University Of Florida

This early-phase trial tests a personalized RNA vaccine for people with recurrent medulloblastoma, a type of brain tumor. The vaccine is made from the patient's own tumor material and aims to train the immune system to fight the cancer. The study includes up to 24 participants ag…

This early-stage trial tests a personalized cell therapy for children with recurrent neuroblastoma or newly diagnosed DIPG, two aggressive cancers. The treatment uses the child's own immune cells (dendritic cells and T cells) and stem cells, trained to attack their specific tumor…

This study tests a special stem cell transplant for children, teens, and young adults (ages 6 months to 25 years) with solid tumors that have come back or not responded to treatment. The transplant uses cells from a donor, with certain immune cells removed to reduce side effects,…

This early-phase study tests whether adding melatonin to standard cooling therapy can improve brain outcomes in newborns with hypoxic-ischemic encephalopathy (HIE), a condition caused by oxygen loss at birth. About 70 full-term infants will receive different doses of melatonin to…

This early study tests whether a smart brain implant can help people with spinocerebellar ataxia type 6, a condition that causes trouble with balance and coordination. Five adults will get the implant, which records brain signals and adjusts stimulation automatically. The goal is…

This early-phase trial tests a personalized RNA vaccine made from each patient's own tumor. It aims to teach the immune system to attack the cancer. The study includes adults with glioblastoma and children with high-grade gliomas or medulloblastoma. The main goals are to see if t…

This study compares three mobile health methods to help underserved primary care patients stop smoking: two smartphone apps (iCanQuit and iCanQuit+Motiv8) and the Florida quit line. Over 1,300 participants will be followed to see which approach leads to more people quitting, meas…

This study tests a program to help adults in Lebanon quit smoking cigarettes or waterpipes. Participants receive phone counseling, nicotine patches, educational materials, and their doctors get training and electronic reminders. The goal is to see if this combination increases th…

This early-phase trial is testing whether a combination of immune-based treatments is safe and feasible for children and young adults (ages 4–30) with a recurrent form of medulloblastoma, a type of brain cancer. The treatment includes personalized dendritic cell vaccines, immune …

This study tests a new dye called Magtrace that stays in the lymph nodes for weeks. For women with non-invasive breast cancer (DCIS) having a mastectomy, this dye may allow doctors to safely delay lymph node removal until after the breast tissue is checked for hidden invasive can…

This study tests a decision tool to help select women with bladder cancer who can safely keep their reproductive organs during bladder removal surgery. Currently, standard surgery removes the bladder, uterus, ovaries, and part of the vagina, which can harm sexual health, mental h…

This pilot study is testing whether combining a GLP-1 weight-loss drug (like semaglutide or tirzepatide) with a hormonal IUD can help obese patients with early-stage endometrial cancer avoid surgery or preserve fertility. Twenty participants will receive the drug and IUD, and res…

This study tests whether high intensity focused ultrasound (HIFU) can control prostate cancer that has come back after radiation therapy. About 25 men will receive one session of HIFU using the Focal One device. Researchers will check if the cancer remains absent in the treated a…

This study tests a new robotic surgery technique for kidney cancer that avoids clamping blood vessels and using stitches to close the kidney. The goal is to preserve as much kidney function as possible and reduce the risk of long-term kidney disease. About 59 adults with small ki…

This phase 2 trial is testing whether an artificial intelligence system can find the best doses of three drugs (irinotecan, sonidegib, and sorafenib) for people with advanced liver cancer. The study will enroll 12 adults whose cancer has not responded to other treatments. The goa…

This study tests whether a gentle electrical current applied to the lower spine can boost the effects of balance training in adults aged 65 to 95 who have trouble walking and balancing. Participants will perform balance exercises while receiving either real or sham spinal stimula…

This study tests a stem cell transplant method that removes certain immune cells (T-cells and B-cells) from the donor cells. The goal is to reduce graft-versus-host disease, a serious complication where donor cells attack the patient's body. The trial includes 20 children and you…

This study tests whether adding tivozanib (a drug that targets blood vessel growth) to atezolizumab (an immunotherapy) can help the immune system attack cancers that normally resist immunotherapy. The trial includes people with several cancer types like bile duct, pancreatic, pro…

