Can sound waves soothe pain? new study investigates

NCT ID NCT05303415

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether low-intensity focused ultrasound can change how the brain processes pain signals. Healthy volunteers will receive ultrasound and fMRI scans to measure brain activity during heat pain. The goal is to understand the technique's effects, not to treat pain directly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
low-intensity focused ultrasound
What this could lead to
If successful, this could help develop new non-invasive ways to manage pain by targeting brain activity.
What could go wrong
This is an early-stage study in healthy volunteers, not patients. It measures brain signals, not actual pain relief, so results may not lead to a treatment.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Fralin Biomedical Research Institute

    RECRUITING

    Roanoke, Virginia, 24016, United States

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