Can cold also turn off pain? new study investigates

NCT ID NCT07395869

Not yet recruiting Knowledge-focused Sponsor: Aalborg University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will test whether a phenomenon called 'offset analgesia'—where pain briefly increases then drops sharply—can be triggered by cold temperatures, not just heat. Researchers will also map where pain and itch receptors are located on the body. Thirty healthy adults aged 18-60 will participate, rating their sensations on a scale. The goal is to better understand how pain and itch work, which could inform future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could improve understanding of how the body processes pain and itch, potentially guiding future pain treatments.
What could go wrong: This is a small, early-stage study in healthy volunteers, not patients. Results may not apply to real-world pain conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN

Contacts and locations

Locations

Center for Neuroplasticity and Pain Faculty of Medicine, Aalborg University Selma Lagerløfs Vej 249 9260 Gistrup, Denmark

Aalborg, Aalborg, 9620, Denmark

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