This early-stage trial is testing a personalized cell therapy for adults with recurrent oligodendroglioma, a type of brain tumor. The treatment involves taking a patient's own immune cells and stem cells, modifying them in the lab, and giving them back to fight the tumor. The mai…

This early-stage trial tests a new therapy made from a patient's own immune cells, modified to better target and attack glioblastoma and other high-grade gliomas. The cells are designed to recognize a protein called CD70 found on these tumors. The main goals are to see if the tre…

This study is testing whether a drug called tadalafil (often used for erectile dysfunction) combined with a home cycling program can help boys with Duchenne muscular dystrophy. The drug aims to improve blood flow to muscles, which is often poor in DMD, while exercise builds stren…

This study is testing a tailored tobacco cessation program for cancer survivors and their caregivers. The program includes four sessions delivered by phone or video, focusing on quitting techniques and support. Researchers want to see how many people enroll and complete the progr…

This early-stage trial tests whether RNA-lipid particle vaccines can be safely made and given to adults with recurrent glioblastoma, an aggressive brain cancer. The vaccines are designed to teach the immune system to attack tumor cells. The study will enroll 24 participants and f…

This study compares two strategies to reduce bleeding risk in people who take two blood thinners after having a stent placed in their heart. The goal is to see if lowering the dose of one drug works as well as switching to a different drug. About 78 adults who have had a stent wi…

This study looks at whether adjusting the dose of the blood thinner cangrelor based on individual test results can better control clotting in people with coronary artery disease who are waiting for surgery. About 50 adults will receive either a standard or tailored dose to find t…

This study is testing whether giving less radiation, based on a patient's HPV type and levels of HPV DNA in the blood, can control throat cancer as well as standard higher doses. About 250 adults with favorable-prognosis oropharyngeal cancer will receive 70, 60, or 50 gray of rad…

This phase 2 trial tests whether giving two chemotherapy drugs (gemcitabine and docetaxel) directly into the bladder can prevent low-grade bladder cancer from coming back. About 34 adults with intermediate-risk disease will receive the treatment. The main goal is to see how long …

This study looks at two strategies to reduce bleeding in people with coronary artery disease who have had a stent placed and are on blood thinners. One approach is to switch from a stronger blood thinner to a milder one while keeping aspirin. The other is to stop aspirin and stay…

This study tests whether the antibiotic minocycline can lower blood pressure in people whose hypertension does not respond to standard treatments. Researchers will give 120 adults either minocycline or a placebo daily for three months to see if the drug works by changing gut bact…

This study tests a drug called tocilizumab-aazg in 30 adults who have had a burst brain aneurysm. The goal is to see if the drug is safe and might help prevent strokes that can happen after the bleeding. Participants will receive the drug within 24 hours of the aneurysm rupture a…

This study tests a mobile app that lets teen heart transplant patients record themselves taking their anti-rejection medication. The goal is to improve medication adherence and reduce the risk of organ rejection and hospital stays. About 100 teens aged 10-21 who have had a heart …

This study tests whether a genetic score (ABCD-GENE) can help doctors choose the right blood thinner for patients after a heart stent. Currently, patients take two blood thinners for months. The score would guide whether to switch to a milder drug or drop one of the two. The tria…

This expanded access program offers a special stem cell purification technique (CD34+ selection) for patients undergoing stem cell transplants. The method removes many T-cells from the donated stem cells, which lowers the risk of a serious complication called graft-versus-host di…

This study tests a new type of brain implant with two leads to better control severe essential tremor in 10 adults who already have a standard implant. The goal is to see if this approach improves tremor control and can lead to a smarter, adaptive system. This is an early feasibi…

This study compares two blood thinners, prasugrel and ticagrelor, when used alone after stopping aspirin in people with coronary artery disease who have had a stent placed. About 48 participants will take one of the two drugs for three weeks to see which one better prevents blood…

This study compares two blood thinners—low-dose ticagrelor and standard clopidogrel—in 50 stable heart disease patients getting a stent. The goal is to see which drug better prevents blood clots around the time of the procedure. Participants take the assigned drug plus aspirin fo…

