PAIN

This study tests a new type of heart stent made from magnesium that slowly dissolves over time. It is designed to open blocked arteries in people with coronary artery disease. About 1,859 participants will receive either the dissolving stent or a standard permanent stent. The goa…

This study tests if shining a special light (photobiomodulation) on the cervix before inserting a copper IUD can lower pain. 72 women will either get real light or a fake treatment, and report their pain levels. If it works, this simple, drug-free method could help more women cho…

This study looks at a new way to treat cervical radiculopathy, a condition causing neck and arm pain from a pinched nerve. Since some people can't tolerate direct treatment on their painful arm, researchers will test if gently moving the opposite arm can provide relief. Forty adu…

This study will test whether a virtual reality (VR) mindfulness program can help patients feel less anxious and experience less pain during minimally invasive vascular surgery done under local anesthesia. About 160 adults will be randomly assigned to either receive the VR mindful…

This study compares two ultrasound-guided nerve blocks—transversalis fascia plane block and erector spinae plane block—for pain relief after cesarean section. Sixty women having a planned C-section will receive one of the two blocks, and researchers will measure pain scores and h…

This study tests whether adding tizanidine to the standard drug pregabalin can better relieve pain in people with fibromyalgia. Fibromyalgia causes widespread pain, fatigue, and emotional distress, and current treatments often provide only modest relief. The trial will enroll 164…

This study tests a program called SPARK for adults aged 50 and older who have ongoing pain, depressive symptoms, and trouble moving around. Participants will receive 8 nurse visits at home to learn ways to cope with pain and improve mood. The goal is to see if this approach reduc…

This study looks at whether adding core-strengthening exercises to a standard knee and hip exercise program can help reduce pain and improve knee alignment in women with patellofemoral pain syndrome (knee pain around the kneecap). Thirty-six women aged 19-35 with knee pain lastin…

This study looks at whether watching a liquid-gel or sand hourglass during a blood draw can help children aged 5 to 10 feel less pain, fear, and anxiety. About 120 kids will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, non-drug …

This study compares ketamine to morphine for treating sudden, severe pain in children visiting the emergency department. About 1,010 children with belly pain or a broken arm or leg will receive one of the two medicines. The goal is to see if ketamine works just as well but causes…

This study looks at whether live music therapy can lower pain in newborns with hypoxic-ischemic encephalopathy (a type of brain injury from lack of oxygen) who are receiving cooling therapy. About 22 babies in the NICU will either get standard care or standard care plus a 15-minu…

This study explores whether a 6-week virtual reality (VR) program can help 50 adults with chronic pain learn about pain science and management. Participants will use VR to watch educational content and do guided exercises. The goal is to see if this approach is feasible, acceptab…

This study tests whether using virtual reality (VR) or a combination of hypnosis and VR can help women feel less pain and anxiety during a diagnostic hysteroscopy, a common gynecological procedure. About 45 adults will be split into three groups: standard care, VR plus standard c…

This study looks at whether listening to music and chewing gum can help women feel less pain and anxiety while getting stitches for an episiotomy (a cut made during childbirth). Sixty first-time mothers will be asked to rate their pain, anxiety, and satisfaction. The goal is to f…

This study tests a telephone-based program to help 220 veterans who smoke and have chronic pain quit smoking. The program uses interactive voice response (IVR) to provide support and track progress. Researchers will measure how many participants stay smoke-free for 6 to 12 months…

This study looks at two simple, drug-free methods—Helfer Skin Tap (gentle tapping near the injection site) and a vibrating device—to see if they can lower pain and fear in children aged 5 to 10 getting a shot in the emergency room. About 186 children will be randomly assigned to …

This study tests whether low-level laser therapy can reduce perineal pain and improve wound healing in women who had a vaginal birth with tearing. About 206 new mothers will receive either real laser treatment or a fake (sham) treatment shortly after delivery. Researchers will me…

This study compares two nerve block techniques for pain after breast removal surgery (mastectomy). One block is placed under a chest muscle, the other combines both under and over the muscle. The goal is to see which provides better pain relief and reduces the need for opioid pai…

This study tests whether a daily 200 mg dose of cannabidiol (CBD) for 12 weeks can reduce inflammation, ease pain, improve sleep, and boost quality of life in 100 Brazilian Jiu-Jitsu athletes. Participants must be 18-40, train at least 3 times a week, and have no recent cannabis …

