University Of Florida

This study tests whether a higher dose of proton radiation, focused on tumors seen on MRI, can better control high-risk prostate cancer. About 100 participants will receive radiation over 8-9 weeks, plus hormone therapy for 18 months. The goal is to lower the chance of cancer ret…

This large phase 3 trial tests whether newer blood thinner combinations (ticagrelor plus aspirin or rivaroxaban plus aspirin) are better than the standard clopidogrel plus aspirin at preventing stroke, brain bleeding, or death from blood vessel disease. Over 1,600 participants wi…

This study tests whether polyphenols from muscadine wine, served as a non-alcoholic beverage, can improve cognitive performance, memory, mood, and anxiety in healthy adults over 50. Participants will drink either the polyphenol-rich beverage or a placebo and complete a series of …

This study tests whether a brief, personalized online tool (MyHealthPath) can increase the number of adults with obesity who start a comprehensive behavioral weight loss program. Participants will be randomly assigned to receive either the tailored tool or informational material.…

This study tests a new robotic surgery technique for kidney cancer that avoids clamping blood vessels and using stitches to close the kidney. The goal is to preserve as much kidney function as possible and reduce the risk of long-term kidney disease. About 59 adults with small ki…

This study tests a new dye called Magtrace that stays in the lymph nodes for weeks. For women with non-invasive breast cancer (DCIS) having a mastectomy, this dye may allow doctors to safely delay lymph node removal until after the breast tissue is checked for hidden invasive can…

This study tests a digital program designed to help young adults (ages 18-28) who are not in college and live in disadvantaged communities reduce risky drinking. The program combines a brief motivational interview with a session that encourages engagement in enjoyable, alcohol-fr…

This phase 2 trial tests the drug tazemetostat in 10 people with recurrent, treatment-resistant, or metastatic malignant peripheral nerve sheath tumors (MPNST), a rare and aggressive cancer. Participants take tazemetostat pills twice daily for up to 2 years. The main goal is to s…

This study looks at whether cleaning the mouth of very premature infants every 3-4 hours can reduce harmful bacteria and lower the risk of pneumonia and other breathing problems. Researchers will follow 40 infants born before 32 weeks and weighing less than 1500 grams, comparing …

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity from primary care clinics will take part. One group gets extra support and motivation to use these tools, while the other group gets basic informatio…

This study provided a single patient with recurrent osteosarcoma (a type of bone cancer) access to a personalized treatment made from their own tumor's genetic material. The therapy, called RNA-loaded lipid particles (RNA-LPs), was given intravenously to try to control the cancer…

This study tests a specially engineered donor graft called Orca-Q in children and young adults with blood cancers who need a stem cell transplant. The graft is designed to help the new cells take hold and reduce complications. The trial is currently on hold, but aims to enroll 40…

This study tests a new RNA-lipid particle vaccine for children and young adults (ages 3-25) with recurrent high-grade glioma or osteosarcoma that has spread to the lungs. The vaccine is made from the patient's own tumor material and aims to train the immune system to attack the c…

This study follows 3000 men with prostate cancer to compare how proton therapy and standard photon radiation affect quality of life and side effects like bowel urgency. Participants receive standard care at proton or photon centers, and researchers track bowel, urinary, and sexua…

This phase II trial is testing a combination of liposomal irinotecan (Onivyde) and FOLFOX chemotherapy given before surgery to people with pancreatic cancer that can be removed. The study includes 45 adults with early-stage disease. The goal is to see if this approach is safe and…

This was a planned Phase 1 study to test NP-101, a drug made from black seed, in people with liver cancer that cannot be removed by surgery. Participants would have taken NP-101 daily for 28 days before receiving standard Y-90 radiation treatment. The goal was to find the safest …

This study tests whether a daily kava drink can help active smokers who don't plan to quit reduce their smoking and lower their risk of lung cancer. Twenty adult smokers will take kava daily for several months. Researchers will check how well participants stick with the regimen, …

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (temozolomide chemotherapy and Tumor Treating Fields) can help people with newly diagnosed glioblastoma live longer without their cancer growing. About 40 adults with this aggressive brain …

This study tests a new type of deep brain stimulation for essential tremor that only delivers electricity when a tremor is detected, rather than constantly. The goal is to reduce side effects like slurred speech and walking problems, and make the battery last longer. About 20 adu…