This phase 2 trial tests the safety and feasibility of combining three treatments—tumor-treating electric fields (Optune GIO), MRI-guided laser ablation (NeuroBlate), and the immunotherapy drug pembrolizumab (Keytruda)—in 20 adults with recurrent glioblastoma. Participants receiv…

This phase 2 trial tests whether a low dose of anti-thymocyte globulin (ATG), followed by verapamil, can help preserve the body's ability to produce insulin in adolescents and young adults recently diagnosed with type 1 diabetes. The study will enroll 60 people aged 6 to 35 who h…

This study looks at whether high-intensity interval training (HIIT) is better than moderate exercise for improving heart health in women who finished chemotherapy for breast cancer. About 158 participants will be assigned to either HIIT or moderate exercise to see which approach …

This study looks at whether switching from a standard blood thinner (clopidogrel) to a lower-dose version of another (prasugrel) can better control blood clotting in heart patients who have both high bleeding and high clotting risks after getting a stent. About 40 adults who have…

This study tests whether adding a special PET-CT scan (POSLUMA) to standard MRI can better detect serious prostate cancer in men whose MRI results are uncertain (PIRADS 2 or 3). About 30 men who have not had a biopsy before will get both scans before their scheduled biopsy. The g…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests a free, self-paced web program that teaches adults how diet and screening can help prevent colorectal cancer. Participants complete six online lessons covering nutrition risks and screening options. Researchers will measure whether the program increases people's …

This study tests a web-based program called T.E.C.H. Parenting that teaches parents of middle-schoolers how to talk about media and set rules around it. The goal is to reduce kids' exposure to substance use in movies, shows, and online content, which may lower their risk of tryin…

This study tests different strategies to increase HPV vaccination among 9- to 12-year-olds in rural North Central Florida. Clinics will be randomly assigned to offer clinician training alone, training plus parent reminders, or all three including help accessing healthcare. Resear…

This study looks at whether drinking cranberry juice every day for 70 days can improve how well healthy adults aged 30 to 55 handle stress and multitask. Participants will do mental and physical tasks while researchers measure their thinking, mood, and stress levels. The study al…

This pilot study tests whether a single session of breathing air with slightly higher carbon dioxide and lower oxygen can improve speech, cough, and movement in people with Parkinson's disease. Participants are randomly assigned to one of two breathing patterns, each lasting abou…

This study tests whether a 2-week gratitude journaling activity is feasible and acceptable for people with temporomandibular disorder (TMD) and other chronic pain conditions. Sixty participants will either write down things they are grateful for or reflect on daily activities. Re…

This study looks at ways to improve the mental health and quality of life for people with a Left Ventricular Assist Device (LVAD) and their family caregivers. After leaving the hospital, both patients and caregivers often struggle with stress and lower well-being. Participants wi…

This study tests whether a nicotine cessation program can help women with breast cancer quit nicotine before reconstructive surgery. About 20 women who use nicotine and are scheduled for mastectomy or lumpectomy with reconstruction will take part. The program includes up to four …

This study tests a new approach for people with worsening heart failure who have too much fluid in their body. Instead of going to the hospital for IV treatment, patients get a water pill (furosemide) as a shot under the skin at home. The study will enroll 100 adults with heart f…

This study tests a new pain self-management program designed specifically for Black adults aged 50 to 92 who have long-term muscle or joint pain (like arthritis or back pain). The program aims to reduce pain during movement and improve daily life. Researchers will compare pain le…

This study tests a device called Walkasins, worn on the legs, that vibrates to give sensory feedback to older adults who have lost some feeling in their feet. The goal is to see if it helps them walk more automatically and with less mental effort. The study involves 30 people age…

This study tests whether combining a special walking exercise with mild electrical brain stimulation can improve thinking and walking in adults aged 65 and older who have memory or mobility problems. Participants will do walking tasks while receiving either real or fake brain sti…

This study tests a 5-week virtual cognitive training program for people aged 65-85 with mild cognitive impairment (MCI). Participants attend weekly two-hour group sessions online, learning memory strategies, mindfulness, and planning skills. Researchers want to see if the shorter…

This study tests whether adding four weekly virtual physical therapy sessions to standard home exercises helps runners with chronic leg pain. About 85 runners aged 18-65 will be followed for 6 months. The goal is to see if this approach reduces pain and improves movement quality.

