New gel may cut pain and bleeding after mouth surgery

NCT ID NCT05773781

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a gel called PuraBond, applied to the surgical wound during mouth or throat surgery, can reduce pain and bleeding afterward. 73 patients were randomly assigned to receive the gel or not. Researchers measured pain levels over 30 days and tracked complications like bleeding and hospital readmission.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

PuraBond (a gel-like 3-D matrix applied to the surgical wound)

What this could lead to

If it works, this gel could become a simple way to reduce pain and bleeding after mouth or throat surgery.

What could go wrong

This is a small, early-stage trial (73 people) and the results may not apply to everyone. The gel might not provide meaningful benefit over standard care.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Hemorrhage intraepithelial neoplasia metastatic squamous cell carcinoma oral cavity cancer oropharynx cancer Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Liverpool University Hospitals Foundation Trust (LUHFT)

    Liverpool, L9 7AL, United Kingdom