This early-stage trial tests a new approach for children whose high-grade glioma has come back after standard treatments. It combines specially grown stem cells with an immunotherapy drug called nivolumab. The main goals are to see if the treatment is safe and possible to deliver…

This study tests whether metformin, a widely used diabetes drug, is safe for people with a specific genetic form of ALS (C9orf72). Over 24 weeks, 41 participants will take metformin to see if it reduces toxic proteins linked to the disease. The goal is to determine if metformin c…

This study tests an AI tool called AIDP that analyzes MRI scans to help diagnose Parkinson's disease and two similar conditions (MSA and PSP). Researchers at 21 sites will compare the AI's diagnosis to that of movement disorder specialists. The goal is to see if the tool can impr…

This study explores why cranberries prevent urinary tract infections (UTIs) in some women but not others. Researchers will test the urine of 55 healthy women before and after drinking cranberry juice to see if it stops bacteria from sticking to the bladder. The goal is to identif…

This study tests whether a nerve block placed in the face can reduce pain and the need for strong opioid drugs after cleft palate surgery in children. The goal is to help kids start eating and drinking sooner and go home faster. The study involves 40 children having cleft palate …

This study investigates whether a hemp-derived cannabidiol (CBD) extract can safely reduce anxiety and improve sleep in adults with moderate to severe anxiety. Over four weeks, participants take 50 to 150 mg of CBD daily, with doses adjusted based on tolerance. The trial tracks s…

This study tests whether using a genetic test (CYP2D6) to choose pain medications can improve pain control and quality of life for 100 adults undergoing elective ventral hernia repair. Participants receive either standard pain meds or meds guided by their genetic profile. The goa…

This study tests whether guided meditation delivered through a tablet or virtual reality headset can reduce the risk of delirium in hospitalized adults. Delirium is a sudden state of confusion that can occur during a hospital stay, especially in the ICU. The trial will measure ch…

This study tests whether a non-invasive electrical stimulation applied to the back can boost the benefits of walking therapy for people with incomplete spinal cord injury. 18 adults with chronic spinal cord injury will receive either real or fake stimulation during their walking …

This study looks at whether drinking cranberry juice for 70 days can improve thinking, motor accuracy, and reduce stress in healthy adults aged 30-55 who often multitask. Participants will be randomly assigned to one of two cranberry juices or a placebo. The goal is to see if the…

This pilot study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve letter learning in 100 adolescents with dyslexia. Participants will learn new letter-sound relationships during six 30-minute sessions while receiving either ac…

This study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can improve speech recovery in people with aphasia after stroke or brain injury. Twelve adults with apraxia of speech will receive either active or sham stimulation during 16 wee…

This study tests whether a daily supplement made from yeast cell walls can increase bowel movements in healthy adults who currently go once a day or less. 70 participants will take either the yeast supplement or a placebo for 28 days. Researchers will track stool frequency, diges…

This study tests whether a drug called istradefylline, combined with short periods of breathing low-oxygen air (acute intermittent hypoxia), can improve breathing in people with ALS. About 40 adults with ALS and healthy volunteers will take part. The goal is to see if this combin…

This study looks at whether listening to music with special sonic enhancements can help people feel calmer and improve emotional well-being. About 76 adults aged 18 to 89 will listen to 15 minutes of music during an online Zoom session and complete surveys before and after. The g…

This early-stage trial tests a special cord blood product (CFL001) in 9 adults with chronic sacroiliac joint pain. The main goal is to check safety, but researchers will also look for signs of pain relief and improved quality of life. Participants receive a single injection, and …

This study is testing whether a daily supplement made from baker's yeast can improve digestion and reduce gut symptoms in healthy adults aged 50 to 99. Participants take 15 grams of the supplement each day and report any changes in how their stomach feels. The goal is to see if t…

This study tests if shining a special near-infrared light on the head and through the nose can improve memory and brain function in older adults at risk for Alzheimer's disease. The treatment, called photobiomodulation, is low-risk and aims to boost brain cell energy. 168 partici…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study explores whether wearable accelerometers and cameras can automatically detect delirium in intensive care unit patients by tracking changes in movement and facial expressions. Delirium, a sudden state of confusion, often goes undetected despite being common in hospitali…

This study looks at whether eating yellow or white potatoes every day can increase levels of lutein and zeaxanthin in the blood and skin. These are nutrients that help with eye health. About 30 adults will eat potatoes daily and have their levels measured. The goal is to see if p…