This study tests whether a mobile app with guided imagery therapy can reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this approach lowers pain…

This study tests whether a newer dental sealer (CeraSeal) causes less pain after root canal treatment compared to a standard one (Endoplus). About 118 adults with painful tooth nerve inflammation will take part. Patients will report their pain levels at 24 hours, 72 hours, and 7 …

This study looks at whether craniosacral therapy, a gentle manual therapy, can help reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers will either receive the therapy or be in a co…

This study looks at two fun ways to help children aged 7 to 10 feel less pain, fear, and anxiety during a skin prick test for allergies. One method uses virtual reality goggles to distract the child, and the other uses a vibrating device called Buzzy. About 111 children will be r…

This study is testing a smartphone app called I-STAMP that helps people with advanced cancer manage their pain and keep track of their medications. About 73 participants will use the app and then rate how easy and helpful it is. The goal is to see if the app is user-friendly and …

This study tests whether injecting a patient's own fat into a chronic wound can reduce pain better than standard care alone. About 62 adults with wounds lasting over 3 months will be randomly assigned to receive either fat grafting plus standard wound care or standard care alone.…

This study tests whether a mix of nitrous oxide (laughing gas) and oxygen can reduce pain during in-office bladder Botox injections for overactive bladder. About 96 adult women will either receive the gas or a placebo mask alongside standard numbing medication. Researchers will m…

This study tests whether a gel made from propolis (a bee product) can reduce tooth sensitivity and color change after professional teeth whitening. Sixty-six adults will receive either the propolis gel, a standard desensitizing gel, or a placebo before bleaching. Their pain and t…

This study tests whether a 4-week program combining ergonomic training with exercise can reduce pain, improve sleep quality, and lower anxiety in nursing students. Sixty students will be split into two groups: one receives the program, the other continues their usual studies. Res…

This study looks at whether using a stress ball or getting a gentle hand massage during eye surgery can help reduce anxiety, pain, and keep blood pressure and heart rate steady. About 174 adults having eye surgery while awake will be split into three groups: hand massage, stress …

This study looks at whether adding alprazolam (a medicine for anxiety) to standard ibuprofen can better control pain after a root canal. About 110 adults with tooth pain will be randomly assigned to get either ibuprofen alone or ibuprofen plus alprazolam. They will rate their pai…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will receive banana leaf dressings, and their pain and healing will be compared to past patients. The goal is to see if this low-cost, widely availab…

This study tests whether a special type of nerve stimulation (TENS based on wrist-ankle acupuncture) combined with a painkiller (tramadol) can reduce pain during egg retrieval for IVF. Sixty women will be randomly assigned to receive either the real stimulation or a fake version,…

This study tests two different nasal sprays (sufentanil and ketamine) to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free …

This study looks at whether playing a guessing game can lower fear, pain, and bad feelings in children aged 6 to 12 when they get blood drawn. About 70 kids will take part, and their pain, fear, and emotions will be measured using special scales. The goal is to find a simple, fun…

This study looks at whether listening to music or using virtual reality can reduce pain, anxiety, and fear in children aged 6-12 with leukemia who need painful mouth sore care. About 45 children will be split into three groups: one gets music, one gets VR, and one gets standard c…

This study tests whether electroacupuncture (a type of acupuncture with mild electric pulses) can ease a cluster of tough symptoms—pain, fatigue, trouble sleeping, anxiety, depression, and brain fog—in breast cancer survivors who are on hormone therapy. About 228 women will get e…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises as effectively as in-person physiotherapy. 264 adults aged 50 and older with knee pain will be split into three groups: in-person sessions, AI-guided home exercises, or a mix of…

This study tests two pain medicines given before egg retrieval in IVF to see which works better. About 177 women aged 18-45 will receive either indomethacin suppository, IV paracetamol, or both. Pain levels will be tracked right after the procedure and for several days.

