New nasal spray could replace needles for kids in pain

NCT ID NCT06364072

Completed Symptom relief Sponsor: Cessatech A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a nasal spray containing two painkillers (sufentanil and ketamine) for children aged 1 to 17 with moderate to severe pain in the emergency room. The goal was to see if it is safe, tolerable, and effective. Results showed the spray reduced pain and was well-tolerated, with only mild side effects like sedation or nasal irritation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sufentanil and Ketamine nasal spray
What this could lead to: If successful, this could provide a needle-free, fast-acting pain relief option for children in emergency settings.
What could go wrong: This is an early-phase study with only 155 participants, so larger trials are needed to confirm safety and effectiveness. Side effects like sedation or breathing issues are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN

Contacts and locations

Locations

Birmingham Women's and Children's NHS Foundation Trust

Birmingham, United Kingdom
Complejo Hospitalario Universitario de Santiago (CHUS)

Santiago de Compostela, Spain
Hospital General Universitario Dr. Balmis

Alicante, Spain
Hospital Sant Joan de Deu

Barcelona, Spain
Royal London Hospital

London, United Kingdom
Sheffield Children's Hospital

Sheffield, United Kingdom
Universidad Autonoma de Madrid (UAM) - Hospital Universitario La Paz (HULP) -

Madrid, Spain

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