This study explores whether artificial intelligence and video monitoring can recognize pain and delirium in intensive care unit (ICU) patients who cannot communicate verbally. Researchers will use cameras, accelerometers, and other sensors to capture facial expressions and body m…

This study tests whether listening to music enhanced with sonic augmentation technology—which embeds natural body rhythms like breathing and heart rate into the music—can improve health and wellness. Thirty-six adults will listen to either the augmented music or a Mozart piece, a…

This Phase 2 trial tests whether dichloroacetate (DCA), a drug that affects cell energy use, can alter tumor metabolism in people with recurrent glioblastoma. Forty patients scheduled for surgery will either receive DCA or no drug for one week before their operation. Researchers …

This study looks at whether hospitals can safely reduce the use of fall prevention alarms. About 300 hospital staff and units will try different strategies like education and feedback to see if they can lower alarm use without increasing patient falls. The goal is to improve pati…

This study looks at whether eating sweet corn every day for 4 weeks can increase levels of healthy nutrients called carotenoids in the blood and improve gut health. Researchers will measure carotenoids in the skin and blood, and track any digestive symptoms or changes in gut bact…

This study follows over 1,800 adults who had early-stage lung cancer treatment to see how often they get CT scans and whether scanning every 6 months helps them live longer than yearly scans. Researchers will also check if scan frequency differs by race, income, or location. The …

This study looks at how fresh and processed sweet corn affect blood sugar levels and hunger. About 45 healthy adults will eat different sweet corn products and have their blood sugar measured over two hours. The goal is to find out which types of sweet corn have a lower glycemic …

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study is testing a new method to monitor the immune system after a liver transplant. The goal is to see if a personalized approach can help doctors adjust immunosuppression drugs more accurately, reducing the risk of rejection or infection. Forty adult liver transplant recip…

This study compares two versions of school-based mental health screening to see which helps more African-American elementary students get the mental health services they need. Researchers will track referrals and disciplinary incidents across many schools. The goal is to find bet…

This study tests a new microfluidic device that uses a very small blood sample to measure how well immune cells (neutrophils) function in premature newborns. The goal is to see if this test can predict which babies will develop sepsis, a life-threatening infection. Researchers wi…

This study is creating a database of medical information and biological samples (blood, urine, and cheek swabs) from 1,000 newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. The goal is to measure biomarkers in the blood that cou…

This registry studies how genetic information can help doctors choose the best antiplatelet medication for people who have had a heart stent procedure. Over 1,600 participants will provide DNA samples and be followed for 12 months to track heart events and bleeding. The goal is t…

This study tests a web-based tool called CHOICES that provides tailored information about reproductive health options for people with sickle cell disease or trait. The study involves 506 adults aged 18-45 who plan to have a child within two years. The goal is to see if the tool i…

This study collects medical information and tissue samples (blood, liver, and lung) from up to 5,000 people with Alpha-1 Antitrypsin Deficiency. The samples are stored and shared with researchers to learn more about the disease. No treatment or medication is given. Anyone interes…

This study tests a computer system that uses patient data to predict complications after surgery. Doctors and the computer will each give risk scores for 200 patients, and researchers will compare which is more accurate. The goal is to see if technology can help improve surgical …

This study uses artificial intelligence to analyze video recordings of surgeons during operations, identifying risky postures that can lead to muscle and joint pain. Researchers will then give surgeons a short educational session and video feedback to see if it helps them move mo…

This study looks at whether giving patients genetic test results early can help doctors choose better medications. About 492 adults with at least three prescriptions will be randomly assigned to get immediate or delayed genetic testing. The goal is to see if this approach improve…

This study looks at blood markers in 90 sepsis patients who develop confusion or delirium. Researchers will take blood samples over 72 hours to measure proteins linked to brain injury. The goal is to find patterns that predict recovery or long-term problems.

This study planned to see if an artificial intelligence (AI) program called qXR-LN could help radiologists find more lung nodules and cancers on chest X-rays. Researchers would compare how often nodules were detected before and after the AI was put into use. The study was withdra…

This study investigates why cranberry juice prevents urinary tract infections (UTIs) in some women but not others. Researchers will have 160 healthy women who are prone to UTIs drink cranberry juice or a placebo (apple juice) daily for three weeks. They will measure how well the …