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests a wearable device that sends gentle, low-frequency electromagnetic fields to the brain to help people who had a stroke more than 6 months ago recover arm movement and reduce disability. About 25 adults with chronic stroke will use the device in a clinic to see if…

This study tests whether taking zinc supplements can help Botox injections last longer for people with cervical dystonia, a condition that causes painful neck muscle spasms. About 25 adults will take either zinc or a placebo daily for 3 months, then switch to the other for anothe…

This study tests whether a new type of deep brain stimulation (called patterned DBS) is safe and tolerable for people with Parkinson's disease to use at home. About 60 adults who already have a DBS device will try the new stimulation pattern for two weeks. The goal is to see if t…

This study tests whether adding polyphenol-rich beans and lentils to the daily diet can improve skin health in women aged 45-65. Over 12 weeks, 50 women will eat either pulses or white rice, and researchers will measure skin sensitivity to UV light, moisture loss, and redness. Th…

This early-phase study tests whether giving oxytocin (a nasal spray) alongside oxycodone can reduce the drug's abuse potential while still easing pain. Researchers will measure pain response, subjective effects, and decision-making in 45 healthy older adults over six lab sessions…

This study tests whether giving extra oxygen early after a spinal cord injury can help recovery. It involves 12 adults with recent traumatic spinal cord injuries who are on a breathing machine. The goal is to see if this treatment is safe and feasible, and if it improves oxygen l…

This study tests whether a device that sends gentle magnetic pulses to specific brain areas can improve thinking and memory in older adults. It includes 20 people aged 65 to 84—half with mild dementia and half without. Participants receive either real or sham stimulation to see i…

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests a new method to program deep brain stimulation (DBS) for Parkinson's disease using the brain's own electrical signals. Instead of the usual time-consuming manual adjustments, doctors will use these signals to pick the best stimulation settings. The goal is to imp…

This study tests whether regular, caring phone calls from trained volunteers can reduce loneliness, depression, and thoughts of suicide in older adults who are homebound and receive community services. About 400 people aged 65 and older will be assigned to one of two types of pho…

Many older adults who survive an ICU stay with delirium continue to have trouble with memory, attention, and planning. This pilot study tests whether a noninvasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can safely improve these cognitive pr…

This study tests whether a wearable device that gently vibrates arm muscles can improve arm and hand function in people with multiple sclerosis (MS). Fifteen adults with relapsing-remitting MS will use the device at home for 4 weeks. Researchers will measure dexterity, coordinati…

This study is testing a program called MyCarePulse and ASCENT to help cancer patients overcome food-related challenges. About 100 adults recently diagnosed with certain cancers will either receive the program or standard care. The goal is to see if the program improves food secur…

This study tests whether a nutritional supplement called Epidiferphane can reduce common side effects of taxane chemotherapy, such as nerve damage and anemia, in breast cancer patients. About 74 participants will receive Epidiferphane alongside their standard chemo to see if it h…

This study tests whether using a special dye (ICG) to map the arm's lymph vessels can make daily arm massage more effective at preventing lymphedema (swelling) after breast cancer surgery. 30 women will be randomly assigned to either ICG-guided massage or traditional massage, and…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests whether walking programs can reduce fatigue in older breast cancer survivors (age 60+). 24 participants will either walk at a center or at home. The goal is to find a practical way to improve energy and well-being after cancer treatment.

