New nasal spray could replace needles for kids in pain
NCT ID NCT06364072
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a nasal spray containing two painkillers (sufentanil and ketamine) for children aged 1 to 17 with moderate to severe pain in the emergency room. The goal was to see if it is safe, tolerable, and effective. Results showed the spray reduced pain and was well-tolerated, with only mild side effects like sedation or nasal irritation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sufentanil and Ketamine nasal spray
What this could lead to
If successful, this could provide a needle-free, fast-acting pain relief option for children in emergency settings.
What could go wrong
This is an early-phase study with only 155 participants, so larger trials are needed to confirm safety and effectiveness. Side effects like sedation or breathing issues are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Birmingham Women's and Children's NHS Foundation Trust
Birmingham, United Kingdom
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Complejo Hospitalario Universitario de Santiago (CHUS)
Santiago de Compostela, Spain
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Hospital General Universitario Dr. Balmis
Alicante, Spain
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Hospital Sant Joan de Deu
Barcelona, Spain
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Royal London Hospital
London, United Kingdom
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Sheffield Children's Hospital
Sheffield, United Kingdom
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Universidad Autonoma de Madrid (UAM) - Hospital Universitario La Paz (HULP) -
Madrid, Spain