University Of Florida

This early-stage study tests a new RNA-based vaccine for adults whose glioblastoma (a fast-growing brain cancer) has come back. The main goals are to see if the vaccine can be made safely and to find the best dose. About 24 participants will receive the vaccine to check for side …

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (chemotherapy plus a device that sends electric fields to the brain) can help people with newly diagnosed glioblastoma, an aggressive brain cancer. About 40 adults with good physical functi…

This study tests a drug called tazemetostat in 10 people with a rare type of nerve tumor (MPNST) that has returned or spread. The goal is to see if the drug can shrink tumors or stop them from growing. Participants take the drug by mouth and are monitored with scans to measure re…

This study tests whether a daily kava drink can help active smokers (who don't plan to quit) smoke less and lower their risk of lung cancer. Twenty adults who smoke at least 5 cigarettes a day will take kava for 4 months. Researchers will check how well participants stick with th…

This study looks at whether giving women with chest pain and no major blockages a combination of heart medications (statins, blood pressure drugs, and aspirin) can lower their risk of heart attacks, strokes, or hospital stays. About 2,500 women took part, and half got the intensi…

This early-stage trial tests a personalized treatment for children with recurrent neuroblastoma or newly diagnosed DIPG, two aggressive cancers. The approach combines targeted drugs with a custom-made immune therapy using the child's own cells, including dendritic cells, immune c…

This study looks at whether a time-restricted eating plan (fasting 16 hours each day) can improve memory and thinking in overweight adults over 65 who have mild memory concerns. Participants either follow the fasting plan or attend healthy aging classes for 24 weeks. The goal is …

This study tests a safe, low-cost light therapy (near-infrared photobiomodulation) to see if it can improve memory and brain function in 168 older adults at higher risk for Alzheimer's disease. Participants receive either real or sham light treatment for 12 weeks, and researchers…

This early-stage trial tests a new approach for children whose high-grade glioma has come back after standard treatments. It combines specially grown stem cells with an immunotherapy drug called nivolumab. The main goals are to see if the treatment is safe and possible to deliver…

This study tests whether a higher dose of proton radiation, precisely aimed at tumors seen on MRI, can better control high-risk prostate cancer. About 100 participants will receive radiation over 8-9 weeks, plus hormone therapy for 18 months. The main goal is to see if this appro…

This study tests a new RNA vaccine for children and young adults (ages 3-25) with recurrent high-grade glioma (a brain cancer) or osteosarcoma (a bone cancer). The vaccine aims to train the body's immune system to attack cancer cells. The trial will check safety, the right dose, …

This early-stage study aimed to find the safest dose of NP-101, a drug made from black seed, when given alongside standard radiation therapy (Y-90) for people with liver cancer that cannot be surgically removed. The goal was to see if NP-101 could boost the immune system to impro…

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity or overweight plus related health issues will take part. Half will get a 52-week program with support, and the other half will receive educational ma…

This study tests whether combining two drugs (atezolizumab and tivozanib) can help the immune system attack cancers that usually don't respond to immunotherapy, like certain prostate, pancreatic, and breast cancers. About 29 adults with advanced or metastatic disease who have alr…

This study tests a combination of three chemotherapy drugs (liposomal irinotecan, 5-FU, and oxaliplatin) given before surgery to people with pancreatic cancer that can be removed. The goal is to see if this approach is safe and helps reduce complications after surgery. About 45 a…

This study tests whether newer blood thinners (rivaroxaban or ticagrelor) are better than the standard drug clopidogrel at preventing stroke or death in people with severely narrowed brain arteries. About 1,683 participants who recently had a stroke due to 70-99% narrowing of a m…

This study compares two types of radiation therapy for prostate cancer: proton therapy and standard photon therapy (IMRT). Researchers are tracking quality of life, side effects, and cancer control in 3000 men over time. The goal is to see if one approach causes fewer bowel or ur…

This study tests a specially engineered donor graft (Orca-Q) in children and young adults with certain blood cancers who need a stem cell transplant. The goal is to see if this graft is safe and helps the new cells take hold. About 40 participants will be enrolled.