This study compares three types of injections (steroid, ozone, and sugar water) to see which provides the best pain relief for people with mild to moderate carpal tunnel syndrome. About 105 adults aged 18-65 who have not responded to other treatments will take part. The goal is t…

This study tests a web-based program to help people with advanced cancer and their caregivers. The program aims to reduce symptoms like depression, pain, fatigue, and sleep problems in patients, and lower stress and depression in caregivers. About 40 patient-caregiver pairs will …

This study tests whether rinsing the surgical area with a mix of ketamine and a standard numbing medicine (bupivacaine) can better control pain after gallbladder removal than the numbing medicine alone. Sixty adults having laparoscopic gallbladder surgery will be randomly assigne…

This study tests whether a non-visual audio biofeedback device (like NOICE or Quest 3) can reduce how much cold water hurts. One hundred adults will try the device and also do a control session with nothing. The goal is to see if the device lowers pain scores and anxiety during a…

This study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from hormone therapy. The program includes exercise, education, and regular check-ins. Researchers will see if it reduces pain and helps patients stick with their treatment. The…

This study looks at whether listening to music after a planned cesarean section can help reduce pain, anxiety, and improve bonding between mother and baby. Researchers will enroll 70 first-time mothers in Turkey. Participants will listen to music and report their pain and anxiety…

This study looks at whether listening to calming music during a nail biopsy can lower pain and anxiety. About 30 adults having the procedure will be randomly assigned to either hear a playlist or get standard care. Afterward, they will rate their pain, anxiety, and satisfaction. …

This study tests whether adding a steroid called dexamethasone to a standard nerve block can prevent severe "rebound pain" after hand surgery. About 60 adults having hand surgery under a nerve block will be randomly assigned to receive either the steroid or a placebo. The main go…

This study tests whether a single dose of (2R,6R)-HNK, a drug related to ketamine, can reduce short-term pain in healthy adults without the addictive risks of opioids. Up to 92 volunteers aged 18-60 will receive either the drug, a placebo, or no treatment, and undergo pain tests …

This study tests whether a personalized, AI-generated video (using a nurse avatar) can improve recovery for 128 adults after coronary artery bypass surgery. Patients will receive either standard discharge instructions or the AI-enhanced version. Researchers will measure pain, anx…

This study looks at whether listening to music can help manage pain and stress in adults who need a wrist fracture set without surgery. 192 participants will be randomly assigned to hear their favorite music, music chosen by a therapist, or no music at all. Pain levels and vital …

This study tests whether adding the allergy drug diphenhydramine (Benadryl) to standard sedation medicine can reduce pain during a first-trimester abortion procedure. About 98 adults having an abortion at 13 weeks or earlier will receive either diphenhydramine or a placebo alongs…

This study tests whether a short virtual reality mindfulness session at the bedside can improve well-being and reduce anxiety in hospitalized adults. About 42 patients will try VR and then compare their feelings to standard care. The goal is to see if this simple, drug-free tool …

This study tests whether giving a single dose of ketamine during open-heart surgery can reduce chronic pain that sometimes lasts for months after the operation. About 100 adults having planned heart surgery will be randomly assigned to receive either ketamine or a placebo. Resear…

This study tests if listening to a short audio-guided mindfulness exercise can help reduce pain for people waiting to see an orthopedic doctor. About 300 adults will be randomly assigned to different lengths of mindfulness practice. The goal is to see if even a brief session can …

This study tests whether a special bone cement (made with bioactive glass) combined with ultrasound can safely stabilize bones and reduce pain in people with advanced cancer that has spread to the pelvis. Only 8 participants will receive the treatment alongside standard care, and…

This study tests whether giving lidocaine through an IV during and after major non-cardiac surgery helps patients recover faster. About 2,290 adults will be randomly assigned to receive lidocaine or a placebo. The goal is to see if lidocaine reduces hospital stay length, pain, an…

This study looks at two simple, drug-free ways to help manage pain during a bone marrow aspiration and biopsy. About 80 adults with cancer will either fake cough, squeeze a stress ball, or receive standard care during the procedure. They will then rate their pain on a scale of 0 …

This study compares two injections—botulinum toxin (Botox) and local anesthetic—to see which better relieves pain from neuromas (painful nerve endings) after limb trauma or amputation. About 100 adults with moderate to severe pain will receive one injection and be followed for 8 …

This study compares a computer-controlled anesthesia device (SleeperOne® 5) with a traditional syringe for numbing children's mouths before tooth extraction. About 28 children aged 3-5 will take part, and their pain, anxiety, and heart rate will be measured. The goal is to see if…

This study tests whether a ketorolac nasal spray works better than a ketamine nasal spray for reducing pain before a finger nerve block. About 64 adults with finger injuries will rate their pain and any side effects. The goal is to find a more comfortable way to numb the finger.

