Pain pill showdown: ultracet vs. voltaren for back inflammation

NCT ID NCT00766402

Terminated Symptom relief Sponsor: Johnson & Johnson Taiwan Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compared two pain medications—Ultracet (tramadol/acetaminophen) and Voltaren (diclofenac)—in people with ankylosing spondylitis who were already taking disease-modifying anti-rheumatic drugs (DMARDs). The goal was to see which one worked better for pain relief over 8 weeks. Only 8 people enrolled, and the study was terminated early, so the results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tramadol/acetaminophen (Ultracet) and diclofenac (Voltaren)
What this could lead to: If successful, this could show that adding a pain reliever like Ultracet helps people with ankylosing spondylitis manage pain better while continuing their regular anti-rheumatic drugs.
What could go wrong: This was a very small, early-terminated Phase 4 study with only 8 participants, so results are not reliable. Pain relief may not differ between the two drugs, and side effects like nausea or dizziness are possible.

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PAIN SPONDYLITIS, ANKYLOSING

Contacts and locations

Locations

Johnson & Johnson Taiwan Ltd.

Taipei, Taiwan

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