PAIN

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This Phase 2 trial tests whether a single dose of (2R,6R)-hydroxynorketamine (HNK), a non-addictive ketamine metabolite, can reduce acute pain in 92 healthy adults. Participants receive either HNK or a placebo intravenously and undergo pain tests, brain scans, and safety monitori…

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This study will test whether listening to 60 minutes of instrumental Turkish classical music can reduce pain, improve neck awareness, and enhance balance in 19 adults with chronic neck pain. Participants will listen once, and their pain and balance will be measured before and aft…

This study tests whether using virtual reality (VR) for mindfulness can help people feel less anxious and experience less pain during minor vascular surgery done under local anesthesia. 160 adults with varicose veins will be randomly assigned to either wear VR glasses with guided…

This study tests whether adding neck-strengthening exercises to standard physical therapy can reduce pain and improve shoulder function in people with shoulder impingement syndrome. Forty-two adults with shoulder pain will be split into two groups: one gets standard therapy alone…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study tests whether wearing a virtual reality headset during dental treatment can reduce pain and anxiety in children aged 6 to 12. Eighty children will be randomly assigned to either use VR or receive standard care. Researchers will measure pain, stress, and how willing kid…

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This study compares two sizes of IV cannulas (18-gauge vs 20-gauge) in emergency patients to see if the larger one causes more pain or is harder to insert. About 204 adults with low-to-moderate difficulty for IV access will be randomly assigned to one size. Patients will wear gog…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises at home, reducing pain and improving function as well as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving …

This study tests whether applying a lavender oil blend to the skin around the surgical area can improve recovery quality after lung surgery. Researchers will compare the lavender oil to plain almond oil in 124 adults. The main goal is to see if aromatherapy helps reduce pain and …

This early-stage trial will test the safety and tolerability of a new experimental drug called IG001119 in 64 healthy volunteers. Participants will receive either the drug or a placebo tablet. The study aims to understand how the drug behaves in the body and identify any side eff…

This study tests whether a gel made from the Libidibia ferrea plant can reduce tooth sensitivity after professional whitening. Seventy-five adults will receive either the experimental gel, a standard desensitizing gel, or a placebo before bleaching with hydrogen peroxide. Partici…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests whether listening to calming music or using virtual reality can reduce pain, anxiety, and fear in children aged 6-12 with leukaemia who need care for painful mouth sores caused by chemotherapy. Forty-five children will be randomly assigned to a music group, a VR …

This study tests whether a special acupuncture method called Jin's Three-Needle technique, combined with electroacupuncture, can ease pain and improve neck movement in people with cervical spondylosis. 104 adults with neck pain and a specific traditional Chinese medicine pattern …

This study tests whether a gel made from propolis (a bee product) can reduce tooth sensitivity after professional whitening. 66 adults will receive either propolis gel, a standard desensitizer, or a placebo before bleaching. Their pain and color change will be tracked for two wee…

This study tests two common painkillers, indomethacin and paracetamol, given before egg retrieval in IVF. 177 women aged 18-45 will rate their pain after the procedure. The goal is to find a better way to manage pain during this common fertility treatment.

This study tests whether listening to a 1- or 2-minute guided mindfulness audio can reduce pain in people waiting for orthopedic care. 300 adults will be randomly assigned to one of two mindfulness exercises or a control. The goal is to see if a brief, easy-to-use technique can m…

This study tests whether a daily 200 mg dose of cannabidiol (CBD) for 12 weeks can reduce inflammation, ease pain, improve sleep, and boost quality of life in Brazilian Jiu-Jitsu athletes. One hundred healthy athletes aged 18-40 who train at least 3 times a week will be randomly …

This study will test whether listening to Turkish music after a planned cesarean section helps reduce pain, anxiety, and improve mother-baby bonding. Seventy first-time mothers will be enrolled. The researchers will measure pain and anxiety levels using standard scales and assess…

This Stanford study tests whether a short virtual reality mindfulness session can improve mental well-being and reduce anxiety in hospitalized adults. 42 participants will try the VR app and also receive standard care, acting as their own comparison. The goal is to see if immersi…

This study tests whether adding diphenhydramine (an antihistamine) to standard sedation medicine reduces pain during first-trimester abortion. About 98 adults will receive either diphenhydramine or a placebo alongside usual care. The goal is to see if this simple addition improve…

