PAIN

This study aims to see if a new type of heart stent called Freesolve is as safe and effective as a standard metal stent (Xience). Freesolve is made of magnesium and is designed to dissolve in the artery over time. The study will involve about 1,859 adults with clogged heart arter…

This study is testing a phone-based counseling program designed to help Veterans who have chronic pain quit smoking. The program uses automated phone calls (IVR) to provide support and strategies. Researchers want to see if this approach helps people quit smoking more successfull…

This study is testing a new mouth rinse called MucoLock to see if it can safely reduce severe mouth pain and burning sensations. Participants will use the rinse like mouthwash three times a day for 28 days. The main goal is to measure changes in pain levels and see how the treatm…

This study is testing a program where nurses visit older adults in their homes to help them better manage chronic pain and feelings of depression. Over eight weekly visits, nurses will work one-on-one with participants to set personal goals, teach pain and mood management skills,…

This study is testing whether a special audio technology can help people tolerate pain better. Researchers want to see if listening to specific sounds through a device can raise a person's pain threshold during a cold water test. They are looking for 100 healthy adults to try the…

This study is testing whether craniosacral therapy, a gentle hands-on treatment, can help reduce pain, depression, and improve quality of life for primary caregivers of individuals with special needs. Thirty female caregivers will be assigned to either receive the therapy session…

This study aims to see if watching a simple hourglass can help children feel less pain, fear, and anxiety during a routine blood draw. Researchers will compare two types of hourglasses—one with sand and one with colorful liquid gel—to see which works better as a distraction. The …

This study aims to find the best way to manage pain after a common breast cancer surgery called a modified radical mastectomy. Researchers will compare two types of nerve block injections given near the shoulder blade to see which one provides better pain relief in the first 24 h…

This pilot study is testing whether using virtual reality (VR) or a combination of VR and hypnosis can help reduce pain and anxiety for women undergoing a diagnostic hysteroscopy. The study will compare these non-drug approaches to standard care in 45 participants. The main goals…

This study aims to see if listening to music or using virtual reality can help reduce pain, anxiety, and fear for children with leukemia during painful mouth care procedures. It will involve 45 children aged 6-12 who are receiving treatment. Researchers will compare these distrac…

This study aims to see if a mix of nitrous oxide and oxygen gas (often called laughing gas) can help reduce pain during Botox injections into the bladder. Researchers will compare the gas to a placebo (sham mask) in about 96 women who are already scheduled to get the injections. …

This study aims to find the best way to manage pain after a single-visit root canal treatment. It will compare pain levels in 110 adults who receive either ibuprofen alone or ibuprofen combined with a low-dose anxiety medication (alprazolam). Participants will track their pain fo…

This study aims to see if one of two common steroids (methylprednisolone or dexamethasone) helps patients wake up faster from muscle-relaxing drugs used during anesthesia. Researchers will measure how quickly patients recover muscle control, and also track their pain and nausea a…

This study is testing whether botulinum toxin (Botox) injections work better than standard numbing injections for reducing nerve pain that develops after limb injury or amputation. Researchers will compare pain relief over 24 weeks in 100 adults who have had this type of pain for…

This study is testing whether live music therapy can help reduce pain in newborns with a brain injury caused by lack of oxygen during birth. These babies are undergoing a cooling treatment to protect their brains, but routine nursing care can still cause them pain and stress. Res…

This study is testing if simple, guided breathing exercises can help reduce the pain and anxiety people often feel when getting needles inserted for their dialysis treatment. It will involve 90 patients who regularly receive dialysis. They will be randomly assigned to try one of …

This study is testing a program designed to help breast cancer patients in Ethiopia who experience joint pain, stiffness, and fatigue from their hormone therapy. The program, adapted from one used in China, combines home exercises, education, and symptom tracking. Researchers wil…

This study is testing if adding a continuous lidocaine (a common numbing medicine) drip into a patient's IV during and after major surgery helps them recover faster. Researchers want to see if it shortens the hospital stay, reduces the need for strong opioid painkillers, and impr…

This study is testing whether injecting a patient's own fat tissue into a chronic wound can reduce pain and help it heal better. Researchers will compare this fat grafting procedure plus standard wound care against standard care alone in 62 adults with wounds that haven't healed …

This study aims to see which of two pain-relief nasal sprays works better for reducing discomfort before a finger-numbing injection in the emergency room. Adults with finger injuries will be randomly given either a ketorolac or ketamine nasal spray five minutes before the procedu…

This study aims to see if a painless light treatment, called photobiomodulation, can reduce discomfort when getting a copper IUD inserted. Researchers will compare real light therapy to a simulated treatment in 72 women. The main goal is to measure if the light helps lower pain d…