This study looks at whether a daily dose of kava can help smokers who want to quit. Researchers will check if kava makes it easier to stop smoking, reduces stress, and improves sleep. About 76 adults who smoke at least 5 cigarettes a day and want to quit will take part for 4 mont…

This pilot study is testing whether the drug linaclotide, usually used for constipation, can prepare the bowel for colonoscopy as well as the standard 4-liter PEG drink. Ten adults scheduled for colonoscopy will take two doses of linaclotide along with Gatorade and a clear liquid…

This study tests whether doing specific shoulder exercises for 6 weeks before reverse shoulder replacement surgery helps patients regain better internal rotation (the ability to reach behind the back). Researchers will compare range of motion, strength, and daily activities betwe…

This study tests a six-week exercise program for older adults (ages 65-90) who recently finished home health care and have trouble moving or thinking. Participants will do task-oriented resistance exercises at home with some remote coaching. The goal is to see if the program is p…

This study tests a new way to use deep brain stimulation (DBS) for essential tremor. Normally, DBS runs all the time, which can cause side effects and make the treatment less effective over time. The researchers will program the device to automatically turn off when you are aslee…

This study tests whether a gentle electrical stimulation on the ear (taVNS) can improve speech understanding in noisy environments for older adults with age-related hearing loss. 36 participants aged 55-80 will receive either active or sham stimulation. The goal is to see if this…

This study tests whether a nerve block injection near the cheek can relieve severe headaches after a brain bleed (subarachnoid hemorrhage). The injection contains a numbing medicine and a steroid. The goal is to see if it reduces the need for opioid painkillers. About 195 adults …

This study tests whether a mild nerve stimulation device (tVNS) can make exposure therapy work better for people with OCD. About 56 adults with moderate to severe OCD will receive either real or fake stimulation during therapy sessions. The goal is to see if the combination reduc…

This study tests a light-based treatment called photobiomodulation (PBM) for pain caused by temporomandibular disorder (TMD). About 130 adults with long-term jaw or face pain will receive either real PBM or a sham treatment to see if it reduces pain. The goal is to find a safe, n…

This study is testing whether a novel exercise program using both arms and legs can help protect the heart in women undergoing chemotherapy for breast cancer. Researchers will measure heart function and blood vessel health in 68 participants. The goal is to find a safe, practical…

This study tests whether taking cannabidiol (CBD) extract under the tongue three times a day can safely ease knee osteoarthritis pain and reduce the need for NSAID painkillers. Thirty adults with moderate to severe knee pain will receive either CBD or a placebo for several weeks.…

This study is testing whether a mild electrical current applied to the scalp (tDCS) can improve working memory in older adults with mild cognitive impairment (MCI). Researchers will compare the effects of real tDCS versus a sham (fake) version in 110 participants aged 60-95. The …

This study is testing a mobile app called uSafeUS+ that aims to help college students drink less and lower their risk of sexual assault. Researchers will enroll 90 students aged 18-25 from participating universities. Participants will use the app for one month and complete survey…

This study looks at whether eating yellow or white potatoes every day can increase levels of lutein and zeaxanthin in the blood and skin. These are nutrients that help with eye health. About 30 adults will eat potatoes daily and have their levels measured. The goal is to see if p…

This study tests whether giving emergency room doctors genetic information about patients can help choose safer medications and reduce return visits. About 1,200 adults aged 40 and older who frequently visit the ER will be randomly assigned to receive genetic testing or usual car…

This early-phase study is testing whether omega-3 fatty acids can reduce inflammation in the heart muscle of people with heart failure with preserved ejection fraction (HFpEF). Researchers will use special MRI scans before and after an iron-based infusion to detect changes in inf…

This study looks at how physical activity and thinking skills change as people age, focusing on Hispanic and non-Hispanic adults aged 55-85. Researchers want to see if it's possible to enroll 100 volunteers and gather early data on aging patterns. The goal is to better understand…

This study looks at how emergency department (ED) doctors handle non-traumatic dental pain, like toothaches. Researchers will interview ED providers and analyze national data to understand why antibiotics and opioids are prescribed and what makes it hard to manage these cases. Th…

This study watches children aged 3 to 9 who need a dental device called a distal shoe after losing a baby tooth early. The goal is to see how often gum problems happen and what makes treatment work best. Researchers hope to create better guidelines for dentists to monitor and man…

This study is testing whether a website with a virtual community health educator can help Black and Hispanic cancer patients in Florida learn about and sign up for clinical trials. About 350 adults will be randomly assigned to either a standard information portal or one with a vi…