This study tests whether a special glass-based bone cement, used with ultrasound during surgery, can safely stabilize bones and reduce pain in people with advanced cancer that has spread to the pelvis. Eight adults aged 18 to 80 with painful pelvic bone tumors will receive the tr…

This study tests whether using a stress ball or receiving a hand massage during eye surgery can lower patients' anxiety, pain, and stress levels. 174 adults having eye surgery under local anesthesia will be randomly assigned to one of three groups: stress ball, hand massage, or s…

This study tests whether listening to calming music during a nail biopsy can lower pain and anxiety. About 30 adults will be randomly assigned to hear a playlist or get standard care. After the procedure, they will rate their pain, anxiety, and satisfaction. The goal is to see if…

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests whether a personalized AI-generated video, delivered by a nurse avatar, can improve recovery for people after coronary artery bypass surgery. About 128 patients will either get standard discharge instructions or the AI video plus standard care. Researchers will m…

This study will compare three different injections—glucocorticoid, ozone, and 5% dextrose—to see which provides the best pain relief for people with mild to moderate carpal tunnel syndrome. Researchers will enroll 105 adults aged 18 to 65 who have not responded to conservative tr…

This study will test whether giving a single dose of ketamine during open-heart surgery can reduce chronic pain that often lingers for months after the operation. Researchers will compare 100 adults who receive either ketamine or a placebo during surgery, then track their pain le…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will have their wounds covered with banana leaves, and their pain and healing will be compared to past patients. The goal is to see if this simple, l…

This study tests whether giving the numbing drug lidocaine through an IV during and after major non-cardiac surgery can help patients recover faster and use fewer opioids. About 2,290 adults having elective surgery will be randomly assigned to receive lidocaine or a placebo. Rese…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study is testing a smartphone app called I-STAMP that helps people with advanced cancer keep track of their pain and medications. About 73 participants will use the app and rate how easy it is to use and how helpful it is. The goal is to see if the app can make managing canc…

This study tests whether low-level laser therapy can reduce pain and improve healing of perineal tears after vaginal birth. 206 new mothers will receive either real laser treatment or a sham (fake) treatment. Researchers will measure pain and wound healing right after birth and a…

This study tests whether injecting a patient's own fat into chronic wounds can reduce pain better than standard wound care alone. Sixty-two adults with wounds lasting over 3 months will be randomly assigned to receive either fat grafting plus standard care or standard care only. …

This study looks at two simple, drug-free methods—Helfer Skin Tap (gentle tapping near the injection site) and vibration—to see if they can lower pain and fear in children aged 5-10 getting a shot in the emergency room. About 186 children will be randomly assigned to one of these…

This study looks at whether craniosacral therapy, a gentle manual therapy, can reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers aged 18-55 will either receive the therapy or be i…

This study tests whether a 6-week virtual reality (VR) program can help adults with chronic pain learn about pain science and manage their symptoms. Fifty participants will use VR headsets for one hour each week to watch educational content and do guided exercises. The goal is to…

This study compares two injections—botulinum toxin (Botox) and local anesthetic—to see which better relieves pain from nerve damage (neuroma) after limb injury or amputation. About 100 adults with moderate to severe pain will receive one injection and be followed for 8 weeks. The…

This study compares two types of nerve blocks for pain after modified radical mastectomy. One block is placed under the chest muscle, the other above it, and a third combines both. The goal is to see which approach reduces opioid use and pain scores most effectively. Sixty women …

This study tests a program called AIMSS-CARE for breast cancer patients who have joint and muscle pain from their hormone therapy. The program includes exercise, education, symptom tracking, and follow-up. Eighty-eight patients in Ethiopia will be randomly assigned to the program…

This study compares two types of dental sealers used after root canal treatment to see which causes less pain. About 118 adults with painful tooth inflammation will receive either a tricalcium silicate sealer or a resin-based sealer. Pain levels will be measured at 24 hours, 72 h…

This study tests if shining a special light (photobiomodulation) on the cervix before inserting a copper IUD can reduce pain. 72 women will receive either real or fake light treatment, and their pain levels will be compared. The goal is to make IUD insertion more comfortable and …

