Can watching someone get better make you feel less pain?
NCT ID NCT04646460
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how seeing someone else benefit from a placebo treatment, along with your own past experiences, can influence the placebo effect. Researchers will use brain scans (fMRI) to understand these effects in 120 healthy adults. The goal is to learn what makes placebos work better and last longer, which could help improve pain relief in the future.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could reveal how to boost placebo effects in real treatments, potentially improving pain management without drugs.
- What could go wrong
- This is an early-stage, small study (120 participants) focused on understanding mechanisms, not testing a treatment. Results may not translate to clinical practice.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 120 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Dec 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * No current psychiatric or major neurological diagnosis * No reported substance abuse within the last six months * Capable of performing experimental tasks (e.g., are able to read, able to cooperate with fMRI examination) * Fluent or native speakers of English * No current or recent history of pathological pain or reported neurological disorders * Abstained from alcohol and substance use for 48 hours * Provided informed consent * Passed fMRI screening test Exclusion Criteria: * Current presence of pain * Current or past history of primary psychiatric disorder * Current or past history of psychoactive substance abuse or dependence * Dementias * Movement disorders except familial tremor * CNS infection * CNS vasculitis, inflammatory disease or autoimmune disease * CNS demyelinating disease (e.g. multiple sclerosis) * Space occupying lesions (mass lesions, tumors) * Congenital CNS abnormality (e.g. cerebral palsy) * Seizure disorder * History of closed head trauma with loss of consciousness * History of cerebrovascular disease (stroke, TIAs) * Abnormal MRI (except changes accounted for by technical factors or UBOs) * Neuroendocrine disorders (e.g., Cushings disease) * Uncorrected hypothyroidism or hyperthyroidism * Current or past history of cancer * Recent history (within two years) of myocardial infarction, severe cardiovascular disease, or currently active cardiovascular disease (e.g. angina, cardiomyopathy) * Uncontrolled hypertension or hypotension * Chronic pain syndromes * Chronic fatigue syndromes * Subjects unable to tolerate the scanning procedures (e.g., claustrophobia) * Prior treatment within the last month with any of the following: antidepressants, mood stabilizers, glucocorticoids, opiates * Prior treatment with any of the following: antipsychotics, isoniazid, centrally active antihypertensive drugs (e.g. clonidine, reserpine) * Metal in body or prior history working with metal fragments (e.g., as a machinist) * Pregnancy * Any other contraindications for MRI examination (e.g., metallic implants such as pacemakers, surgical aneurysm clips, or known metal fragments embedded in the body) * Claustrophobia
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Dartmouth College
Hanover, New Hampshire, 03755, United States
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