This study looks at whether doing certain breathing exercises or spinal stimulation before using a breathing machine (ventilator) can keep the diaphragm strong. The diaphragm is the main muscle for breathing, and ventilators can sometimes weaken it. Sixteen healthy adults will tr…

This study looks at how a treatment called High-Intensity Focused Ultrasound (HiFU) changes brain activity in people with essential tremor (shaking hands). Ten adults over 50 who haven't been helped by standard medications will have their brain waves recorded before and after tre…

This study looks at how pain is processed in people with fibromyalgia and rheumatoid arthritis, two conditions that cause long-term pain. Researchers will measure pressure pain thresholds in 150 adults to compare pain mechanisms. The goal is to better understand the differences a…

This study aims to understand how the shoulder tendon changes right after two different exercise programs. Researchers will use ultrasound to measure tendon thickness before and after exercise in 24 adults, some with shoulder pain and some without. The goal is to see which exerci…

This study is looking at how certain genes affect the immune system and may increase the risk of developing type 1 diabetes. Researchers will collect blood samples from 2,800 people to study immune cells and genetic risk factors. The goal is to better understand why some people d…

This study is tracking 300 adults who are already scheduled to have a procedure called endoscopic submucosal dissection (ESD) to remove abnormal growths in their digestive tract. Researchers want to see how often the lesion can be removed in one piece with clear margins, and how …

This study explores how aging affects the ability to learn who to trust. Researchers will use real-time fMRI to give older adults feedback on their brain activity while they practice trust-related tasks. The goal is to see if this brain training can improve their decision-making …

This study looks at whether a noninvasive device that stimulates the vagus nerve can improve the ability to understand speech in noisy environments for people who have had a traumatic brain injury. Researchers will compare brain responses and speech test scores with and without t…

This study tests a workshop for dentists, hygienists, and assistants to improve how they interact with children aged 2-10 during dental visits. The training is based on a proven behavior program for preschoolers. Researchers will compare providers who get the training immediately…

This study tests a noninvasive light sensor placed on the thumb to measure oxygen levels in children with heart failure. Researchers want to see if these measurements can show how severe the heart failure is. The study will enroll 130 children and young adults under 25 who are st…

This study from the University of Florida is looking at how listening to calming music might affect your health and sense of calm. About 100 participants will listen to a 15-minute music session, fill out surveys, and some will also have their heart rate monitored and give saliva…

This study looks at whether improving the clarity of patient instructions helps people stick to their daily radiation therapy schedule and feel more at ease. Researchers will give 650 first-time radiation patients updated, easy-to-understand materials and track missed treatments,…

This study tests a tele-education program called ECHO Diabetes for primary care providers at 18 federally qualified health centers across the U.S. Providers attend twice-monthly online sessions for 6 months, led by a team at the University of Florida. The goal is to see if this t…

This study is testing two blood tests that look for HPV DNA and RNA to see if they can track how well cervical cancer responds to surgery, radiation, and chemotherapy. Researchers will enroll 55 adults with HPV-related cervical cancer and compare the test results with standard im…

This study looks at whether Parent-Child Interaction Therapy (PCIT) can help parents and children dealing with anxiety, depression, and stress. About 80 parents of children aged 2-7 will complete surveys and provide saliva samples to measure oxytocin levels. The goal is to unders…

This study looks at how losing weight and improving diabetes after bariatric surgery changes brain function and thinking skills. Researchers will also test if a non-invasive nerve stimulation device, started 30 days after surgery, can further improve brain health. The study invol…

This study tests whether wearing goggles that briefly block vision can improve balance training. Participants aged 18-30 or 65-89 will walk on a balance beam while the goggles alternate between clear and occluded vision. Balance is measured before, after, and two weeks later. The…

This study looks at whether measuring big toe strength can help doctors understand nerve damage caused by chemotherapy (called CIPN). Researchers will compare 30 people with CIPN to healthy adults using a special device called ToeScale. Participants will also answer questionnaire…

This study looks at how severe traumatic injury changes the bone marrow and gut, leading to long-term anemia and microbiome disruption. Researchers will collect bone marrow, blood, and stool samples from 275 adults with serious blunt trauma. The goal is to understand these intera…