This study tests whether a mix of nitrous oxide (laughing gas) and oxygen can reduce pain during in-office bladder Botox injections for overactive bladder. About 96 adult women will receive either the gas plus standard numbing medicine or a sham mask plus standard care. Participa…

This study tests whether adding tizanidine (a muscle relaxant) to pregabalin (a standard pain drug) works better than pregabalin alone for fibromyalgia pain. About 164 adults with daily pain will be followed for 12 weeks. The goal is to see if the combination reduces pain and imp…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study tests whether adding ketamine to a standard painkiller (bupivacaine) and rinsing the surgical area during gallbladder removal can better control pain after surgery. Sixty adults having laparoscopic gallbladder removal will be randomly assigned to receive either the sta…

This study looks at two simple, drug-free ways to help reduce pain during bone marrow aspiration and biopsy, a common but painful procedure for diagnosing blood cancers. About 80 adult cancer patients will either fake cough, squeeze a stress ball, or receive standard care during …

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study tests whether listening to music for 20 minutes before a wrist fracture reduction can lower pain and stress. 192 adults will be randomly assigned to hear their favorite music, a therapist-chosen song, or no music. Researchers will measure pain scores, heart rate, and b…

This study will test whether listening to music or chewing sugar-free gum can reduce pain and anxiety during episiotomy repair—the stitching of a cut made during childbirth. Sixty women who have a vaginal birth with an episiotomy will be randomly assigned to one of three groups: …

This study tests whether adding a steroid called dexamethasone to a numbing nerve block can prevent severe "rebound pain" after hand surgery. About 60 adults will be randomly assigned to receive either the steroid or a placebo. The goal is to see if fewer people experience intens…

This study will test whether watching a liquid-gel or sand hourglass during blood collection can reduce pain, fear, and anxiety in children aged 5 to 10. About 120 children will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, non-d…

This study tests whether a nasal spray of ketorolac (an anti-inflammatory) or ketamine (a pain reliever) works better to reduce pain before a finger nerve block in the emergency room. About 64 adults with finger injuries will receive one of the two sprays, and their pain levels, …

This study looks at whether playing a guessing game during blood collection can lower fear, pain, and bad feelings in children ages 6 to 12. About 70 kids will take part, and their pain, fear, and emotions will be measured using special scales. The goal is to find a simple, fun w…

This study compares two ultrasound-guided nerve blocks (TFP and ESP) to control pain after cesarean section. The goal is to see which block provides better pain relief and reduces the need for opioid painkillers. Sixty women having a planned C-section will participate, and their …

This study compares two ways to manage pain after a root canal. One group gets ibuprofen alone, the other gets ibuprofen plus alprazolam, a medicine that reduces anxiety. 110 adults with tooth pain will rate their pain over 24 hours. The goal is to see if adding alprazolam leads …

This study tests whether a gentle, hands-on movement technique applied to the non-painful side can reduce pain and disability in people with cervical radiculopathy (nerve pain in the neck and arm). It includes 40 adults who will receive a single session of this technique. The goa…

This study tests whether a mobile app that plays guided imagery sessions can help reduce chronic abdominal pain in children aged 7 to 12. Participants listen to 10-15 minute audio sessions five days a week for eight weeks, alongside their usual care. The goal is to see if this ap…

This study tests if a special type of nerve stimulation (TENS-WAA) combined with a painkiller (tramadol) can reduce pain during egg retrieval for IVF. Sixty women will be randomly assigned to receive either the real nerve stimulation or a sham version, both with the painkiller. T…

This pilot study will test whether live, improvised music therapy can lower pain levels in 22 newborns with hypoxic-ischemic encephalopathy (HIE) who are undergoing cooling therapy. Each baby will receive either standard care alone or standard care plus a 15-minute music session …

This study will test whether watching a virtual reality movie or using a vibrating Buzzy device can reduce pain, fear, and anxiety in children aged 7 to 10 during allergy skin prick tests. About 111 children will be randomly assigned to one of three groups: virtual reality, Buzzy…

This pilot study will test whether virtual reality (VR) or a combination of VR and hypnosis (Hypno-VR) can help reduce pain and anxiety during a diagnostic hysteroscopy, a common gynecological procedure. 45 adult patients will be randomly assigned to standard care, VR, or Hypno-V…

