Brain scans reveal how placebo cream eases pain

NCT ID NCT04653064

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study uses brain scans to explore how a placebo cream affects pain perception across different body sites. Researchers will apply a cream described as pain-relieving (though it is just a scrub) to healthy volunteers and measure their pain responses to heat. The goal is to understand how the brain represents pain and how placebos can reduce it, which may inform future non-drug pain treatments.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
placebo cream (exfoliating skin scrub)
What this could lead to
If successful, this could improve understanding of how placebos reduce pain, potentially leading to better non-drug pain management strategies.
What could go wrong
This is an early-stage, small study focused on brain mechanisms, not a treatment trial. The placebo effect is well-known but often inconsistent, and results may not translate to real-world pain relief.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Dartmouth College

    RECRUITING

    Hanover, New Hampshire, 03755, United States

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