New pain shot could ease recovery after hemorrhoid surgery

NCT ID NCT02468128

Completed Symptom relief Sponsor: Lumosa Therapeutics Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a single injection of a long-acting painkiller called SDE in 221 adults recovering from hemorrhoid surgery. Half received the drug and half a placebo. Researchers measured pain levels and how much extra pain medicine was needed over 48 hours. The goal was to see if SDE provides better pain control after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sebacoyl dinalbuphine ester (SDE), a long-acting painkiller injection
What this could lead to: If it works, this could provide a single-injection option for managing pain after hemorrhoid surgery, reducing the need for other pain medications.
What could go wrong: This is a completed Phase 2/3 trial, but results may not apply to other types of surgery or pain. The drug may cause side effects like nausea or dizziness, and it may not work better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain pain agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESIA DISORDER PAIN

Contacts and locations

Locations

Chang Gung Memorial Hospital at Chiayi

Chiayi City, Chiayi Hsien, 61363, Taiwan
Chang Gung Memorial Hospital at Kaohsiung

Kaohsiung City, 88301, Taiwan
Chang Gung Memorial Hospital at Keelung

Keelung, 20401, Taiwan
Chang Gung Memorial Hospital at Linkou

Linkou District, New Taipei City, 244, Taiwan
Cheng Ching General Hospital

Taichung, 40764, Taiwan
Tri-Service General Hospital

Taipei, 114, Taiwan

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