks at 50 newborn infants who need a breathing machine (mechanical ventilation). Researchers want to see if measuring tiny changes in skin moisture (skin conductance) can help tell how much pain or stress the baby feels. They will also test if holding the baby skin-t…

This study looks at why some stroke survivors develop long-term pain called central poststroke pain (CPP). Researchers will use brain scans to see how brain connections change in people with CPP. The goal is to better understand what causes this pain, which could lead to better t…

This study tracks how common pain and anesthesia drugs behave in the bodies of children and teens aged 0 to 18. Researchers will measure drug levels in up to 500 participants who are already receiving these medications as part of their standard care. The goal is to create better …

This study follows 5,000 adults with spinal conditions to track their pain, work status, and quality of life over time. Participants fill out questionnaires before and after treatment. The goal is to learn which treatments work best for different types of spinal disease.

This study looks at how stress impacts pain, hormone levels, and mood in 120 people with and without HIV, cannabis use disorder, and depression. Participants will complete two sessions of a pain stress task and provide blood samples to measure cortisol and other stress hormones. …

This study looks at how short walks affect pain in older adults who have muscle or joint pain. Researchers will measure pain during movement and how the body adapts to pain. 40 adults who have had pain in the past month can join. The goal is to better understand the link between …

This study looks at whether children diagnosed with a specific learning disorder that affects written expression have different fingertip touch, hand grip strength, and pain sensitivity compared to healthy children. Researchers will measure these sensations using simple tools lik…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study is working on a tool to objectively measure pain and how well pain treatments work, especially for children and teens who may have trouble describing their pain. Researchers will use pupil responses to see how pain relievers affect nerve sensitivity. The study involves…

This study uses brain scans (fMRI) to understand how the sedative remimazolam changes brain activity, memory, and pain perception. About 60 healthy adults will receive the drug and undergo memory tests and mild pain stimulation while being scanned. The goal is to learn how the dr…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and respond to moderate exercise. Participants will do strength and aerobic exercises while their pain tolerance and sensitivity are measured. The goal is to understan…

This study looks at how common nerve pain is in people aged 80 and older. Researchers will check pain levels and overall health in 450 volunteers. The goal is to better understand the link between nerve pain and aging, not to test a new treatment.

This study looks at how a single session of cardiovascular exercise affects pain sensitivity in people who have had a stroke and in healthy individuals. Researchers will measure pain thresholds before and after exercise in 60 participants. The goal is to understand why exercise c…

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to g…

This study looks at how eating a high-fat meal affects pain sensitivity and inflammation in people with chronic spinal cord injury. Researchers will compare a high-fat meal to a moderate-fat meal in 40 adults. They aim to understand links between body composition, diet, and pain.

This study looks at how hormones like testosterone and estradiol influence pain sensitivity in cisgender and transgender individuals. Researchers will test pain responses to heat, cold, and pressure, and analyze blood samples for hormone levels and immune markers. The goal is to …

This study looks at how metabolic markers like insulin resistance and body measurements relate to pain and central sensitization in women with lipedema. Researchers will assess 59 women using questionnaires and physical measurements. The goal is to better understand these connect…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is feasible for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and some will be interviewed. The goal is to see if th…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This study looks at whether Native American adults who smoke can lower their risk of chronic pain by quitting smoking for 4 weeks. Researchers will measure pain sensitivity and other health markers before and after a stop-smoking program. The goal is to see if this approach is fe…

This study looks at how gentle electrical brain stimulation changes the way the brain processes pain. Researchers will use EEG and fMRI to measure brain activity in 60 healthy adults while they experience pressure pain. The goal is to better understand the brain circuits involved…

This study looks at whether giving ICU teams real-time feedback and extra nurse support helps them consistently use a set of proven care steps for patients on breathing machines. About 8,100 critically ill adults will take part across multiple ICUs. The goal is to find practical …