This early-stage study tests a combination of immune therapies in 12 children and young adults (ages 4-30) whose medulloblastoma has returned. The treatment uses specially trained immune cells, vaccines, and stem cells along with a drug that helps the immune system attack the can…

This study tests whether metformin, a common diabetes drug, is safe and tolerable for people with a specific genetic form of ALS (C9orf72 ALS). About 41 participants will take metformin for 24 weeks. The goal is to see if it can reduce harmful proteins in the body that are linked…

This early-phase study tests a personalized cell therapy for adults with glioblastoma and children with high-grade gliomas. The treatment uses a patient's own immune cells, modified to target a protein called CD70 on tumor cells and to better navigate to the brain. The main goals…

This study tests a new type of deep brain stimulator for people with essential tremor, a condition that causes uncontrollable shaking. Unlike standard devices that stimulate the brain constantly, this "closed-loop" system only delivers stimulation when it senses tremor activity. …

This early-phase study tests whether a new type of immune cell therapy is safe and possible to make for people with aggressive brain tumors called high-grade gliomas. The therapy uses a patient's own immune cells, modified to recognize and attack tumor cells that carry a specific…

This early-phase study tests a new treatment for adults with a type of brain tumor called oligodendroglioma that has come back or is growing. The treatment uses the patient's own immune cells (dendritic cells, T cells, and stem cells) combined with targeted drugs. The main goals …

This study provided a single patient with recurrent osteosarcoma (a type of bone cancer) access to an experimental treatment made from their own tumor's genetic material. The treatment, called RNA-loaded lipid particles (RNA-LPs), was designed to help the immune system fight the …

This study is testing whether a daily probiotic supplement can help preserve the body's ability to produce insulin in adults with Type 1 diabetes. Researchers are giving 46 participants either the probiotic or a placebo for 24 weeks to see if it's safe and if it affects the immun…

This study looks at whether cranberries can prevent urinary tract infections (UTIs) in women who are prone to them. Researchers will test if cranberry juice makes urine more resistant to E. coli bacteria. The study involves 55 healthy women who will drink cranberry juice and prov…

This study looks at whether pregnant women eating two eggs each day can lead to longer, healthier babies at birth. Researchers in Rwanda are giving eggs to some mothers and comparing their babies to those whose mothers ate their usual diet. The goal is to find a simple, affordabl…

This study tests whether a nerve block placed in the face can reduce pain and the need for strong painkillers after cleft palate repair in children. About 40 children having this surgery will receive the nerve block. The goal is to help them start eating and drinking sooner and g…

This study tests whether a fiber from baker's yeast (mannooligosaccharides) can improve digestion and reduce stomach discomfort in older adults. Researchers will track daily gut symptoms and changes in gut bacteria in 40 healthy volunteers aged 50-99. The goal is to see if this n…

This study tests whether a medication called istradefylline, combined with short periods of breathing air with less oxygen (acute intermittent hypoxia), can improve breathing in people with ALS. About 40 adults with ALS and healthy volunteers will take part. The goal is to see if…

This study tests whether a non-invasive device that sends a mild electrical current to the spine can improve walking when combined with treadmill training. 18 adults with incomplete spinal cord injury will receive either real or fake stimulation during 36 sessions. The goal is to…

This early-stage study tests a special cord blood product (CFL001) in 9 adults with sacroiliac joint pain. The main goal is to check safety and see if it helps reduce pain and improve quality of life. Participants receive a single injection and are monitored for side effects and …

This study looks at whether a fermented papaya supplement can improve driving and thinking skills in healthy older adults aged 70 to 80. Participants take three doses of the supplement in one day and then complete a driving simulator test. The goal is to see if the supplement red…

This study looks at whether adding epinephrine to a nerve block behind the cheek can lessen bleeding during sinus surgery for people with chronic sinusitis. About 80 adults will take part. The goal is to see if this approach makes the surgery cleaner and potentially safer.

This study tests whether a daily supplement made from yeast (called yeast mannan) can increase how often healthy adults who have bowel movements once a day or less go to the bathroom. About 70 adults will take either the yeast supplement or a placebo for 28 days. Researchers will…

This study looks at whether listening to music with special sonic enhancements can help people feel calmer and improve emotional well-being. About 76 adults aged 18 to 89 will listen to 15 minutes of music during an online Zoom session and complete surveys before and after. The g…

This study looks at whether using a simple genetic test (CYP2D6) can help doctors prescribe better opioid painkillers for people recovering from ventral hernia repair. About 100 adults having elective surgery will be split into two groups: one gets standard pain management, the o…

This study is testing whether drinking cranberry juice every day for over two months can help people who do a lot of multitasking. Researchers want to see if it improves mental focus, reduces feelings of stress and fatigue, and changes stress-related body signals. The study will …

This study looks at whether genetic testing can help doctors choose the right medications for patients who often have less access to personalized care. About 492 adults with at least three active prescriptions will have their DNA tested to see how it affects their response to dru…

This study looks at whether listening to music enhanced with Sonic Augmentation Technology (SAT) can improve health and wellness. About 36 adults aged 18-89 who work at UF Health Jacksonville will listen to a 15-minute music session and complete surveys and saliva tests. The goal…

This study looks at whether eating sweet corn every day for 4 weeks can increase levels of healthy pigments called carotenoids in your blood and skin. It also checks if corn affects digestion and gut bacteria. About 40 healthy adults will participate to see if this common vegetab…

This study follows 347 heart surgery patients to find out why some develop swallowing problems. Researchers will identify risk factors and create simple bedside tests to catch these issues early. The goal is to improve care and prevent complications after cardiac surgery.

