University Of Florida

This study is testing whether combining two existing cancer drugs can help control advanced cancers that usually don't respond to standard immunotherapy. The trial is for adults with specific advanced cancers, like certain types of pancreatic, breast, and prostate cancer, who hav…

This study is testing whether metformin, a common diabetes medication, is safe and tolerable for people with a specific genetic form of ALS caused by a C9orf72 mutation. Researchers want to see if taking metformin for 24 weeks can reduce levels of harmful proteins in the brain an…

This study is testing a new 'smart' version of deep brain stimulation for people with severe essential tremor. The device is designed to sense when a tremor is starting and deliver stimulation only at that moment, rather than running continuously. Researchers hope this approach w…

This early-stage study is testing a new, personalized vaccine made from a patient's own tumor RNA. It aims to see if this vaccine is safe and to find the best dose for adults with a type of brain cancer called glioblastoma and for children with high-grade brain tumors. The vaccin…

This early-stage trial is testing whether a combination of specially prepared stem cells and an immunotherapy drug (nivolumab) can help children and young adults with aggressive brain tumors that have returned after standard treatment. The study involves 12 participants aged 4-26…

This study is testing whether a more intensive combination of common heart medications (statins, blood pressure pills, and aspirin) can better protect women who have chest pain and signs of heart stress, but whose main heart arteries are not severely blocked. It compares this str…

This study is testing whether a probiotic supplement called Lactobacillus johnsonii N6.2 can help people with Type 1 diabetes. Researchers want to see if improving gut health can help preserve the body's ability to produce insulin. The trial involves 46 adults who will take the p…

This is a small, early-stage study testing a complex, personalized immune therapy for children and young adults whose medulloblastoma, a type of brain cancer, has come back. The goal is to see if it's safe and possible to combine several treatments: a custom-made vaccine, special…

This study is testing a personalized computer program designed to help doctors find the best dose of anti-rejection drugs for people who have received a liver transplant. It aims to better balance the risk of the body rejecting the new organ against the side effects of the medica…

This study is testing whether cleaning the mouths of very small premature babies more often can help prevent serious lung infections and breathing problems. Researchers are comparing mouth care done every 3-4 hours to care done every 12 hours in 40 babies. They will check if more…

This study is testing whether adding an immunotherapy drug (pembrolizumab) to the standard two-part treatment for glioblastoma can help patients live longer without their cancer getting worse. It will involve about 40 adults with newly diagnosed glioblastoma who have already had …

This is an early-stage safety study testing a new type of personalized cell therapy for aggressive brain tumors in adults and children. Doctors take a patient's own immune cells, modify them in a lab to better target and attack cancer cells that have a specific marker called CD70…

This study is testing whether the drug tazemetostat can help control a rare and aggressive cancer called malignant peripheral nerve sheath tumor (MPNST) that has come back or spread. It is for patients aged 12 and older whose cancer has not responded to other treatments. The main…

This study is testing whether a daily supplement made from kava, a plant from the Pacific Islands, can help people who smoke reduce their tobacco use and lower their risk of developing lung cancer. Researchers will give the supplement to 20 adult smokers in Florida who currently …

This early-stage study is testing whether modified immune cells can be safely used to treat aggressive brain tumors in children and adults. Researchers are collecting patients' own immune cells, modifying them to target a specific protein found on tumor cells, and then reinfusing…

This study is testing whether changing Invisalign clear aligners every 3 days instead of the standard 7 days leads to more predictable tooth movement and faster treatment. Researchers will compare the two schedules in 40 healthy adults with mild to moderate crowding. The goal is …

This large study aims to find the best medication to prevent future strokes in people who have recently had a stroke caused by a severely narrowed brain artery. It will compare newer blood-thinning drugs (rivaroxaban and ticagrelor) to the standard drug (clopidogrel) in over 1,60…

This early-stage study is testing a personalized treatment for adults whose oligodendroglioma, a type of brain tumor, has come back or gotten worse. Doctors will use a patient's own tumor and immune cells to create a custom vaccine and immune cell therapy, given alongside standar…

This early-stage study is testing personalized mRNA vaccines for adults with recurrent glioblastoma, an aggressive brain cancer. Researchers will create vaccines using genetic material from each patient's own tumor tissue, combined with a standard mRNA component. The main goals a…

This early-stage study aimed to test the safety and find the right dose of a natural compound called NP-101 in people with advanced liver cancer that cannot be removed by surgery. The compound, derived from black seed, was given alongside a standard radiation treatment (Y-90) to …