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track how insomnia develops over the first year, using questionnaires to measure sleep quality and severity. The goal is to understand what factors—like treatment type or em…

This study is building a long-term registry of pain-related information from 300 people eligible for military healthcare. Participants complete surveys about their pain and overall well-being, and donate blood and saliva samples. The goal is to gather data that may help improve f…

This study looks at how immersive virtual reality changes the way the brain processes chronic pain, compared to a placebo effect. Researchers will measure brain activity and pain tolerance in 78 adults with temporomandibular disorder (jaw pain). The goal is to develop new, low-ri…

This study follows 8,000 adults in Denmark who are getting a screening colonoscopy for colorectal cancer. Researchers want to know how much pain or discomfort people feel during the procedure and whether that affects their decision to come back for another screening two years lat…

This early-phase study at the University of Florida is testing whether combining oxytocin (a nasal spray) with the opioid oxycodone can reduce pain while lowering the drug's abuse potential. Forty-five healthy adults who have used opioids recreationally will take part in six lab …

This study uses brain scans to explore how a placebo cream affects pain perception across different body sites. Researchers will apply a cream described as pain-relieving (though it is just a scrub) to healthy volunteers and measure their pain responses to heat. The goal is to un…

This study tests whether low-dose buccal buprenorphine (a film placed in the cheek) can provide pain relief similar to a standard dose of oxycodone but with less potential for abuse. 120 healthy adults will receive different doses of buprenorphine, oxycodone, or placebo in separa…

This study looks at how age and sex influence the effects of THC, the main psychoactive ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who use cannabis regularly. They will measure pain relief, intoxication, impairment, and how the body…

This study looks at how the pain and sedation drug remifentanil behaves in low-weight patients in the intensive care unit who are on breathing machines. Researchers will measure drug levels in the blood and check vital signs like blood pressure. The goal is to find the right dose…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the compound that makes you high). Researchers will give both substances to 30 regular cannabis users who are not seeking treatment. They want to see if CBD can reduce the abuse potenti…

This study looks at whether swelling (edema) after total knee replacement changes the way a TENS machine needs to be set. TENS is a device that uses mild electrical pulses to help with pain. Researchers will test three different TENS modes on 125 adults before and after knee surg…

This study looks at how short-term pain affects the ability of older adults to learn and remember a new way of walking. Researchers will apply a cream with capsaicin (the stuff that makes chili peppers hot) and a heat pack to one leg to create temporary pain. Participants will wa…

This study looks at how immune cells and inflammatory molecules differ in people with migraine, especially those who also have autoimmune diseases like multiple sclerosis, rheumatoid arthritis, or endometriosis. Researchers will compare blood samples from 396 women to measure reg…

This study looks at pain in people with ADPKD, a kidney disease that often causes pain in the belly, side, and back. Researchers will use sensory tests and questionnaires to understand the pain better. They will compare results from 150 patients with those from healthy volunteers…

This study looks at whether keeping a regular sleep schedule can improve heart and metabolic health in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will measure changes in sleep timing, blood pressure, heart rate, and other health ma…

This study looks at how smoking high-potency cannabis affects pain relief, feelings of being high, and drug levels in the blood. Researchers will test 30 near-daily cannabis users who are not seeking treatment. Participants will smoke either placebo, low-dose, or high-dose THC ca…

This study aims to learn more about how pain and itch work in the body, specifically on the face. Thirty healthy adults will have their skin tested with different substances that cause itching or pain, and they will rate their sensations. The goal is to better understand these fe…

This observational study will examine the relationship between core stability and reaction time, hand-eye coordination, pain, and function in 52 people with rotator cuff lesions, comparing them to healthy individuals. Participants will undergo various endurance and strength tests…

This study is testing a new physical therapy protocol for people over 50 who have had arthroscopic rotator cuff surgery. Researchers will track shoulder function, pain levels, and sleep quality over the recovery period. The goal is to gather better evidence on what helps patients…