This study looks at whether a gentle brain stimulation technique called tDCS can improve how well the brain's networks work together during walking and thinking tasks. Researchers will test 60 older adults with mild memory concerns, giving them either real or fake stimulation whi…

This study compares how well radiologists find lung nodules and early lung cancer on chest X-rays with and without the help of an artificial intelligence (AI) tool. It includes adults over 35 getting routine chest X-rays, but excludes those already known to have lung cancer. The …

This study tests a computer system that uses routine hospital data to predict risks of complications after surgery. Researchers will compare the computer's risk scores to those made by surgeons and anesthesiologists for the same patients. About 200 healthcare providers will parti…

This study is collecting information from over 1,600 people who have had a heart stent procedure and received genetic testing to guide their blood thinner medication. Researchers want to learn how factors like ancestry and other genes affect treatment success and safety. The goal…

This study tests a computer program that uses brain scans to tell apart Parkinson's disease from two similar conditions. About 315 people with these diagnoses will get an MRI and a checkup at one of 21 medical centers. The computer's diagnosis will be compared to the opinion of t…

This study looks at 90 adults with sepsis who develop confusion or delirium. Researchers measure specific proteins in the blood to see if they can predict brain injury and long-term outcomes. No new treatments are tested—the goal is to better understand how sepsis affects the bra…

This study looks at why cranberry juice helps some women avoid urinary tract infections (UTIs) but not others. Researchers think the answer lies in the gut microbiome—the unique mix of bacteria in each person's digestive system. 160 healthy women who are prone to UTIs will drink …

This study collects medical information and tissue samples (blood, liver, lung) from people with Alpha-1 Antitrypsin Deficiency to build a research bank. The goal is to help scientists better understand the disease and develop new treatments. Anyone with Alpha-1 can join, and no …

This study tests whether a mild, non-invasive stimulation of the vagus nerve (through the ear) can help teenagers with dyslexia learn new letter-sound connections. About 100 adolescents with either typical reading skills or dyslexia will take part. They will complete six 30-minut…

This study tests a new microfluidic device that uses a very small blood sample (about half a teaspoon) to measure how well infection-fighting cells (neutrophils) work in premature babies. Sepsis is a major cause of death and long-term health problems in preterm infants, and curre…

This study looks at whether cleaning the mouth of very premature babies more often (every 3-4 hours vs every 12 hours) can reduce harmful bacteria and lower the risk of lung infections and other breathing problems. About 40 babies born before 32 weeks and weighing less than 1500 …

This study tests a web-based program called CHOICES to help adults with sickle cell disease or trait learn about their reproductive health. The goal is to see if the program improves knowledge about genetic risks, safe contraception, and pregnancy options. 506 men and women aged …

This study is creating a large database of medical information and biological samples from 1,000 infants born with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. Researchers will measure blood-based biomarkers to better understand the cond…

This study examines whether a common gene variation (CYP2C19) affects the long-term risk of serious heart and blood vessel problems, such as heart attacks, strokes, and limb complications. Researchers will analyze medical records from 13,000 adults who have already had genetic te…

This study aims to develop a better way to monitor the immune system in people who have received a liver transplant. Researchers will check if a new method can help doctors give the right amount of immunosuppression drugs to prevent rejection while avoiding infections. The study …

This study looks at two different school-based mental health screening methods to see which one helps more African-American elementary students get the mental health services they need. Researchers will track how many students are referred to help and how many disciplinary issues…

This study uses artificial intelligence to analyze video recordings of surgeons during operations. The goal is to identify poor posture and movements that lead to work-related muscle and joint pain. Researchers will also test if showing surgeons their own video and risk data help…

This study looks at how different ways of processing sweet corn change its effect on blood sugar. About 45 healthy adults will eat sweet corn or drink a sugar solution on separate mornings, and have their blood sugar measured. The goal is to learn which corn products are better f…