Brain scans reveal how placebo cream eases pain
NCT ID NCT04653064
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This study uses brain scans to explore how a placebo cream affects pain perception across different body sites. Researchers will apply a cream described as pain-relieving (though it is just a scrub) to healthy volunteers and measure their pain responses to heat. The goal is to understand how the brain represents pain and how placebos can reduce it, which may inform future non-drug pain treatments.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- placebo cream (exfoliating skin scrub)
- What this could lead to
- If successful, this could improve understanding of how placebos reduce pain, potentially leading to better non-drug pain management strategies.
- What could go wrong
- This is an early-stage, small study focused on brain mechanisms, not a treatment trial. The placebo effect is well-known but often inconsistent, and results may not translate to real-world pain relief.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dartmouth College
RECRUITINGHanover, New Hampshire, 03755, United States
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