This study aims to find the best nasal spray medication for quickly relieving severe pain in children who come to the emergency room with injuries like broken bones. Researchers will compare two pain-relieving sprays—sufentanil and ketamine—given alongside standard care to see wh…

This study is testing if a virtual reality (VR) mindfulness program can help patients feel less anxious and experience less pain during minor vascular surgeries done with local anesthesia. Researchers will enroll 160 patients, with half using the VR program and half receiving sta…

This small pilot study will test if banana leaves can be used as a dressing for second-degree burns to help reduce pain and improve healing. It will involve 30 adult patients with recent, small burns and compare their results to past patients. The main goal is to see if using ban…

This study is testing if a new computer-controlled device (SleeperOne®) is better than a standard syringe at reducing pain and anxiety when children get a baby tooth pulled. Researchers will compare the two methods in 28 children aged 3 to 5 years old. The goal is to find a gentl…

This study is testing a new physical therapy approach for people with neck and arm pain from a pinched nerve in the neck. It will see if gently moving and stretching the *opposite*, pain-free arm can help reduce pain and improve movement in the painful arm. This could help patien…

This study is testing whether listening to music can help reduce pain for adults getting their broken wrist set without surgery. Researchers will compare pain levels in 192 patients who either listen to their own music, listen to a therapist's music selection, or receive standard…

This study is testing whether a special training program can help nursing students who experience pain, poor sleep, or anxiety. The program combines lessons on proper posture and body mechanics with guided exercise videos. Researchers will compare 60 students who either receive t…

This study aims to see if two simple, drug-free techniques can make shots less scary and painful for children in the emergency room. Researchers will test a quick skin tap and a gentle vibration against standard care in about 186 kids aged 5 to 10. They will measure the children'…

This study aims to see if simple, drug-free methods can help new mothers feel better during a common medical procedure. Researchers will test whether listening to relaxing music or chewing gum can reduce pain and anxiety for women getting stitches (an episiotomy repair) after vag…

This study is testing a new smartphone app called I-STAMP, designed to help people with advanced cancer manage their pain and track their medications. Researchers want to see if the app is easy to use and helpful for patients. The study will involve about 73 participants who have…

This study is testing if using virtual reality (VR) can help adults feel less pain, anxiety, stress, and loneliness while they are in the hospital. Researchers want to see if using VR with a trained guide works as well as using it alone. They will enroll 200 stable adult patients…

This study aims to see if a gentle, low-level laser treatment can help reduce pain and improve healing for women who have tearing during vaginal birth. It will compare the real laser therapy to a fake (sham) treatment in over 200 new mothers. The main goal is to find a safe, non-…

This study aims to see if two simple distraction techniques—fake coughing or squeezing a stress ball—can help reduce pain for patients undergoing a bone marrow aspiration and biopsy. The procedure is used to diagnose blood cancers and other diseases but can be painful. Researcher…

This study is testing whether a virtual reality (VR) program can be a useful tool for teaching people with chronic pain about their condition. Fifty adults with chronic pain will use a VR headset for six weeks to learn about pain science and coping strategies. The main goal is to…

This study aims to see if adding the muscle relaxant tizanidine to the standard drug pregabalin works better for reducing fibromyalgia pain than pregabalin alone. It will involve 164 adults with fibromyalgia who experience daily pain. Participants will be randomly assigned to one…

This study aims to find out which of two common dental materials causes less pain after a root canal procedure. It will compare a bioceramic sealer (CeraSeal) with a resin-based sealer (Endoplus) in 118 adults with severe tooth pain. Patients will track their pain levels for a we…

This study is testing a new AI-powered app designed to act like a virtual physiotherapist for people with knee osteoarthritis. It provides exercise videos and real-time feedback on movements to help manage pain from home. Researchers will compare the app's effectiveness to tradit…

This study aims to find which of two ultrasound-guided nerve block techniques works better to control pain after a cesarean section. Researchers will compare the Transversalis Fascia Plane block and the Erector Spinae Plane block in 60 women having planned C-sections. The main go…

This study is testing if adding the anesthetic ketamine to a standard pain-relief rinse can better control pain after gallbladder removal surgery. It will compare two groups of 30 patients each to see which rinse leads to less pain and lower use of strong opioid painkillers in th…

This large study aims to find out if a drug called ketamine works as well as the standard morphine for treating severe pain in children who come to the emergency room with a broken bone or bad stomach ache. Researchers want to see if ketamine causes fewer serious side effects lik…