This study compares a computer-controlled anesthetic device (SleeperOne) to a traditional syringe for numbing kids' teeth before extraction. 28 children aged 3-5 will be randomly assigned to one method. Pain, anxiety, and heart rate will be measured to see if the device makes the…

This study tests whether a 4-week program combining ergonomic training with exercise can reduce pain, improve sleep quality, and lower anxiety in nursing students. Sixty participants will be randomly assigned to either the program or standard curriculum. The goal is to see if the…

This early-phase trial investigates whether m-Cresol, a preservative used in many injectable medications like insulin, causes pain at the injection site. Eighteen healthy volunteers will receive three injections in their belly: one with a low concentration of m-Cresol, one with a…

This study looks at how the way your foot presses on the ground might be linked to where and how much pain you feel. Researchers will measure foot pressure in 53 healthy young adults (ages 18-35) while they stand and walk, and ask them to rate any pain. The goal is to understand …

This study will analyze blood samples from 90 people — 30 healthy, 30 with diabetes but no nerve issues, and 30 with diabetic peripheral neuropathy (nerve damage causing pain). Researchers will look for unique molecules in the blood that could serve as early warning signs. The go…

This study follows 150 adults with severe arm or leg injuries that required a tourniquet to stop bleeding. Researchers will track how long the tourniquet was used and check for pain, nerve damage, and recovery over 6 months. The goal is to see if longer tourniquet use increases t…

This study aims to develop a new pain assessment scale, called EDEX, specifically for extremely premature infants born before 27 weeks. Current scales may not work well for these fragile babies, who show pain in subtle ways. Researchers will create the scale and then test it agai…

This study looks at a new way to assess pain in intensive care patients who are on breathing machines and cannot speak. It uses a special tool (AlgiScan) and a behavioral checklist to adjust pain medicine more safely. Researchers will compare data from 400 adults to see if the ne…

This study aims to translate and adapt the COMFORTneo pain assessment scale into French for newborns. Researchers will work with 50 healthcare professionals from French neonatal units to ensure the translated items are accurate and easy to understand. The goal is to provide a rel…

This study gives a natural brain chemical called adrenomedullin to 26 people with migraines to see if it triggers an attack. Participants first receive a migraine-preventing drug (erenumab) to block related receptors. The goal is to understand how migraines start, not to test a n…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This study will test whether a phenomenon called 'offset analgesia'—where pain briefly increases then drops sharply—can be triggered by cold temperatures, not just heat. Researchers will also map where pain and itch receptors are located on the body. Thirty healthy adults aged 18…

This study looks at how self-compassion and self-belief relate to pain, body awareness, and healthy behaviors in people 65 and older. Researchers will ask 150 older adults to fill out online questionnaires. The goal is to understand these connections better, not to test a treatme…

This study looks at how seeing someone else benefit from a placebo treatment, along with your own past experiences, can influence the placebo effect. Researchers will use brain scans (fMRI) to understand these effects in 120 healthy adults. The goal is to learn what makes placebo…

This study gives people with persistent post-traumatic headache a hormone called amylin (or a placebo) to see if it triggers migraine-like headaches. The goal is to understand why headaches continue after a mild brain injury. Only 21 adults will take part, and the results may hel…

This study looks at whether pramlintide, a drug similar to the hormone amylin, can cause migraine attacks in people who get migraines without aura. Researchers will give 21 participants either pramlintide or a placebo and watch for headaches over 12 hours. The goal is to understa…

This study looks at how giving dexamethasone (a steroid) with a nerve block affects the amount of the numbing drug bupivacaine in the blood. Forty patients having shoulder surgery will receive the nerve block, with dexamethasone given either near the nerve or into a vein. Researc…

This early-phase study investigates whether the opioid system is involved in placebo effects on both physical pain and the pain of social rejection. Sixty adults who recently experienced an unwanted breakup will receive either naloxone (which blocks opioids) or saline, and be tol…

This study compares two common steroids—methylprednisolone and dexamethasone—given during nose surgery to see how they affect how quickly the muscle relaxant rocuronium is reversed by sugammadex. Researchers will measure reversal time, pain, nausea, and other recovery outcomes in…