Vitamin B6 put to the test: could a common vitamin raise your pain tolerance?

NCT ID NCT06415383

Completed Symptom relief Sponsor: University of Reading Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 trial from the University of Reading tested whether taking high-dose vitamin B6 (100 mg daily) can increase how much heat and electric shock healthy adults can handle before feeling pain. 43 participants were randomly assigned to get either vitamin B6 or a placebo for a period, then their pain thresholds and tolerance were measured. The goal is to see if this common vitamin might offer a simple way to reduce pain sensitivity.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vitamin B6 (pyridoxal phosphate)
What this could lead to: If it works, this could point toward a simple, low-cost supplement for managing pain sensitivity.
What could go wrong: This is a small, early-phase study in healthy adults, not patients with chronic pain. Results may not apply to real-world pain conditions, and high-dose B6 can cause nerve damage with long-term use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN

Contacts and locations

Locations

University of Reading

Reading, Berkshire, RG6 6AL, United Kingdom

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