This study is testing a new, personalized vaccine made from a patient's own tumor RNA. It aims to teach the immune system to recognize and attack cancer cells in children and young adults whose aggressive brain tumors or bone cancer have come back. The main goals are to see if th…

This study is testing whether a daily fasting schedule can help improve brain function and overall health in older adults who are overweight and noticing memory problems. For 24 weeks, participants will either follow a time-restricted eating plan (fasting for about 16 hours each …

This early-stage study is testing a new, personalized treatment for children with two aggressive cancers: recurrent neuroblastoma or a newly diagnosed brain stem tumor called DIPG. Doctors create a custom treatment using the patient's own immune cells and tumor material, aiming t…

This study is testing a more precise form of radiation therapy for men with high-risk prostate cancer. It uses proton beams and advanced MRI scans to deliver a stronger radiation dose directly to the visible tumor inside the prostate, while trying to limit damage to surrounding h…

This study is observing patients who have had a heart stent procedure to see if using a genetic test to choose their blood thinner medication leads to better outcomes. Researchers are tracking about 1,600 patients for a year to see if this personalized approach helps prevent futu…

This study compares two school-based mental health screening approaches to help African-American elementary students get needed mental health services. Researchers are testing whether enhanced screening methods can reduce the gap in unmet mental health needs that disproportionate…

This study is testing whether a non-invasive light therapy can improve brain health and memory in older adults who are at increased risk for Alzheimer's disease. Researchers are using near-infrared light delivered through a headset and nasal device to 168 participants over 12 wee…

This large study compares two standard radiation treatments for prostate cancer: proton therapy and photon therapy. It aims to see which one leads to better quality of life, fewer side effects, and effective disease control for 3,000 men. The study is observational, meaning patie…

This study is testing whether a combination of three chemotherapy drugs is safe and effective when given before surgery for pancreatic cancer. The goal is to shrink tumors to make them easier to remove completely. The trial involves 45 adults with newly diagnosed pancreatic cance…

This study is testing whether adding a new type of PET scan (called POSLUMA) to a standard MRI can improve the detection of serious prostate cancer in men whose initial MRI results are unclear. Researchers want to see if this combined approach is more accurate than using MRI alon…

This study is testing a new computer software tool that analyzes brain scans to help doctors tell the difference between Parkinson's disease and similar movement disorders. Researchers at 21 medical centers are comparing the tool's accuracy against diagnoses made by expert neurol…

This study aimed to test a new iron-based tracer called Magtrace. The goal was to see if it could help patients with a very early form of breast cancer (DCIS) avoid having lymph nodes removed during their mastectomy surgery. If invasive cancer was later found in the breast tissue…

This study is testing a new computer system designed to predict a patient's risk of complications after major surgery. The system analyzes patient data in real-time and generates a risk score. Researchers are comparing how accurate these computer-generated scores are against the …

This study aimed to see if an artificial intelligence (AI) tool could help radiologists find more lung nodules and diagnose lung cancer earlier on standard chest X-rays. It planned to compare detection rates before and after the AI was introduced into hospital systems. The trial …

This study is testing a new, very small blood test to help doctors spot sepsis (a serious bloodstream infection) earlier in premature babies. Researchers are using a drop of blood to see if they can predict which babies will get sick and have a harder recovery. The goal is to cre…

This study is testing whether eating two eggs every day during pregnancy can help babies be born longer and healthier. It involves 956 pregnant women in Rwanda. Half will eat two eggs daily, while the other half follow their usual diet, to see if the eggs make a difference in the…

This study aims to prevent work-related pain and injuries in surgeons by using artificial intelligence to analyze video of them during operations. Researchers will record 20 surgeons during 10 surgeries each to identify risky postures and movements that lead to muscle and joint p…

This study is testing if adding a drug called epinephrine to a specific nerve block can reduce bleeding during sinus surgery. It involves 80 adults with chronic sinusitis who are scheduled for a common procedure called FESS. The goal is to see if this approach makes the surgery s…

This study is testing whether a drug called istradefylline, when combined with short periods of breathing low-oxygen air, can help people with ALS breathe more deeply. It involves 40 participants, including people with ALS and healthy adults, across four separate study visits. Th…