This study tests whether listening to positive self-affirmation audio recordings can reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two participants will be split into two groups, with one group listening to the affirmations daily. The goal…

This study looks at how the way your foot presses against the ground might be linked to where and how much pain you feel. Researchers will measure foot pressure in 53 healthy young adults aged 18-35 and ask about their pain. The goal is to understand if foot pressure patterns can…

This study looks at how being kind to yourself (self-compassion) and believing in your abilities (self-efficacy) relate to body awareness, pain, and healthy habits in people 65 and older. Researchers will ask 150 older adults to fill out online questionnaires. The goal is to bett…

This study looks at how the body's opioid system influences placebo effects on both physical pain and the pain of social rejection. Sixty adults who recently went through an unwanted breakup will receive either a drug that blocks opioids (naloxone) or a saltwater spray, then unde…

This study follows 150 adults with severe arm or leg injuries who needed a tourniquet to stop bleeding. Researchers will track how long the tourniquet was used and check for pain, nerve pain, and recovery over 6 months. The goal is to see if longer tourniquet use increases the ch…

This study looks at how the steroid dexamethasone affects levels of the painkiller bupivacaine in the blood when given with a nerve block for shoulder surgery. Forty adults will receive the nerve block with dexamethasone either near the nerve or through a vein. Blood samples will…

This study looks at whether pramlintide, a substance similar to a natural hormone, can cause migraine-like headaches in people who have had persistent headaches for at least a year after a mild traumatic brain injury. About 21 adults aged 18 to 65 will receive either pramlintide …

This study aims to create a new pain assessment scale called EDEX for extremely premature infants born before 27 weeks. These babies show pain differently than older preemies, and current tools may not work well. Researchers will compare the new scale with an existing one in 68 i…

This study looks at whether a natural brain chemical called adrenomedullin can cause migraine attacks in people who already get migraines. Researchers will give the chemical to 26 adults with migraine without aura, after they have taken a preventive migraine drug (erenumab). The …

This study looks at how expecting pain affects the way your muscles work together when you walk. Healthy adults aged 18-35 will be split into two groups: one group will first feel real pain from a cream, then be tricked into thinking a harmless cream is painful; the other group w…

This study looks at how two common steroids, methylprednisolone and dexamethasone, affect how quickly a muscle relaxant wears off after nose surgery. It will involve 130 adults having septoplasty or rhinoplasty. The goal is to see which steroid leads to faster recovery, less pain…

This study looks at how healthy adults experience pain and itch from hot and cold sensations. Researchers will also test how expectations (placebo/nocebo) affect these feelings. 30 volunteers aged 18-60 will rate their pain on a scale. No treatment is given—this is purely to unde…

This early-stage study looks at how a drug called efavirenz changes the levels of a new pain medicine, suzetrigine, in the body. It involves 18 healthy adults and aims to understand safety and drug processing, not to treat pain. Results will help guide future use of suzetrigine.

This study looks at whether a substance called pramlintide, which is similar to a natural hormone (amylin), can cause migraine attacks in people who have migraine without aura. About 21 adults with a history of this type of migraine will receive either pramlintide or a placebo, a…

This study follows 100 adults who have had a combat-related traumatic brain injury (TBI) to learn why some develop long-term chronic pain. Participants join within 14 days of injury and are tracked for 6 months. Researchers will check pain levels, mental health, and physical fact…

This study looks at a new way to assess pain in intensive care unit (ICU) patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to better measure pain and adjust painkillers. The goal is to see if this approach reduc…

This study aims to translate and adapt the COMFORTneo pain assessment tool into French for newborns. Researchers will work with 50 healthcare professionals to ensure the translated version is accurate and easy to understand. The goal is to improve pain management for newborns in …

This study looks at blood samples from 90 people: 30 healthy, 30 with diabetes but no nerve issues, and 30 with diabetic nerve pain. Researchers search for unique blood markers that could help diagnose nerve damage earlier. The goal is to better understand the disease and find ne…

This study looks at how seeing someone else get effective treatment, along with your own past success or failure with a treatment, can strengthen or weaken the placebo effect for pain and unpleasant images. About 120 healthy adults will be split into four groups to test these fac…