This study is testing a new way to predict if people with stable coronary artery disease will have a heart attack or heart injury during a planned stent procedure. Researchers will use a genetic score (ABCD-GENE) to sort 500 participants into high- or low-risk groups. The goal is…

This study tests a new imaging method called iRAI that uses sound waves to monitor proton radiation delivery in real time for prostate cancer patients. Researchers will compare the actual radiation dose measured by iRAI with the planned dose from CT scans. The goal is to see if i…

This study looks at how severe injuries change the way bone marrow stem cells work, especially in older adults. Researchers will collect bone marrow and blood samples from 400 trauma patients to understand why some develop long-term anemia and muscle loss. The goal is to learn mo…

This early-phase study at the University of Florida is testing whether combining oxytocin (a nasal spray) with the opioid oxycodone can reduce pain while lowering the drug's abuse potential. Forty-five healthy adults who have used opioids recreationally will take part in six lab …

This study looks at how steep head-down position and two types of anesthesia (total IV vs. balanced) change eye pressure in women having robotic surgery for gynecologic cancer. Researchers will measure eye pressure in 40 participants to see which anesthesia method causes less pre…

This study collects brain tumor tissue samples from 4,000 children and adults undergoing brain surgery. The samples are stored in a tissue bank at the University of Florida for future research. The goal is to help scientists find better treatments and cures for brain tumors.

This study looks at how the thoughts and beliefs of people with chronic low back pain and their physical therapists affect how well physical therapy works. Participants will receive standard care including spinal manipulation, exercise, and education. The goal is to understand th…

This study looks at how severe infections (sepsis) and major injuries change the way the body produces certain immune cells called myeloid cells. Researchers want to understand why these changes can lead to ongoing inflammation and a weakened immune system. The study will follow …

This study looks at what happens to blood and bone marrow after a severe injury. Researchers want to understand why some trauma patients develop a weakened immune system and get serious infections like sepsis. About 255 adults with severe fractures will give blood and a small bon…

This study tests a new way to mark the area where a breast tumor was removed, so radiation therapy can be more accurately aimed afterward. About 50 adults with early-stage breast cancer or a precancerous condition called DCIS will take part. The goal is to see if this marking hel…

This study tests two types of brief, low-oxygen breathing treatments in 18 adults with recent spinal cord injury (2 weeks to 6 months after injury). The goal is to see which treatment better improves breathing strength and cough function. Researchers will also look at genetic dif…

This study tests whether artificial intelligence can predict which older adults with mild memory problems will improve after cognitive training. Researchers will use brain MRI scans from 75 participants to train a machine learning tool. The goal is to personalize future treatment…

This study aims to learn more about alpha-1 antitrypsin deficiency, a genetic condition that can affect the lungs and liver. Researchers will enroll up to 50,000 people who are at risk due to symptoms or family history. Participants will complete questionnaires to help track heal…

This study looks at how red light and blue light affect tooth temperature during dental work and whether that leads to pain afterward. Researchers will measure temperature changes in the tooth and check in with 50 participants after their procedure. The goal is to see if red ligh…

This study tests whether short episodes of breathing low-oxygen air can improve breathing strength in people with chronic spinal cord injury. Participants will try three different breathing sessions (low oxygen, low oxygen with extra carbon dioxide, and normal air) to see which w…

This study from the University of Florida is looking at how two genetic lung conditions—Alpha-1 antitrypsin deficiency and cystic fibrosis—affect immune cells called macrophages. Researchers will collect blood and measure lung function in 220 adults to see how well these cells wo…

This study uses MRI scans to track muscle damage and fat buildup in boys and men with Duchenne or Becker muscular dystrophy over 5-10 years. Researchers will compare these images with how well participants can walk and perform daily activities. The goal is to find better ways to …

This study looks at whether removing the parathyroid gland can improve physical function and mobility in adults aged 60 and older with primary hyperparathyroidism. Researchers will track changes in walking, strength, and daily activity before and after surgery, and analyze blood …

This study looks at how Friedreich's ataxia affects the heart and nerves using advanced imaging, exercise tests, and biopsies. Researchers will track 203 people with the condition to find better ways to measure disease progression. The goal is to improve future treatment studies,…