Vitamin B6 put to the test: could a common vitamin raise your pain tolerance?
NCT ID NCT06415383
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 trial from the University of Reading tested whether taking high-dose vitamin B6 (100 mg daily) can increase how much heat and electric shock healthy adults can handle before feeling pain. 43 participants were randomly assigned to get either vitamin B6 or a placebo for a period, then their pain thresholds and tolerance were measured. The goal is to see if this common vitamin might offer a simple way to reduce pain sensitivity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Vitamin B6 (pyridoxal phosphate)
What this could lead to
If it works, this could point toward a simple, low-cost supplement for managing pain sensitivity.
What could go wrong
This is a small, early-phase study in healthy adults, not patients with chronic pain. Results may not apply to real-world pain conditions, and high-dose B6 can cause nerve damage with long-term use.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Reading
Reading, Berkshire, RG6 6AL, United Kingdom