This study aims to see if playing a guessing game can help reduce fear, pain, and distress for children aged 6 to 12 during routine blood draws. Researchers will compare the experience of children who play the game to those who receive standard care. The goal is to find a simple,…

This study aims to see if applying a sugar-free, sweet-tasting solution before a dental numbing shot helps reduce pain for children. Researchers will compare the solution to plain water in 54 children aged 6-12 who need routine dental work. They will measure pain using child repo…

This study is testing if a smartphone app with guided relaxation sessions can help children with chronic stomach pain. Kids aged 7-12 will use the app for 8 weeks while continuing their usual care. Researchers will check if the app reduces pain and improves the child's mood and d…

This study is testing if adding a common steroid (dexamethasone) to a standard numbing injection for hand surgery can prevent a sudden return of severe pain, known as 'rebound pain,' in the first two days after surgery. It will compare 60 patients receiving the steroid mix to tho…

This study aims to see if using distraction methods can make allergy skin prick tests less scary and painful for children. Researchers will compare virtual reality headsets and a vibrating 'Buzzy' device against standard care in 111 kids aged 7-10. The goal is to find better ways…

This study is testing whether listening to a short daily audio recording of positive self-affirmation statements can help reduce pain, depression, anxiety, and stress in women recovering from mastectomy surgery. It will compare 42 patients who listen to the recording against thos…

This study is testing whether a special type of electrical skin stimulation, based on wrist-ankle acupuncture theory, can improve pain relief when used alongside standard pain medication during egg retrieval for IVF. Researchers will compare the real stimulation to a fake (sham) …

This study is testing whether having women urinate standing in the shower, instead of sitting on a toilet, after certain gynecologic surgeries helps reduce pain and prevents the bladder from not emptying fully. Researchers want to see if this simple change in position lowers the …

This study aims to understand why combat-related brain injuries often lead to long-term chronic pain. Researchers will follow 100 veterans with recent mild-to-moderate brain injuries for six months, tracking their pain levels, psychological state, and physical function. The goal …

This study aims to understand what causes headaches after a mild head injury. Researchers will give a hormone-like substance called pramlintide to 21 people with long-term post-traumatic headaches to see if it triggers their migraine-like pain. The goal is to learn more about the…

This research study aims to understand how the brain naturally reduces pain, a phenomenon called 'offset analgesia.' Researchers will test if this pain-relief effect works with cold temperatures as it does with heat. The study involves 30 healthy adults who will have small areas …

This study aims to understand if the length of time a tourniquet is used to stop bleeding after a severe arm or leg injury is linked to a higher chance of developing long-term pain. Researchers will follow 150 adult patients who needed a tourniquet for up to six months after thei…

This study aims to understand if a natural brain chemical called adrenomedullin can trigger migraine attacks. Researchers will give participants a migraine prevention drug (erenumab) first to block one pathway, then give adrenomedullin to see if it still causes a migraine. The go…

This study aims to create a new scale specifically designed to assess pain and discomfort in extremely premature infants born before 27 weeks of pregnancy. Researchers will observe 68 babies in a neonatal intensive care unit to develop and test this new tool, called EDEX, because…

This study aims to understand how two common pain medications, bupivacaine and dexamethasone, are absorbed into the bloodstream when given together during a nerve block for shoulder surgery. Researchers will compare blood levels when one drug is mixed directly with the nerve bloc…

This study aims to understand how the expectation of pain affects muscle coordination during walking. Researchers will compare two groups of healthy adults: one with a past painful experience and one without. Both groups will be told a harmless cream might cause pain, and their w…

This study aims to create a French version of a tool used to assess pain in newborn babies. Researchers will work with healthcare professionals to translate and adapt the COMFORTneo scale, which is already used in other countries. The goal is to provide French neonatal units with…

This study aims to understand how the brain's natural pain-relief system is involved in the 'placebo effect' for both emotional pain (like rejection) and physical pain. Researchers will recruit 60 healthy adults who have recently experienced an unwanted romantic breakup. Particip…

This study aims to understand how the brain creates the placebo effect, specifically for pain relief. Researchers will use brain scans (fMRI) to see how watching someone else experience pain relief, combined with a person's own initial success or failure with a fake treatment, in…

This study aims to understand what causes migraines by testing if a hormone-like drug called pramlintide can trigger a migraine attack. Researchers will give the drug or a placebo to 21 adults with migraine without aura and watch for 12 hours to see if a migraine starts. The goal…

This research aims to understand how psychological factors like self-compassion (being kind to yourself) and self-efficacy (belief in your abilities) are connected to physical health in older adults. The study will survey 150 people aged 65 and older using online questionnaires a…