Could a cheap numbing drug cut opioid use after surgery?
NCT ID NCT07224711
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving the numbing drug lidocaine through an IV during and after major non-cardiac surgery can help patients recover faster and use fewer opioids. About 2,290 adults having elective surgery will be randomly assigned to receive lidocaine or a placebo. Researchers will measure how long patients stay in the hospital, how much pain medicine they need, and their pain levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lidocaine
What this could lead to
If it works, this could provide a simple, low-cost way to speed recovery and reduce opioid use after major surgery.
What could go wrong
This is a single-center trial, and lidocaine may cause side effects like blurred vision or sedation. The benefit may be small or not apply to all surgeries.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
Contact Email: •••••@•••••
Contact Email: •••••@•••••