This study is testing whether using a patient's genetic information to guide opioid painkiller prescriptions after hernia surgery is practical and effective. It will compare this personalized approach to standard care in 100 adults having planned hernia repair. The goal is to see…

This study is testing whether drinking cranberry juice daily for over two months can help healthy adults between 30 and 55 years old cope better with the mental and physical stress of multitasking. Researchers want to see if the juice improves focus, accuracy, mood, and reduces s…

This study is testing a new way to manage pain after cleft palate repair surgery in children. Instead of relying heavily on strong opioid painkillers, doctors are testing a targeted nerve block injected near the cheekbone. The goal is to see if this block can reduce pain, lower t…

This small pilot study is testing whether a guided prayer and relaxation program can help adults with sickle cell disease manage their daily pain and stress. Researchers want to see if this non-drug approach, used alongside regular pain medication, can improve sleep and potential…

This is a very early, small study to first check if a special cord blood product (CFL001) is safe for people with chronic pain in the sacroiliac joint, a common cause of lower back pain. Nine adults with significant, long-lasting pain who haven't gotten enough relief from standar…

This study compares two ultrasound methods for placing epidural anesthesia in boys having circumcision surgery. Researchers want to see if a newer 'biplane' ultrasound helps doctors place the pain-blocking injection more accurately on the first try. If successful, this could mean…

This study aims to understand why cranberry juice helps prevent urinary tract infections (UTIs) in some women but not others. Researchers are testing whether women can be divided into 'responders' and 'non-responders' based on how their bodies process cranberry compounds. The stu…

This study aims to understand why some patients develop swallowing problems after heart surgery. Researchers are following 347 patients to identify risk factors and create simple bedside screening tools. The goal is to improve care by predicting and catching these complications e…

This study tests an online education program designed to help adults with sickle cell disease or trait make informed decisions about having children. The program provides information about genetic risks, reproductive options, and pregnancy safety. Researchers want to see if this …

This study aims to understand how eating yellow and white sweet corn daily affects nutrient levels and digestive health. Researchers will measure specific nutrients in the blood and skin, and monitor gut bacteria and any digestive symptoms in 40 adults over 4 weeks. The goal is t…

This study is creating a large collection of medical information and tissue samples (like blood, liver, or lung tissue) from people with Alpha-1 Antitrypsin Deficiency. The goal is to build a resource for future scientists to study this genetic condition. Participants provide inf…

This study is testing if a supplement made from baker's yeast can improve gut health in older adults. Researchers will give 40 participants the supplement daily for three weeks to see if it helps with digestion and changes gut bacteria. The goal is to learn if this ingredient cou…

This study is testing if a gentle, non-invasive stimulation device worn on the ear can help teenagers with dyslexia learn new letters and sounds more effectively. Researchers want to see if the device is comfortable to use over several sessions and if it changes how the brain res…

This study aims to develop new, less invasive ways to measure how the body uses energy and maintains its daily rhythms. Researchers are enrolling 15 overweight adults aged 65+ to follow a time-restricted eating pattern. They will use smart rings and blood tests to see if this eat…

This study is testing whether genetic screening can help doctors choose medications that work better for individual patients, particularly focusing on underserved communities. Researchers are comparing patients who receive this genetic testing with those who receive standard care…

This study aims to understand if a special music technology can help improve emotional well-being and calm the body's stress response. Participants will listen to 15 minutes of music online and fill out surveys about their feelings before and after. The goal is to learn how this …

This study aims to create a large database and collect samples from infants who experienced a brain injury from lack of oxygen during birth (HIE). It involves up to 1,000 infants in Florida and will gather their medical information along with blood and other samples. The goal is …

This study aims to understand why some sepsis patients develop sudden confusion or delirium, a condition linked to worse survival. Researchers will measure specific proteins in the blood of 90 emergency room patients with sepsis, comparing those with and without mental changes. T…

This study aims to understand if listening to music enhanced with special technology can help people feel calmer and improve their sense of wellness. Researchers will enroll 36 adult employees to listen to either the special music or regular classical music for 15 minutes. They w…

This study is exploring whether a gentle, non-invasive form of brain stimulation can improve walking and navigation skills in older adults who have noticed some memory changes. Researchers will use a technique called tDCS on 60 participants while they walk and do thinking tasks. …

This study aims to understand why cranberry juice helps prevent urinary tract infections (UTIs) in some women but not others. Researchers are looking at how a person's gut bacteria might affect how their body processes the juice. They will compare urine samples and gut bacteria f…