New study tracks COVID-19 vaccine side effects in kids ages 5 to 16

NCT ID NCT05157191

Completed Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study follows children and adolescents aged 5 to 16 who receive an mRNA COVID-19 vaccine to monitor for side effects like injection site pain, fever, and other reactions. Participants report symptoms for a week after each dose, and some provide blood samples to measure antibody levels. The goal is to better understand the safety and immune response of COVID-19 vaccines in younger populations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA COVID-19 vaccine
What this could lead to: If successful, this study could provide clear safety data on COVID-19 vaccines in children, helping guide vaccination recommendations.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all children or vaccine types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Drug-Related Side Effects and Adverse Reactions Injection Site Reaction Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVERSE DRUG EVENT INJECTION SITE REACTION PAIN

Contacts and locations

Locations

Centers for Disease Control and Prevention

Atlanta, Georgia, 30333, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Columbia University

New York, New York, 10027, United States
Duke University

Durham, North Carolina, 27710, United States
Kaiser Permanente Northern California

Oakland, California, 94612, United States

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